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Article ; Online: Effect of prepared herbal mouthwash in maintaining the oral health of school children: A single-blind randomised control trial.

Fahim, M F M / Zarnigar, Prof

2023

Abstract: Background and aim: Oral health is a vital indicator of overall well-being, quality of life, and general health, with historical roots in Unani medicine (i.e. preventive measures, oral hygiene, and treatment). This study aims to assess the efficacy and ... ...

Abstract	Background and aim: Oral health is a vital indicator of overall well-being, quality of life, and general health, with historical roots in Unani medicine (i.e. preventive measures, oral hygiene, and treatment). This study aims to assess the efficacy and safety of prepared herbal mouthwash in maintaining oral health among school children. Experimental procedure: 110 schoolchildren were randomly assigned to the test group (treated with herbal mouthwash -Anacyclus pyrenthrum DC, Punica granutum (pericarp), Capparis spinosa (root bark), and Quercus infectoria Oliv (galls)) and the control group (treated with 0.2 % Chlorhexidine Mouthwash) for 30-days. The response was assessed by DMFT, Salivary pH, Oral hygiene index-simplified (OHI-S), Plaque index (Loe & Silness) (PI), Plaque index simplified (O'Leary et al., 1972) (PI-S), Gingival Index (Löe-Silness) (GI), and Bleeding on probing (BOP) on baseline and 30th day GI and PI were further assessed on 60th, 90th and 120th days to determine the sustainable effect of the intervention. Results: After treatment, Mean OHI-S, PI, PI-S, GI and BOP significantly reduced on the 30th day from baseline (p ≤ 0.001) in both groups. After discontinuing intervention, both groups showed significantly lower PI and GI scores on the 120th day from baseline. (p < 0.001). Conclusion: This study revealed that prepared mouthwash is safe and significantly effective in maintaining oral health, and it could be used as an adjunct to mechanical oral hygiene measures.
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2183945-1
ISSN	1878-7541 ; 1550-8307
ISSN (online)	1878-7541
ISSN	1550-8307
DOI	10.1016/j.explore.2023.12.003
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Zs.A 6635: Show issues

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Article: Exploring Raoultella planticola: Implications for Pediatric Health.

Bautista, Aaron L / Wissa, Ramy / Fahim, Mariam

Cureus

2024 Volume 16, Issue 3, Page(s) e57262

Abstract: The case presentation discusses the clinical evaluation and treatment of a two-year-old female exhibiting symptoms such as dysuria, constipation, and foul-smelling urine. Upon evaluation, the patient was found to be co-infected with Raoultella planticola ...

Abstract	The case presentation discusses the clinical evaluation and treatment of a two-year-old female exhibiting symptoms such as dysuria, constipation, and foul-smelling urine. Upon evaluation, the patient was found to be co-infected with Raoultella planticola and Escherichia coli. This co-infection poses unique challenges in diagnosis and treatment, as both pathogens may contribute to the manifestation of symptoms. The initial diagnosis of Raoultella planticola is notable, given its relatively rare occurrence and the potential for misdiagnosis. This case study contributes to our understanding of diagnosing and distinguishing symptoms at various stages of the illness, particularly in cases of co-infection. Following an initial urinalysis and urine culture confirming the presence of both pathogens, a 10-day course of antibiotics was prescribed. Subsequent examinations at Rady Children's Hospital-San Diego included kidney and abdomen imaging to rule out underlying issues. The co-infection underscores the importance of thorough diagnostic procedures and tailored treatment approaches. Additionally, it highlights the need for heightened awareness among healthcare providers regarding emerging pathogens and their potential clinical implications.
Language	English
Publishing date	2024-03-30
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.57262
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Article ; Online: Unsteady blood flow of Carreau fluid in a porous saturated medium with stenosis under the influence of acceleration and magnetic fields: A comprehensive analysis.

