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Article ; Online: Prediction of Translational Regulation by Network Interaction in Synaptic Plasticity Induced with Centella asiatica

Nurhadi Ibrahim / Ibrahim Nadian / Dimas R. Noor / Fadilah Fadilah

The Scientific World Journal, Vol

2023 Volume 2023

Abstract: Background. Recently, human life expectancy, aging, and age-related health disorders, especially neurodegenerative diseases such as Alzheimer’s disease (AD), have increased. The increasing number of AD patients causes a heavy social and economic burden ... ...

Abstract	Background. Recently, human life expectancy, aging, and age-related health disorders, especially neurodegenerative diseases such as Alzheimer’s disease (AD), have increased. The increasing number of AD patients causes a heavy social and economic burden on society. Since there is no treatment for AD, utilization of natural products is currently accepted as an alternative or integrative treatment agent against AD. Methods. Selection of protein databases related to synaptic plasticity was obtained from a gene bank. The protein-protein interaction (PPI) analysis was performed using Cytoscape 3.9.1. Prediction of Centella asiatica target constituents and their relationship with target synaptic plasticity was performed using STITCH, followed by GO and KEGG pathway enrichment analysis and molecular binding of ligands to presynaptic and postsynaptic receptors afterwards. Results. From the protein database, 446 protein coding genes related to synaptic plasticity were found. PPI and KEGG pathway analysis showed potentiality to inhibit AKT and mTORC1 pathways. The targeted proteins were TSC1, Rheb, and FMRP. Conclusion. This study showed potentiality of Centella asiatica in AD through its binding to several proteins such as TSC1, Rheb, and FMRP. This compound in Centella asiatica was able to bind to the AKT1 and mTOR signaling pathways. Centella asiatica may behold greater potency in AD therapy.
Keywords	Technology ; T ; Medicine ; R ; Science ; Q
Subject code	571 ; 572
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Case Report

Fadilah Fadilah / Anindita Basuki / Hidayat Rizal / Desdiani Desdiani

F1000Research, Vol

Delayed treatment of tuberculosis of the elbow joint [version 2; peer review: 2 approved]

2022 Volume 10

Abstract: Extrapulmonary tuberculosis (TB) is known to occur in the musculoskeletal system, including the elbow joints. These cases are rarely found because the signs and symptoms are not specific to extrapulmonary TB or other diseases. We report a case of a 24- ... ...

Abstract	Extrapulmonary tuberculosis (TB) is known to occur in the musculoskeletal system, including the elbow joints. These cases are rarely found because the signs and symptoms are not specific to extrapulmonary TB or other diseases. We report a case of a 24-year-old male, who complained about pain in his left elbow and noticed swelling. Initially, he complained about pain all over his left arm, after several reflexology massages to alleviate his toothache. However, instead of seeking medical treatment, he visited a traditional massage therapist every week without improvement in his left arm pain including his left elbow for almost one year. Examination showed skin perforation with discharge. He also had fever during the first few days when the elbow became swollen. Weight loss and a decreased appetite were also noticed by the patient. The patient went to the orthopedic department and underwent surgery. Radiological examination indicated bone erosion on the left humerus and radius, while posteroanterior chest X-ray did not show any abnormality. Histopathological examinations from biopsy and fluid aspiration showed granulomas and datia Langhans cells. Mycobacterium tuberculosis was found on acid-fast bacteria smear and culture. The patient was administered multidrug tuberculosis therapy, which consisted of two months of an intensive phase and seven months of a continuation phase, in accordance with the World Health Organization’s guidelines for extrapulmonary tuberculosis treatment. He has currently undergone the continuation phase of the treatment and his condition has improved. Early detection of tuberculosis of the elbow can prevent damage to joint structure and impairment of joint function.
Keywords	Elbow ; Arthritis ; Tuberculosis ; Delayed treatment ; eng ; Medicine ; R ; Science ; Q
Subject code	630
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
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Article: A narrative review of genomic characteristics, serotype, immunogenicity, and vaccine development of

Sari, Ratna Fathma / Fadilah, Fadilah / Maladan, Yustinus / Sarassari, Rosantia / Safari, Dodi

Clinical and experimental vaccine research

2024 Volume 13, Issue 2, Page(s) 91–104

Abstract: This narrative review describes genomic characteristic, serotyping, immunogenicity, and vaccine development ... ...

Abstract	This narrative review describes genomic characteristic, serotyping, immunogenicity, and vaccine development of
Language	English
Publishing date	2024-04-30
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2684652-4
ISSN	2287-366X ; 2287-3651
ISSN (online)	2287-366X
ISSN	2287-3651
DOI	10.7774/cevr.2024.13.2.91
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Article ; Online: Hibiscus sabdariffa Linn. Extract Increases the mRNA Expression of the Arcuate Nucleus Leptin Receptor and is Predicted in silico as an Anti-obesity Agent.

