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Book: Épidémiologie et prévention du cancer colorectal

Faivre, Jean

(Springer digest)

2001

Author's details	Jean Faivre
Series title	Springer digest
Keywords	Colorectal Neoplasms ; Dickdarmkrebs ; Epidemiologie ; Prävention
Subject	Verhütung ; Vorbeugung ; Prophylaxe ; Vorsorge ; Colorektaler Krebs ; Colorectalcarcinom ; Kolorektales Karzinom ; Kolorektales Carcinom ; Dickdarmkarzinom ; Krankheitsverbreitung
Language	French
Size	110 S. : Ill., graph. Darst., Kt.
Publisher	Springer
Publishing place	Paris u.a.
Publishing country	France
Document type	Book
Note	Literaturverz. S. 106 - 109
HBZ-ID	HT013235936
ISBN	2-287-59727-1 ; 978-2-287-59727-5
Database	Catalogue ZB MED Medicine, Health

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2002 A 841	order for loan	Magazin

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Article ; Online: Clinical trials that will change practices: News in palliative radiotherapy.

Agnoux, E / Renan, A / Faivre, J-C

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2023 Volume 27, Issue 8, Page(s) 746–753

Abstract: Palliative radiotherapy is used to alleviate cancer-related symptoms. Symptomatic responses to palliative radiotherapy may however take several weeks, meaning that patients need to survive long enough to derive a real benefit. Oncologists can be ... ...

Abstract	Palliative radiotherapy is used to alleviate cancer-related symptoms. Symptomatic responses to palliative radiotherapy may however take several weeks, meaning that patients need to survive long enough to derive a real benefit. Oncologists can be optimistic when estimating survival for patients with advanced cancer and as a consequence some patients receiving palliative radiotherapy die before experiencing any gain. Models of patient survival have limited accuracy, particularly for predicting whether patients will die within the next 30 days. Dedicated rapid access palliative radiotherapy clinics, in which patients are assessed, simulated and treated on the same day, reduce the number of patient visits to the radiation oncology department and hence the burden on the patient as well as costs. Teleconsultation and advanced practice nurses can play a crucial role in providing rapid access to palliative radiotherapy in a dedicated palliative radiotherapy service. Single-fraction palliative radiotherapy should be offered to eligible patients if they are able to attend treatment and could potentially benefit from symptom palliation, irrespective of predicted life expectancy. Technical and organizational innovations have been proposed in order to dispense with the computed tomography scanner by carrying out the dosimetry on a recent diagnostic scanner or a magnetic resonance imaging scanner with integrated linear acceleration system. Stereotactic body radiation therapy makes it possible to envisage greater and more lasting analgesic benefits in patients with painful bone metastasis and good prognosis. Flash radiotherapy remains at the preclinical stage.
MeSH term(s)	Humans ; Palliative Care/methods ; Bone Neoplasms/secondary ; Pain ; Radiosurgery ; Costs and Cost Analysis ; Radiotherapy/methods
Language	English
Publishing date	2023-10-25
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2023.08.004
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Article ; Online: Comparison of Hyaluronidase-Mediated Degradation Kinetics of Commercially Available Hyaluronic Acid Fillers In Vitro.

Faivre, Jimmy / Wu, Kevin / Gallet, Mélanie / Sparrow, Julia / Bourdon, François / Gallagher, Conor J

Aesthetic surgery journal

2024

Abstract: Background: Hyaluronic acid (HA)-based fillers are degradable with hyaluronidase, which allows for better management of adverse effects and reversal of suboptimal treatment outcomes.: Objectives: To compare the enzymatic degradation kinetics of 16 ... ...

