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  1. Article ; Online: Vastus lateralis flap for trochanteric sarcoma reconstruction following prior main pedicle dissection: A case report.

    Fadel, Zahir T / Basaeed, Amani J / Ashi, Mohammed B / Aljaaly, Hattan A

    Experimental and therapeutic medicine

    2024  Volume 27, Issue 6, Page(s) 249

    Abstract: The reconstruction of trochanteric defects presents a challenge to the reconstructive surgeon. There have been a number of locoregional reconstructive options described in the literature. These include flaps based on the lateral circumflex femoral artery ...

    Abstract The reconstruction of trochanteric defects presents a challenge to the reconstructive surgeon. There have been a number of locoregional reconstructive options described in the literature. These include flaps based on the lateral circumflex femoral artery and its branches, such as the tensor fascia lata, vastus lateralis (VL), anterolateral thigh (ALT) flaps. The present case further complicated this challenge as the patient had multiple recurrences of a sarcoma overlying the trochanteric region, with previous surgical resections, reconstruction and radiotherapy. The present case study describes an approach to harvesting the VL flap in a patient with previously harvested ALT.
    Language English
    Publishing date 2024-04-12
    Publishing country Greece
    Document type Case Reports
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2024.12537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Case report: reverse lateral arm flap in a patient with previously harvested radial artery.

    Fadel, Zahir T / Ashi, Mohammed B / Magram, Weaam S

    Case reports in plastic surgery & hand surgery

    2022  Volume 9, Issue 1, Page(s) 169–172

    Abstract: The radial artery supplies various locoregional flaps used for elbow reconstruction. A reverse lateral arm flap is a reliable choice, despite sacrificing the radial artery in some cases. We describe using a reverse lateral arm flap for elbow soft tissue ... ...

    Abstract The radial artery supplies various locoregional flaps used for elbow reconstruction. A reverse lateral arm flap is a reliable choice, despite sacrificing the radial artery in some cases. We describe using a reverse lateral arm flap for elbow soft tissue reconstruction in a patient with a previously harvested radial artery.
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Case Reports
    ISSN 2332-0885
    ISSN 2332-0885
    DOI 10.1080/23320885.2022.2099395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lower Extremity Nerve Decompression for Diabetic Peripheral Neuropathy: A Systematic Review and Meta-analysis.

    Fadel, Zahir T / Imran, Wafa M / Azhar, Turki

    Plastic and reconstructive surgery. Global open

    2022  Volume 10, Issue 8, Page(s) e4478

    Abstract: Background: Diabetic peripheral neuropathy (DPN) is a leading cause of morbidity. This systematic review and meta-analysis evaluate the efficacy of lower extremity nerve decompression in reducing DPN symptoms and complications.: Methods: A database ... ...

    Abstract Background: Diabetic peripheral neuropathy (DPN) is a leading cause of morbidity. This systematic review and meta-analysis evaluate the efficacy of lower extremity nerve decompression in reducing DPN symptoms and complications.
    Methods: A database search was performed using Medline, Embase, Google Scholar, and Cochrane Central Register of Controlled Trials. Articles addressing surgical decompression of lower limb peripheral nerves in patients with diabetes were screened for inclusion. Two independent reviewers undertook the assessment. Methodological quality measures were the Cochrane risk of bias and Newcastle-Ottawa scale.
    Results: The pooled sample size from 21 studies was 2169 patients. Meta-analysis of 16 observational studies showed significant improvement in the visual analog scale (VAS) (
    Conclusions: Meta-analysis of observational studies highlights the efficacy of lower extremity nerve decompression in reducing DPN symptoms, ulcerations, and amputations. Releasing the tibial nerve in the tarsal tunnel region was the most effective observed procedure. Nevertheless, high-quality RCTs are required to support the utility of this intervention in DPN.
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004478
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7091: Show issues Location:
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  4. Article: Variations in the Anatomical Structures of the Guyon Canal.

    Fadel, Zahir T / Samargandi, Osama A / Tang, David T

    Plastic surgery (Oakville, Ont.)

    2017  Volume 25, Issue 2, Page(s) 84–92

    Abstract: Background: Compression neuropathy of the ulnar nerve at the Guyon canal is commonly seen by hand surgeons. Different anatomical variations of structures related to the Guyon canal have been reported in the literature. A thorough knowledge of the normal ...