Kartinah, Neng Tine / Anggraini, Suci / Fadilah, Fadilah / Rickie, Rickie

Current computer-aided drug design

2023

Abstract: Background: Leptin is predominant in regulating body weight by stimulating energy expenditure through its neuronal action in the brain. Moreover, it is projected to adipose tissue and induces adipocyte browning by activating the β3-adrenergic receptor ( ... ...

Abstract	Background: Leptin is predominant in regulating body weight by stimulating energy expenditure through its neuronal action in the brain. Moreover, it is projected to adipose tissue and induces adipocyte browning by activating the β3-adrenergic receptor (β3AR). However, the expression of leptin receptor (Lep-R) and β3AR in people with obesity is downregulated. Aim: We hypothesized that Hibiscus sabdariffa Linn. extract (HSE) would increase hypothalamus arcuate nucleus (ARC) Lep-R and white adipose tissue (WAT) β3AR mRNA expression in DIO rats. This study also analyzed the potency of H. sabdariffa bioactive compounds as activators of Lep-R and β3AR by an in-silico experiment. Methods: Twenty-four male Sprague-Dawley rats were divided into four groups: Control (standard food), DIO (high-fat diet), DIO-Hib200 (HFD+HSE 200 mg/kg BW), and DIO-Hib400 (HFD+HSE400 mg/kg BW). HSE was administered orally for five weeks, once a day. Results: HSE administration significantly (P<0,05) increased the ARC Lep-R expression. The Lee index significantly decreased to the normal range (≤ 310) with p<0,001 for DIO-Hib200 and p<0,01 for DIO-Hib400. Among 39 bioactive compounds, 5-O-caffeoyl shikimic acid exhibited high free binding scores (-8,63) for Lep-R, and myricetin_3_arabinogalactoside had high free binding scores (-9,39) for β3AR. These binding predictions could activate Lep-R and β3AR. Conclusion: This study highlights that HSE could be a potential therapeutic target for obesity by increasing LepR mRNA and leptin sensitivity, enhancing energy expenditure, and reducing obesity.
Language	English
Publishing date	2023-08-22
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6697
ISSN (online)	1875-6697
DOI	10.2174/1573409920666230822115144
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Article ; Online: Prediction of Translational Regulation by Network Interaction in Synaptic Plasticity Induced with

Ibrahim, Nurhadi / Nadian, Ibrahim / Noor, Dimas R / Fadilah, Fadilah

TheScientificWorldJournal

2023 Volume 2023, Page(s) 4199614

Abstract: Background: Recently, human life expectancy, aging, and age-related health disorders, especially neurodegenerative diseases such as Alzheimer's disease (AD), have increased. The increasing number of AD patients causes a heavy social and economic burden ... ...

Abstract	Background: Recently, human life expectancy, aging, and age-related health disorders, especially neurodegenerative diseases such as Alzheimer's disease (AD), have increased. The increasing number of AD patients causes a heavy social and economic burden on society. Since there is no treatment for AD, utilization of natural products is currently accepted as an alternative or integrative treatment agent against AD. Methods: Selection of protein databases related to synaptic plasticity was obtained from a gene bank. The protein-protein interaction (PPI) analysis was performed using Cytoscape 3.9.1. Prediction of Results: From the protein database, 446 protein coding genes related to synaptic plasticity were found. PPI and KEGG pathway analysis showed potentiality to inhibit AKT and mTORC1 pathways. The targeted proteins were TSC1, Rheb, and FMRP. Conclusion: This study showed potentiality of
MeSH term(s)	Humans ; Centella/chemistry ; Triterpenes/pharmacology ; Plant Extracts/pharmacology ; Neuronal Plasticity
Chemical Substances	Triterpenes ; Plant Extracts
Language	English
Publishing date	2023-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075968-X
ISSN	1537-744X ; 1537-744X
ISSN (online)	1537-744X
ISSN	1537-744X
DOI	10.1155/2023/4199614
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Article ; Online: Untranslated region-5' and viral protein 1-based genetic stability analysis of bulk polio in Indonesia 2010-2019

Andi Yasmon / Normasari Normasari / Fithriyah Fithriyah / Fadilah Fadilah

Journal of the Medical Sciences, Vol 53, Iss

2021 Volume 4

Abstract: Cases of vaccine-associated paralytic poliomyelitis (VAPP) continued increasingly from 2010-2019 in the world. Oral polio vaccine (OPV) is the live attenuated virus-based vaccine that could genetically revert to neurovirulent during the vaccine ... ...

