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  1. Article ; Online: The role of adenosine A

    Launay, Agathe / Nebie, Ouada / Vijaya Shankara, Jhenkruthi / Lebouvier, Thibaud / Buée, Luc / Faivre, Emilie / Blum, David

    Neuropharmacology

    2022  Volume 226, Page(s) 109379

    Abstract: Adenosine signals through four distinct G protein-coupled receptors that are located at various synapses, cell types and brain areas. Through them, adenosine regulates neuromodulation, neuronal signaling, learning and cognition as well as the sleep-wake ... ...

    Abstract Adenosine signals through four distinct G protein-coupled receptors that are located at various synapses, cell types and brain areas. Through them, adenosine regulates neuromodulation, neuronal signaling, learning and cognition as well as the sleep-wake cycle, all strongly impacted in neurogenerative disorders, among which Alzheimer's Disease (AD). AD is a complex form of cognitive deficits characterized by two pathological hallmarks: extracellular deposits of aggregated β-amyloid peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. Both lesions contribute to the early dysfunction and loss of synapses which are strongly associated to the development of cognitive decline in AD patients. The present review focuses on the pathophysiological impact of the A
    MeSH term(s) Humans ; Alzheimer Disease/metabolism ; Adenosine ; Tauopathies/drug therapy ; tau Proteins ; Amyloid beta-Peptides/metabolism ; Receptor, Adenosine A2A/metabolism
    Chemical Substances Adenosine (K72T3FS567) ; tau Proteins ; Amyloid beta-Peptides ; Receptor, Adenosine A2A
    Language English
    Publishing date 2022-12-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2022.109379
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  2. Article ; Online: Impact of chronic doxycycline treatment in the APP/PS1 mouse model of Alzheimer's disease.

    Gomez-Murcia, Victoria / Carvalho, Kevin / Thiroux, Bryan / Caillierez, Raphaëlle / Besegher, Melanie / Sergeant, Nicolas / Buée, Luc / Faivre, Emile / Blum, David

    Neuropharmacology

    2022  Volume 209, Page(s) 108999

    Abstract: Due to the pathophysiological complexity of Alzheimer's disease, multitarget approaches able to mitigate several pathogenic mechanisms are of interest. Previous studies have pointed to the neuroprotective potential of Doxycycline (Dox), a safe and ... ...

    Abstract Due to the pathophysiological complexity of Alzheimer's disease, multitarget approaches able to mitigate several pathogenic mechanisms are of interest. Previous studies have pointed to the neuroprotective potential of Doxycycline (Dox), a safe and inexpensive second-generation tetracycline. Dox has been particularly reported to slow down aggregation of misfolded proteins but also to mitigate neuroinflammatory processes. Here, we have evaluated the pre-clinical potential of Dox in the APP/PS1 mouse model of amyloidogenesis. Dox was provided to APP/PS1 mice from the age of 8 months, when animals already exhibit amyloid pathology and memory deficits. Spatial memory was then evaluated from 9 to 10 months of age. Our data demonstrated that Dox moderately improved the spatial memory of APP/PS1 mice without exerting major effect on amyloid lesions. While Dox did not alleviate overall glial reactivity, we could evidence that it rather enhanced the amyloid-dependent upregulation of several neuroinflammatory markers such as CCL3 and CCL4. Finally, Dox exerted differentially regulated the levels of synaptic proteins in the hippocampus and the cortex of APP/PS1 mice. Overall, these observations support that chronic Dox delivery does not provide major pathophysiological improvements in the APP/PS1 mouse model.
    MeSH term(s) Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Disease Models, Animal ; Doxycycline/pharmacology ; Doxycycline/therapeutic use ; Hippocampus/metabolism ; Mice ; Mice, Transgenic ; Presenilin-1/genetics ; Presenilin-1/metabolism
    Chemical Substances Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Presenilin-1 ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2022-02-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2022.108999
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  3. Article ; Online: Morcellement hystéroscopique: technique Myosure™

    Deffieux, X / Faivre, E / Fournet, S / Fernandez, H

    Journal de gynecologie, obstetrique et biologie de la reproduction

    2013  Volume 42, Issue 1, Page(s) 86–90

    Title translation Hysteroscopic morcellation: Myosure™ procedure.
    MeSH term(s) Contraindications ; Female ; Humans ; Hysteroscopy/instrumentation ; Hysteroscopy/methods ; Myometrium/pathology ; Myometrium/surgery ; Suction/instrumentation ; Suction/methods ; Uterus/pathology ; Uterus/surgery
    Language French
    Publishing date 2013-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 121670-3
    ISSN 1773-0430 ; 0368-2315 ; 0150-9918
    ISSN (online) 1773-0430
    ISSN 0368-2315 ; 0150-9918
    DOI 10.1016/j.jgyn.2012.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 855: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Uterine remnant: An uncommon finding after transvaginal hysterectomy.

