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Article ; Online: Computed tomographic features of an axillary liposarcoma with hepatic metastasis.

Biedak, Nathan / Graham, Julia / Faissler, Dominik / Sato, Amy

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

2023 Volume 64, Issue 6, Page(s) E68–E72

Abstract: A geriatric dog presented for lethargy, dyspnea, and urinary incontinence. Thoracic radiographs demonstrated a large, mixed fat, and soft tissue opaque axillary mass and a pulmonary mass. Computed tomography (CT) further characterized these masses and ... ...

Abstract	A geriatric dog presented for lethargy, dyspnea, and urinary incontinence. Thoracic radiographs demonstrated a large, mixed fat, and soft tissue opaque axillary mass and a pulmonary mass. Computed tomography (CT) further characterized these masses and revealed innumerable fat-attenuating hepatic masses and cranial mediastinal lymphadenopathy. Histopathology of the axillary and hepatic masses confirmed grade two primary axillary liposarcoma with hepatic metastasis. Cytology of the pulmonary mass was consistent with a pulmonary carcinoma. This is the first published CT description of fat-attenuating metastatic hepatic liposarcoma in a dog.
MeSH term(s)	Animals ; Dogs ; Liposarcoma/diagnostic imaging ; Liposarcoma/veterinary ; Liposarcoma/pathology ; Tomography, X-Ray Computed/veterinary ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/veterinary ; Lung Neoplasms/veterinary ; Dog Diseases/diagnostic imaging ; Dog Diseases/pathology
Language	English
Publishing date	2023-08-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2142058-0
ISSN	1740-8261 ; 1058-8183
ISSN (online)	1740-8261
ISSN	1058-8183
DOI	10.1111/vru.13286
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Article ; Online: Diagnosis and management of dogs with degenerative myelopathy: A survey of neurologists and rehabilitation professionals.

Bouché, Teryn V / Coates, Joan R / Moore, Sarah A / Faissler, Dominik / Rishniw, Mark / Olby, Natasha J

Journal of veterinary internal medicine

2023 Volume 37, Issue 5, Page(s) 1815–1820

Abstract: Background: Antemortem diagnosis of degenerative myelopathy (DM) in dogs is presumptive and there are no accepted guidelines for the management of this condition.: Hypothesis/objectives: Describe current practices of neurology clinicians and physical ...

Abstract	Background: Antemortem diagnosis of degenerative myelopathy (DM) in dogs is presumptive and there are no accepted guidelines for the management of this condition. Hypothesis/objectives: Describe current practices of neurology clinicians and physical rehabilitation professionals in the diagnosis and management of DM. Animals: None. Methods: Online surveys examining diagnosis and management of DM were constructed and distributed via neurology and rehabilitation listservs. Results: One hundred ninety neurology and 79 rehabilitation professionals from 20 countries participated. Most neurology (142/189) and rehabilitation (23/39) respondents required genetic testing for the superoxide dismutase 1 (SOD1) mutation and 82/189 neurologists also required spinal magnetic resonance imaging (MRI) for presumptive DM diagnosis. Most neurology respondents recommended exercise (187/190) and physical rehabilitation (184/190). Over 50% (102/190) of neurology respondents perform rechecks on dogs diagnosed with DM. Rehabilitation respondents reported preservation or improvement of strength (78/79) and coordination (77/79) as therapeutic goals. At-home exercises (75/79), underwater treadmill (64/79), gait training (55/79), and strength building exercises (65/79) were used to maintain strength (58/79), coordination (56/79), muscle mass (56/79), and improve overall wellbeing (54/79). Neurology respondents reported that owners elect euthanasia when dogs become nonambulatory paraparetic whereas rehabilitation respondents report euthanasia when paraplegia and incontinence develop. Conclusion and clinical importance: The majority of dogs diagnosed with DM have not undergone advanced imaging, the combination of history, neurological findings, and genetic testing is heavily relied upon. Whereas the diagnosis of DM is frequently made by veterinary neurologists, continued care is often performed by rehabilitation professionals or primary veterinarians.
MeSH term(s)	Humans ; Dogs ; Animals ; Spinal Cord Diseases/diagnosis ; Spinal Cord Diseases/therapy ; Spinal Cord Diseases/veterinary ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/pathology ; Amyotrophic Lateral Sclerosis/veterinary ; Neurologists ; Superoxide Dismutase-1/genetics ; Mutation ; Dog Diseases/diagnosis ; Dog Diseases/therapy ; Dog Diseases/genetics
Chemical Substances	Superoxide Dismutase-1 (EC 1.15.1.1)
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.16829
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Article ; Online: Diagnosis and management of dogs with degenerative myelopathy: A survey of neurologists and rehabilitation professionals

Bouché, Teryn V. / Coates, Joan R. / Moore, Sarah A. / Faissler, Dominik / Rishniw, Mark / Olby, Natasha J.