Fahim, Muhammad / Sajid, Muhammad / Ali, Nasir / Naveed, Muhammad

Computers in biology and medicine

2023 Volume 164, Page(s) 107278

Abstract: Blood flow in stenosed arteries is a common cause of cardiovascular diseases, leading to serious health problems. The present study aims to investigate the unsteady Womersley blood flow in a stenosed, porous saturated artery under the influence of ... ...

Abstract	Blood flow in stenosed arteries is a common cause of cardiovascular diseases, leading to serious health problems. The present study aims to investigate the unsteady Womersley blood flow in a stenosed, porous saturated artery under the influence of acceleration and magnetic fields. The study utilizes a Carreau constitutive equation to model blood rheology and employs the finite difference technique to compute the governing equations under the assumption of unsteady, unidirectional, and laminar flow. The importance of this study lies in its potential to provide a better understanding of the complex behavior of hemodynamic flow in the presence of external fields and porous media, which has significant implications for the control and management of cardiovascular diseases. In particular, the study analyses the impacts of non-dimensional parameters, such as magnetic field, channel permeability, acceleration field, Weissenberg number, and stenosis amplitude, on critical flow variables, such as velocity, resistivity, wall shear stress, and flow rate. Our calculations suggest that a magnetic field is an effective instrument for regulating hemodynamic flow because it increases resistance by up to 8.31% while decreasing flow by up to 8.44%. Channel permeability, on the other hand, improves blood velocity by up to 33.35% while eliminating resistance by up to 23.43%. Furthermore, greater acceleration fields decrease resistivity while increasing velocity, flow rate, and wall shear stress. Additionally, the severity of the stenosis and the Weissenberg number substantially affect flow factors. By raising the stenosis amplitude, resistivity rises, and other flow characteristics diminish, whereas modifying the Weissenberg number causes the reverse effect.
MeSH term(s)	Humans ; Cardiovascular Diseases ; Porosity ; Constriction, Pathologic ; Computer Simulation ; Hemodynamics/physiology ; Arteries ; Magnetic Fields ; Acceleration ; Stress, Mechanical ; Models, Cardiovascular ; Blood Flow Velocity/physiology
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2023.107278
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Zs.A 653: Show issues

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Article ; Online: Prostate cancer invasion is promoted by the miR-96-5p-induced NDRG1 deficiency through NF-κB regulation.

Soror, A A / Eshagh, R / Fahim, M R / Jamshidian, A / Monfared, G H

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti

2024 Volume 38, Issue 2, Page(s) 95–101

Abstract: Background: The N-myc downstream-regulated gene 1 (NDRG1) has been discovered as a significant gene in the progression of cancers. However, the regulatory mechanism of NDRG1 remained obscure in prostate cancer (PCa).: Methods: The miR-96-5p and NDRG1 ...

Title translation	Invaze karcinomu prostaty je podporována nedostatkem NDRG1 vyvolaným miR-96-5p prostřednictvím regulace NF-κB.
Abstract	Background: The N-myc downstream-regulated gene 1 (NDRG1) has been discovered as a significant gene in the progression of cancers. However, the regulatory mechanism of NDRG1 remained obscure in prostate cancer (PCa). Methods: The miR-96-5p and NDRG1 expression levels were evaluated in PCa cell lines, and prostate tissues, and validated in public databases by real-time polymerase chain reaction, western blot analysis, and immunohistochemistry. The function of miR-96-5p and NDRG1 were investigated by scratch assay and transwell assays in vitro, and mouse xenograft assay in vivo. The candidate pathway regulated by NDRG1 was conducted by the next-generation gene sequencing technique. Immunofluorescence and luciferase assays were used to detect the relation between miR-96-5p, NDRG1, and NF-kB pathway. Results: Overexpressing NDRG1 suppresses the migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro, and inhibits metastasis in vivo. Moreover, miR-96-5p contributes to NDRG1 deficiency and promotes PCa cell migration and invasion. Furthermore, NDRG1 loss activates the NF-kB pathway, which stimulates p65 and IKBa phosphorylation and induces EMT in PCa. Conclusions: MiR-96-5p promotes the migration and invasion of PCa by targeting NDRG1 and regulating the NF-kB pathway.
MeSH term(s)	MicroRNAs/genetics ; Humans ; Male ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; NF-kappa B/metabolism ; Animals ; Cell Line, Tumor ; Mice ; Neoplasm Invasiveness ; Epithelial-Mesenchymal Transition ; Cell Movement ; Gene Expression Regulation, Neoplastic
Chemical Substances	N-myc downstream-regulated gene 1 protein ; MicroRNAs ; Intracellular Signaling Peptides and Proteins ; Cell Cycle Proteins ; NF-kappa B ; MIRN96 microRNA, human
Language	English
Publishing date	2024-05-02
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1217739-8
ISSN	1802-5307 ; 0862-495X
ISSN (online)	1802-5307
ISSN	0862-495X
DOI	10.48095/ccko202495
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Zs.A 4181: Show issues

