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  1. Article ; Online: Should we use ferritin in the diagnostic criteria of iron deficiency in heart failure patients?

    Gentil, Jaqueline Rodrigues de Souza / Fabricio, Camila Godoy / Tanaka, Denise Mayumi / Suen, Vivian Marques Miguel / Volpe, Gustavo Jardim / Marchini, Júlio Sérgio / Simões, Marcus Vinícius

    Clinical nutrition ESPEN

    2020  Volume 39, Page(s) 119–123

    Abstract: Background and aims: Iron deficiency (ID) is a common comorbidity in patients with chronic heart failure (HF) and is associated with worse prognosis. We aimed at comparing the currently European Society of Cardiology (ESC) criterion for diagnosis of ID ( ...

    Abstract Background and aims: Iron deficiency (ID) is a common comorbidity in patients with chronic heart failure (HF) and is associated with worse prognosis. We aimed at comparing the currently European Society of Cardiology (ESC) criterion for diagnosis of ID (ferritin < 100 μg/L or ferritin 100-299 μg/L with transferrin saturation [TSAT] < 20%) with either isolated low TSAT or isolated low ferritin on survival, in a cohort of HF patients.
    Methods: This was an observational prospective study, investigating ambulatory patients with HF and reduced ejection fraction (n = 108). All patients were assessed for clinical aspects and iron indexes. The primary endpoint was all-cause death.
    Results: Abnormal iron status was observed in 50 (46%) of patients. During the median follow-up time of 857.5 [647-899] days, 31 patients died (29%). In univariate analyses ESC-criterion (p = 0.022) and isolated TSAT <20% (p = 0.002), but not isolated ferritin <100 μg/L (p = 0.439), were significantly related to an increased risk of all-cause death. However, in multivariate analyses only TSAT <20% (HR = 2.3; [95% CI: 1.11-4.85]; p = 0.026) was independently related to all-cause mortality.
    Conclusions: Our results indicated that diagnosis of ID based on isolated TSAT <20% identifies HF patients with worse prognosis, while ferritin was not associated with mortality risk, suggesting that ferritin should not be taken into account for evaluation of clinical impact of ID in HF patients.
    MeSH term(s) Anemia, Iron-Deficiency/diagnosis ; Ferritins ; Heart Failure/complications ; Heart Failure/diagnosis ; Humans ; Iron ; Prospective Studies
    Chemical Substances Ferritins (9007-73-2) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2020-08-05
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2020.07.008
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  2. Article: Should we use ferritin in the diagnostic criteria of iron deficiency in heart failure patients?

    Gentil, Jaqueline Rodrigues de Souza / Fabricio, Camila Godoy / Tanaka, Denise Mayumi / Suen, Vivian Marques Miguel / Volpe, Gustavo Jardim / Marchini, Júlio Sérgio / Simões, Marcus Vinícius

    European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2020 Oct., v. 39

    2020  

    Abstract: Iron deficiency (ID) is a common comorbidity in patients with chronic heart failure (HF) and is associated with worse prognosis. We aimed at comparing the currently European Society of Cardiology (ESC) criterion for diagnosis of ID (ferritin < 100 μg/L ... ...

    Abstract Iron deficiency (ID) is a common comorbidity in patients with chronic heart failure (HF) and is associated with worse prognosis. We aimed at comparing the currently European Society of Cardiology (ESC) criterion for diagnosis of ID (ferritin < 100 μg/L or ferritin 100–299 μg/L with transferrin saturation [TSAT] < 20%) with either isolated low TSAT or isolated low ferritin on survival, in a cohort of HF patients.This was an observational prospective study, investigating ambulatory patients with HF and reduced ejection fraction (n = 108). All patients were assessed for clinical aspects and iron indexes. The primary endpoint was all-cause death.Abnormal iron status was observed in 50 (46%) of patients. During the median follow-up time of 857.5 [647–899] days, 31 patients died (29%). In univariate analyses ESC-criterion (p = 0.022) and isolated TSAT <20% (p = 0.002), but not isolated ferritin <100 μg/L (p = 0.439), were significantly related to an increased risk of all-cause death. However, in multivariate analyses only TSAT <20% (HR = 2.3; [95% CI: 1.11–4.85]; p = 0.026) was independently related to all-cause mortality.Our results indicated that diagnosis of ID based on isolated TSAT <20% identifies HF patients with worse prognosis, while ferritin was not associated with mortality risk, suggesting that ferritin should not be taken into account for evaluation of clinical impact of ID in HF patients.
    Keywords clinical nutrition ; comorbidity ; death ; ferritin ; heart failure ; iron ; mortality ; multivariate analysis ; patients ; prognosis ; prospective studies ; risk ; society ; transferrin
    Language English
    Dates of publication 2020-10
    Size p. 119-123.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-light
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2020.07.008
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Pentoxifylline reduces inflammation and prevents myocardial perfusion derangements in experimental chronic Chagas' cardiomyopathy.