Journal of Veterinary Internal Medicine. 2023 , v. 37, no. 5 p.1815-1820

2023

Abstract: BACKGROUND: Antemortem diagnosis of degenerative myelopathy (DM) in dogs is presumptive and there are no accepted guidelines for the management of this condition. HYPOTHESIS/OBJECTIVES: Describe current practices of neurology clinicians and physical ... ...

Abstract	BACKGROUND: Antemortem diagnosis of degenerative myelopathy (DM) in dogs is presumptive and there are no accepted guidelines for the management of this condition. HYPOTHESIS/OBJECTIVES: Describe current practices of neurology clinicians and physical rehabilitation professionals in the diagnosis and management of DM. ANIMALS: None. METHODS: Online surveys examining diagnosis and management of DM were constructed and distributed via neurology and rehabilitation listservs. RESULTS: One hundred ninety neurology and 79 rehabilitation professionals from 20 countries participated. Most neurology (142/189) and rehabilitation (23/39) respondents required genetic testing for the superoxide dismutase 1 (SOD1) mutation and 82/189 neurologists also required spinal magnetic resonance imaging (MRI) for presumptive DM diagnosis. Most neurology respondents recommended exercise (187/190) and physical rehabilitation (184/190). Over 50% (102/190) of neurology respondents perform rechecks on dogs diagnosed with DM. Rehabilitation respondents reported preservation or improvement of strength (78/79) and coordination (77/79) as therapeutic goals. At‐home exercises (75/79), underwater treadmill (64/79), gait training (55/79), and strength building exercises (65/79) were used to maintain strength (58/79), coordination (56/79), muscle mass (56/79), and improve overall wellbeing (54/79). Neurology respondents reported that owners elect euthanasia when dogs become nonambulatory paraparetic whereas rehabilitation respondents report euthanasia when paraplegia and incontinence develop. CONCLUSION AND CLINICAL IMPORTANCE: The majority of dogs diagnosed with DM have not undergone advanced imaging, the combination of history, neurological findings, and genetic testing is heavily relied upon. Whereas the diagnosis of DM is frequently made by veterinary neurologists, continued care is often performed by rehabilitation professionals or primary veterinarians.
Keywords	electronic discussion groups ; euthanasia ; exercise ; gait ; magnetism ; muscle tissues ; mutation ; physical therapy ; superoxide dismutase ; surveys ; veterinary medicine
Language	English
Dates of publication	2023-09
Size	p. 1815-1820.
Publishing place	John Wiley & Sons, Inc.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	92798-3
ISSN	1939-1676 ; 0891-6640
ISSN (online)	1939-1676
ISSN	0891-6640
DOI	10.1111/jvim.16829
Database	NAL-Catalogue (AGRICOLA)

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Article: Prolonged survival after craniectomy with skull reconstruction and adjuvant definitive radiation therapy in three dogs with multilobular osteochondrosarcoma

Holmes, Molly E / Keyerleber, Michele A / Faissler, Dominik

Veterinary radiology & ultrasound. 2019 July, v. 60, no. 4

2019

Abstract: Multilobular osteochondrosarcoma is an uncommon canine tumor but presents a treatment challenge when arising on the skull. This retrospective case series study aimed to describe outcome of a multimodality treatment approach involving aggressive surgical ... ...

Abstract	Multilobular osteochondrosarcoma is an uncommon canine tumor but presents a treatment challenge when arising on the skull. This retrospective case series study aimed to describe outcome of a multimodality treatment approach involving aggressive surgical resection and adjuvant definitive radiation therapy in a group of dogs with multilobular osteochondrosarcoma of the calvarium. Clinical, imaging, treatment, and outcome data were collected from retrospective review of medical records. Three dogs met inclusion criteria. The presenting clinical complaint was the presence of a mass effect of the skull in all three dogs and concurrent neurologic abnormalities in one dog. Advanced imaging revealed aggressive lytic and proliferative tumors arising from the calvarium in all three dogs. All dogs were treated surgically with a modified craniectomy, repaired with a titanium mesh—polymethyl methacrylate bone cement implant or a low prolife titanium mesh plate and followed by adjuvant definitive radiation therapy with 2.5 Gy per fraction for 22 daily fractions. There were no major immediate surgical complications and radiation was well tolerated overall. Neurologic improvement was seen in the patient that presented with neurologic disease. Survival times from surgery were 387, 422, and 730 days and from the time of radiation were 358, 397, and 677 days. Findings in this sample of three dogs supported the use of aggressive therapy with a combination of surgical craniectomy and cranioplasty utilizing a titanium mesh implant and high dose definitive radiation therapy for local control and prolonged survival times in dogs with multilobular osteochondrosarcoma of the skull.
Keywords	adjuvants ; cement ; dogs ; image analysis ; medical records ; neoplasms ; patients ; polymethylmethacrylate ; radiotherapy ; resection ; skull ; titanium
Language	English
Dates of publication	2019-07
Size	p. 447-455.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2142058-0
ISSN	1740-8261 ; 1058-8183
ISSN (online)	1740-8261
ISSN	1058-8183
DOI	10.1111/vru.12750
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Article ; Online: Prolonged survival after craniectomy with skull reconstruction and adjuvant definitive radiation therapy in three dogs with multilobular osteochondrosarcoma.

