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  1. Article ; Online: A Report of the Telepsychiatric Evaluation of SARS-CoV-2 Patients.

    Zarghami, Arman / Farjam, Mojtaba / Fakhraei, Bahareh / Hashemzadeh, Kosar / Yazdanpanah, Mohammad Hosein

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2020  Volume 26, Issue 12, Page(s) 1461–1465

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Anxiety Disorders/diagnosis ; COVID-19/diagnosis ; COVID-19/psychology ; Female ; Humans ; Inpatients/statistics & numerical data ; Iran/epidemiology ; Male ; Middle Aged ; Outpatients/statistics & numerical data ; Pandemics/statistics & numerical data ; Sex Factors ; Telemedicine/methods ; Telemedicine/statistics & numerical data ; Video Recording/statistics & numerical data
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2020.0125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Polymorphisms of serotonin transporter gene and psychological status in patients with multiple sclerosis.

    Farjadian, Shirin / Fakhraei, Bahareh / Niknam, Zahra / Nasiri, Mahboubeh / Azad, Aslan / Farjam, Mojtaba / Nikseresht, Alireza

    Iranian journal of neurology

    2019  Volume 17, Issue 3, Page(s) 105–110

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2019-02-07
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2685400-4
    ISSN 2252-0058 ; 2008-384X
    ISSN (online) 2252-0058
    ISSN 2008-384X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A Report of the Telepsychiatric Evaluation of SARS-CoV-2 Patients

    Zarghami, Arman / Farjam, Mojtaba / Fakhraei, Bahareh / Hashemzadeh, Kosar / Yazdanpanah, Mohammad Hosein

    Telemed. j. e. health

    Abstract: Objective: During the current coronavirus disease 2019 (COVID-19) pandemic, telemedicine has been brought to the forefront of attention. This report aimed to assess psychiatric comorbidities in COVID-19 patients by utilizing telepsychiatry. Methods: ... ...

    Abstract Objective: During the current coronavirus disease 2019 (COVID-19) pandemic, telemedicine has been brought to the forefront of attention. This report aimed to assess psychiatric comorbidities in COVID-19 patients by utilizing telepsychiatry. Methods: COVID-19 patients admitted in Fasa University Hospital and nonhospitalized outpatients of Fasa city were interviewed by a psychiatrist through video chat for a 1-month period (March-April, 2020). Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Assessment (GAD-7), and Perceived Stress Scale-14 (PSS 14) questionnaires were administered for all patients. Each patient's mental status was recorded, and if any psychiatric problem was diagnosed, supportive psychotherapy, pharmacotherapy, and follow-up visits based on the patient's condition were started. Result: From a total of 82 COVID-19 patients who entered the study, 32 (39.03%) and 50 (60.97%) subjects were inpatients and outpatients, respectively. Moreover, 32 (39.03%) subjects were male and 50 (60.97%) were female. Insomnia seen in 24 (29.3%) patients and adjustment disorder in 13 (15.9%) patients were the most common psychiatric disorders among a total of 33 (40.2%) patients suffering from mental illness. Female and hospitalized patients presented significantly more frequent comorbidities than males and outpatients. Conclusions: Psychiatric disorders were significantly more common in patients with hospital admission than those without and more frequent in female versus male subjects. There were no significant differences between male and female subjects with and without admission according to the PHQ-9, GAD-7, and PSS-14 scores. It was concluded that telepsychiatry in the early stages of mental problems during a catastrophic event like the coronavirus pandemic, can be an efficient instrument for the screening of psychosomatic comorbidities, so that pharmacological treatment (considering possible drug interactions with COVID-19 medications) and psychotherapeutic intervention can be optimized by psychiatrists.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #593620
    Database COVID19

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  4. Article ; Online: A Report of the Telepsychiatric Evaluation of SARS-CoV-2 Patients

    Zarghami, Arman / Farjam, Mojtaba / Fakhraei, Bahareh / Hashemzadeh, Kosar / Yazdanpanah, Mohammad Hosein

    Telemedicine and e-Health ; ISSN 1530-5627 1556-3669

    2020  

    Keywords Health Informatics ; Health Information Management ; General Medicine ; covid19
    Language English
    Publisher Mary Ann Liebert Inc
    Publishing country us
    Document type Article ; Online
    DOI 10.1089/tmj.2020.0125
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: CD21 positive B cell: a novel target for treatment of multiple sclerosis.

