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Article ; Online: Risk factors for in-hospital complications in patients with acute ischemic stroke: Retrospective cohort in a national reference hospital in Peru

Vences, Miguel A. / Failoc-Rojas, Virgilio E. / Urrunaga-Pastor, Diego / Hurtado-Roca, Yamilée

Heliyon. 2023 May, v. 9, no. 5 p.e15810-

2023

Abstract: To describe the clinical and demographic characteristics of patients with acute cerebral infarction treated at a national reference hospital in Peru and determine the risk factors for in-hospital complications. We conducted a retrospective cohort study ... ...

Abstract	To describe the clinical and demographic characteristics of patients with acute cerebral infarction treated at a national reference hospital in Peru and determine the risk factors for in-hospital complications. We conducted a retrospective cohort study including 192 patients with acute ischemic stroke in a national reference hospital in Peru from January to September 2021. Clinical, demographic and paraclinical information was recorded from medical records. We estimated risk ratios and 95% confidence intervals using regression models with Poisson family and robust variance for the bivariate and multivariate model, adjusting for age, sex and risk factors for stroke. At least one in-hospital complication occurred in 32.3% of the patients. The most frequent complications were infectious in 22.4%, followed by 17.7% of neurological complications, with other complications, such as thromboembolism, immobility and miscellaneous, being much less frequent. Regression analysis showed that stroke severity (RR = 1.76; 95%CI:1.09-2.86) and albumin greater than 3.5 mg/dL (RR = 0.53; 95%CI: 0.36-0.79) were independent risk factors for the presence of in-hospital complications. A high rate of in-hospital complications were observed, among which infectious and neurological complications were the most frequent. Stroke severity was a risk factor and albumin greater than 3.5 mg/dL was a protective factor for the incidence of in-hospital complications. These results can serve as a starting point for establishing stroke care systems that consider differentiated flows for the prevention of in-hospital complications.
Keywords	albumins ; cohort studies ; hospitals ; infarction ; regression analysis ; risk factors ; stroke ; variance ; Peru ; Acute ; Ischemic stroke ; Complications ; Risk factors (Source: MeSH)
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15810
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fatal leukodystrophy in Costello syndrome: a case report.

Failoc-Rojas, Virgilio E / Ugaz, Piero A Quiroz / León, Dante A Loconi / Zeña-Ñañez, Sandra

BMC pediatrics

2023 Volume 23, Issue 1, Page(s) 374

Abstract: Background: Costello syndrome (CS) is a rare genetic condition characterized by dysregulation of the signaling pathway, phenotypic alteration due to fetal macrosomia or growth retardation, facial abnormalities, loose skin, cardiovascular abnormalities, ... ...

Abstract	Background: Costello syndrome (CS) is a rare genetic condition characterized by dysregulation of the signaling pathway, phenotypic alteration due to fetal macrosomia or growth retardation, facial abnormalities, loose skin, cardiovascular abnormalities, and a variable degree of intellectual disability. Case presentation: We describe the case of a 20-month-old male patient with fetal macrosomia and polyhydramnios, presenting psychomotor development delay and growth limitation during the first months of life. CS was diagnosed at four months of age after detecting a variant of the HRAS gene c.35G > C (p.G12A). A clinical description of his condition was recorded throughout his life, including cardiovascular diseases, endocrine disorders, and recurrent infections. At 20 months of age, after presenting events of marked hypotonia and generalized seizures, brain magnetic resonance revealed symmetrical lesions of the infra- and supratentorial white matter in both cerebral hemispheres, which resulted in the diagnosis of cerebral leukodystrophy. The patient had a rapid and progressive deterioration that eventually led to death. Conclusions: This is the first report of a case of CS in Peru. In addition, this is a case that presented with multisystemic conditions culminating in leukodystrophy, which is a rare event according to the literature.
MeSH term(s)	Pregnancy ; Female ; Humans ; Male ; Infant ; Costello Syndrome/complications ; Costello Syndrome/diagnosis ; Costello Syndrome/genetics ; Fetal Macrosomia ; Genes, ras ; Intellectual Disability/genetics ; Cardiovascular Abnormalities
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-023-04166-z
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Article: Association between chronic kidney disease and mortality in patients with a confirmed COVID-19 diagnosis.

Puicón-Suárez, Jacqueline Betsabe / Zeña-Ñañez, Sandra / Failoc-Rojas, Virgilio E

PeerJ

2022 Volume 10, Page(s) e13437

Abstract: Objective: To determine the association between chronic kidney disease (CKD) and mortality in persons with a confirmed coronavirus disease 2019 (COVID-19) diagnosis.: Methods: Cross-sectional secondary baseline study. The study population consisted ... ...

