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  1. Article ; Online: Biomarkers and Corresponding Biosensors for Childhood Cancer Diagnostics.

    Gharehzadehshirazi, Azadeh / Zarejousheghani, Mashaalah / Falahi, Sedigheh / Joseph, Yvonne / Rahimi, Parvaneh

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 3

    Abstract: Although tremendous progress has been made in treating childhood cancer, it is still one of the leading causes of death in children worldwide. Because cancer symptoms overlap with those of other diseases, it is difficult to predict a tumor early enough, ... ...

    Abstract Although tremendous progress has been made in treating childhood cancer, it is still one of the leading causes of death in children worldwide. Because cancer symptoms overlap with those of other diseases, it is difficult to predict a tumor early enough, which causes cancers in children to be more aggressive and progress more rapidly than in adults. Therefore, early and accurate detection methods are urgently needed to effectively treat children with cancer therapy. Identification and detection of cancer biomarkers serve as non-invasive tools for early cancer screening, prevention, and treatment. Biosensors have emerged as a potential technology for rapid, sensitive, and cost-effective biomarker detection and monitoring. In this review, we provide an overview of important biomarkers for several common childhood cancers. Accordingly, we have enumerated the developed biosensors for early detection of pediatric cancer or related biomarkers. This review offers a restructured platform for ongoing research in pediatric cancer diagnostics that can contribute to the development of rapid biosensing techniques for early-stage diagnosis, monitoring, and treatment of children with cancer and reduce the mortality rate.
    MeSH term(s) Humans ; Child ; Neoplasms/diagnosis ; Biomarkers ; Biosensing Techniques/methods ; Biomarkers, Tumor ; Early Detection of Cancer/methods
    Chemical Substances Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23031482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Electrochemical Sensing of Gallic Acid in Beverages Using a 3D Bio-Nanocomposite Based on Carbon Nanotubes/Spongin-Atacamite.

    Falahi, Sedigheh / Falahi, Sepideh / Zarejousheghani, Mashaalah / Ehrlich, Hermann / Joseph, Yvonne / Rahimi, Parvaneh

    Biosensors

    2023  Volume 13, Issue 2

    Abstract: Gallic acid (GA) is one of the most important polyphenols, being widely used in the food, cosmetic, and pharmaceutical industries due to its biological effects such as antioxidant, antibacterial, anticancer, antiviral, anti-inflammatory, and ... ...

    Abstract Gallic acid (GA) is one of the most important polyphenols, being widely used in the food, cosmetic, and pharmaceutical industries due to its biological effects such as antioxidant, antibacterial, anticancer, antiviral, anti-inflammatory, and cardioprotective properties. Hence, simple, fast, and sensitive determination of GA is of particular importance. Considering the fact that GA is an electroactive compound, electrochemical sensors offer great potential for GA quantitation due to their fast response time, high sensitivity, and ease of use. A simple, fast, and sensitive GA sensor was fabricated on the basis of a high-performance bio-nanocomposite using spongin as a natural 3D polymer, atacamite, and multi-walled carbon nanotubes (MWCNTs). The developed sensor showed an excellent response toward GA oxidation with remarkable electrochemical features due to the synergistic effects of 3D porous spongin and MWCNTs, which provide a large surface area and enhance the electrocatalytic activity of atacamite. At optimal conditions by differential pulse voltammetry (DPV), a good linear relationship was obtained between peak currents and GA concentrations in a wild linear range of 500 nM to 1 mM. Subsequently, the proposed sensor was used to detect GA in red wine as well as in green and black tea, confirming its great potential as a reliable alternative to conventional methods for GA determination.
    MeSH term(s) Gallic Acid/analysis ; Nanotubes, Carbon/chemistry ; Electrochemical Techniques/methods ; Beverages ; Nanocomposites/chemistry ; Electrodes ; Limit of Detection
    Chemical Substances Gallic Acid (632XD903SP) ; Nanotubes, Carbon ; atacamite ; spongin
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13020262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High-Performance Three-Dimensional Spongin-Atacamite Biocomposite for Electrochemical Nonenzymatic Glucose Sensing.

