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  1. Article: Papuloerythroderma of Ofuji in a Young Man.

    Patel, Raj H / Fagan, Kiley / Chitnavis, Padma V / Grider, Douglas

    Cureus

    2023  Volume 15, Issue 3, Page(s) e36598

    Abstract: Papuloerythroderma of Ofuji (PEO) is a rare skin disorder characterized by a distinctive pattern of pruritic, flat-topped, erythematous papules which coalesce into an erythroderma-like eruption with classic sparing of the skin folds. Although the ... ...

    Abstract Papuloerythroderma of Ofuji (PEO) is a rare skin disorder characterized by a distinctive pattern of pruritic, flat-topped, erythematous papules which coalesce into an erythroderma-like eruption with classic sparing of the skin folds. Although the pathogenesis of this condition is incompletely understood, previous reports have suggested a notable link between PEO and various forms of malignancy and immunocompromised states. Here, we report a case of a healthy young male with no comorbidities who presented with the classical features of PEO that responded well to combination therapy comprised of topical corticosteroids and phototherapy.
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Myxoid perineurioma: an entity with many mimics.

    Kim, Seo Hyun / Fagan, Kiley / Dorsey, Susan B / Grider, Douglas J

    Dermatology online journal

    2023  Volume 29, Issue 1

    Abstract: We present a case of a female patient who presented with a 0.6cm flesh-colored "rubbery" papule on the left thigh. Biopsy revealed a dermal myxoid tumor containing spindled cells, tapered nuclei, indistinct cell borders, and a large number of mast cells. ...

    Abstract We present a case of a female patient who presented with a 0.6cm flesh-colored "rubbery" papule on the left thigh. Biopsy revealed a dermal myxoid tumor containing spindled cells, tapered nuclei, indistinct cell borders, and a large number of mast cells. The spindle cells stained negative for S100 protein and Sox10 on immunohistochemistry, excluding myxoid neurofibroma, but positive for epithelial membrane antigen (EMA), and CD34, supporting a diagnosis of myxoid perineurioma. Interestingly, the mast cells showed cytoplasmic and nuclear positivity for microphthalmia transcription factor (MiTF). The lesion was fully excised one year later with identical histopathology and ancillary immunohistochemical profile.
    MeSH term(s) Humans ; Female ; Nerve Sheath Neoplasms/metabolism ; Nerve Sheath Neoplasms/pathology ; Immunohistochemistry ; S100 Proteins ; Biopsy ; Diagnosis, Differential
    Chemical Substances S100 Proteins
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
    DOI 10.5070/D329160216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Non-psoriatic uses of calcipotriol: a concise updated review.

    Patel, Riya T / Gay, Jane J / Fagan, Kiley K / Eikenberg, Joshua D

    Dermatology online journal

    2023  Volume 29, Issue 3

    Abstract: Calcipotriol (calcipotriene) is a synthetic vitamin D3 derivative that is a standard treatment option for psoriasis. It is generally well tolerated with minimal side effects. Due to its ability to reduce keratinocyte proliferation and induce keratinocyte ...

    Abstract Calcipotriol (calcipotriene) is a synthetic vitamin D3 derivative that is a standard treatment option for psoriasis. It is generally well tolerated with minimal side effects. Due to its ability to reduce keratinocyte proliferation and induce keratinocyte differentiation as well as its immunomodulatory effects, calcipotriol has been used to treat a variety of skin disorders such as atopic dermatitis, actinic keratoses, lichen planus, seborrheic keratoses, and vitiligo [1]. We surveyed the literature examining the use of calcipotriol for non-psoriatic dermatologic disease.
    MeSH term(s) Humans ; Calcitriol/therapeutic use ; Dermatitis, Atopic ; Drug-Related Side Effects and Adverse Reactions ; Psoriasis/drug therapy
    Chemical Substances calcipotriene (143NQ3779B) ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2026239-5
    ISSN 1087-2108 ; 1087-2108
    ISSN (online) 1087-2108
    ISSN 1087-2108
    DOI 10.5070/D329361422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: An Extraordinary Cause of Colonic Obstruction: Merkel Cell Carcinoma of Unknown Primary.

    Ganjineh, Brandon / Abel, William / Reddy, Shravani / Fagan, Kiley / Grider, Douglas

    ACG case reports journal

    2023  Volume 10, Issue 6, Page(s) e01088

    Abstract: Merkel cell carcinoma is an aggressive and rare neuroendocrine skin cancer with documented metastases to the liver, lungs, and, seldom, the gastrointestinal tract. Metastases to the colon are rare but are seen with primary skin lesions or recurrent ... ...

    Abstract Merkel cell carcinoma is an aggressive and rare neuroendocrine skin cancer with documented metastases to the liver, lungs, and, seldom, the gastrointestinal tract. Metastases to the colon are rare but are seen with primary skin lesions or recurrent disease. Presented is a patient with large bowel obstruction secondary to a large hepatic flexure mass. Pathologic workup revealed Merkel cell carcinoma, and a dermatologic evaluation did not identify a primary cutaneous lesion. This is the first reported case of Merkel cell carcinoma of unknown primary presenting as large bowel obstruction.
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000001088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Unexpected Granulomatous Dermatitis: Challenge.

    Murray, Douglas W / Fagan, Kiley K / Eikenberg, Joshua D / Grider, Douglas J

    The American Journal of dermatopathology

    2023  Volume 45, Issue 5, Page(s) e37–e38

    MeSH term(s) Humans ; Dermatitis/diagnosis ; Autoimmune Diseases
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Erythematous Patches and Plaques: What to Make of a Rash that Looks Like Pepperoni Pizza? Challenge.