Abstract	Cases of vaccine-associated paralytic poliomyelitis (VAPP) continued increasingly from 2010-2019 in the world. Oral polio vaccine (OPV) is the live attenuated virus-based vaccine that could genetically revert to neurovirulent during the vaccine production process or when the virus replicates in the human body. The poliovirus neurovirulence is determined by the UTR-5' region and VP1 coding region. UTR-5' played a role in protein translation and VP1 was responsible for the immunogenicity of the virus. Some reported mutations in UTR-5' and VP1 could affect the neurovirulence of poliovirus. In this study, we analyzed the genetic stability of the UTR-5' and VP1 in the bulk of OPV types -1 and -3 produced in 2010 - 2019. The results of the analysis of UTR-5' sequences in Sabin strain types-1 and -3 and VP1 sequences on Sabin virus type 1 did not show any mutations. Meanwhile, the VP1 sequences in Sabin strain type 3 showed nucleotide mutation C2493U that caused the substitution amino acid Thr6Ile amino acid in all samples of the type 3 bulk polio test. Based on the results of in silico analysis, this mutation in VP1 did not contribute significantly to the neurovirulence of the virus.
Keywords	poliovirus ; utr-5’ ; vp1 ; sabin ; genetic characterization ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Universitas Gadjah Mada
Document type	Article ; Online
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Article: Targeted Sequencing of Germline Breast Cancer Susceptibility Genes for Discovering Pathogenic/Likely Pathogenic Variants in the Jakarta Population.

Panigoro, Sonar Soni / Paramita, Rafika Indah / Siswiandari, Kristina Maria / Fadilah, Fadilah

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 9

Abstract: Germline predisposition plays an important role in breast cancer. Different ethnic populations need respective studies on cancer risks pertinent to germline variants. We aimed to discover the pathogenic and likely pathogenic variants (P/LP-Vs) of ... ...

Abstract	Germline predisposition plays an important role in breast cancer. Different ethnic populations need respective studies on cancer risks pertinent to germline variants. We aimed to discover the pathogenic and likely pathogenic variants (P/LP-Vs) of germline breast cancer susceptibility genes and to evaluate their correlation with the clinical characteristics in Jakarta populations. The pure DNA was extracted from the blood buffy coat, using reagents from the QIAamp DNA Mini Kit® (Qiagen, Hilden, Germany). The DNA libraries were prepared using the TargetRich™ Hereditary Cancer Panel (Kailos Genetics®, Huntsville, AL, USA). The barcoded DNA libraries were sequenced using the Illumina NextSeq 500 platform. In-house bioinformatics pipelines were used to analyze the gene variants. We identified 35 pathogenic and likely pathogenic (P/LP-Vs) variants (28 frameshift, 5 nonsense, and 2 splice-site variants). The P/LP-Vs group was statistically significantly different in luminal B status (p < 0.05) compared with the non-P/LP-Vs group. The P/LP-Vs found both in BRCA1/2 genes and non-BRCA genes may increase the risk of breast cancer and alter drug responses. The screening of multigene variants is suggested, rather than BRCA testing only. Prior knowledge of the germline variants status is important for optimal breast cancer diagnosis and optimal therapy.
Language	English
Publishing date	2022-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12092241
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Article ; Online: Network pharmacology integrated molecular dynamics reveals the bioactive compounds and potential targets of Tinospora crispa Linn. as insulin sensitizer.

Zuhri, Ummu Mastna / Purwaningsih, Erni Hernawati / Fadilah, Fadilah / Yuliana, Nancy Dewi

PloS one

2022 Volume 17, Issue 6, Page(s) e0251837

Abstract: Insulin resistance is a metabolic disorder characterized by the decreased response to insulin in muscle, liver, and adipose cells. This condition remains a complex phenomenon that involves several genetic defects and environmental stresses. In the ... ...

Abstract	Insulin resistance is a metabolic disorder characterized by the decreased response to insulin in muscle, liver, and adipose cells. This condition remains a complex phenomenon that involves several genetic defects and environmental stresses. In the present study, we investigated the mechanism of known phytochemical constituents of Tinospora crispa and its interaction with insulin-resistant target proteins by using network pharmacology, molecular docking, and molecular dynamics (MD) simulation. Tinoscorside A, Makisterone C, Borapetoside A and B, and β sitosterol consider the main phytoconstituents of Tinospora crispa by its binding with active sites of main protein targets of insulin resistance potential therapy. Moreover, Tinoscorside A was revealed from the docking analysis as the ligand that binds most strongly to the target protein, PI3K. This finding was strengthened by the results of MD simulation, which stated that the conformational stability of the ligand-protein complex was achieved at 15 ns and the formation of hydrogen bonds at the active site. In conclusion, Tinospora crispa is one of the promising therapeutic agent in type 2 diabetes mellitus management. Regulation in glucose homeostasis, adipolysis, cell proliferation, and antiapoptosis are predicted to be the critical mechanism of Tinospora crispa as an insulin sensitizer.
MeSH term(s)	Diabetes Mellitus, Type 2/drug therapy ; Humans ; Insulin/metabolism ; Insulin Resistance ; Insulin, Regular, Human/therapeutic use ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Network Pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Tinospora/chemistry
Chemical Substances	Insulin ; Insulin, Regular, Human ; Ligands ; Plant Extracts
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0251837
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Article ; Online: Case Report: Delayed treatment of tuberculosis of the elbow joint.