    Falahi, Sedigheh / Jaafar, Alaa / Petrenko, Iaroslav / Zarejousheghani, Mashaalah / Ehrlich, Hermann / Rahimi, Parvaneh / Joseph, Yvonne

    ACS applied bio materials

    2022  Volume 5, Issue 2, Page(s) 873–880

    Abstract: The design of sensitive and cost-effective biocomposite materials with high catalytic activity for the effective electrooxidation of glucose plays a key role in developing enzyme-free glucose sensors. The porous three-dimensional (3D) spongin scaffold of ...

    Abstract The design of sensitive and cost-effective biocomposite materials with high catalytic activity for the effective electrooxidation of glucose plays a key role in developing enzyme-free glucose sensors. The porous three-dimensional (3D) spongin scaffold of marine sponge origin provides an excellent template for the growth of atacamite crystals and improves the activity of atacamite as a catalyst. By using the design of experiment method, the influence of different parameters on the electrode efficiency was optimized. The optimized sensor based on spongin-atacamite showed distinguished performance toward glucose with two linear ranges of 0.4-200 μM and 0.2-10 mM and high sensitivities of 3908.4 and 600.5 μA mM
    MeSH term(s) Chlorides ; Copper/chemistry ; Electrochemical Techniques/methods ; Glucose ; Reproducibility of Results
    Chemical Substances Chlorides ; atacamite ; Copper (789U1901C5) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.1c01248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Non-Coding RNA-Based Biosensors for Early Detection of Liver Cancer.

    Falahi, Sedigheh / Rafiee-Pour, Hossain-Ali / Zarejousheghani, Mashaalah / Rahimi, Parvaneh / Joseph, Yvonne

    Biomedicines

    2021  Volume 9, Issue 8

    Abstract: Primary liver cancer is an aggressive, lethal malignancy that ranks as the fourth leading cause of cancer-related death worldwide. Its 5-year mortality rate is estimated to be more than 95%. This significant low survival rate is due to poor diagnosis, ... ...

    Abstract Primary liver cancer is an aggressive, lethal malignancy that ranks as the fourth leading cause of cancer-related death worldwide. Its 5-year mortality rate is estimated to be more than 95%. This significant low survival rate is due to poor diagnosis, which can be referred to as the lack of sufficient and early-stage detection methods. Many liver cancer-associated non-coding RNAs (ncRNAs) have been extensively examined to serve as promising biomarkers for precise diagnostics, prognostics, and the evaluation of the therapeutic progress. For the simple, rapid, and selective ncRNA detection, various nanomaterial-enhanced biosensors have been developed based on electrochemical, optical, and electromechanical detection methods. This review presents ncRNAs as the potential biomarkers for the early-stage diagnosis of liver cancer. Moreover, a comprehensive overview of recent developments in nanobiosensors for liver cancer-related ncRNA detection is provided.
    Language English
    Publishing date 2021-08-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9080964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Creation of a 3D Goethite-Spongin Composite Using an Extreme Biomimetics Approach.

    Kubiak, Anita / Voronkina, Alona / Pajewska-Szmyt, Martyna / Kotula, Martyna / Leśniewski, Bartosz / Ereskovsky, Alexander / Heimler, Korbinian / Rogoll, Anika / Vogt, Carla / Rahimi, Parvaneh / Falahi, Sedigheh / Galli, Roberta / Langer, Enrico / Förste, Maik / Charitos, Alexandros / Joseph, Yvonne / Ehrlich, Hermann / Jesionowski, Teofil

    Biomimetics (Basel, Switzerland)

    2023  Volume 8, Issue 7

    Abstract: The structural biopolymer spongin in the form of a 3D scaffold resembles in shape and size numerous species of industrially useful marine keratosan demosponges. Due to the large-scale aquaculture of these sponges worldwide, it represents a unique ... ...

    Abstract The structural biopolymer spongin in the form of a 3D scaffold resembles in shape and size numerous species of industrially useful marine keratosan demosponges. Due to the large-scale aquaculture of these sponges worldwide, it represents a unique renewable source of biological material, which has already been successfully applied in biomedicine and bioinspired materials science. In the present study, spongin from the demosponge
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics8070533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Spongin as a Unique 3D Template for the Development of Functional Iron-Based Composites Using Biomimetic Approach In Vitro.

