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  1. Article: Watching TV and Cognition: The SPAH 2-Year Cohort Study of Older Adults Living in Low-Income Communities.

    Fajersztajn, Laís / Di Rienzo, Vanessa / Nakamura, Carina Akemi / Scazufca, Marcia

    Frontiers in neurology

    2021  Volume 12, Page(s) 628489

    Abstract: Watching TV is a highly prevalent leisure activity among older adults and, in many cases, the only leisure option of those living in low-income communities. While engaging in leisure activities have proven to protect older adults from cognitive decline, ... ...

    Abstract Watching TV is a highly prevalent leisure activity among older adults and, in many cases, the only leisure option of those living in low-income communities. While engaging in leisure activities have proven to protect older adults from cognitive decline, the effects of watching TV on cognition of this population is controversial in the literature. This study investigated the impact of watching TV on global cognitive function, immediate memory, verbal fluency, risk of dementia of amnestic mild cognitive impairment (aMCI) in a cohort of older adults residents of socioeconomically deprived areas of São Paulo, Brazil. We used data from the São Paulo Aging & Health Study (SPAH). Participants aged 65 years or over, with no dementia diagnosis at baseline and who completed the 2-year follow-up assessment were included in this study (
    Language English
    Publishing date 2021-06-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.628489
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  2. Article ; Online: Hypoxia: From Placental Development to Fetal Programming.

    Fajersztajn, Lais / Veras, Mariana Matera

    Birth defects research

    2017  Volume 109, Issue 17, Page(s) 1377–1385

    Abstract: Hypoxia may influence normal and different pathological processes. Low oxygenation activates a variety of responses, many of them regulated by hypoxia-inducible factor 1 complex, which is mostly involved in cellular control of ... ...

    Abstract Hypoxia may influence normal and different pathological processes. Low oxygenation activates a variety of responses, many of them regulated by hypoxia-inducible factor 1 complex, which is mostly involved in cellular control of O
    Language English
    Publishing date 2017-10-16
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2472-1727
    ISSN (online) 2472-1727
    DOI 10.1002/bdr2.1142
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  3. Article: Air Pollution: A Neglected Risk Factor for Dementia in Latin America and the Caribbean.

    Dos Santos, Nathália Villa / Yariwake, Victor Yuji / Marques, Karina do Valle / Veras, Mariana Matera / Fajersztajn, Laís

    Frontiers in neurology

    2021  Volume 12, Page(s) 684524

    Abstract: The risk of dementia and Alzheimer's disease in Latin America and the Caribbean (LAC) rises with increasing age and polluted air. Currently, at least 172 million people breathe unhealthy levels of air pollution in LAC countries. Several cohort studies ... ...

    Abstract The risk of dementia and Alzheimer's disease in Latin America and the Caribbean (LAC) rises with increasing age and polluted air. Currently, at least 172 million people breathe unhealthy levels of air pollution in LAC countries. Several cohort studies have indicated that air pollution increases the risk of developing dementia and neurodegenerative diseases, but the mechanisms underlying the association are still not clear. Air pollution causes and aggravates five established risk factors for dementia (obesity, hypertension, stroke, diabetes mellitus, and heart diseases) and is linked to three other risk factors (physical inactivity, cognitive inactivity, and depression). Some of these risk factors could be mediating the association between air pollution and dementia. Reducing the risks for dementia is crucial and urgently needed in LAC countries. There is room for improving air quality in many urban areas in the LAC region and other low- and middle-income countries (LMICs), a routealready explored by many urban areas in developing regions. Moreover, reducing air pollution has proved to improve health outcomes before. In this article, we propose that despite the ongoing and valid scientific discussion, if air pollution can or cannot directly affect the brain and cause or aggravate dementia, we are ready to consider air pollution as a potentially modifiable risk factor for dementia in LAC and possibly in other LMICs. We suggest that controlling and reducing current air pollution levels in LAC and other LMIC regions now could strongly contribute.
    Language English
    Publishing date 2021-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.684524
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  4. Article: Prevalence of Older Adult Disability and Primary Health Care Responsiveness in Low-Income Communities.