    Tanaka, Denise Mayumi / Fabricio, Camila Godoy / Marin-Neto, José A / de Barros Filho, Antônio Carlos Leite / de Oliveira, Luciano Fonseca Lemos / Mejia, Jorge / Almeida, Rafael Ribeiro / de Souza Vieira, Raquel / Lopes, Carla Duque / Batah, Sabrina Setembre / Moreira, Henrique Turin / de Lourdes Higuchi, Maria / Neto, Edecio Cunha / Fabro, Alexandre Todorovic / Nekolla, Stephan G / Romano, Minna Moreira Dias / Simões, Marcus Vinícius

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2023  Volume 30, Issue 6, Page(s) 2327–2337

    Abstract: Background: Myocardial perfusion defect (MPD) is common in chronic Chagas cardiomyopathy (CCC) and is associated with inflammation and development of left ventricular systolic dysfunction. We tested the hypothesis that pentoxifylline (PTX) could reduce ... ...

    Abstract Background: Myocardial perfusion defect (MPD) is common in chronic Chagas cardiomyopathy (CCC) and is associated with inflammation and development of left ventricular systolic dysfunction. We tested the hypothesis that pentoxifylline (PTX) could reduce inflammation and prevent the development of MPD in a model of CCC in hamsters.
    Methods and results: We investigated with echocardiogram and rest myocardial perfusion scintigraphy at baseline (6-months after T. cruzi infection/saline) and post-treatment (after additional 2-months of PTX/saline administration), female Syrian hamsters assigned to 3 groups: T. cruzi-infected animals treated with PTX (CH + PTX) or saline (CH + SLN); and uninfected control animals (CO). At the baseline, all groups showed similar left ventricular ejection fraction (LVEF) and MPD areas. At post-treatment evaluation, there was a significant increase of MPD in CH + SLN group (0.8 ± 1.6 to 9.4 ± 9.7%), but not in CH + PTX (1.9 ± 3.0% to 2.7 ± 2.7%) that exhibited MPD area similar to CO (0.0 ± 0.0% to 0.0 ± 0.0%). The LVEF decreased in both infected groups. Histological analysis showed a reduced inflammatory infiltrate in CH + PTX group (395.7 ± 88.3 cell/mm
    Conclusions: The prolonged use of PTX is associated with positive effects, including prevention of MPD development and reduction of inflammation in the chronic hamster model of CCC.
    MeSH term(s) Cricetinae ; Animals ; Female ; Chagas Cardiomyopathy/diagnostic imaging ; Pentoxifylline/pharmacology ; Pentoxifylline/therapeutic use ; Stroke Volume ; Ventricular Function, Left ; Tomography, X-Ray Computed ; Chagas Disease ; Inflammation ; Perfusion
    Chemical Substances Pentoxifylline (SD6QCT3TSU)
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-023-03270-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: A normal sodium diet preserves serum sodium levels during treatment of acute decompensated heart failure: A prospective, blind and randomized trial

    Fabricio, Camila Godoy / Tanaka, Denise Mayumi / Souza Gentil, Jaqueline Rodrigues de / Ferreira Amato, Cristiana Alves / Marques, Fabiana / Schwartzmann, Pedro Vellosa / Schmidt, André / Simões, Marcus Vinícius

    European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2019 Aug., v. 32

    2019  

    Abstract: We tested the hypothesis that a normal sodium diet could be associated with preservation of serum sodium during treatment of acute decompensated heart failure (ADHF).Forty-four patients hospitalized for ADHF were blindly randomized by using block method ... ...

