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  1. Article ; Online: Depression symptoms and cognition in multiple sclerosis: Longitudinal evidence of a specific link to executive control.

    Anderson, Jordyn R / Fitzgerald, Kathryn C / Murrough, James W / Katz Sand, Ilana B / Sorets, Tali R / Krieger, Stephen C / Riley, Claire S / Fabian, Michelle T / Sumowski, James F

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2023  Volume 29, Issue 13, Page(s) 1632–1645

    Abstract: Background: Depression symptoms are prevalent in multiple sclerosis (MS) and associated with poorer cognition in cross-sectional studies; it is unknown whether changes in depression symptoms track with cognitive changes longitudinally.: Objective: ... ...

    Abstract Background: Depression symptoms are prevalent in multiple sclerosis (MS) and associated with poorer cognition in cross-sectional studies; it is unknown whether changes in depression symptoms track with cognitive changes longitudinally.
    Objective: Investigate whether changes in depression symptoms correspond with cognitive changes over time in MS, and identify specific cognitive functions related to depression symptoms.
    Method: Persons with early relapse-onset MS (
    Results: Change in depression symptoms was related to change in executive control (
    Conclusions: Executive control tracks with depression symptoms, raising hope that management of mood may improve executive control. The specific link between executive control and anhedonia implicates dysfunctional reward processing as a key component of MS depression.
    MeSH term(s) Humans ; Executive Function ; Multiple Sclerosis/complications ; Multiple Sclerosis/psychology ; Depression ; Cross-Sectional Studies ; Neuropsychological Tests ; Cognition
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585231198746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4428: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Disparities by Race in Pregnancy Care and Clinical Outcomes in Women With Multiple Sclerosis: A Diverse Multicenter Cohort

    Radzik, Anne Marie / Amezcua, Lilyana / Anderson, Annika / Gilmore, Serena / Ahmad, Sophie / Brandstadter, Rachel / Fabian, Michelle T / Graham, Edith L / Hodgkinson, Sophia / Horton, Lindsay / Jacobs, Dina A / Katz Sand, Ilana B / Kohli, Amit / Levine, Libby / McLemore, Monica / Okai, Annette F / Patel, Jasmin / Poole, Shane / Riley, Claire /
    Satyanarayan, Sammita / Tardo, Lauren / Verter, Elizabeth / Villacorta, Veronica / Zimmerman, Vanessa / Zuroff, Leah / Williams, Mitzi J / Houtchens, Maria K / Bove, Riley

    Neurology

    2024  Volume 102, Issue 4, Page(s) e208100

    Abstract: Background and objectives: Racial disparities exist in both neurologic and obstetric populations, underscoring the importance of evaluating pregnancy outcomes in diverse women with multiple sclerosis (MS). The objective of this multicenter retrospective ...

    Abstract Background and objectives: Racial disparities exist in both neurologic and obstetric populations, underscoring the importance of evaluating pregnancy outcomes in diverse women with multiple sclerosis (MS). The objective of this multicenter retrospective study was to compare pregnancy care and outcomes between Black and Hispanic (underrepresented) and White women with MS.
    Methods: Demographic and clinical data were extracted from medical records of 9 US MS centers for women with MS/clinically isolated syndrome who delivered live births between 2010 and 2021. Sites identified at last 15 consecutive Black/Hispanic women and a matching number of White women. Socioeconomic factors, pregnancy, and MS care/outcomes were compared between groups (underrepresented and White and then Black and Hispanic) using Wilcoxon rank sum (
    Results: Overall, 294 pregnancies resulting in live births were analyzed ( 81 Black, 67 Hispanic, and 146 White mothers). Relative to underrepresented women, White women lived in areas of higher median (interquartile range [IQR]) Child Opportunity Index (79 [45.8] vs 22 [45.8],
    Discussion: In this geographically diverse multicenter cohort, underrepresented women entered pregnancy with higher disability and fewer health care resources. Pregnancy represents a pivotal window where structural factors affect maternal and fetal health and neurologic trajectories; it is a critical period to optimize care and health outcomes.
    MeSH term(s) Infant ; Pregnancy ; Child ; Humans ; Female ; Multiple Sclerosis ; Retrospective Studies ; Prenatal Care ; Demyelinating Diseases ; Mothers
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000208100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.153: Show issues Location:
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  3. Article ; Online: Psychological resilience is linked to motor strength and gait endurance in early multiple sclerosis.

    Klineova, Sylvia / Brandstadter, Rachel / Fabian, Michelle T / Sand, Ilana Katz / Krieger, Stephen / Leavitt, Victoria M / Lewis, Christina / Riley, Claire S / Lublin, Fred / Miller, Aaron E / Sumowski, James F

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2019  Volume 26, Issue 9, Page(s) 1111–1120

    Abstract: Background: Psychologically resilient persons persist despite obstacles and bounce back after adversity, leading to better outcomes in non-neurologic populations. It is unknown whether psychological resilience relates to objective functional outcomes in ...

    Abstract Background: Psychologically resilient persons persist despite obstacles and bounce back after adversity, leading to better outcomes in non-neurologic populations. It is unknown whether psychological resilience relates to objective functional outcomes in multiple sclerosis (MS).
    Objective: To determine whether psychological resilience explains differential objective cognitive and motor functioning in persons with early MS.
    Methods: Psychological resilience was assessed in 185 patients with early MS and 50 matched healthy controls with the
    Results: Higher CDRS-10 among patients was linked to better MSFC and motor outcomes (but not cognition), with the most robust relationships for gross motor function (grip strength, gait endurance). Findings were independent of mood and fatigue. CDRS-10 was unrelated to MS disease burden. CDRS-10 was also specifically linked to motor outcomes in healthy controls.
    Conclusion: Functional outcomes vary across persons with MS, even when disease burden and neurologic disability are low. These findings identify high psychological resilience as a non-disease-specific contributor to motor strength and endurance, which may explain differential outcomes across patients.
    Language English
    Publishing date 2019-06-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458519852725
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4428: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Detection of subtle gait disturbance and future fall risk in early multiple sclerosis.