    Murray, Douglas W / Fagan, Kiley K / Timmermann, Paul C / Grider, Douglas J

    The American Journal of dermatopathology

    2023  Volume 45, Issue 6, Page(s) e43–e44

    MeSH term(s) Humans ; Erythema/diagnosis ; Exanthema/diagnosis ; Meat Products
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unexpected Granulomatous Dermatitis.

    Murray, Douglas W / Fagan, Kiley K / Eikenberg, Joshua D / Grider, Douglas J

    The American Journal of dermatopathology

    2023  Volume 45, Issue 5, Page(s) 348–349

    MeSH term(s) Humans ; Dermatitis/diagnosis ; Dermatitis/etiology ; Autoimmune Diseases
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pseudolymphoma to Lymphoma: A Case of Chronic Reactive Lymphoid Hyperplasia Transforming to Primary Cutaneous Marginal Zone Lymphoma.

    Singh, Neha / Fagan, Kiley K / Patel, Riya T / Grider, Douglas J

    The American Journal of dermatopathology

    2023  Volume 45, Issue 4, Page(s) 250–253

    Abstract: Abstract: Primary cutaneous marginal zone lymphoma (PCMZL) is a low-grade malignant B-cell lymphoma that originates from the skin. It often presents as erythematous solitary or multiple papules, nodules, and/or plaques. It is one of the 3 main subtypes ... ...

    Abstract Abstract: Primary cutaneous marginal zone lymphoma (PCMZL) is a low-grade malignant B-cell lymphoma that originates from the skin. It often presents as erythematous solitary or multiple papules, nodules, and/or plaques. It is one of the 3 main subtypes of primary cutaneous B-cell lymphomas. PCMZLs are believed to develop from chronic antigenic stimulation such as from tick-borne bacteria, vaccines, tattoo pigment, or other foreign body. In addition, cutaneous lymphoid hyperplasia, a documented precursor to malignant PCMZL, often presents in response to areas of chronic inflammation. Cutaneous lymphoid hyperplasia and PCMZL share several clinical and histological similarities that require clinicopathologic suspicion, immunohistochemical ancillary studies, and histopathologic analysis to accurately differentiate the 2 entities. Although gene rearrangement studies have historically been of limited value in the diagnosis of PCMZL, recent studies investigating molecular markers have identified the presence of multiple genetic abnormalities that have helped to better characterize the disease and aid in diagnosis. In addition, newer studies have found associations between PCMZL and gastrointestinal disorders, including Helicobacter pylori and inflammatory bowel disorders. In this article, we describe a case of a 56-year-old patient with a history of ulcerative colitis presenting with chronic reactive lymphoid hyperplasia that transformed to primary cutaneous marginal zone lymphoma.
    MeSH term(s) Humans ; Middle Aged ; Pseudolymphoma/pathology ; Skin Neoplasms/pathology ; Hyperplasia ; Lymphoma ; Lymphoma, B-Cell/pathology ; Lymphoma, B-Cell, Marginal Zone/pathology
    Language English
    Publishing date 2023-02-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Erythematous Patches and Plaques: What to Make of a Rash that Looks like Pepperoni Pizza?

    Murray, Douglas W / Fagan, Kiley K / Timmermann, Paul C / Grider, Douglas J

    The American Journal of dermatopathology

    2023  Volume 45, Issue 6, Page(s) 427–428

    MeSH term(s) Humans ; Exanthema/diagnosis ; Erythema/diagnosis ; Meat Products
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Interstitial Mycosis Fungoides: An Unusual Mimic of Interstitial Granuloma Annulare Not to Miss.

    Singh, Neha / Fagan, Kiley K / Grider, Douglas J

    Case reports in dermatological medicine

    2022  Volume 2022, Page(s) 3506738

    Abstract: Interstitial mycosis fungoides is a rare histopathologic variant of mycosis fungoides that may resemble interstitial granuloma annulare, inflammatory morphea, and interstitial granulomatous dermatitis. Reported is a case of a 62-year-old African American ...

    Abstract Interstitial mycosis fungoides is a rare histopathologic variant of mycosis fungoides that may resemble interstitial granuloma annulare, inflammatory morphea, and interstitial granulomatous dermatitis. Reported is a case of a 62-year-old African American female who presented with an asymptomatic, progressive rash of the left underarm and abdomen with histologic features suggestive of granuloma annulare. Biopsies revealed an interstitial pattern of cells in the dermis with prominent small aggregates of atypical lymphocytes, a few atypical lymphocytes in the lower epidermis, and a mild increase in dermal mucin. Immunohistochemistry staining revealed the atypical lymphocytes to be positive for CD3 and CD8 and negative for CD4 and CD7, an aberrant immunoprofile. Mixed in the dermis with the atypical lymphoid cells were a few CD68 positive histiocytes and S100 protein positive dermal dendritic cells. T-cell receptor beta gene rearrangement studies showed nearly the same clonal peaks for TCRB rearrangement in two biopsy specimens from separate sites, all supporting a diagnosis of interstitial mycosis fungoides. The patient is undergoing treatment with full body narrowband UVB (nbUVB) phototherapy with notable improvement in skin discoloration and resolution of several abdominal lesions. A diagnosis of interstitial mycosis fungoides is challenging to make based on clinical features alone and is often clinically misdiagnosed. Awareness of histopathologic features is critical to make an accurate diagnosis and thus patient management.
    Language English
    Publishing date 2022-09-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2684644-5
    ISSN 2090-6471 ; 2090-6463
    ISSN (online) 2090-6471
    ISSN 2090-6463
    DOI 10.1155/2022/3506738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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