Abstract	Objective: To determine the association between chronic kidney disease (CKD) and mortality in persons with a confirmed coronavirus disease 2019 (COVID-19) diagnosis. Methods: Cross-sectional secondary baseline study. The study population consisted of 243,065 patients confirmed to have COVID-19 during May-December 2020. Stata 16.0 was used for statistical analysis, Chi-square test was used for bivariate analysis, and Poisson regression with robust variances was used for multiple analysis. Results: The prevalence of patients with a confirmed COVID-19 diagnosis who had CKD and died was 1.42 times the prevalence of mortality in those without CKD. The comorbidities combined with CKD that presented the highest probability of mortality were diabetes mellitus and hypertension. Conclusions: CKD is associated with a high mortality rate in patients with a confirmed COVID-19 diagnosis. Patients with CKD, diabetes mellitus, and arterial hypertension have a higher prevalence of mortality than those without comorbidities.
MeSH term(s)	Humans ; COVID-19/diagnosis ; Cross-Sectional Studies ; COVID-19 Testing ; Diabetes Mellitus/diagnosis ; Hypertension/complications ; Renal Insufficiency, Chronic/diagnosis
Language	English
Publishing date	2022-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.13437
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Article: Risk factors for in-hospital complications in patients with acute ischemic stroke: Retrospective cohort in a national reference hospital in Peru.

Vences, Miguel A / Failoc-Rojas, Virgilio E / Urrunaga-Pastor, Diego / Hurtado-Roca, Yamilée

Heliyon

2023 Volume 9, Issue 5, Page(s) e15810

Abstract: Objective: To describe the clinical and demographic characteristics of patients with acute cerebral infarction treated at a national reference hospital in Peru and determine the risk factors for in-hospital complications.: Methods: We conducted a ... ...

Abstract	Objective: To describe the clinical and demographic characteristics of patients with acute cerebral infarction treated at a national reference hospital in Peru and determine the risk factors for in-hospital complications. Methods: We conducted a retrospective cohort study including 192 patients with acute ischemic stroke in a national reference hospital in Peru from January to September 2021. Clinical, demographic and paraclinical information was recorded from medical records. We estimated risk ratios and 95% confidence intervals using regression models with Poisson family and robust variance for the bivariate and multivariate model, adjusting for age, sex and risk factors for stroke. Results: At least one in-hospital complication occurred in 32.3% of the patients. The most frequent complications were infectious in 22.4%, followed by 17.7% of neurological complications, with other complications, such as thromboembolism, immobility and miscellaneous, being much less frequent. Regression analysis showed that stroke severity (RR = 1.76; 95%CI:1.09-2.86) and albumin greater than 3.5 mg/dL (RR = 0.53; 95%CI: 0.36-0.79) were independent risk factors for the presence of in-hospital complications. Conclusions: A high rate of in-hospital complications were observed, among which infectious and neurological complications were the most frequent. Stroke severity was a risk factor and albumin greater than 3.5 mg/dL was a protective factor for the incidence of in-hospital complications. These results can serve as a starting point for establishing stroke care systems that consider differentiated flows for the prevention of in-hospital complications.
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15810
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Factors related to depression in elderly patients attending primary health care centres in Chiclayo (Peru).

Failoc-Rojas, Virgilio E / Meoño, Aldo Del Pielago

Revista Colombiana de psiquiatria (English ed.)

2021 Volume 50, Issue 4, Page(s) 285–289

Abstract: Objectives: The aim of this work is to evaluate the factors related to depression in older adults seen in the health centres of Chiclayo.: Methods: An observational, prospective, analytical study that included adults over 60 years of age residing in ... ...

Abstract	Objectives: The aim of this work is to evaluate the factors related to depression in older adults seen in the health centres of Chiclayo. Methods: An observational, prospective, analytical study that included adults over 60 years of age residing in the Chiclayo district (Peru). The abbreviated depression scale of Yesavage was used. Univariate analysis was performed, presented as frequencies and percentages, as well as bivariate analysis using chi-squared. Adjusted logistic regressions were calculated for age and gender. Results: A total of 302 older adults participated in this study. The median age was 73 years. It was found that 30.8 % had depressive signs, and 18.2 % had some degree of cognitive deterioration. Just over half (160, 52.98 %) had a socio-familial risk, and 29 (9.60 %) were detected in the dependent functional assessment. There was an association in the analysis of depression, age group, cognitive impairment, socio-family assessment (P < .05). In the multivariate analysis adjusted for age and gender, cognitive deterioration and socio-family assessment continued to be risk factors. Conclusions: Depression is associated with a deficiency in the cognitive state, with familial partner risk being an influential factor that may be preventable.
MeSH term(s)	Aged ; Cross-Sectional Studies ; Depression/epidemiology ; Humans ; Middle Aged ; Peru ; Primary Health Care ; Prospective Studies
Language	Spanish
Publishing date	2021-11-04
Publishing country	Spain
Document type	Journal Article ; Observational Study
ISSN	2530-3120
ISSN (online)	2530-3120
DOI	10.1016/j.rcpeng.2021.10.003
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Article ; Online: The role of angiogenesis inhibitors associated with tyrosine kinase inhibitors in the first-line treatment for EGFR-mutated advanced lung cancer.