Holmes, Molly E / Keyerleber, Michele A / Faissler, Dominik

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

2019 Volume 60, Issue 4, Page(s) 447–455

Abstract	Multilobular osteochondrosarcoma is an uncommon canine tumor but presents a treatment challenge when arising on the skull. This retrospective case series study aimed to describe outcome of a multimodality treatment approach involving aggressive surgical resection and adjuvant definitive radiation therapy in a group of dogs with multilobular osteochondrosarcoma of the calvarium. Clinical, imaging, treatment, and outcome data were collected from retrospective review of medical records. Three dogs met inclusion criteria. The presenting clinical complaint was the presence of a mass effect of the skull in all three dogs and concurrent neurologic abnormalities in one dog. Advanced imaging revealed aggressive lytic and proliferative tumors arising from the calvarium in all three dogs. All dogs were treated surgically with a modified craniectomy, repaired with a titanium mesh-polymethyl methacrylate bone cement implant or a low prolife titanium mesh plate and followed by adjuvant definitive radiation therapy with 2.5 Gy per fraction for 22 daily fractions. There were no major immediate surgical complications and radiation was well tolerated overall. Neurologic improvement was seen in the patient that presented with neurologic disease. Survival times from surgery were 387, 422, and 730 days and from the time of radiation were 358, 397, and 677 days. Findings in this sample of three dogs supported the use of aggressive therapy with a combination of surgical craniectomy and cranioplasty utilizing a titanium mesh implant and high dose definitive radiation therapy for local control and prolonged survival times in dogs with multilobular osteochondrosarcoma of the skull.
MeSH term(s)	Animals ; Bone Neoplasms/radiotherapy ; Bone Neoplasms/surgery ; Bone Neoplasms/veterinary ; Chondrosarcoma/radiotherapy ; Chondrosarcoma/surgery ; Chondrosarcoma/veterinary ; Combined Modality Therapy/veterinary ; Craniotomy/veterinary ; Dog Diseases/radiotherapy ; Dog Diseases/surgery ; Dogs ; Female ; Male ; Osteosarcoma/radiotherapy ; Osteosarcoma/surgery ; Osteosarcoma/veterinary ; Radiotherapy, Adjuvant/veterinary ; Reconstructive Surgical Procedures/veterinary ; Skull/surgery
Language	English
Publishing date	2019-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2142058-0
ISSN	1740-8261 ; 1058-8183
ISSN (online)	1740-8261
ISSN	1058-8183
DOI	10.1111/vru.12750
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Article: Questions cause of spinal cord compression in dog.

Boudrieau, Randy J / Faissler, Dominik

Journal of the American Veterinary Medical Association

2010 Volume 237, Issue 1, Page(s) 24; author reply 24–5

MeSH term(s)	Animals ; Dog Diseases/diagnostic imaging ; Dog Diseases/etiology ; Dog Diseases/pathology ; Dogs ; Intervertebral Disc Degeneration/diagnostic imaging ; Intervertebral Disc Degeneration/pathology ; Intervertebral Disc Degeneration/veterinary ; Intervertebral Disc Displacement/diagnostic imaging ; Intervertebral Disc Displacement/pathology ; Intervertebral Disc Displacement/veterinary ; Occipital Bone/abnormalities ; Radiography ; Spinal Cord Compression/diagnostic imaging ; Spinal Cord Compression/etiology ; Spinal Cord Compression/veterinary
Language	English
Publishing date	2010-07-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.237.1.24
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Article ; Online: Surgical management of a canine intracranial abscess due to a bite wound.

Bilderback, Ann L / Faissler, Dominik

Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

2009 Volume 19, Issue 5, Page(s) 507–512

Abstract: Objective: To describe the successful surgical management of a brain abscess in a dog secondary to bite wound.: Case summary: A 10-year-old neutered female Welsh Corgi/Chihuahua, weighing 5.3 kg, was presented for evaluation of seizures, ataxia, and ... ...