    Farjam, Mojtaba / Ebrahimpour, Azin / Fakhraei, Bahareh

    Medical hypotheses

    2013  Volume 80, Issue 5, Page(s) 556–557

    Abstract: Etiologic-based therapy is an ideal pharmacological option to treat or prevent diseases. There is no known etiology for multiple sclerosis (MS); however, environmental risk factors have been suggested to predispose genetically susceptible people to be ... ...

    Abstract Etiologic-based therapy is an ideal pharmacological option to treat or prevent diseases. There is no known etiology for multiple sclerosis (MS); however, environmental risk factors have been suggested to predispose genetically susceptible people to be affected by the disease. One of these risk factors is infection with Epstein-Barr virus (EBV). Eradication of this virus has not been effective in modulation of MS, probably due to being inhabitant in the CD21 (EBV receptor) positive B cells. To eradicate this virus, targeting CD21 on these EBV-infected B cells is hypothesized here. A sequential study plan to test this hypothesis has been suggested too. This study might eventually suggest an effective immunopharmacological strategy to treat MS. Moreover, testing this strategy will help in better clarification of the role of EBV in MS disease triggering and predisposition.
    MeSH term(s) Anti-Inflammatory Agents/therapeutic use ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Epstein-Barr Virus Infections/drug therapy ; Epstein-Barr Virus Infections/immunology ; Humans ; Models, Immunological ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/immunology ; Receptors, Complement 3d/antagonists & inhibitors ; Receptors, Complement 3d/immunology
    Chemical Substances Anti-Inflammatory Agents ; Receptors, Complement 3d
    Language English
    Publishing date 2013-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2013.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association between serotonin transporter gene polymorphisms and childhood asthma.

    Farjadian, Shirin / Moghtaderi, Mozhgan / Fakhraei, Bahareh / Nasiri, Mahboubeh / Farjam, Mojtaba

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2013  Volume 50, Issue 10, Page(s) 1031–1035

    Abstract: Background: Asthma is a common chronic inflammatory disease of the airways in which genetic factors play a major role in its pathogenesis. High serotonin serum levels in patients with asthma suggest that serotonin is involved in the pathophysiology of ... ...

    Abstract Background: Asthma is a common chronic inflammatory disease of the airways in which genetic factors play a major role in its pathogenesis. High serotonin serum levels in patients with asthma suggest that serotonin is involved in the pathophysiology of the disease. Serotonin clearance is mediated by the serotonin reuptake transporter, and functional polymorphisms in this gene lead to altered serotonin reuptake efficiency.
    Objective: The aim of this study was to investigate the relationship between serotonin transporter gene polymorphisms and asthma.
    Methods: Serotonin transporter gene polymorphisms (5-HTTLPR, rs35521 and STin2.VNTR) were assessed by PCR-based methods in 100 children with mild to moderate persistent asthma and compared with 100 healthy controls.
    Results: There were no significant differences in allele, genotype or haplotype frequencies between patients and controls. No association was observed between SERT gene polymorphisms after stratification of patients for sex, age, spirometry indices, family history, passive smoking behavior and concomitant allergic rhinitis. Significant differences were observed in the distribution of 5-HTTLPR alleles (p = 0.025) and genotypes (p = 0.021) between patients with and without atopic dermatitis.
    Conclusions: Despite strong evidence suggesting the role of serotonin in the pathophysiology of asthma, we found no association between serotonin transporter gene polymorphisms and mild to moderate persistent asthma. Further serotonin transporter gene analyses in patients with severe asthma may open up new horizons in the utilization of common serotonin regulators to treat asthma, based on their pharmacogenetic effects. However, serotonin may also be indirectly influenced by emotional stress during asthma attacks.
    MeSH term(s) Asthma/genetics ; Child ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Parents ; Polymorphism, Genetic ; Serotonin Plasma Membrane Transport Proteins
    Chemical Substances SLC6A4 protein, human ; Serotonin Plasma Membrane Transport Proteins
    Language English
    Publishing date 2013-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.3109/02770903.2013.834503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Serotonin transporter gene polymorphisms in Southwestern Iranian patients with irritable bowel syndrome.

