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  1. Book: Oral cancer

    Fakhry, Carole / Pitman, Karen T. / Kiess, Ana P. / Eisele, David W.

    evaluation, therapy, and rehabilitation

    2020  

    Author's details Carole Fakhry,Karen T. Pitman, Ana P. Kiess, David W Eisele
    Keywords premalignant oral lesions ; squamous cell cancer ; oral cancer reconstruction ; salivary gland malignancies ; oral cancer surgery ; 807
    Subject code 610
    Language English
    Size xx, 441 Seiten, Illustrationen, 28 cm x 21.6 cm, 1633 g
    Edition 1. Auflage
    Publisher Thieme
    Publishing place New York
    Publishing country United States
    Document type Book
    Note Zugang zur Online-Ausgabe über Code
    HBZ-ID HT020588102
    ISBN 978-1-62623-968-5 ; 1-62623-968-1 ; 9781626239692 ; 162623969X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1308 available for loan (reading room) Lesesaal EG
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  2. Book: HPV and head and neck cancers

    Fakhry, Carole / D’Souza, Gypsyamber

    (Head and neck cancer clinics)

    2015  

    Author's details Carole Fakhry ; Gypsyamver D'Souza ed
    Series title Head and neck cancer clinics
    Keywords Oropharyngeal ; Squamous cell carcinoma ; Cancer screening ; Behavioral aspects
    Language English
    Size XXI, 127 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place New Dehli u.a.
    Publishing country India
    Document type Book
    HBZ-ID HT018711040
    ISBN 978-81-322-2412-9 ; 81-322-2412-4 ; 9788132224136 ; 8132224132
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 2653 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Plasma Circulating Tumor HPV DNA and HPV-Related Oropharynx Cancer-A Caution-Reply.

    D'Souza, Gypsyamber / Fakhry, Carole

    JAMA otolaryngology-- head & neck surgery

    2022  Volume 148, Issue 10, Page(s) 993–994

    MeSH term(s) Circulating Tumor DNA ; DNA, Viral ; Humans ; Oropharyngeal Neoplasms/pathology ; Oropharynx/pathology ; Papillomaviridae/genetics ; Papillomavirus Infections
    Chemical Substances Circulating Tumor DNA ; DNA, Viral
    Language English
    Publishing date 2022-08-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2022.2455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.87: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Novel Oral Cancer Survival Calculator-Do We Have a Crystal Ball?

    Mady, Leila J / Koch, Wayne M / Fakhry, Carole

    JAMA otolaryngology-- head & neck surgery

    2023  Volume 149, Issue 11, Page(s) 1000–1002

    MeSH term(s) Humans ; Mouth Neoplasms ; Risk Assessment
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2023.1976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.87: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The evolving landscape of oropharyngeal cancer: a window of opportunity for primary prevention.

    Windon, Melina J / D'Souza, Gypsyamber / Fakhry, Carole

    Journal of the National Cancer Institute

    2023  Volume 115, Issue 12, Page(s) 1454–1456

    MeSH term(s) Humans ; Incidence ; Oropharyngeal Neoplasms/epidemiology ; Oropharyngeal Neoplasms/prevention & control ; Papillomaviridae ; Primary Prevention
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djad171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Epidemiology of HPV Related Malignancies.

    Scott-Wittenborn, Nicholas / Fakhry, Carole

    Seminars in radiation oncology

    2021  Volume 31, Issue 4, Page(s) 286–296

    Abstract: Human papillomavirus is the most common sexually transmitted infection in the world and had been linked to both anogenital and oropharyngeal cancers. It causes nearly 100% of cervical cancers and an increasing portion of oropharyngeal cancers. The ... ...