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Article ; Online: Impact of a clinical pharmacist on optimising the quality use of medicines according to the acute coronary syndrome (ACS) secondary prevention guidelines and medication adherence following discharge in patients with ACS in Sri Lanka: a prospective non-randomised controlled trial study protocol.

Bagyawantha, Nanayakkara Muhandiramalaya Yasakalum / Coombes, Ian D / Gawarammana, Indika / Fahim, Mohamed

BMJ open

2023 Volume 13, Issue 2, Page(s) e059413

Abstract: Objectives: Ensuring quality use of medicines (QUM) through clinical pharmacy services can improve therapeutic outcomes of patients diagnosed with acute coronary syndrome (ACS). The major objective of this study is to demonstrate the added value of a ... ...

Abstract	Objectives: Ensuring quality use of medicines (QUM) through clinical pharmacy services can improve therapeutic outcomes of patients diagnosed with acute coronary syndrome (ACS). The major objective of this study is to demonstrate the added value of a clinical pharmacist to the medical and nursing team providing care to patients with ACS on the continuation of quality use of the patients' medicine after discharge. Study design: This protocol outlines a prospective, non-blinded, non-randomised, controlled interventional study. Study setting: The study will be conducted at the professorial medical wards of a tertiary care teaching hospital in Sri Lanka. Participants: Sample size will be 746 patients in both control and intervention arms. Patients diagnosed with ACS who are 18 years old or above and expected to visit the hospital for their routine clinic follow-ups after discharge will be recruited and randomised 1:1 to either the intervention group or the control group. Patients who are diagnosed and suffering from psychological disorders will be excluded from this study. Interventions: The planned interventions that will be delivered at discharge include review and optimisation of medications, assessing patient adherence and providing discharge medication counselling. Data will be collected at recruitment, 1 month, 3 months and 6 months' time intervals in both groups. Improvement of patients' medication adherence, reduction of hospital readmissions, reduction of drug-related problems, the attitude of doctors and nurses towards clinical pharmacy services and the cost-effectiveness of the clinical pharmacy services will be the major outcomes of this study. Ethics and dissemination: Ethical approval for this study has been obtained from the ethics review committee, Faculty of Medicine, University of Peradeniya (2019/EC/26) and the trial is registered at the Sri Lanka Clinical Trials Registry. The results of this study will be disseminated via conference proceedings, journal publications and thesis presentations. Trial registration number: SLCTR/2019/039.
MeSH term(s)	Humans ; Adolescent ; Patient Discharge ; Secondary Prevention/methods ; Acute Coronary Syndrome/drug therapy ; Pharmacists ; Prospective Studies ; Sri Lanka ; Medication Adherence
Language	English
Publishing date	2023-02-09
Publishing country	England
Document type	Clinical Trial ; Controlled Clinical Trial ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-059413
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Article: Modeling and implementation of a low-cost IoT-smart weather monitoring station and air quality assessment based on fuzzy inference model and MQTT protocol.

Fahim, Mohamed / El Mhouti, Abderrahim / Boudaa, Tarik / Jakimi, Abdeslam

Modeling earth systems and environment

2023 , Page(s) 1–18

Abstract: The automatic weather system serves to inform farmers, tourists, planners, and others with precise information to help them take the appropriate action. Today, with the advancement of smart technologies, the system has evolved into many sensing methods ... ...