Abstract	Background: Hyaluronic acid (HA)-based fillers are degradable with hyaluronidase, which allows for better management of adverse effects and reversal of suboptimal treatment outcomes. Objectives: To compare the enzymatic degradation kinetics of 16 commercially available HA-based fillers, representing 6 manufacturing technologies. Methods: In this nonclinical study, a recently developed in vitro multidose hyaluronidase administration protocol was used to induce degradation of HA-based fillers, which allowed for real-time evaluation of viscoelastic properties at near static conditions. Each filler was exposed to repeated doses of hyaluronidase at intervals of 5 minutes to reach the degradation threshold of G' ≤ 30 Pa. Results: Noticeable differences in degradation characteristics were observed based on the design and technology of different filler classes. Vycross fillers were the most difficult to degrade and the Cohesive Polydensified Matrix filler was the least difficult to degrade. Preserved Network Technology products demonstrated proportional increases in gel degradation time and enzyme volume required for degradation across the individual RHA products and indication categories. No obvious relationship was observed between gel degradation characteristics and the individual parameters of HA concentration, HA chain length, or the degree of modification of each filler when analyzed separately; however, a general correlation was identified with certain physicochemical properties. Conclusions: Manufacturing technology was the most important factor influencing the reversibility of an HA product. An understanding of the differential degradation profiles of commercially available fillers will allow clinicians to select products that offer a higher margin of safety due to their preferential reversibility.
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjae032
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Article ; Online: Stereotactic body radiation therapy for bone oligometastases.

Naessens, C / Chamois, J / Supiot, S / Faivre, J-C / Arnaud, A / Thureau, S

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2023 Volume 28, Issue 1, Page(s) 111–118

Abstract: Stereotactic body radiation therapy is effective for the local management of oligometastases (at most five metastases) with a benefit in survival and local control. Most studies on the management of oligometastases focus on all oligometastatic sites in ... ...

Abstract	Stereotactic body radiation therapy is effective for the local management of oligometastases (at most five metastases) with a benefit in survival and local control. Most studies on the management of oligometastases focus on all oligometastatic sites in primary cancer and very few focus on a single oligometastatic site. In particular, there are few data on bone oligometastases, which represent one of the preferred sites for secondary cancer locations. This article focuses on the benefit of stereotactic radiotherapy for bone oligometastases of all cancers by histological types, and reviews the results of major studies in this field.
MeSH term(s)	Humans ; Neoplasms/pathology ; Neoplasms, Second Primary ; Radiosurgery/methods
Language	English
Publishing date	2023-10-12
Publishing country	France
Document type	Practice Guideline
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2023.04.006
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Article ; Online: Hypofractionated radiotherapy for invasive squamous cell carcinoma of the scalp in the elderly: Efficacy and tolerance, preliminary results.

Jacques, J / Renard, S / Demogeot, N / Faivre, J C / Peiffert, D

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2023 Volume 27, Issue 4, Page(s) 290–295

Abstract: Purpose: Skin squamous cells carcinomas (SCC) are frequently tumor, especially in the elderly population. Surgical excision is the standard treatment. But for patients suffering large tumor or/with comorbidity, a conservative approach with irradiation ... ...

Abstract	Purpose: Skin squamous cells carcinomas (SCC) are frequently tumor, especially in the elderly population. Surgical excision is the standard treatment. But for patients suffering large tumor or/with comorbidity, a conservative approach with irradiation can be proposed. The hypofractionated schedule is used to shorten the overall treatment time with same results and without compromising therapeutic outcomes. The aim of this study is to assess the efficacy and tolerance of hypofractionated radiotherapy for invasive SCC of the scalp in elderly. Patients and methods: We included patients suffering from SCC of the scalp and treated by hypofractionated radiotherapy at the Institut de cancérologie de Lorraine or centre Émile-Durkeim d'Épinal, from January 2019 to December 2021. Characteristics of patients, size of the lesion and side effects were collected retrospectively. Tumor size at 6 months corresponded to the primary endpoint. Toxicity was collected for the secondary endpoint. Results: Twelve patients with a median age of 85 years old were included. The mean size was 4,5cm with a bone invasion in 2/3 of cases. Radiotherapy was delivered after surgical excision for half of the patient. The dose delivered was 54Gy in 18 daily fractions size. Six months after irradiation: 6/11 patients had no residual lesion, 2/11 had a partial response with a residual lesion of about 1cm. 3 patients presented local recurrence. One patient died within 6 months of radiotherapy because of another comorbidity. In total, 25% had presented a grade 3 acute radiation dermatitis, no grade 4 toxicity. Conclusion: Short term of moderately hypofractionated schedule radiotherapy was a success with complete or partial response for more than 70% of the patients in squamous cell carcinomas. There is no major side effect.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Scalp ; Retrospective Studies ; Radiation Dose Hypofractionation ; Carcinoma, Squamous Cell/radiotherapy ; Carcinoma, Squamous Cell/surgery ; Radiodermatitis/etiology ; Treatment Outcome
Language	English
Publishing date	2023-05-11
Publishing country	France
Document type	Journal Article
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2023.01.003
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Article: Strengthening the Key Features of Volumizing Fillers: Projection Capacity and Long-Term Persistence.

