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Article ; Online: State-of-the-art for contrast-enhanced mammography.

Covington, Matthew F / Salmon, Samantha / Weaver, Bradley D / Fajardo, Laurie L

2024 Volume 97, Issue 1156, Page(s) 695–704

Abstract: Contrast-enhanced mammography (CEM) is an emerging breast imaging technology with promise for breast cancer screening, diagnosis, and procedural guidance. However, best uses of CEM in comparison with other breast imaging modalities such as tomosynthesis, ...

Abstract	Contrast-enhanced mammography (CEM) is an emerging breast imaging technology with promise for breast cancer screening, diagnosis, and procedural guidance. However, best uses of CEM in comparison with other breast imaging modalities such as tomosynthesis, ultrasound, and MRI remain inconclusive in many clinical settings. This review article summarizes recent peer-reviewed literature, emphasizing retrospective reviews, prospective clinical trials, and meta-analyses published from 2020 to 2023. The intent of this article is to supplement prior comprehensive reviews and summarize the current state-of-the-art of CEM.
MeSH term(s)	Humans ; Female ; Retrospective Studies ; Prospective Studies ; Contrast Media ; Mammography/methods ; Breast Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging ; Sensitivity and Specificity
Chemical Substances	Contrast Media
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1093/bjr/tqae017
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Book: A comprehensive approach to stereotactic breast biopsy

Fajardo, Laurie L.

1996

Title variant	Stereotactic breast biopsy
Author's details	ed. by Laurie L. Fajardo
Keywords	Biopsy, Needle / methods ; Stereotaxic Techniques ; Breast Diseases / pathology ; Breast Diseases / radiography ; Mamma ; Biopsie ; Stereotaktische Biopsie
Subject	Brust ; Busen ; Weibliche Brust
Language	English
Size	XIII, 301 S. : Ill., graph. Darst.
Publisher	Blackwell
Publishing place	Berlin u.a.
Document type	Book
HBZ-ID	HT007439754
ISBN	0-86542-467-5 ; 978-0-86542-467-8
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Autologous Fat Grafting to the Breast: An Educational Review.

Winkler, Nicole S / Tran, Alexander / Kwok, Alvin C / Freer, Phoebe E / Fajardo, Laurie L

Journal of breast imaging

2024 Volume 4, Issue 2, Page(s) 209–221

Abstract: Autologous fat grafting (AFG) is a technique that is increasingly utilized in breast cosmetic and reconstructive surgery. In this procedure, fat is aspirated by liposuction from one area of the body and injected into the breast. The procedure and process ...

Abstract	Autologous fat grafting (AFG) is a technique that is increasingly utilized in breast cosmetic and reconstructive surgery. In this procedure, fat is aspirated by liposuction from one area of the body and injected into the breast. The procedure and process of AFG has evolved over the last few decades, leading to more widespread use, though there is no standard method. Autologous fat grafting is generally considered a safe procedure but may result in higher utilization of diagnostic imaging due to development of palpable lumps related to fat necrosis. Imaging findings depend on surgical technique but typically include bilateral, symmetric, retromammary oil cysts and scattered dystrophic and/or coarse calcifications when AFG is used for primary breast augmentation. More focal findings occur when AFG is used to improve specific areas of cosmetic deformity, scarring, or pain following breast cancer surgery. As with any cause of fat necrosis, imaging features tend to appear more benign over time, with development of rim calcifications associated with oil cysts and a shift in echogenicity of oil cyst contents on ultrasound towards anechoic in some cases. This article reviews the AFG procedure, uses, complications, and imaging findings.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ISSN	2631-6129
ISSN (online)	2631-6129
DOI	10.1093/jbi/wbab055
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Article ; Online: Should women be informed of breast density?