Abstract	The automatic weather system serves to inform farmers, tourists, planners, and others with precise information to help them take the appropriate action. Today, with the advancement of smart technologies, the system has evolved into many sensing methods to gather real-time climate data. This article investigates the modeling and implementation of a low-cost weather station device that also functions to measure air quality. The proposed system based on the Internet of Things (IoT) allows access to real-time climate data for a given area. This system monitors environmental conditions such as ambient temperature, humidity, atmospheric pressure, altitude, and levels of harmful atmospheric gases like CO
Language	English
Publishing date	2023-02-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2821317-8
ISSN	2363-6211 ; 2363-6203
ISSN (online)	2363-6211
ISSN	2363-6203
DOI	10.1007/s40808-023-01701-w
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Article ; Online: Rabies: Perils and Prevention, an Insight into Practices and Perception in Residents of Pakistan

Shaikh, Saif Ullah / Zaid, Faryal / Shaikh, Zahida / Faisal Fahim, Muhammad

Iranian biomedical journal

2023 Volume 27, Issue 1, Page(s) 66–71

Abstract: Background: There is a sheer lack of knowledge in treating rabies in Pakistan. To decrease the number of victims every year, immunization and awareness programs are the basic necessities of Pakistani population. The aim of this study was to highlight ... ...

Abstract	Background: There is a sheer lack of knowledge in treating rabies in Pakistan. To decrease the number of victims every year, immunization and awareness programs are the basic necessities of Pakistani population. The aim of this study was to highlight the lack of learning strategies and how to overcome this problem, so as to eliminate rabies. Methods: This cross-sectional study was conducted on 692 respondents, aged 8-50 years, in Karachi city of Pakistan from January 2022 to June 2022. The study was based on demographic characteristics and basic knowledge of rabies, mode of transmission, clinical signs, and range of animal host species. Binary logistic regression analysis was performed to know the risk factor of rabies among different age groups, marital status, occupation, etc. Results: Results revealed that all the age groups were at risk of the wrong knowledge about rabies, odds = 1.182 and odds = 1.775 for 20-30 and 31-40 years of age, respectively; however, 31-40 years were at the high risk of showing odds=3.597 (95% C.I 1.621-7.983). The correlation of occupation was also checked with rabies knowledge. Only doctors (odds = 1.396) and students (odds = 1.955) showed their unawareness about rabies. Conclusion: This study highlights the grave situation that holds the country in the form of rabies. Through this study we aspire to raise awareness regarding the transmission, spread, and control of rabies
MeSH term(s)	Animals ; Rabies/epidemiology ; Rabies/prevention & control ; Pakistan/epidemiology ; Cross-Sectional Studies ; Health Knowledge, Attitudes, Practice ; Perception
Language	English
Publishing date	2023-01-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2489282-8
ISSN	2008-823X ; 1028-852X
ISSN (online)	2008-823X
ISSN	1028-852X
DOI	10.52547/ibj.3841
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Zs.A 6776: Show issues

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Article ; Online: Fully automated sinogram-based deep learning model for detection and classification of intracranial hemorrhage.

Sindhura, Chitimireddy / Al Fahim, Mohammad / Yalavarthy, Phaneendra K / Gorthi, Subrahmanyam

Medical physics

2023 Volume 51, Issue 3, Page(s) 1944–1956

Abstract: Purpose: To propose an automated approach for detecting and classifying Intracranial Hemorrhages (ICH) directly from sinograms using a deep learning framework. This method is proposed to overcome the limitations of the conventional diagnosis by ... ...