    Abstract Background: Compression neuropathy of the ulnar nerve at the Guyon canal is commonly seen by hand surgeons. Different anatomical variations of structures related to the Guyon canal have been reported in the literature. A thorough knowledge of the normal contents and possible variations is essential during surgery and exploration.
    Objectives: To review the recognized anatomical variations within and around the Guyon canal.
    Methods: This study is a narrative review in which relevant papers, clinical studies, and anatomical studies were selected by searching electronic databases (PubMed and EMBASE). Extensive manual review of references of the included studies was performed. We also describe a case report of an aberrant muscle crossing the Guyon canal.
    Results: This study identified several variations in the anatomical structures of the Guyon canal reported in the literature. Variations of the ulnar nerve involved its course, branching pattern, deep motor branch, superficial sensory branch, dorsal cutaneous branch, and the communication with the median nerve. Ulnar artery variations involved its course, branching pattern, the superficial ulnar artery, and the dorsal perforating artery. Aberrant muscles crossing the Guyon canal were found to originate from the antebrachial fascia, pisiform bone, flexor retinaculum, the tendon of palmaris longus, flexor carpi ulnaris, or flexor carpi radialis; these muscles usually fuse with the hypothenar group.
    Conclusion: The diverse variations of the contents of the Guyon canal were adequately described in the literature. Taking these variations into consideration is important in preventing clinical misinterpretation and avoiding potential surgical complications.
    Language English
    Publishing date 2017-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2869727-3
    ISSN 2292-5511 ; 2292-5503
    ISSN (online) 2292-5511
    ISSN 2292-5503
    DOI 10.1177/2292550317694851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effects of seasonal changes in temperature and humidity on incidence of necrotizing soft tissue infections in Halifax, Canada, 2001-2015.

    Fadel, Zahir T / Burke, Emily / Joukhadar, Nadim / Samargandi, Osama A / Bezuhly, Michael

    Saudi medical journal

    2019  Volume 40, Issue 5, Page(s) 469–474

    Abstract: Objectives: To explore weather seasonal variation in Necrotizing soft tissue infections (NSTI) in Halifax, Nova Scotia, Canada could be attributed to changes in environmental factors of temperature and humidity specifically.: Methods: A retrospective ...

    Abstract Objectives: To explore weather seasonal variation in Necrotizing soft tissue infections (NSTI) in Halifax, Nova Scotia, Canada could be attributed to changes in environmental factors of temperature and humidity specifically.
    Methods: A retrospective chart review of NSTIs between 2001 and 2015. Regional temperature and humidity data were obtained from the Environment Canada Agency, Halifax, Canada. Chi-square was used for categorical variables and continuous data was used for correlation analyses. Logistic regression was performed to analyze mortality. Results: Of 170 NSTI patients identified, more presented from March to July, especially when the temperature was greater than 10ºC. Higher incidence per 100,000 persons correlated with increased monthly temperatures (p less than 0.01). Monthly NSTI incidence was inversely related to mean humidity (p=0.005). Causative organism was associated with mean weekly temperature (p less than 0.01) but not humidity (p=0.66). Low body mass index, higher American Society of Anesthesiologists class, long intensive care unit stay, and shorter overall hospital stay were associated with mortality. No correlation was identified between temperature and humidity and mortality.
    Conclusion: This study demonstrates a tendency toward more frequent cases of NSTI with warmer, but less humid weather, without effect on severity or mortality.
    MeSH term(s) Adult ; Aged ; Canada/epidemiology ; Chi-Square Distribution ; Enterobacteriaceae/pathogenicity ; Fasciitis, Necrotizing/epidemiology ; Fasciitis, Necrotizing/microbiology ; Female ; Humans ; Humidity ; Incidence ; Length of Stay/statistics & numerical data ; Logistic Models ; Male ; Middle Aged ; Retrospective Studies ; Seasons ; Severity of Illness Index ; Soft Tissue Infections/epidemiology ; Soft Tissue Infections/etiology ; Soft Tissue Infections/microbiology ; Soft Tissue Infections/mortality ; Streptococcus/pathogenicity ; Temperature ; Time Factors
    Language English
    Publishing date 2019-04-18
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
    DOI 10.15537/smj.2019.5.24096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2330: Show issues Location:
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    Zs.MB 6: Show issues

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  6. Article ; Online: The Assessment of Major Histocompatibility Complex (MHC) Class-I Expression in Different Neuromuscular Diseases.