Fajardo, Laurie L

Journal of the American College of Radiology : JACR

2013 Volume 10, Issue 1, Page(s) 9–10

MeSH term(s)	Adult ; Aged ; American Cancer Society ; Breast/pathology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/prevention & control ; Cell Transformation, Neoplastic/pathology ; Early Detection of Cancer/methods ; Female ; Humans ; Mammography/methods ; Mammography/statistics & numerical data ; Middle Aged ; Patient Advocacy ; Patient Education as Topic ; Practice Guidelines as Topic ; Predictive Value of Tests ; Truth Disclosure ; United States
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274861-1
ISSN	1558-349X ; 1546-1440
ISSN (online)	1558-349X
ISSN	1546-1440
DOI	10.1016/j.jacr.2012.06.002
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Article ; Online: Characteristics of Invasive Breast Cancer Detected by Digital Breast Tomosynthesis on Screening and Diagnostic Mammograms.

Baydoun, Serine E / Yang, Limin / Xiong, Jinhu / Fajardo, Laurie L

Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes

2020 Volume 72, Issue 2, Page(s) 242–250

Abstract: Objective: To determine whether there is added benefit for 3D mammography in the context of screening and diagnostic imaging, particularly relating to known prognostic characteristics, including histopathology, receptor status, and axillary lymph node ... ...

Abstract	Objective: To determine whether there is added benefit for 3D mammography in the context of screening and diagnostic imaging, particularly relating to known prognostic characteristics, including histopathology, receptor status, and axillary lymph node involvement. Methods: An institutional review board-approved retrospective review was performed of our mammography and pathology databases from October 2012 to May 2015 to identify biopsy-proven invasive breast carcinoma detected on screening and diagnostic mammograms by 2D plus 3D (2D + 3D) imaging. Percentages of cancer detection by 2D and 3D were compared. Correlation with histopathology and lymph node status was analyzed. Results: Of 53 cancers diagnosed on 12 543 screening mammograms, 36 (67.9%) were better visualized on 3D (not visualized, equivocal, or only seen in retrospect on 2D). Of the 62 cancers diagnosed on 4090 diagnostic mammograms, 24 (38.7%) cancers were better detected on 3D. A statistically significant greater number of cancers were better detected on 3D in the screening compared to the diagnostic mammograms (67.9% vs 38.7%, Conclusion: Three-dimension increases invasive breast cancer detection, particularly pathologically less aggressive tumors, in both screening and diagnostic mammograms with more benefit for the screening population. Three-dimensional mammography detected more breast cancer associated with metastatic axillary lymph nodes in the screening population.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Axilla ; Breast/diagnostic imaging ; Breast/pathology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Humans ; Imaging, Three-Dimensional/methods ; Lymph Nodes/pathology ; Lymphatic Metastasis/diagnostic imaging ; Lymphatic Metastasis/pathology ; Mammography/methods ; Middle Aged ; Retrospective Studies
Language	English
Publishing date	2020-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	418190-6
ISSN	1488-2361 ; 0846-5371 ; 0008-2902
ISSN (online)	1488-2361
ISSN	0846-5371 ; 0008-2902
DOI	10.1177/0846537119888389
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Article ; Online: Evaluation and comparison of a CdTe based photon counting detector with an energy integrating detector for X-ray phase sensitive imaging of breast cancer.

Ghani, Muhammad U / Omoumi, Farid H / Wu, Xizeng / Fajardo, Laurie L / Zheng, Bin / Liu, Hong

Journal of X-ray science and technology

2021 Volume 30, Issue 2, Page(s) 207–219

Abstract: Purpose: To compare imaging performance of a cadmium telluride (CdTe) based photon counting detector (PCD) with a CMOS based energy integrating detector (EID) for potential phase sensitive imaging of breast cancer.: Methods: A high energy inline ... ...