Abstract	Objective: To describe the successful surgical management of a brain abscess in a dog secondary to bite wound. Case summary: A 10-year-old neutered female Welsh Corgi/Chihuahua, weighing 5.3 kg, was presented for evaluation of seizures, ataxia, and falling to the left 8 days after a presumptive fight with another dog. On examination at presentation, the dog was alert, responsive, and ambulatory with tetra-ataxia, falling to the left, left-sided postural deficits, and absent left menace response. Within 24 hours, the dog progressed to nonambulatory tetraparesis with minimal motor, absent postural reactions of all limbs, left nasal hypalgesia, reduced gag reflex, and depressed mentation. Computed tomographic images of the brain were suggestive of a bite wound fracture of the right parietal bone with secondary meningoencephalitis, right parietal lobe abscessation, and white matter edema adjacent to the bone fracture. A modified right rostrotentorial craniectomy was performed, the abscess was identified, contents of the abscess were removed, and the surgical site was flushed extensively before closing. Corynebacterium spp. was cultured from within the abscess. Within hours of surgery, the dog was quiet but alert, responsive, and sitting up in her cage. In addition to surgical intervention, intensive care, broad-spectrum IV antimicrobials, and supportive therapy led to significant neurologic improvement with only occasional seizures and mild postural reaction deficits of the left hindlimb remaining. New or unique information provided: Abscess formation within the CNS is uncommon in dogs and cats and is associated with a high mortality rate. In veterinary medicine the management of brain abscesses is controversial with limited information available regarding treatment. This is the first case report that demonstrates surgical intervention in combination with antimicrobial therapy can be used successfully in the treatment of a canine brain abscess.
MeSH term(s)	Animals ; Anti-Bacterial Agents/therapeutic use ; Brain Abscess/drug therapy ; Brain Abscess/pathology ; Brain Abscess/surgery ; Brain Abscess/veterinary ; Dog Diseases/drug therapy ; Dog Diseases/pathology ; Dog Diseases/surgery ; Dogs ; Female
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2009-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2077212-9
ISSN	1476-4431 ; 1479-3261
ISSN (online)	1476-4431
ISSN	1479-3261
DOI	10.1111/j.1476-4431.2009.00467.x
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Article: Surgical management of a canine intracranial abscess due to a bite wound

Bilderback, Ann L / Faissler, Dominik

Journal of veterinary emergency and critical care. 2009 Oct., v. 19, no. 5

2009

Abstract: To describe the successful surgical management of a brain abscess in a dog secondary to bite wound. A 10-year-old neutered female Welsh Corgi/Chihuahua, weighing 5.3 kg, was presented for evaluation of seizures, ataxia, and falling to the left 8 days ... ...

Abstract	To describe the successful surgical management of a brain abscess in a dog secondary to bite wound. A 10-year-old neutered female Welsh Corgi/Chihuahua, weighing 5.3 kg, was presented for evaluation of seizures, ataxia, and falling to the left 8 days after a presumptive fight with another dog. On examination at presentation, the dog was alert, responsive, and ambulatory with tetra-ataxia, falling to the left, left-sided postural deficits, and absent left menace response. Within 24 hours, the dog progressed to nonambulatory tetraparesis with minimal motor, absent postural reactions of all limbs, left nasal hypalgesia, reduced gag reflex, and depressed mentation. Computed tomographic images of the brain were suggestive of a bite wound fracture of the right parietal bone with secondary meningoencephalitis, right parietal lobe abscessation, and white matter edema adjacent to the bone fracture. A modified right rostrotentorial craniectomy was performed, the abscess was identified, contents of the abscess were removed, and the surgical site was flushed extensively before closing. Corynebacterium spp. was cultured from within the abscess. Within hours of surgery, the dog was quiet but alert, responsive, and sitting up in her cage. In addition to surgical intervention, intensive care, broad-spectrum IV antimicrobials, and supportive therapy led to significant neurologic improvement with only occasional seizures and mild postural reaction deficits of the left hindlimb remaining. Abscess formation within the CNS is uncommon in dogs and cats and is associated with a high mortality rate. In veterinary medicine the management of brain abscesses is controversial with limited information available regarding treatment. This is the first case report that demonstrates surgical intervention in combination with antimicrobial therapy can be used successfully in the treatment of a canine brain abscess.
Keywords	Corynebacterium ; abscess ; antimicrobial agents ; bone fractures ; bones ; brain ; cages ; case studies ; cats ; computed tomography ; dogs ; edema ; fighting ; meningoencephalitis ; mortality ; reflexes ; seizures ; surgery ; veterinary medicine
Language	English
Dates of publication	2009-10
Size	p. 507-512.
Publisher	Blackwell Publishing Inc
Publishing place	Malden, USA
Document type	Article
ZDB-ID	2077212-9
ISSN	1476-4431 ; 1479-3261
ISSN (online)	1476-4431
ISSN	1479-3261
DOI	10.1111/j.1476-4431.2009.00467.x
Database	NAL-Catalogue (AGRICOLA)