    Montoro Pazzini Watfe, Giovana / Fajersztajn, Lais / Ribeiro, Euler / Rossi Menezes, Paulo / Scazufca, Marcia

    Life (Basel, Switzerland)

    2020  Volume 10, Issue 8

    Abstract: In Brazil and in most low- and middle-income countries (LMICs), information about how prepared the health care system is for the rapid aging of the population is scarce. We investigated the prevalence of disability and areas of life affected by ... ...

    Abstract In Brazil and in most low- and middle-income countries (LMICs), information about how prepared the health care system is for the rapid aging of the population is scarce. We investigated the prevalence of disability and areas of life affected by disability among elders of the public primary health care in São Paulo and Manaus, Brazil. We investigated whether people with disability visited a primary care professional more frequently, the individual characteristics associated with disability, and differences by city. We randomly selected participants aged ≥60 years (
    Keywords covid19
    Language English
    Publishing date 2020-08-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life10080133
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  5. Article ; Online: Depressive and subthreshold depressive symptomatology among older adults in a socioeconomically deprived area in Brazil.

    Nakamura, Carina Akemi / Scazufca, Marcia / Peters, Tim J / Fajersztajn, Lais / Van de Ven, Pepijn / Hollingworth, William / Araya, Ricardo / Moreno-Agostino, Darío

    International journal of geriatric psychiatry

    2021  Volume 37, Issue 2

    Abstract: Depressive and subthreshold depressive symptomatology are common but often neglected in older adults.: Objective: This study aimed to assess rates of depressive and subthreshold depressive symptomatology, and the characteristics associated, among ... ...

    Abstract Depressive and subthreshold depressive symptomatology are common but often neglected in older adults.
    Objective: This study aimed to assess rates of depressive and subthreshold depressive symptomatology, and the characteristics associated, among older adults living in a socioeconomically deprived area of Brazil.
    Methods: This study is part of the PROACTIVE cluster randomised controlled trial. 3356 adults aged 60+ years and registered in 20 primary health clinics were screened for depressive symptomatology with the Patient Health Questionnaire-9 (PHQ-9). Depressive status was classified according to the total PHQ-9 score and the presence of core depressive symptoms (depressed mood and anhedonia) as follows: no depressive symptomatology (PHQ-9 score 0-4, or 5-9 but with no core depressive symptom); subthreshold depressive symptomatology (PHQ-9 score 5-9 and at least one core depressive symptom); and depressive symptomatology (PHQ-9 score ≥ 10). Sociodemographic information and self-reported chronic conditions were collected. Relative risk ratios and 95% CIs were obtained using a multinomial regression model.
    Results: Depressive and subthreshold depressive symptomatology were present in 30% and 14% of the screened sample. Depressive symptomatology was associated with female gender, low socioeconomic conditions and presence of chronic conditions, whereas subthreshold depressive symptomatology was only associated with female gender and having hypertension.
    Conclusions: Depressive and subthreshold depressive symptomatology is highly prevalent in this population registered with primary care clinics. Strategies managed by primary care non-mental health specialists can be a first step for improving this alarming and neglected situation among older adults.
    MeSH term(s) Aged ; Brazil/epidemiology ; Depression/psychology ; Female ; Humans ; Odds Ratio ; Patient Health Questionnaire ; Self Report
    Language English
    Publishing date 2021-12-03
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.5665
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2208: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Effects of functional physical activity on the maintenance of motor function in Alzheimer's disease.

    Fajersztajn, Laís / Cordeiro, Renata Cereda / Andreoni, Solange / Garcia, Jacqueline Takayanagi

    Dementia & neuropsychologia

    2017  Volume 2, Issue 3, Page(s) 233–240

    Abstract: It is widely known that older adults, even frail individuals, can improve their physical function using appropriately targeted exercise. Nevertheless, older adults with Alzheimer's disease (AD) have been excluded from the majority of studies on exercise. ...