Abstract	Purpose: To compare imaging performance of a cadmium telluride (CdTe) based photon counting detector (PCD) with a CMOS based energy integrating detector (EID) for potential phase sensitive imaging of breast cancer. Methods: A high energy inline phase sensitive imaging prototype consisting of a microfocus X-ray source with geometric magnification of 2 was employed. The pixel pitch of the PCD was 55μm, while 50μm for EID. The spatial resolution was quantitatively and qualitatively assessed through modulation transfer function (MTF) and bar pattern images. The edge enhancement visibility was assessed by measuring edge enhancement index (EEI) using the acrylic edge acquired images. A contrast detail (CD) phantom was utilized to compare detectability of simulated tumors, while an American College of Radiology (ACR) accredited phantom for mammography was used to compare detection of simulated calcification clusters. A custom-built phantom was employed to compare detection of fibrous structures. The PCD images were acquired at equal, and 30% less mean glandular dose (MGD) levels as of EID images. Observer studies along with contrast to noise ratio (CNR) and signal to noise ratio (SNR) analyses were performed for comparison of two detection systems. Results: MTF curves and bar pattern images revealed an improvement of about 40% in the cutoff resolution with the PCD. The excellent spatial resolution offered by PCD system complemented superior detection of the diffraction fringes at boundaries of the acrylic edge and resulted in an EEI value of 3.64 as compared to 1.44 produced with EID image. At equal MGD levels (standard dose), observer studies along with CNR and SNR analyses revealed a substantial improvement of PCD acquired images in detection of simulated tumors, calcification clusters, and fibrous structures. At 30% less MGD, PCD images preserved image quality to yield equivalent (slightly better) detection as compared to the standard dose EID images. Conclusion: CdTe-based PCDs are technically feasible to image breast abnormalities (low/high contrast structures) at low radiation dose levels using the high energy inline phase sensitive imaging technique.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Cadmium Compounds ; Female ; Humans ; Phantoms, Imaging ; Photons ; Quantum Dots ; Tellurium ; X-Rays
Chemical Substances	Cadmium Compounds ; Tellurium (NQA0O090ZJ) ; cadmium telluride (STG188WO13)
Language	English
Publishing date	2021-12-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2012019-9
ISSN	1095-9114 ; 0895-3996
ISSN (online)	1095-9114
ISSN	0895-3996
DOI	10.3233/XST-211028
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Article ; Online: Dual-energy phase retrieval algorithm for inline phase sensitive x-ray imaging system.

Ghani, Muhammad U / Yan, Aimin / Fajardo, Laurie L / Wu, Xizeng / Liu, Hong

Optics express

2021 Volume 29, Issue 17, Page(s) 26538–26552

Abstract: Phase retrieval is vital for quantitative x-ray phase contrast imaging. This work presents an iterative method to simultaneously retrieve the x-ray absorption and phase images from a single x-ray exposure. The proposed approach uses the photon-counting ... ...

Abstract	Phase retrieval is vital for quantitative x-ray phase contrast imaging. This work presents an iterative method to simultaneously retrieve the x-ray absorption and phase images from a single x-ray exposure. The proposed approach uses the photon-counting detectors' energy-resolving capability in providing multiple spectrally resolved phase contrast images from a single x-ray exposure. The retrieval method is derived, presented, and experimentally tested with a multi-material phantom in an inline phase contrast imaging setup. By separating the contributions of photoelectric absorption and Compton scattering to the attenuation, the authors divide the phase contrast image into two portions, the attenuation map arises from photoelectric absorption and a pseudo phase contrast image generated by electron density. This way one can apply the Phase Attenuation Dualiby (PAD) algorithm and Fresnel propagation for the iteration. The retrieval results from the experimental images show that this iterative method is fast, accurate, robust against noise, and thus yields noticeable enhancement in contrast to noise ratios.
Language	English
Publishing date	2021-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.431623
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Article ; Online: Imaging Features of Nonmalignant and Malignant Architectural Distortion Detected by Tomosynthesis.

Vijapura, Charmi / Yang, Limin / Xiong, Jinhu / Fajardo, Laurie L

AJR. American journal of roentgenology

2018 Volume 211, Issue 6, Page(s) 1397–1404

Abstract: Objective: The objective of our study was to determine the ability of tomosynthesis (3D) to detect nonmalignant and malignant architectural distortion (AD) on 3D screening mammograms compared with digital mammography (2D) only and to correlate the 3D ... ...