    Ssi-Yan-Kai, G / Faivre, E / Prevot, S / Deffieux, X / De Laveaucoupet, J

    Diagnostic and interventional imaging

    2016  Volume 97, Issue 1, Page(s) 101–103

    MeSH term(s) Female ; Humans ; Hysterectomy, Vaginal ; Middle Aged ; Uterus/diagnostic imaging ; Uterus/surgery
    Language English
    Publishing date 2016-01
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 2648283-6
    ISSN 2211-5684 ; 2211-5684
    ISSN (online) 2211-5684
    ISSN 2211-5684
    DOI 10.1016/j.diii.2014.11.026
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  5. Article ; Online: Uterine remnant: An uncommon finding after transvaginal hysterectomy.

    Ssi-Yan-Kai, G / Faivre, E / Prevot, S / Deffieux, X / De Laveaucoupet, J

    Diagnostic and interventional imaging

    2016  Volume 97, Issue 2, Page(s) 239–241

    MeSH term(s) Female ; Humans ; Hysterectomy, Vaginal ; Middle Aged ; Uterus/pathology ; Uterus/surgery
    Language English
    Publishing date 2016-02
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 2648283-6
    ISSN 2211-5684 ; 2211-5684
    ISSN (online) 2211-5684
    ISSN 2211-5684
    DOI 10.1016/j.diii.2014.04.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Neuroprotective effects of D-Ala(2)GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model.

    Faivre, Emilie / Hölscher, Christian

    Alzheimer's research & therapy

    2013  Volume 5, Issue 2, Page(s) 20

    Abstract: Introduction: Type 2 diabetes mellitus has been identified as a risk factor for Alzheimer's disease (AD). An impairment of insulin signaling as well as a desensitization of its receptor has been found in AD brains. Glucose-dependent insulinotropic ... ...

    Abstract Introduction: Type 2 diabetes mellitus has been identified as a risk factor for Alzheimer's disease (AD). An impairment of insulin signaling as well as a desensitization of its receptor has been found in AD brains. Glucose-dependent insulinotropic polypeptide (GIP) normalises insulin signaling by facilitating insulin release. GIP directly modulates neurotransmitter release, LTP formation, and protects synapses from the detrimental effects of beta-amyloid fragments on LTP formation, and cell proliferation of progenitor cells in the dentate gyrus. Here we investigate the potential therapeutic property of the new long lasting incretin hormone analogue D-Ala(2)GIP on key symptoms found in a mouse model of Alzheimer' disease (APPswe/PS1detaE9).
    Methods: D-Ala(2)GIP was injected for 21 days at 25 nmol/kg ip once daily in APP/PS1 male mice and wild type (WT) littermates aged 6 or 12 months of age. Amyloid plaque load, inflammation biomarkers, synaptic plasticity in the brain (LTP), and memory were measured.
    Results: D-Ala(2)GIP improved memory in WT mice and rescued the cognitive decline of 12 months old APP/PS1 mice in two different memory tasks. Furthermore, deterioration of synaptic function in the dentate gyrus and cortex was prevented in 12 months old APP/PS1 mice. D-Ala(2)GIP facilitated synaptic plasticity in APP/PS1 and WT mice and reduced the number of amyloid plaques in the cortex of D-Ala(2)GIP injected APP/PS1 mice. The inflammatory response in microglia was also reduced.
    Conclusion: The results demonstrate that D-Ala(2)GIP has neuroprotective properties on key hallmarks found in AD. This finding shows that novel GIP analogues have the potential as a novel therapeutic for AD.
    Language English
    Publishing date 2013-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2506521-X
    ISSN 1758-9193
    ISSN 1758-9193
    DOI 10.1186/alzrt174
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  7. Article ; Online: D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer's disease mouse model.