    Abstract Human papillomavirus is the most common sexually transmitted infection in the world and had been linked to both anogenital and oropharyngeal cancers. It causes nearly 100% of cervical cancers and an increasing portion of oropharyngeal cancers. The geographical burden of cervical HPV infection and associated cancers is not uniform and is mainly found in low middle income countries in South America, Africa, and Asia. However, HPV-positive oropharyngeal cancer is rapidly becoming more prevalent in high middle income countries. With the development of vaccines which prevent HPV infection, the World Health Organization has designated the extirpation of HPV and its associated cancers a priority. Countries that have implemented adequate vaccine programs have shown a decrease in HPV prevalence. Understanding the epidemiology of HPV and its associated cancers is fundamental in improving vaccine programs and other health programs.
    MeSH term(s) Female ; Humans ; Oropharyngeal Neoplasms/epidemiology ; Oropharyngeal Neoplasms/prevention & control ; Papillomaviridae ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Prevalence ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/prevention & control
    Language English
    Publishing date 2021-08-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2021.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3654: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Radiomics Features in Predicting Human Papillomavirus Status in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review, Quality Appraisal, and Meta-Analysis.

    Ansari, Golnoosh / Mirza-Aghazadeh-Attari, Mohammad / Mosier, Kristine M / Fakhry, Carole / Yousem, David M

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 7

    Abstract: We sought to determine the diagnostic accuracy of radiomics features in predicting HPV status in oropharyngeal squamous cell carcinoma (SCC) compared to routine paraclinical measures used in clinical practice. Twenty-six articles were included in the ... ...

    Abstract We sought to determine the diagnostic accuracy of radiomics features in predicting HPV status in oropharyngeal squamous cell carcinoma (SCC) compared to routine paraclinical measures used in clinical practice. Twenty-six articles were included in the systematic review, and thirteen were used for the meta-analysis. The overall sensitivity of the included studies was 0.78, the overall specificity was 0.76, and the overall area under the ROC curve was 0.84. The diagnostic odds ratio (DOR) equaled 12 (8, 17). Subgroup analysis showed no significant difference between radiomics features extracted from CT or MR images. Overall, the studies were of low quality in regard to radiomics quality score, although most had a low risk of bias based on the QUADAS-2 tool. Radiomics features showed good overall sensitivity and specificity in determining HPV status in OPSCC, though the low quality of the included studies poses problems for generalizability.
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14070737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Is 2045 Optimistic?-Concerns Regarding Rising Vaccine Hesitancy-Reply.

    Zhang, Yuehan / Fakhry, Carole / D'Souza, Gypsyamber

    JAMA oncology

    2022  Volume 8, Issue 3, Page(s) 482–483

    MeSH term(s) Humans ; Vaccination Hesitancy
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.7166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Projected Association of Human Papillomavirus Vaccination With Oropharynx Cancer Incidence in the US, 2020-2045.

    Zhang, Yuehan / Fakhry, Carole / D'Souza, Gypsyamber

    JAMA oncology

    2021  Volume 7, Issue 10, Page(s) e212907

    Abstract: Importance: Oropharynx cancer (OPC) incidence has increased for several decades in the US. It is unclear when and how this trend will be affected by current HPV vaccination trends.: Objective: To assess the association of HPV vaccination with future ... ...