    Abstract We tested the hypothesis that a normal sodium diet could be associated with preservation of serum sodium during treatment of acute decompensated heart failure (ADHF).Forty-four patients hospitalized for ADHF were blindly randomized by using block method to a low sodium diet (LS: 3 g/day of dietary sodium chloride; n = 22, 59.5 ± 11.9 y.o., 50% males. LVEF = 30.0 ± 13.6%); and a normal sodium diet (NS: 7 g/day; n = 22, 56.4 ± 10.3 y.o., 68% males; LVEF = 27.8 ± 11.7%), and both groups were submitted to fluid restriction of 1.000 mL/day. At the 7th day of intervention 16 patients of LS group and 15 patients of NS group were assessed for difference in serum sodium. Both groups had equivalent decongestion, reflected by similar percent reduction of body weight (LS: −5.0 ± 4.7% vs NS: −4.5 ± 5.2%. p = 0.41). Reduction of the N terminal fragment of type B natriuretic peptide (NT-proBNP) was significant only in the NS (−1497.0 [−18843.0 − 1191.0]. p = 0.04). The LS group showed lower levels of serum sodium (135.4 ± 3.5 mmol/L) compared to the NS group (137.5 ± 1.9 mmol/L; p = 0.04). Four cases of hyponatremia were observed only in the LS group (22%). The NS group exhibited higher mean blood pressure values (79.4 ± 2.4 mmHg vs 75.5 ± 3.0 mmHg. p = 0.03), and lower heart rate (73.2 ± 1.6 bpm vs 75.5 ± 2.1 bpm. p = 0.02).These results suggest that a normal sodium diet, when compared to a low sodium diet, is associated with similar degrees of decongestion, but with higher levels of natremia, blood pressure and lower neurohormonal activation during ADHF treatment.clinicaltrials.gov Identifier no. NCT03722069.
    Keywords blood pressure ; blood serum ; body weight ; heart failure ; heart rate ; hyponatremia ; low sodium diet ; males ; natriuretic peptides ; patients ; sodium ; sodium chloride
    Language English
    Dates of publication 2019-08
    Size p. 145-152.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2019.03.009
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: A normal sodium diet preserves serum sodium levels during treatment of acute decompensated heart failure: A prospective, blind and randomized trial.

    Fabricio, Camila Godoy / Tanaka, Denise Mayumi / Souza Gentil, Jaqueline Rodrigues de / Ferreira Amato, Cristiana Alves / Marques, Fabiana / Schwartzmann, Pedro Vellosa / Schmidt, André / Simões, Marcus Vinícius

    Clinical nutrition ESPEN

    2019  Volume 32, Page(s) 145–152

    Abstract: Background: We tested the hypothesis that a normal sodium diet could be associated with preservation of serum sodium during treatment of acute decompensated heart failure (ADHF).: Methods and results: Forty-four patients hospitalized for ADHF were ... ...

    Abstract Background: We tested the hypothesis that a normal sodium diet could be associated with preservation of serum sodium during treatment of acute decompensated heart failure (ADHF).
    Methods and results: Forty-four patients hospitalized for ADHF were blindly randomized by using block method to a low sodium diet (LS: 3 g/day of dietary sodium chloride; n = 22, 59.5 ± 11.9 y.o., 50% males. LVEF = 30.0 ± 13.6%); and a normal sodium diet (NS: 7 g/day; n = 22, 56.4 ± 10.3 y.o., 68% males; LVEF = 27.8 ± 11.7%), and both groups were submitted to fluid restriction of 1.000 mL/day. At the 7th day of intervention 16 patients of LS group and 15 patients of NS group were assessed for difference in serum sodium. Both groups had equivalent decongestion, reflected by similar percent reduction of body weight (LS: -5.0 ± 4.7% vs NS: -4.5 ± 5.2%. p = 0.41). Reduction of the N terminal fragment of type B natriuretic peptide (NT-proBNP) was significant only in the NS (-1497.0 [-18843.0 - 1191.0]. p = 0.04). The LS group showed lower levels of serum sodium (135.4 ± 3.5 mmol/L) compared to the NS group (137.5 ± 1.9 mmol/L; p = 0.04). Four cases of hyponatremia were observed only in the LS group (22%). The NS group exhibited higher mean blood pressure values (79.4 ± 2.4 mmHg vs 75.5 ± 3.0 mmHg. p = 0.03), and lower heart rate (73.2 ± 1.6 bpm vs 75.5 ± 2.1 bpm. p = 0.02).
    Conclusions: These results suggest that a normal sodium diet, when compared to a low sodium diet, is associated with similar degrees of decongestion, but with higher levels of natremia, blood pressure and lower neurohormonal activation during ADHF treatment.
    Trial registration: clinicaltrials.gov Identifier no. NCT03722069.
    MeSH term(s) Diet, Sodium-Restricted ; Double-Blind Method ; Female ; Heart Failure/blood ; Heart Failure/therapy ; Humans ; Male ; Middle Aged ; Prospective Studies ; Sodium/blood ; Treatment Outcome
    Chemical Substances Sodium (9NEZ333N27)
    Language English
    Publishing date 2019-04-16
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2019.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prolonged dipyridamole administration reduces myocardial perfusion defects in experimental chronic Chagas cardiomyopathy.