    Brandstadter, Rachel / Ayeni, Oluwasheyi / Krieger, Stephen C / Harel, Noam Y / Escalon, Miguel X / Katz Sand, Ilana / Leavitt, Victoria M / Fabian, Michelle T / Buyukturkoglu, Korhan / Klineova, Sylvia / Riley, Claire S / Lublin, Fred D / Miller, Aaron E / Sumowski, James F

    Neurology

    2020  Volume 94, Issue 13, Page(s) e1395–e1406

    Abstract: Objective: To test the hypothesis that higher-challenge gait and balance tasks are more sensitive than traditional metrics to subtle patient-reported gait dysfunction and future fall risk in early multiple sclerosis (MS).: Methods: Persons with early ...

    Abstract Objective: To test the hypothesis that higher-challenge gait and balance tasks are more sensitive than traditional metrics to subtle patient-reported gait dysfunction and future fall risk in early multiple sclerosis (MS).
    Methods: Persons with early MS (n = 185; ≤5 years diagnosed) reported gait function (MS Walking Scale) and underwent traditional disability metrics (Expanded Disability Status Scale [EDSS], Timed 25 Foot Walk). Patients and healthy controls (n = 50) completed clinically feasible challenge tasks of gait endurance (2-Minute Walk Test), standing balance (NIH Toolbox), and dynamic balance (balance boards; tandem walk on 2 ten-foot boards of different widths, 4.5 and 1.5 in). MRI assessed global and regional brain volumes, total T2 lesion volume (T2LV), infratentorial T2LVs and counts, and cervical cord lesion counts. Falls, near falls, and fall-related injuries were assessed after 1 year. We examined links between all tasks and patient-reported gait, MRI markers, and fall data.
    Results: Patients performed worse on higher challenge balance, but not gait, tasks compared with healthy controls. Worse patient-reported gait disturbance was associated with worse performance on all tasks, but only dynamic balance was sensitive to mild patient-reported gait difficulty. Balance tasks were more correlated with MRI metrics than were walking tasks or EDSS score. Thirty percent of patients reported either a fall or near fall after 1 year, with poor dynamic balance as the only task independently predicting falls.
    Conclusions: Balance plays a leading role in gait dysfunction early in MS. Clinically feasible higher-challenge balance tasks were most sensitive to patient-reported gait, MRI disease markers, and risk of future falls, highlighting potential to advance functional outcomes in clinical practice and trials.
    MeSH term(s) Accidental Falls ; Adult ; Demyelinating Diseases/complications ; Disability Evaluation ; Female ; Gait Analysis/methods ; Gait Disorders, Neurologic/diagnosis ; Gait Disorders, Neurologic/etiology ; Humans ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/complications ; Postural Balance/physiology
    Language English
    Publishing date 2020-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000008938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.153: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 18: Show issues
    Zs.MO 374: Show issues

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  5. Article: Open-label, add-on trial of cetirizine for neuromyelitis optica.

    Katz Sand, Ilana / Fabian, Michelle T / Telford, Russell / Kraus, Thomas A / Chehade, Mirna / Masilamani, Madhan / Moran, Thomas / Farrell, Colleen / Ebel, Shelly / Cook, Lawrence J / Rose, John / Lublin, Fred D

    Neurology(R) neuroimmunology & neuroinflammation

    2018  Volume 5, Issue 2, Page(s) e441

    Abstract: Objective: This pilot study preliminarily examined the efficacy and tolerability of cetirizine as an add-on to standard therapy for neuromyelitis optica (NMO).: Methods: Eligible participants met the Wingerchuk 2006 diagnostic criteria or had a ... ...

    Abstract Objective: This pilot study preliminarily examined the efficacy and tolerability of cetirizine as an add-on to standard therapy for neuromyelitis optica (NMO).
    Methods: Eligible participants met the Wingerchuk 2006 diagnostic criteria or had a single typical episode along with positive NMO immunoglobulin G. After baseline clinical and laboratory assessments, participants began treatment with cetirizine 10 mg orally daily, in addition to their usual disease-modifying therapy for NMO, and continued for 1 year. The primary end point was the annualized relapse rate (ARR) while on the same disease-modifying therapy before starting cetirizine compared with after taking cetirizine. Additional end points included disability (Expanded Disability Status Scale [EDSS]), relapse severity, tolerability, especially with respect to drowsiness measured by the Epworth Sleepiness Scale (ESS), and laboratory parameters.
    Results: The ARR before cetirizine was 0.4 ± 0.80 and after cetirizine was 0.1 ± 0.24 (
    Conclusions: In this pilot study, cetirizine was well tolerated, and the prespecified primary efficacy end point was satisfied. However, the open-label design and the small sample size of this pilot study preclude definitive conclusions. Further research is needed.
    Classification of evidence: This study provides Class IV evidence that in patients with NMO, the addition of cetirizine to standard therapy is safe, well tolerated, and reduces relapses.
    Language English
    Publishing date 2018-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2767740-0
    ISSN 2332-7812
    ISSN 2332-7812
    DOI 10.1212/NXI.0000000000000441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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