    Abstract It is widely known that older adults, even frail individuals, can improve their physical function using appropriately targeted exercise. Nevertheless, older adults with Alzheimer's disease (AD) have been excluded from the majority of studies on exercise. The functional-task physical activity program is based on activities of daily living, and may be suited for elderly people with AD because it focuses on the maintenance and stimulation of preserved abilities. In addition, session costs are substantially reduced by adopting a group approach. Furthermore, the group approach may improve the social interaction of the demented patient.
    Objectives: To determine whether a functional-task physical activity program in groups can maintain motor function in elderly with AD.
    Methods: 10 elderly diagnosed with mild or moderate AD were assigned into one of two groups: subjects with and without intervention. The intervention consisted of a 12-week function-task physical activity program in groups. Measurements: activities of daily living (Katz and Lawton & Brody questionnaires), mobility (Timed Up and Go Test, Timed Up and Go manual Test and Timed Up and Go Cognitive Test), cognition (Mini-Mental State Examination), behavioral disturbances (Neuropsychiatric Inventory I-brief) and functional balance (Berg Balance Scale).
    Results: A statistically significant difference between the two groups was found regarding the functional balance mean change measured by Berg scale score (p=0.046). A significant improvement of 1.60 points (95%CI[0.22;2.98]) was observed in the intervention group on this scale, while the non-intervention group showed -0.40 points (95%CI[-1.78;0.98], no change).
    Conclusions: It is possible to treat mild and moderate Alzheimer's patients using a group approach. The functional task physical activity program was efficient in functional balance improvement and also appeared to prevent mobility decline.
    Language English
    Publishing date 2017-08-22
    Publishing country Brazil
    Document type Journal Article
    ISSN 1980-5764
    ISSN 1980-5764
    DOI 10.1590/S1980-57642009DN20300013
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  7. Article: Prevalence of Older Adult Disability and Primary Health Care Responsiveness in Low-Income Communities

    Montoro Pazzini Watfe, Giovana / Fajersztajn, Lais / Ribeiro, Euler / Rossi Menezes, Paulo / Scazufca, Marcia

    Abstract: In Brazil and in most low- and middle-income countries (LMICs), information about how prepared the health care system is for the rapid aging of the population is scarce. We investigated the prevalence of disability and areas of life affected by ... ...

    Abstract In Brazil and in most low- and middle-income countries (LMICs), information about how prepared the health care system is for the rapid aging of the population is scarce. We investigated the prevalence of disability and areas of life affected by disability among elders of the public primary health care in São Paulo and Manaus, Brazil. We investigated whether people with disability visited a primary care professional more frequently, the individual characteristics associated with disability, and differences by city. We randomly selected participants aged ≥60 years (n = 1375). The main outcome was disability, evaluated with the 12-item World Health Organization Disability Assessment Schedule (WHODAS 2.0). Exposure variables were consultation with a family physician, sociodemographic characteristics, health status, social support, and lifestyle. The prevalence of global disability was higher in Manaus (66.2% vs. 56.4% in São Paulo). In both cities, participation and mobility were the areas of life most affected by disability. The number of consultations with a family physician was not associated with disability. The high prevalence of disability and associated risk factors indicates that public primary health care is not meeting the needs of elders in both cities. It is warning because most elders in LMICs live in more underserved communities compared to Brazil.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32764217
    Database COVID19

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  8. Article ; Online: Before the first breath: prenatal exposures to air pollution and lung development.

    Veras, Mariana Matera / de Oliveira Alves, Nilmara / Fajersztajn, Lais / Saldiva, Paulo

    Cell and tissue research

    2017  Volume 367, Issue 3, Page(s) 445–455

    Abstract: Various environmental contaminants are known to impair the growth trajectories of major organs, indirectly (gestational exposure) or directly (postnatal exposure). Evidence associates pre-gestational and gestational exposure to air pollutants with ... ...