Abstract	Objective: The objective of our study was to determine the ability of tomosynthesis (3D) to detect nonmalignant and malignant architectural distortion (AD) on 3D screening mammograms compared with digital mammography (2D) only and to correlate the 3D imaging features of nonmalignant and malignant AD with pathology findings. Materials and methods: For this single-institution retrospective study, screening mammography reports from October 1, 2012, to December 1, 2016, that included AD as a finding were reviewed. Associated additional imaging studies and pathology results were also reviewed. Results: Three-dimensional mammography showed statistically significant increased detection of both nonmalignant and malignant AD compared with 2D only (0.10% [24/24,902 examinations] vs 0.01% [1/9470 examinations], p < 0.05; and 0.21% [52/24,902 examinations] vs 0.07% [7/9470 examinations], p < 0.05, respectively). Higher percentages of nonmalignant AD (16%) were occult on ultrasound compared with malignant AD (3%). The pathologic diagnoses of nonmalignant AD included radial scar (42%), sclerosing adenosis (16%), stromal or dense fibrosis (16%), and other miscellaneous benign causes (25%). Morphologically, nonmalignant AD was more likely to show symmetric or spoke-wheel spiculation appearance (58% vs 2%, p < 0.05) and central lucency (25% vs 0%, p < 0.05) than malignant AD, whereas malignant AD was more likely to show asymmetric spiculation (98% vs 42%, p < 0.05) and central mass 60% vs 0%, p < 0.05) than nonmalignant AD. Conclusion: Malignant AD and nonmalignant AD are more readily detected by 3D mammography than 2D mammography. Three-dimensional imaging features of AD can help to distinguish nonmalignant types in which symmetric or spoke-wheel spiculation with central lucency are more often seen and are more often occult on ultrasound.
MeSH term(s)	Aged ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Humans ; Imaging, Three-Dimensional ; Mammography ; Middle Aged ; Predictive Value of Tests ; Radiographic Image Enhancement ; Retrospective Studies
Language	English
Publishing date	2018-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.18.19658
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Article ; Online: A Pilot Study to Assess the Performance of Phase-Sensitive Breast Tomosynthesis.

Fajardo, Laurie L / Hillis, Stephen L / Zheng, Bin / Wong, Molly Donovan / Ghani, Muhammad U / Omoumi, Farid H / Li, Yuhua / Jenkins, Peter / Peterson, Michael E / Wu, Xizeng / Liu, Hong

Radiology

2022 Volume 306, Issue 2, Page(s) e213198

Abstract: Background A new modality, phase-sensitive breast tomosynthesis (PBT), may have similar diagnostic performance to conventional breast tomosynthesis but with a reduced radiation dose. Purpose To perform a pilot study of the performance of a novel PBT ... ...

Abstract	Background A new modality, phase-sensitive breast tomosynthesis (PBT), may have similar diagnostic performance to conventional breast tomosynthesis but with a reduced radiation dose. Purpose To perform a pilot study of the performance of a novel PBT system compared with conventional digital breast tomosynthesis (DBT) in patients undergoing additional diagnostic imaging workup for breast lesions. Materials and Methods In a prospective study from June 2020 to March 2021, participants with suspicious breast lesions detected at screening DBT or MRI were recruited for additional PBT imaging before additional diagnostic workup or biopsy. In this pilot study, nine radiologists independently evaluated image quality and assessed the likelihood of lesion malignancy by retrospectively evaluating DBT and PBT images in two separate reading sessions. Image quality was rated subjectively using a Likert scale from 1 to 5. Areas under the receiver operating characteristic curve (AUCs) were used to compare the lesion classification (malignant vs benign) performance of the radiologists. Results Images in 50 patients (mean age, 56 years ± 12 [SD]; 49 women) with 52 evaluable lesions (28 malignant) were assessed. For image appearance and general feature visibility, DBT images had a higher total mean image quality score (3.8) than PBT images (2.9), with
MeSH term(s)	Female ; Humans ; Middle Aged ; Pilot Projects ; Prospective Studies ; Retrospective Studies ; Breast/diagnostic imaging ; Mammography/methods ; Breast Neoplasms/pathology
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.213198
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Article: Screening mammography, sonography of dense fibrocystic breast tissue.

Fajardo, Laurie L

AJR. American journal of roentgenology

2003 Volume 181, Issue 6, Page(s) 1715

MeSH term(s)	Breast Neoplasms/complications ; Breast Neoplasms/diagnostic imaging ; Female ; Fibrocystic Breast Disease/complications ; Fibrocystic Breast Disease/diagnostic imaging ; Humans ; Mammography ; Ultrasonography, Mammary
Language	English
Publishing date	2003-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/ajr.181.6.1811715
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