Flégeau, Killian / Jing, Jing / Vantou, Camille / Brusini, Romain / Bourdon, François / Faivre, Jimmy

Pharmaceutics

2023 Volume 15, Issue 11

Abstract: Volumizing fillers aim to create or restore facial volume in fat layers. To provide strong tissue lifting and long-term persistence, gels are generally designed with stiff properties, characterized by a high storage modulus (G'). However, clinical ... ...

Abstract	Volumizing fillers aim to create or restore facial volume in fat layers. To provide strong tissue lifting and long-term persistence, gels are generally designed with stiff properties, characterized by a high storage modulus (G'). However, clinical evidence shows a discrepancy between high G' and good lifting capacities, especially after skin tension has been exerted on the gel. To better explore the in vivo behavior of a gel, we first evaluated the elastic moduli of five commercial volumizers (RHA
Language	English
Publishing date	2023-11-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15112585
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Article ; Online: Radiothérapie stéréotaxique des métastases osseuses du squelette périphérique.

Faivre, J-C / Marchesi, V / Thureau, S

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2021 Volume 25, Issue 8, Page(s) 837–842

Abstract: Purpose: Stereotaxic radiotherapy is performed regularly for the irradiation of non-spine bone metastases, but its place is not well understood.: Materials and methods: This article in stereotaxic radiotherapy of non-spine bones oligometastases ... ...

Title translation	Stereotactic body radiation therapy for non-spine bone oligometastatic disease.
Abstract	Purpose: Stereotaxic radiotherapy is performed regularly for the irradiation of non-spine bone metastases, but its place is not well understood. Materials and methods: This article in stereotaxic radiotherapy of non-spine bones oligometastases presents the current scientific data relating to the indications, to virtual simulation, to the delineation of target volumes, to the total dose and fractionation, to the efficacy and tolerance. Results: Oligometastatic patients are classified into 4 categories: oligorecurrences, oligometastasis, oligopersistence, oligoprogression. The prognosis will be evaluated according to the following characteristics: primary tumor, quantitative characteristics, kinetics, qualitative characteristics. The delineation of GTV includes extensions to the soft tissue and bone marrow with the aid of MRI and PET. The CTV corresponds to a margin of 2 to 5mm and the PTV to a margin of 2mm. The most widely used irradiation schemes are: 1 single fraction of 18 to 24Gy/1 fr; 24Gy/2 fr; 27 to 30Gy/3 fr; 30 to 35Gy/5 fr. Stereotaxis provides 90% local control at 1 year and good pain control. The side effects are not very marked. Conclusion: Stereotaxic radiotherapy is feasible, non-invasive, minimally toxic and effective with good local control and good pain relief. The main issue remains selecting the patients most likely to benefit from it.
MeSH term(s)	Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/radiotherapy ; Bone Neoplasms/secondary ; Dose Fractionation, Radiation ; Humans ; Neoplasm Metastasis/radiotherapy ; Organs at Risk ; Prognosis ; Quality Assurance, Health Care ; Radiosurgery/adverse effects ; Radiosurgery/methods ; Treatment Outcome
Language	French
Publishing date	2021-11-03
Publishing country	France
Document type	Journal Article
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2021.09.009
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Article ; Online: Direct Reprogramming of Hepatocytes Into JAK/Stat-Dependent LGR5+ Liver Cells Able to Initiate Intrahepatic Cholangiocarcinoma.