    Faivre, Emilie / Hölscher, Christian

    Journal of Alzheimer's disease : JAD

    2013  Volume 35, Issue 2, Page(s) 267–283

    Abstract: Type 2 diabetes mellitus has been identified as a risk factor for Alzheimer's disease (AD). We have previously shown that glucose-dependent insulinotropic polypeptide (GIP) analogues that originally have been developed to treat diabetes have ... ...

    Abstract Type 2 diabetes mellitus has been identified as a risk factor for Alzheimer's disease (AD). We have previously shown that glucose-dependent insulinotropic polypeptide (GIP) analogues that originally have been developed to treat diabetes have neuroprotective effects in the brains of the APPswe/PS1ΔE9 mouse model of AD. In a previous study, the analogue D-Ala2GIP intraperitoneally (i.p.) in 12 months old animals, an age that represents early phase AD, D-Ala2GIP improved memory in wild type (WT) mice and rescued the cognitive decline of 12 months old AβPP/PS1 mice. Synapse numbers and synaptic plasticity was also protected. Importantly, the amyloid plaque load in the cortex was reduced. In the present study, we tested D-Ala2GIP in 19 months old AβPP/PS1 mice or littermate controls to find out if the drug may have protective effects even at an advanced stage of AD. Mice were injected for 21 days at 25 nmol/kg i.p. once daily. Interestingly, the age-related reduction of synaptic numbers in the DG and cortex was prevented in WT control mice. D-Ala2GIP facilitated synaptic plasticity in AβPP/PS1 and WT mice and reduced the number of amyloid plaques and activated microglia in the cortex of AβPP/PS1 mice. The results show that D-Ala2GIP not only has protective but also regenerative properties in the brain of aged WT mice, and on key biomarkers found in AD in AβPP/PS1 mice. This suggests that novel GIP analogues may have beneficial effects in non-demented aged people and perhaps even in AD patients even when the disease is further progressed.
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Amyloid beta-Protein Precursor/genetics ; Animals ; Blood Glucose/metabolism ; Body Weight/drug effects ; CA1 Region, Hippocampal/drug effects ; Disease Progression ; Encephalitis/drug therapy ; Encephalitis/pathology ; Gastric Inhibitory Polypeptide/pharmacology ; Humans ; Immunohistochemistry ; Injections, Intraperitoneal ; Insulin/blood ; Learning/physiology ; Long-Term Potentiation/drug effects ; Male ; Maze Learning/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neuronal Plasticity/drug effects ; Plaque, Amyloid/drug therapy ; Plaque, Amyloid/pathology ; Presenilin-1/genetics ; Psychomotor Performance/drug effects ; Recognition (Psychology)/drug effects ; Synapses/drug effects
    Chemical Substances Amyloid beta-Protein Precursor ; Blood Glucose ; Insulin ; Presenilin-1 ; glucose-dependent insulinotropic polypeptide, Ala(2)- ; Gastric Inhibitory Polypeptide (59392-49-3)
    Language English
    Publishing date 2013
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-121888
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    Zs.A 6084: Show issues Location:
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  8. Article ; Online: Grossesse et post-partum des patientes porteuses de bandelette sous-urétrale: revue de la littérature.

    Demoulin, G / Thubert, T / Faivre, E / Trichot, C / Deffieux, X

    Journal de gynecologie, obstetrique et biologie de la reproduction

    2013  Volume 42, Issue 6, Page(s) 518–524

    Abstract: Objective: To realize a review of literature to observe the impact of pregnancy and delivery in patients who underwent mid-urethral sling procedure for stress urinary incontinence (SUI), in order to provide recommendations on the route of delivery.: ... ...