    Kurdi, Maher / Alshareef, Aysha / Bamaga, Ahmed K / Fadel, Zahir T / Alrawaili, Moafaq S / Hakamy, Sahar / Mohamed, Fawaz / Abuzinadah, Ahmad R / Addas, Bassam M J / Butt, Nadeem Shafique

    Degenerative neurological and neuromuscular disease

    2021  Volume 11, Page(s) 61–68

    Abstract: Background: Major histocompatibility complex (MHC) class-1 antigen is a glycoprotein expressed in all nucleated cells. The aim of this study was to assess MHC class-I expression in different neuromuscular diseases.: Methods: The authors reviewed the ... ...

    Abstract Background: Major histocompatibility complex (MHC) class-1 antigen is a glycoprotein expressed in all nucleated cells. The aim of this study was to assess MHC class-I expression in different neuromuscular diseases.
    Methods: The authors reviewed the data of 54 patients with neuromuscular diseases. Anti MHC class-I antibody was performed on the frozen muscle tissues using immunohistochemistry. MHC class-I was scored based on its expression on muscle fibers (0: normal, 1: expression <5 fibers, 2: expression in 5-10 fibers, 3: expression in >10 fibers). The pattern was only assessed in cases with MHC class-I scored 3 as: (1: Sarcocapillary, 2: Sarcocapillary and necrotic fibers, 3: Perifascicular). The relationship between MHC class-I expression and neuromuscular diseases was statistically analyzed.
    Results: The mean age of the patients was 39.1 ± 18.5 years. Around 50% of patients showed normal CK levels and 5% of the cases showed elevated CK levels. There was a significance difference in MHC class-I expression between cases with normal and elevated CK levels when MHC class-I score was 3 (p= 0.020). There was a significant difference in MHC class-I expression among different neuromuscular diseases (p<0.001). All cases with idiopathic inflammatory myopathies (IIMs) have expressed MHC class-I in more than 10 fibers. MHC class-I was expressed in 15 cases of non-IIMs.
    Conclusion: MHC class-I cannot be solely used as a biomarker to distinguish IIMs from non-IIMs. The presence of MHC class-I molecules in non-IIMs might be related to immunoproteasomes mechanism. Further studies, with different muscle proteins expression and genomic sequencing, must be conducted to understand the role of MHC Class-I in neuromuscular diseases.
    Language English
    Publishing date 2021-12-30
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1179-9900
    ISSN (online) 1179-9900
    DOI 10.2147/DNND.S340117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Surgical treatment for hepatocellular carcinoma.

    Madkhali, Ahmad A / Fadel, Zahir T / Aljiffry, Murad M / Hassanain, Mazen M

    Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

    2015  Volume 21, Issue 1, Page(s) 11–17

    Abstract: Hepatocellular carcinoma (HCC) is an epithelial tumor derived from hepatocytes; it accounts for 80% of all primary liver cancers and ranks globally as the fourth leading cause of cancer-related deaths. HCC treatment is a multidisciplinary and a ... ...

    Abstract Hepatocellular carcinoma (HCC) is an epithelial tumor derived from hepatocytes; it accounts for 80% of all primary liver cancers and ranks globally as the fourth leading cause of cancer-related deaths. HCC treatment is a multidisciplinary and a multimodal task, with surgery in the form of liver resection and liver transplantation (LT) representing the only potentially curative modality. However, there are variable opinions and discussions about applying these surgical options and using other supporting treatments. This article is a narrative review that includes articles published from 1984 to 2013 located by searching scientific databases such as PubMed, SCOPUS, and Elsevier, with the main keyword of hepatocellular carcinoma in addition to other keywords such as liver transplantation, liver resection, transarterial chemoembolization, portal vein embolization, bridging therapy, and downstaging. In this review, we focus mainly on the surgical treatment options offered for HCC, in order to illustrate the current relevant data available in the literature to help in applying these surgical options and to use other supporting treatment modalities when appropriate.
    MeSH term(s) Carcinoma, Hepatocellular/surgery ; Hepatectomy/methods ; Humans ; Liver Neoplasms/surgery ; Liver Transplantation/methods
    Language English
    Publishing date 2015-01
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 2299174-8
    ISSN 1998-4049 ; 1319-3767
    ISSN (online) 1998-4049
    ISSN 1319-3767
    DOI 10.4103/1319-3767.151216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6710: Show issues Location:
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