Abstract	Purpose: To propose an automated approach for detecting and classifying Intracranial Hemorrhages (ICH) directly from sinograms using a deep learning framework. This method is proposed to overcome the limitations of the conventional diagnosis by eliminating the time-consuming reconstruction step and minimizing the potential noise and artifacts that can occur during the Computed Tomography (CT) reconstruction process. Methods: This study proposes a two-stage automated approach for detecting and classifying ICH from sinograms using a deep learning framework. The first stage of the framework is Intensity Transformed Sinogram Sythesizer, which synthesizes sinograms that are equivalent to the intensity-transformed CT images. The second stage comprises of a cascaded Convolutional Neural Network-Recurrent Neural Network (CNN-RNN) model that detects and classifies hemorrhages from the synthesized sinograms. The CNN module extracts high-level features from each input sinogram, while the RNN module provides spatial correlation of the neighborhood regions in the sinograms. The proposed method was evaluated on a publicly available RSNA dataset consisting of a large sample size of 8652 patients. Results: The results showed that the proposed method had a notable improvement as high as 27% in patient-wise accuracies when compared to state-of-the-art methods like ResNext-101, Inception-v3 and Vision Transformer. Furthermore, the sinogram-based approach was found to be more robust to noise and offset errors in comparison to CT image-based approaches. The proposed model was also subjected to a multi-label classification analysis to determine the hemorrhage type from a given sinogram. The learning patterns of the proposed model were also examined for explainability using the activation maps. Conclusion: The proposed sinogram-based approach can provide an accurate and efficient diagnosis of ICH without the need for the time-consuming reconstruction step and can potentially overcome the limitations of CT image-based approaches. The results show promising outcomes for the use of sinogram-based approaches in detecting hemorrhages, and further research can explore the potential of this approach in clinical settings.
MeSH term(s)	Humans ; Deep Learning ; Image Processing, Computer-Assisted/methods ; Neural Networks, Computer ; Tomography, X-Ray Computed/methods ; Intracranial Hemorrhages/diagnostic imaging ; Algorithms
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1002/mp.16714
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Zs.A 1210: Show issues

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Article ; Online: A Wearable-based Preventive Model To Promote Oral Health Through Personalized Notification.

Fahim, Muhammad / Sharma, Vishal / Duong, Trung Q

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2022 Volume 2022, Page(s) 4282–4285

Abstract: Wearable technology has great potential to develop human-centric healthcare applications. It reshapes our lifestyle by providing information related to physical activities, sleep monitoring, or heartbeat rhythms. In this paper, we present an innovative ... ...

Abstract	Wearable technology has great potential to develop human-centric healthcare applications. It reshapes our lifestyle by providing information related to physical activities, sleep monitoring, or heartbeat rhythms. In this paper, we present an innovative model for oral healthcare, which is prevention-focused to notify individuals about cleaning teeth activity. It is based on a wrist-worn accelerometer device and has two components-first, a computationally lightweight feature extractor-secondly, a robust feed-forward neural network to recognize the cleaning teeth activity. The model performance is measured using standard performance metric F
MeSH term(s)	Humans ; Neural Networks, Computer ; Oral Health ; Toothbrushing ; Wearable Electronic Devices ; Wrist
Language	English
Publishing date	2022-09-10
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC48229.2022.9871128
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Article ; Online: Walthard cyst of spermatic cord in the right inguinal hernia.

Fahim, Muhammad / Oyewole, Bankole / Heatley, Nicholas / Belgaumkar, Ajay

BMJ case reports

2022 Volume 15, Issue 6

Abstract: There are isolated case reports of Walthard cells in paratesticular structures although these benign epithelial cells are commonly found in relation to fallopian tubes. This is a second case report of cystic Walthard rest presented in an elderly man in ... ...

Abstract	There are isolated case reports of Walthard cells in paratesticular structures although these benign epithelial cells are commonly found in relation to fallopian tubes. This is a second case report of cystic Walthard rest presented in an elderly man in right inguinal hernia.
MeSH term(s)	Aged ; Cysts/complications ; Cysts/diagnostic imaging ; Fallopian Tubes ; Female ; Hernia, Inguinal/complications ; Hernia, Inguinal/diagnostic imaging ; Hernia, Inguinal/surgery ; Humans ; Male ; Pelvis ; Spermatic Cord
Language	English
Publishing date	2022-06-06
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-247963
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