Motta-Guerrero, Rodrigo / Recondo, Gonzalo / Cardona, Andres / Corrales, Luis / Arnao, Verónica / Failoc-Rojas, Virgilio E / Aliaga, Carlos

Critical reviews in oncology/hematology

2024 Volume 196, Page(s) 104294

Abstract: Tyrosine kinase inhibitors (TKIs) are the standard treatment for epidermal growth factor receptor mutant (EGFRm) advanced non-small cell lung cancer (NSCLC). Combining TKIs with an angiogenesis inhibitor has shown promise in pre-clinical studies. A ... ...

Abstract	Tyrosine kinase inhibitors (TKIs) are the standard treatment for epidermal growth factor receptor mutant (EGFRm) advanced non-small cell lung cancer (NSCLC). Combining TKIs with an angiogenesis inhibitor has shown promise in pre-clinical studies. A systematic search of clinical trials found that combining erlotinib (a first-generation TKI) with bevacizumab or ramucirumab (angiogenesis inhibitors) improved progression-free survival (PFS) in EGFRm advanced NSCLC patients compared to TKI alone. However, no significant benefit in overall survival (OS) was observed in trials. Similar efficacy was seen in patients with specific EGFR mutations. Third generation TKIs were used as second-line therapy for patients with the T790M mutation. The combination treatment was associated with a higher incidence of severe adverse events. Overall, combining erlotinib or another TKI with an angiogenesis inhibitor is a safe and effective alternative for first-line treatment in EGFRm advanced NSCLC, particularly in countries without access to osimertinib and for patients with the EGFR L858R mutation.
MeSH term(s)	Humans ; Angiogenesis ; Angiogenesis Inhibitors/adverse effects ; Angiogenesis Inhibitors/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; ErbB Receptors ; Erlotinib Hydrochloride/adverse effects ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutation ; Protein Kinase Inhibitors/adverse effects ; Protein Kinase Inhibitors/therapeutic use ; Tyrosine Kinase Inhibitors
Chemical Substances	Angiogenesis Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Erlotinib Hydrochloride (DA87705X9K) ; Protein Kinase Inhibitors ; Tyrosine Kinase Inhibitors
Language	English
Publishing date	2024-02-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2024.104294
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Article: Cerebral hemodynamics and optic nerve sheath diameter acquired via neurosonology in critical patients with severe coronavirus disease: experience of a national referral hospital in Peru.

Heredia-Orbegoso, Omar / Vences, Miguel A / Failoc-Rojas, Virgilio E / Fernández-Merjildo, Diana / Lainez-Chacon, Richard H / Villamonte, Renán

Frontiers in neurology

2024 Volume 15, Page(s) 1340749

Abstract: Aim: We aimed to describe the neurosonological findings related to cerebral hemodynamics acquired using transcranial Doppler and to determine the frequency of elevated ICP by optic nerve sheath diameter (ONSD) measurement in patients with severe ... ...

Abstract	Aim: We aimed to describe the neurosonological findings related to cerebral hemodynamics acquired using transcranial Doppler and to determine the frequency of elevated ICP by optic nerve sheath diameter (ONSD) measurement in patients with severe coronavirus disease (COVID-19) hospitalized in the intensive care unit of a national referral hospital in Peru. Methods: We included a retrospective cohort of adult patients hospitalized with severe COVID-19 and acute respiratory failure within the first 7 days of mechanical ventilation under deep sedoanalgesia, with or without neuromuscular blockade who underwent ocular ultrasound and transcranial Doppler. We determine the frequency of elevated ICP by measuring the diameter of the optic nerve sheath, choosing as best cut-off value a diameter equal to or >5.8 mm. We also determine the frequency of sonographic patterns obtained by transcranial Doppler. Through insonation of the middle cerebral artery. Likewise, we evaluated the associations of clinical, mechanical ventilator, and arterial blood gas variables with ONSD ≥5.8 mm and pulsatility index (PI) ≥1.1. We also evaluated the associations of hemodynamic findings and ONSD with mortality the effect size was estimated using Poisson regression models with robust variance. Results: This study included 142 patients. The mean age was 51.39 ± 13.3 years, and 78.9% of patients were male. Vasopressors were used in 45.1% of patients, and mean arterial pressure was 81.87 ± 10.64 mmHg. The mean partial pressure of carbon dioxide (PaCO Conclusions: A high rate of intracranial hypertension was reported, with ONSD measurement being the most reliable method for estimation. The increase in ICP measured by ONSD in patients with severe COVID-19 on mechanical ventilation is not associated to hypercapnia or elevated intrathoracic pressures derived from protective mechanical ventilation.
Language	English
Publishing date	2024-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1340749
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Article ; Online: Factors Related to Depression in Elderly Patients Attending Primary Health Care Centres in Chiclayo (Peru).