    Title translation Pregnancy and postpartum of women with mid-urethral sling procedure: a review of the literature.
    Abstract Objective: To realize a review of literature to observe the impact of pregnancy and delivery in patients who underwent mid-urethral sling procedure for stress urinary incontinence (SUI), in order to provide recommendations on the route of delivery.
    Material and methods: Literature review from 1995 to 2012 on the database Pubmed/Medline including only studies involving pregnant women with mid-urethral sling procedure.
    Results: Of the 35 published cases, 14 % of patients had a recurrence of SUI symptoms during pregnancy. Nineteen percent of patients who underwent a c-section had SUI symptoms in the immediate postpartum period, against 33 % of patients with vaginal deliveries (P=0.56). In the follow-up of delivery (>3 months), there was a persistent SUI in 20 % (7/34) of patients: 12.5 % (2/16) of women who underwent a c-section and 27.7 % (5/18) of women who had a vaginal delivery (P=0.75).
    Conclusion: Although c-section seems to slightly decrease the risk of recurrence of SUI comparing to the vaginal route, we do not recommend to propose a systematic elective c-section in these patients because of its morbidity and mortality and the possibility of repeat mid-urethral sling procedure.
    MeSH term(s) Cesarean Section ; Delivery, Obstetric/methods ; Female ; Humans ; MEDLINE ; Postpartum Period ; Pregnancy ; Pregnancy Complications ; Recurrence ; Suburethral Slings ; Urinary Incontinence, Stress/complications ; Urinary Incontinence, Stress/epidemiology ; Urinary Incontinence, Stress/surgery
    Language French
    Publishing date 2013-10
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 121670-3
    ISSN 1773-0430 ; 0368-2315 ; 0150-9918
    ISSN (online) 1773-0430
    ISSN 0368-2315 ; 0150-9918
    DOI 10.1016/j.jgyn.2012.10.004
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Effects of GIP analogues in neuronal signalling, cell proliferation and learning and memory.

    Faivre, E / Hamilton, A / Holscher, C

    Regulatory peptides

    2010  Volume 164, Issue 1, Page(s) 40–41

    Language English
    Publishing date 2010-09-9
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 225685-x
    ISSN 0167-0115
    ISSN 0167-0115
    DOI 10.1016/j.regpep.2010.07.103
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    Zs.A 1593: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Multi-Omics Data Integration Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during Lactation in Adult Mouse Offspring.

    Gauvrit, Thibaut / Benderradji, Hamza / Pelletier, Alexandre / Aboulouard, Soulaimane / Faivre, Emilie / Carvalho, Kévin / Deleau, Aude / Vallez, Emmanuelle / Launay, Agathe / Bogdanova, Anna / Besegher, Mélanie / Le Gras, Stéphanie / Tailleux, Anne / Salzet, Michel / Buée, Luc / Delahaye, Fabien / Blum, David / Vieau, Didier

    Nutrients

    2023  Volume 15, Issue 21

    Abstract: Early-life exposure to high-fat diets (HF) can program metabolic and cognitive alterations in adult offspring. Although the hippocampus plays a crucial role in memory and metabolic homeostasis, few studies have reported the impact of maternal HF on this ... ...

    Abstract Early-life exposure to high-fat diets (HF) can program metabolic and cognitive alterations in adult offspring. Although the hippocampus plays a crucial role in memory and metabolic homeostasis, few studies have reported the impact of maternal HF on this structure. We assessed the effects of maternal HF during lactation on physiological, metabolic, and cognitive parameters in young adult offspring mice. To identify early-programming mechanisms in the hippocampus, we developed a multi-omics strategy in male and female offspring. Maternal HF induced a transient increased body weight at weaning, and a mild glucose intolerance only in 3-month-old male mice with no change in plasma metabolic parameters in adult male and female offspring. Behavioral alterations revealed by a Barnes maze test were observed both in 6-month-old male and female mice. The multi-omics strategy unveiled sex-specific transcriptomic and proteomic modifications in the hippocampus of adult offspring. These studies that were confirmed by regulon analysis show that, although genes whose expression was modified by maternal HF were different between sexes, the main pathways affected were similar with mitochondria and synapses as main hippocampal targets of maternal HF. The effects of maternal HF reported here may help to better characterize sex-dependent molecular pathways involved in cognitive disorders and neurodegenerative diseases.
    MeSH term(s) Animals ; Mice ; Female ; Male ; Humans ; Diet, High-Fat/adverse effects ; Obesity/etiology ; Obesity/metabolism ; Multiomics ; Proteomics ; Lactation ; Hippocampus/metabolism ; Maternal Nutritional Physiological Phenomena/physiology ; Prenatal Exposure Delayed Effects/metabolism
    Language English
    Publishing date 2023-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15214691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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