    Abstract Various environmental contaminants are known to impair the growth trajectories of major organs, indirectly (gestational exposure) or directly (postnatal exposure). Evidence associates pre-gestational and gestational exposure to air pollutants with adverse birth outcomes (e.g., low birth weight, prematurity) and with a wide range of diseases in childhood and later in life. In this review, we explore the way that pre-gestational and gestational exposure to air pollution affects lung development. We present results in topics underlining epidemiological and toxicological evidence. We also provide a summary of the biological mechanisms by which air pollution exposure possibly leads to adverse respiratory outcomes. We conclude that gestational and early life exposure to air pollutants are linked to alterations in lung development and function and to other negative respiratory conditions in childhood (wheezing, asthma) that may last into adulthood. Plausible mechanisms encompass changes in maternal physiology (e.g., hypoxia, oxidative stress and inflammation) and DNA alterations in the fetus. Evidence for pre-gestational and gestational effects on the lung is scarce compared with that on early life exposure and further studies are needed. However, the suggested mechanisms are credible and the evidence of pre-gestational and gestational air pollution exposure is robust for adverse birth outcomes. Air pollutants might change lung developmental trajectories of the unborn child predisposing it to diseases later in life highlighting the urgent need for controls on urban air pollution levels worldwide.
    MeSH term(s) Air Pollution/adverse effects ; Animals ; Disease Models, Animal ; Female ; Humans ; Lung/embryology ; Pregnancy ; Premature Birth ; Prenatal Exposure Delayed Effects/epidemiology ; Prenatal Exposure Delayed Effects/pathology ; Prenatal Exposure Delayed Effects/physiopathology ; Respiration
    Language English
    Publishing date 2017
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-016-2509-4
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    Ub I Zs.94: Show issues Location:
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  9. Article ; Online: Short-term effects of fine particulate matter pollution on daily health events in Latin America: a systematic review and meta-analysis.

    Fajersztajn, Laís / Saldiva, Paulo / Pereira, Luiz Alberto Amador / Leite, Victor Figueiredo / Buehler, Anna Maria

    International journal of public health

    2017  Volume 62, Issue 7, Page(s) 729–738

    Abstract: Objectives: Ambient air pollution is among the leading risks for health worldwide and by 2050 will largely overcome deaths due to unsafe sanitation and malaria, but local evidence from Latin America (LA) is scarce. We aimed to summarize the effect of ... ...

    Abstract Objectives: Ambient air pollution is among the leading risks for health worldwide and by 2050 will largely overcome deaths due to unsafe sanitation and malaria, but local evidence from Latin America (LA) is scarce. We aimed to summarize the effect of short-term exposure to fine particulate air pollution (PM
    Methods: The comprehensive search (six online databases and hand-searching) identified studies investigating the short-term associations between PM
    Results: We retrieved 1628 studies. Nine were elected for the qualitative analysis and seven for the quantitative analyses. Each 10 µg/m
    Conclusions: Short-term exposure to PM
    MeSH term(s) Air Pollution/adverse effects ; Cardiovascular Diseases/mortality ; Environmental Exposure/adverse effects ; Humans ; Latin America/epidemiology ; Particulate Matter/adverse effects ; Respiratory Tract Diseases/mortality ; Risk
    Chemical Substances Particulate Matter
    Language English
    Publishing date 2017-03-02
    Publishing country Switzerland
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2274130-6
    ISSN 1661-8564 ; 1661-8556
    ISSN (online) 1661-8564
    ISSN 1661-8556
    DOI 10.1007/s00038-017-0960-y
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    Zs.A 843: Show issues Location:
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  10. Article ; Online: Effects of

    Zantut, Paulo R A / Veras, Mariana M / Yariwake, Victor Y / Takahashi, Walter Y / Saldiva, Paulo H / Young, Lucy H / Damico, Francisco Max / Fajersztajn, Laís

    Cutaneous and ocular toxicology

    2019  Volume 39, Issue 1, Page(s) 1–9

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Cannabinoids/pharmacology ; Cannabis ; Hallucinogens ; Humans ; Retina/drug effects
    Chemical Substances Cannabinoids ; Hallucinogens
    Language English
    Publishing date 2019-11-06
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 605635-0
    ISSN 1556-9535 ; 1556-9527 ; 0731-3829
    ISSN (online) 1556-9535
    ISSN 1556-9527 ; 0731-3829
    DOI 10.1080/15569527.2019.1685534
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