Failoc-Rojas, Virgilio E / Meoño, Aldo Del Pielago

Revista Colombiana de psiquiatria (English ed.)

2020

Title translation	Factores relacionados con depresión en adultos mayores atendidos en atención primaria de salud en Chiclayo.
Abstract	Objectives: The aim of this work is to evaluate the factors related to depression in older adults seen in the health centres of Chiclayo. Methods: An observational, prospective, analytical study that included adults over 60 years of age residing in the Chiclayo district (Peru). The abbreviated depression scale of Yesavage was used. Univariate analysis was performed, presented as frequencies and percentages, as well as bivariate analysis using chi-squared. Adjusted logistic regressions were calculated for age and gender. Results: A total of 302 older adults participated in this study. The median age was 73 years. It was found that 30.8% had depressive signs, and 18.2% had some degree of cognitive deterioration. Just over half (160, 52.98%) had a socio-familial risk, and 29 (9.60%) were detected in the dependent functional assessment. There was an association in the analysis of depression, age group, cognitive impairment, socio-family assessment (P<.05). In the multivariate analysis adjusted for age and gender, cognitive deterioration and socio-family assessment continued to be risk factors. Conclusions: Depression is associated with a deficiency in the cognitive state, with familial partner risk being an influential factor that may be preventable.
Language	Spanish
Publishing date	2020-08-13
Publishing country	Spain
Document type	Journal Article
ISSN	2530-3120
ISSN (online)	2530-3120
DOI	10.1016/j.rcp.2020.05.002
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Article ; Online: Impact of the COVID-19 pandemic on the incidence of dengue fever in Peru.

Plasencia-Dueñas, Rubí / Failoc-Rojas, Virgilio E / Rodriguez-Morales, Alfonso J

Journal of medical virology

2021 Volume 94, Issue 1, Page(s) 393–398

Abstract: Dengue virus and severe acute respiratory syndrome coronavirus 2 coexist in dengue-endemic countries; therefore, the adoption of preventive measures is essential to control the spread of both viruses. We conducted an ecological study to compare the ... ...

Abstract	Dengue virus and severe acute respiratory syndrome coronavirus 2 coexist in dengue-endemic countries; therefore, the adoption of preventive measures is essential to control the spread of both viruses. We conducted an ecological study to compare the temporal patterns of the incidence of dengue before and during the Coronavirus disease 2019 (COVID-19) pandemic in Peru. A time-series analysis comparing the incidence of dengue using a Student's t test with variance correction was performed. Poisson regression was applied to determine the incidence rate ratio (IRR) of dengue before and during the COVID-19 pandemic. The incidence of dengue was found to be increased in all endemic regions of Peru during the COVID-19 pandemic, with the highest incidences registered in Ica (IRR = 90.14), Huánuco (IRR = 38.6), and Ucayali (IRR = 23.78), with the exception of Piura (IRR = 0.83). The highest increases in the number of dengue cases per million inhabitants were in Ucayali (393.38), Tumbes (233.19), Ica (166.08), and Loreto (129.93). The gradient of dengue cases was positive in all endemic regions during the COVID-19 pandemic. The number of dengue cases per million increased during the COVID-19 pandemic throughout Peru and in several endemic regions, with the exception of Piura.
MeSH term(s)	COVID-19/epidemiology ; Coinfection/epidemiology ; Dengue/epidemiology ; Dengue Virus/isolation & purification ; Geography ; Humans ; Incidence ; Peru/epidemiology ; SARS-CoV-2/isolation & purification ; Vector Borne Diseases/epidemiology
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27298
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Article ; Online: Comentarios al artículo: gasometría arterial en adultos clínicamente sanos a 3350 metros de altitud.

Failoc-Rojas, Virgilio E

Revista peruana de medicina experimental y salud publica

2015 Volume 32, Issue 1, Page(s) 201–202

Title translation	Comments to the article: arterial blood gases in clinically healthy adults at 3,350 meters above sea level.
MeSH term(s)	Adult ; Altitude ; Blood Gas Analysis ; Gases ; Humans
Chemical Substances	Gases
Language	Spanish
Publishing date	2015-01
Publishing country	Peru
Document type	Comment ; Letter
ZDB-ID	2120092-0
ISSN	1726-4642 ; 1726-4634
ISSN (online)	1726-4642
ISSN	1726-4634
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