Desdiani, Desdiani / Rizal, Hidayat / Basuki, Anindita / Fadilah, Fadilah

F1000Research

2021 Volume 10, Page(s) 486

Abstract	Extrapulmonary tuberculosis (TB) is known to occur in the musculoskeletal system, including the elbow joints. These cases are rarely found because the signs and symptoms are not specific to extrapulmonary TB or other diseases. We report a case of a 24-year-old male, who complained about pain in his left elbow and noticed swelling. Initially, he complained about pain all over his left arm, after several reflexology massages to alleviate his toothache. However, instead of seeking medical treatment, he visited a traditional massage therapist every week without improvement in his left arm pain including his left elbow for almost one year. Examination showed skin perforation with discharge. He also had fever during the first few days when the elbow became swollen. Weight loss and a decreased appetite were also noticed by the patient. The patient went to the orthopedic department and underwent surgery. Radiological examination indicated bone erosion on the left humerus and radius, while posteroanterior chest X-ray did not show any abnormality. Histopathological examinations from biopsy and fluid aspiration showed granulomas and datia Langhans cells.
MeSH term(s)	Adult ; Elbow Joint ; Humans ; Male ; Mycobacterium tuberculosis ; Pain ; Time-to-Treatment ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Young Adult
Language	English
Publishing date	2021-06-18
Publishing country	England
Document type	Case Reports
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.53488.2
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Article ; Online: The Antifungal Activities of Syzygium aromaticum and Alpinia purpurata Extracts Against Candida krusei: Bioactivity Tests, Molecular Modeling, and Toxicity Tests.

Aisy, Dzia Ulhaq Rohadatul / Adawiyah, Robiatul / Rozaliyani, Anna / Estuningtyas, Ari / Fadilah, Fadilah

Asian Pacific journal of cancer prevention : APJCP

2023 Volume 24, Issue 10, Page(s) 3403–3409

Abstract: Background: Candida krusei is the cause of the fungal infection candidiasis, which has a high mortality rate. Intrinsic resistance to fluconazole can cause the failure of Krusei candidiasis treatment. Therefore, it is necessary to find alternative drugs ...

Abstract	Background: Candida krusei is the cause of the fungal infection candidiasis, which has a high mortality rate. Intrinsic resistance to fluconazole can cause the failure of Krusei candidiasis treatment. Therefore, it is necessary to find alternative drugs to eliminate the fungus. Extracts of Syzygium aromaticum and Alpinia purpurata have been proven to be alternative solutions for treating Candida krusei resistance. Objective: This study aims to explore the active compounds Syzygium aromaticum and Alpinia purpurata as treatments against Candida krusei through bioactivity tests, molecular modeling, and toxicity tests. Methods: Determination of antifungal activity with the agar well diffusion and microbroth dilution method. Molecular modeling was conducted using the following software: Marvin Sketch, LigandScout 4.4.5, AutoDock ver 4.2.6, PyMOL, LigPlus, MOE ver 2008. Result: Bioactivity test results of the two natural extracts against C. krusei ATCC 6258, it was found that the S. aromaticum and A. purpurata extracts have MIC50 values of 0.031 μg/mL and 1.435x105 μg/mL. The molecular modeling found that the compounds Benzotriazole, 1-(4-methyl-3-nitrobenzoyl)-, 1,3,4-Eugenol Acetate, Stigmasta-5,22-dien-3-ol, acetate (3 beta)- and Farnesyl acetate from the two natural extracts, interacts with the active site of the enzyme lanosterol-14-α-demethylase with a binding energy of -8.91, -6.04, -13.53, and -7.15 kcal/mol. The oral acute toxicity test of S. aromaticum and A. purpurata extracts proved that the LD50 was >6000 mg/kg BW and >8000 mg/kg BW. The acute dermal toxicity test of the two extracts showed that the LD50 was >6000 mg/kg BW. Conclusion: S. aromaticum and A. purpurata extracts have been proven to be alternative solutions for treating Candida krusei resistance.
MeSH term(s)	Humans ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Syzygium/chemistry ; Alpinia ; Plant Extracts/chemistry ; Microbial Sensitivity Tests ; Candidiasis/drug therapy ; Candidiasis/microbiology ; Toxicity Tests ; Acetates
Chemical Substances	Antifungal Agents ; Plant Extracts ; Acetates
Language	English
Publishing date	2023-10-01
Publishing country	Thailand
Document type	Journal Article
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.31557/APJCP.2023.24.10.3403
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