    Farjadian, Shirin / Fakhraei, Bahareh / Moeini, Maryam / Nasiri, Mahboubeh / Fattahi, Mohammad Reza

    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

    2013  Volume 14, Issue 2, Page(s) 59–62

    Abstract: Background and study aims: Irritable bowel syndrome is a common chronic functional gastrointestinal disorder of unknown etiology. Serotonin is an important factor in sensory signaling in the brain-gut axis, which plays a key role in intestinal motility ... ...

    Abstract Background and study aims: Irritable bowel syndrome is a common chronic functional gastrointestinal disorder of unknown etiology. Serotonin is an important factor in sensory signaling in the brain-gut axis, which plays a key role in intestinal motility and secretion. Serotonin clearance is mediated by a specific protein called the serotonin reuptake transporter. Transcription activity of the serotonin transporter gene is affected by some polymorphisms in this gene. The aim of this study was to investigate the relationship between serotonin transporter gene polymorphisms and irritable bowel syndrome.
    Patients/material and methods: The 5-HTTLPR, rs25531 and STin2VNTR polymorphisms of the serotonin transporter gene were analyzed by PCR-based methods in 50 patients with irritable bowel syndrome and 100 healthy controls.
    Results: Serotonin transporter polymorphisms were similar in patients and healthy controls. There were no significant differences in allele or genotype frequencies between the two groups.
    Conclusion: Our findings suggest that polymorphisms in the gene encoding for the serotonin transporter are not associated with irritable bowel syndrome. Interactions between environmental factors and predisposing genetic factors are important in the pathophysiology of irritable bowel syndrome, and further genetic and epigenetic research may provide novel insights into the mechanisms contributing to this disease.
    MeSH term(s) Adult ; Alleles ; Female ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Humans ; Iran ; Irritable Bowel Syndrome/genetics ; Male ; Polymorphism, Genetic ; Serotonin Plasma Membrane Transport Proteins/genetics
    Chemical Substances Serotonin Plasma Membrane Transport Proteins
    Language English
    Publishing date 2013-06
    Publishing country Egypt
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2502114-X
    ISSN 2090-2387 ; 1687-1979
    ISSN (online) 2090-2387
    ISSN 1687-1979
    DOI 10.1016/j.ajg.2013.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Lack of association between Helicobacter pylori infection and oral lichen planus.

    Pourshahidi, Sara / Fakhri, Farnaz / Ebrahimi, Hooman / Fakhraei, Bahareh / Alipour, Abbas / Ghapanchi, Janan / Farjadian, Shirin

    Asian Pacific journal of cancer prevention : APJCP

    2012  Volume 13, Issue 5, Page(s) 1745–1747

    Abstract: Oral lichen planus is a premalignant chronic inflammatory mucosal disorder with unknown etiology. It is a multifactorial disease and in addition to genetic background, infections, stress, drug reactions are suggested as risk factors. Helicobacter pylori ... ...

    Abstract Oral lichen planus is a premalignant chronic inflammatory mucosal disorder with unknown etiology. It is a multifactorial disease and in addition to genetic background, infections, stress, drug reactions are suggested as risk factors. Helicobacter pylori which is involved in development of many gastrointestinal lesions may also be implicated in oral lichen planus induction. This is of clear importance for cancer prevention and the present study was performed to determine any association between H. pylori infection and oral lichen planus in southwestern Iran. Anti H. pylori IgG levels were determined in 41 patients and 82 sex-age matched controls. The results showed no association between H. pylori infection and oral lichen planus (51% in patients vs. 66% in control). or any of its clinical presentations.
    MeSH term(s) Adult ; Aged ; Case-Control Studies ; Female ; Helicobacter Infections/blood ; Helicobacter Infections/complications ; Helicobacter Infections/virology ; Helicobacter pylori/pathogenicity ; Humans ; Immunoglobulin G/blood ; Lichen Planus, Oral/blood ; Lichen Planus, Oral/etiology ; Lichen Planus, Oral/pathology ; Male ; Middle Aged ; Prognosis ; Risk Factors ; Young Adult
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2012-08-16
    Publishing country Thailand
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.7314/apjcp.2012.13.5.1745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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