    Abstract Importance: Oropharynx cancer (OPC) incidence has increased for several decades in the US. It is unclear when and how this trend will be affected by current HPV vaccination trends.
    Objective: To assess the association of HPV vaccination with future OPC incidence in the US.
    Design, setting, and participants: This population-based age-period-cohort analysis obtained OPC incidence data from the Surveillance, Epidemiology, and End Results program from 69 562 patients 34 to 83 years of age diagnosed with OPC. The HPV vaccination data were obtained from the National Immunization Survey-Teen (60 124 participants) and National Health Interview Survey (16 904 participants). Data were collected from January 1, 1992, to December 31, 2017. Age-period-cohort forecasting models projected expected 2018 to 2045 OPC incidence under a counterfactual scenario of no HPV vaccination and current levels of HPV vaccination, stratifying by sex. Data analyses were completed by December 2020.
    Exposures: Age- and sex-specific cumulative prevalence of HPV vaccination in 2016 to 2017 projected forward.
    Main outcomes and measures: Projected OPC incidence and number of OPC cases expected to be prevented by HPV vaccination.
    Results: Under current HPV vaccination rates, between 2018 and 2045, OPC incidence is projected to decrease in younger individuals (36-45 years of age: from 1.4 to 0.8 per 100 000 population; 46-55 years of age: from 8.7 to 7.2 per 100 000 population) but continue to increase among older individuals (70-83 years of age: from 16.8 to 29.0 per 100 000 population). The association of HPV vaccination with overall OPC incidence through 2045 will remain modest (no vaccination vs vaccination: 14.3 vs 13.8 per 100 000 population in 2045). By 2045 HPV vaccination is projected to reduce OPC incidence among individuals 36 to 45 years of age (men: 48.1%; women: 42.5%) and 46 to 55 years of age (men: 9.0%; women: 22.6%), but among those 56 years or older, rates are not meaningfully reduced. Between 2018 and 2045, a total of 6334 OPC cases will be prevented by HPV vaccination, of which 88.8% of such cases occur in younger age (≤55 years) groups.
    Conclusions and relevance: According to the projections of this population-based age-period-cohort study, current HPV vaccination rates will have a limited association with overall OPC incidence through 2045 because older individuals who have not yet been vaccinated remain at high risk for OPC. However, reductions in OPC incidence should occur among young and middle-aged adults, the group at lowest risk of diagnosis. These findings forecast a continued shift in the landscape of OPC to an older population.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Alphapapillomavirus ; Cohort Studies ; Female ; Humans ; Immunization ; Incidence ; Male ; Middle Aged ; Oropharyngeal Neoplasms/epidemiology ; Oropharyngeal Neoplasms/prevention & control ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Papillomavirus Vaccines ; Vaccination
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2021.2907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Clinical and genomic characterization of chemoradiation-resistant HPV-positive oropharyngeal squamous cell carcinoma.

    Guo, Theresa / Zamuner, Fernando / Ting, Stephanie / Chen, Liam / Rooper, Lisa / Tamayo, Pablo / Fakhry, Carole / Gaykalova, Daria / Mehra, Ranee

    Frontiers in oncology

    2024  Volume 14, Page(s) 1336577

    Abstract: Introduction: Most patients with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) have an excellent response to chemoradiation, and trials are now investigating de-escalated treatment. However, up to 25% of patients with HPV-positive OPSCC ... ...

    Abstract Introduction: Most patients with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) have an excellent response to chemoradiation, and trials are now investigating de-escalated treatment. However, up to 25% of patients with HPV-positive OPSCC will experience recurrence, and up to 5% will even progress through primary treatment. Currently, there are no molecular markers to identify patients with poor prognosis who would be harmed by de-escalation. Herein we report the clinical and genomic characteristics of persistent HPV-positive OPSCC after definitive platinum-based chemoradiation therapy.
    Methods: Patients with HPV-positive OPSCC treated with curative intent platinum-based chemoradiation between 2007 and 2017 at two institutions and with a persistent locoregional disease were included. We evaluated clinical characteristics, including smoking status, age, stage, treatment, and overall survival. A subset of five patients had tissue available for targeted exome DNA sequencing and RNA sequencing. Genomic analysis was compared to a previously published cohort of 47 treatment-responsive HPV+ OPSCC tumors after batch correction. Mutational landscape, pathway activation, and OncoGPS tumor states were employed to characterize these tumors.
    Results: Ten patients met the inclusion criteria. The tumor and nodal stages ranged from T1 to T4 and N1 to N2 by AJCC 8th edition staging. All patients were p16-positive by immunohistochemistry, and eight with available
    Conclusion: Chemoradiation-resistant HPV-positive OPSCC occurs infrequently but portends a poor prognosis. These tumors demonstrate higher rates of p53 mutation and activation of MYC, SRC, and TGF-beta pathways. A comparison of tumors before and after treatment demonstrates PI3K-EMT-Stem pathways post-treatment in HPV-positive tumors with persistent disease after platinum-based chemoradiation.
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1336577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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