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Article: Successful management of an intracranial phaeohyphomycotic fungal granuloma in a dog

Bentley, R.Timothy / Faissler, Dominik / Sutherland-Smith, James

Journal of the American Veterinary Medical Association. 2011 Aug. 15, v. 239, no. 4

2011

Abstract: Case Description—A 12-month-old castrated male Boxer was examined because of signs of acute, progressive intracranial disease. Clinical Findings—Cytologic and histologic findings were consistent with an intracranial fungal granuloma in the right cerebral ...

Abstract	Case Description—A 12-month-old castrated male Boxer was examined because of signs of acute, progressive intracranial disease. Clinical Findings—Cytologic and histologic findings were consistent with an intracranial fungal granuloma in the right cerebral hemisphere. Fungal culture yielded a Cladophialophora sp. Treatment and Outcome—The granuloma was surgically debulked to remove infected brain tissue and the avascular purulent core. Postoperatively, the patient was treated with fluconazole (2.3 mg/kg [1 mg/lb], PO, q 12 h) for 4 months, followed by voriconazole (3.4 mg/kg [1.5 mg/lb], PO, q 12 h) for a further 10 months. The outcome was considered excellent on the basis of resolution of neurologic signs and a lack of evidence of recurrence of the granuloma during magnetic resonance imaging and CSF analysis 8 months after surgery. Magnetic resonance imaging and CSF analysis 9 weeks after administration of antifungal medications was discontinued (16 months after surgery) confirmed resolution. Clinical Relevance—Intracranial phaeohyphomycosis in small animals is rare and is most commonly associated with Cladophialophora infection. Phaeohyphomycosis frequently causes a focal granuloma, whereas other fungal infections typically cause diffuse meningoencephalitis. In all previous reports of phaeohyphomycosis of the CNS in dogs, treatment has been limited to medical management with conventional antifungal drugs and had failed to prevent death. The present report suggested that combined management of granulomas with surgery and newer triazole medications such as voriconazole may represent a novel strategy that improves the prognosis for this disease.
Keywords	brain ; death ; dogs ; fluconazole ; fungi ; granuloma ; magnetic resonance imaging ; meningoencephalitis ; patients ; prognosis ; surgery
Language	English
Size	p. 480-485.
Document type	Article
ZDB-ID	390811-2
ISSN	1943-569X ; 0003-1488
ISSN (online)	1943-569X
ISSN	0003-1488
DOI	10.2460/javma.239.4.480
Database	NAL-Catalogue (AGRICOLA)

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Article: Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases.

Story, Brett D / Miller, Matthew E / Bradbury, Allison M / Million, Emily D / Duan, Dongsheng / Taghian, Toloo / Faissler, Dominik / Fernau, Deborah / Beecy, Sidney J / Gray-Edwards, Heather L

Frontiers in veterinary science

2020 Volume 7, Page(s) 80

Abstract: Mouse models of human disease remain the bread and butter of modern biology and therapeutic discovery. Nonetheless, more often than not mouse models do not reproduce the pathophysiology of the human conditions they are designed to mimic. Naturally ... ...

Abstract	Mouse models of human disease remain the bread and butter of modern biology and therapeutic discovery. Nonetheless, more often than not mouse models do not reproduce the pathophysiology of the human conditions they are designed to mimic. Naturally occurring large animal models have predominantly been found in companion animals or livestock because of their emotional or economic value to modern society and, unlike mice, often recapitulate the human disease state. In particular, numerous models have been discovered in dogs and have a fundamental role in bridging proof of concept studies in mice to human clinical trials. The present article is a review that highlights current canine models of human diseases, including Alzheimer's disease, degenerative myelopathy, neuronal ceroid lipofuscinosis, globoid cell leukodystrophy, Duchenne muscular dystrophy, mucopolysaccharidosis, and fucosidosis. The goal of the review is to discuss canine and human neurodegenerative pathophysiologic similarities, introduce the animal models, and shed light on the ability of canine models to facilitate current and future treatment trials.
Language	English
Publishing date	2020-03-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2020.00080
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