Chaker, Diana / Desterke, Christophe / Moniaux, Nicolas / Bani, Mohamed-Amine / Oudrhiri, Noufissa / Faivre, Jamila / Turhan, Ali G / Bennaceur-Griscelli, Annelise / Griscelli, Frank

Stem cells (Dayton, Ohio)

2024 Volume 42, Issue 4, Page(s) 301–316

Abstract: Somatic cells that have been partially reprogrammed by the factors Oct4, Sox2, Klf4, and cMyc (OSKM) have been demonstrated to be potentially tumorigenic in vitro and in vivo due to the acquisition of cancer-associated genomic alterations and the absence ...

Abstract	Somatic cells that have been partially reprogrammed by the factors Oct4, Sox2, Klf4, and cMyc (OSKM) have been demonstrated to be potentially tumorigenic in vitro and in vivo due to the acquisition of cancer-associated genomic alterations and the absence of OSKM clearance over time. In the present study, we obtained partially reprogrammed, SSEA1-negative cells by transducing murine hepatocytes with Δ1Δ3-deleted adenoviruses that expressed the 4 OSKM factors. We observed that, under long-term 2D and 3D culture conditions, hepatocytes could be converted into LGR5-positive cells with self-renewal capacity that was dependent on 3 cross-signaling pathways: IL6/Jak/Stat3, LGR5/R-spondin, and Wnt/β-catenin. Following engraftment in syngeneic mice, LGR5-positive cells that expressed the cancer markers CD51, CD166, and CD73 were capable of forming invasive and metastatic tumors reminiscent of intrahepatic cholangiocarcinoma (ICC): they were positive for CK19 and CK7, featured associations of cord-like structures, and contained cuboidal and atypical cells with dissimilar degrees of pleomorphism and mitosis. The LGR5+-derived tumors exhibited a highly vascularized stroma with substantial fibrosis. In addition, we identified pro-angiogenic factors and signaling pathways involved in neo-angiogenesis and vascular development, which represent potential new targets for anti-angiogenic strategies to overcome tumor resistance to current ICC treatments.
MeSH term(s)	Animals ; Mice ; Hepatocytes/metabolism ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/metabolism ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/metabolism ; Bile Ducts, Intrahepatic/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Wnt Signaling Pathway/genetics
Chemical Substances	Receptors, G-Protein-Coupled
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1143556-2
ISSN	1549-4918 ; 1066-5099
ISSN (online)	1549-4918
ISSN	1066-5099
DOI	10.1093/stmcls/sxae006
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Article ; Online: BIRC-3 mutated monoclonal B lymphocytosis without evolution to chronic lymphocytic leukemia (CLL).

Nasr, Amen Allah / Fund, Xavier / Barreau, Sylvain / Desterke, Christophe / Borie, Claire / Oudrhiri, Noufissa / Faivre, Jamila / Bennaceur-Griscelli, A / Turhan, A G

Leukemia & lymphoma

2024 Volume 65, Issue 5, Page(s) 692–695

MeSH term(s)	Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lymphocytosis/genetics ; Lymphocytosis/diagnosis ; Lymphocytosis/pathology ; Mutation ; Baculoviral IAP Repeat-Containing 3 Protein/genetics ; B-Lymphocytes/pathology ; B-Lymphocytes/metabolism ; B-Lymphocytes/immunology ; Male ; Aged ; Clonal Evolution/genetics ; Middle Aged ; Female
Chemical Substances	Baculoviral IAP Repeat-Containing 3 Protein (EC 2.3.2.27) ; BIRC3 protein, human (EC 2.3.2.27)
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Letter ; Case Reports ; Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2024.2308665
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Article ; Conference proceedings: UP TO WHAT AGE PROPOSE MASS SCREENING FOR COLORECTAL CANCER BY FAECAL OCCULT BLOOD TEST? ANALYSIS OF A COHORT IN A WELL-DEFINED POPULATION

Tardieu, E / Manfredi, S / Cottet, V / Faivre, J

Endoscopy

2019 Volume 51, Issue 04

Event/congress	ESGE Days 2019, Prague, Czech Republic, 2019-04-04
Language	English
Publishing date	2019-03-18
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0039-1681624
Database	Thieme publisher's database

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