    Tanaka, Denise Mayumi / de Oliveira, Luciano Fonseca Lemos / Marin-Neto, José Antônio / Romano, Minna Moreira Dias / de Carvalho, Eduardo Elias Vieira / de Barros Filho, Antonio Carlos Leite / Ribeiro, Fernando Fonseca França / Cabeza, Jorge Mejia / Lopes, Carla Duque / Fabricio, Camila Godoy / Kesper, Norival / Moreira, Henrique Turin / Wichert-Ana, Lauro / Schmidt, André / Higuchi, Maria de Lourdes / Cunha-Neto, Edécio / Simões, Marcus Vinícius

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2018  Volume 26, Issue 5, Page(s) 1569–1579

    Abstract: Background: Myocardial perfusion defects (MPD) due to coronary microvascular dysfunction is frequent in chronic Chagas cardiomyopathy (CCC) and may be involved with development of myocardial damage. We investigated whether MPD precedes left ventricular ... ...

    Abstract Background: Myocardial perfusion defects (MPD) due to coronary microvascular dysfunction is frequent in chronic Chagas cardiomyopathy (CCC) and may be involved with development of myocardial damage. We investigated whether MPD precedes left ventricular systolic dysfunction and tested the hypothesis that prolonged use of dipyridamole (DIPY) could reduce MPD in an experimental model of CCC in hamsters.
    Methods and results: We investigated female hamsters 6-months after T. cruzi infection (baseline condition) and control animals, divided into T. cruzi-infected animals treated with DIPY (CH + DIPY) or placebo (CH + PLB); and uninfected animals treated with DIPY (CO + DIPY) or placebo (CO + PLB). The animals were submitted to echocardiogram and rest SPECT-Sestamibi-Tc99m myocardial perfusion scintigraphy. Next, the animals were treated with DIPY (4 mg/kg bid, intraperitoneal) or saline for 30 days, and reevaluated with the same imaging methods. At baseline, the CH + PLB and CH + DIPY groups showed larger areas of perfusion defect (13.2 ± 13.2% and 17.3 ± 13.2%, respectively) compared with CO + PLB and CO + DIPY (3.8 ± 2.2% e 3.5 ± 2.7%, respectively), P < .05. After treatment, we observed: reduction of perfusion defects only in the CH + DIPY group (17.3 ± 13.2% to 6.8 ± 7.6%, P = .001) and reduction of LVEF in CH + DIPY and CH + PLB groups (from 65.3 ± 9.0% to 53.6 ± 6.9% and from 69.3 ± 5.0% to 54.4 ± 8.6%, respectively, P < .001). Quantitative histology revealed greater extents of inflammation and interstitial fibrosis in both Chagas groups, compared with control group (P < .001), but no difference between Chagas groups (P > .05).
    Conclusions: The prolonged use of DIPY in this experimental model of CCC has reduced the rest myocardial perfusion defects, supporting the notion that those areas correspond to viable hypoperfused myocardium.
    MeSH term(s) Animals ; Chagas Cardiomyopathy/diagnostic imaging ; Chagas Cardiomyopathy/drug therapy ; Cricetinae ; Dipyridamole/administration & dosage ; Disease Models, Animal ; Echocardiography ; Female ; Heart/diagnostic imaging ; Heart Ventricles/diagnostic imaging ; Myocardial Perfusion Imaging ; Perfusion ; Technetium Tc 99m Sestamibi ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed ; Trypanosoma cruzi ; Vasodilator Agents/administration & dosage
    Chemical Substances Vasodilator Agents ; Dipyridamole (64ALC7F90C) ; Technetium Tc 99m Sestamibi (971Z4W1S09)
    Language English
    Publishing date 2018-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-018-1198-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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