    Kubiak, Anita / Pajewska-Szmyt, Martyna / Kotula, Martyna / Leśniewski, Bartosz / Voronkina, Alona / Rahimi, Parvaneh / Falahi, Sedigheh / Heimler, Korbinian / Rogoll, Anika / Vogt, Carla / Ereskovsky, Alexander / Simon, Paul / Langer, Enrico / Springer, Armin / Förste, Maik / Charitos, Alexandros / Joseph, Yvonne / Jesionowski, Teofil / Ehrlich, Hermann

    Marine drugs

    2023  Volume 21, Issue 9

    Abstract: Marine sponges of the subclass Keratosa originated on our planet about 900 million years ago and represent evolutionarily ancient and hierarchically structured biological materials. One of them, proteinaceous spongin, is responsible for the formation of ... ...

    Abstract Marine sponges of the subclass Keratosa originated on our planet about 900 million years ago and represent evolutionarily ancient and hierarchically structured biological materials. One of them, proteinaceous spongin, is responsible for the formation of 3D structured fibrous skeletons and remains enigmatic with complex chemistry. The objective of this study was to investigate the interaction of spongin with iron ions in a marine environment due to biocorrosion, leading to the occurrence of lepidocrocite. For this purpose, a biomimetic approach for the development of a new lepidocrocite-containing 3D spongin scaffold under laboratory conditions at 24 °C using artificial seawater and iron is described for the first time. This method helps to obtain a new composite as "Iron-Spongin", which was characterized by infrared spectroscopy and thermogravimetry. Furthermore, sophisticated techniques such as X-ray fluorescence, microscope technique, and X-Ray diffraction were used to determine the structure. This research proposed a corresponding mechanism of lepidocrocite formation, which may be connected with the spongin amino acids functional groups. Moreover, the potential application of the biocomposite as an electrochemical dopamine sensor is proposed. The conducted research not only shows the mechanism or sensor properties of "Iron-spongin" but also opens the door to other applications of these multifunctional materials.
    MeSH term(s) Animals ; Iron ; Biomimetics ; Dopamine ; Porifera
    Chemical Substances Iron (E1UOL152H7) ; ferric oxide (1K09F3G675) ; spongin ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-08-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21090460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Extreme Biomimetics: Designing of the First Nanostructured 3D Spongin-Atacamite Composite and its Application.

    Tsurkan, Dmitry / Simon, Paul / Schimpf, Christian / Motylenko, Mykhaylo / Rafaja, David / Roth, Friedrich / Inosov, Dmytro S / Makarova, Anna A / Stepniak, Izabela / Petrenko, Iaroslav / Springer, Armin / Langer, Enrico / Kulbakov, Anton A / Avdeev, Maxim / Stefankiewicz, Artur R / Heimler, Korbinian / Kononchuk, Olga / Hippmann, Sebastian / Kaiser, Doreen /
    Viehweger, Christine / Rogoll, Anika / Voronkina, Alona / Kovalchuk, Valentine / Bazhenov, Vasilii V / Galli, Roberta / Rahimi-Nasrabadi, Mehdi / Molodtsov, Serguei L / Rahimi, Parvaneh / Falahi, Sedigheh / Joseph, Yvonne / Vogt, Carla / Vyalikh, Denis V / Bertau, Martin / Ehrlich, Hermann

    Advanced materials (Deerfield Beach, Fla.)

    2021  Volume 33, Issue 30, Page(s) e2101682

    Abstract: The design of new composite materials using extreme biomimetics is of crucial importance for bioinspired materials science. Further progress in research and application of these new materials is impossible without understanding the mechanisms of ... ...

    Abstract The design of new composite materials using extreme biomimetics is of crucial importance for bioinspired materials science. Further progress in research and application of these new materials is impossible without understanding the mechanisms of formation, as well as structural features at the molecular and nano-level. It presents a challenge to obtain a holistic understanding of the mechanisms underlying the interaction of organic and inorganic phases under conditions of harsh chemical reactions for biopolymers. Yet, an understanding of these mechanisms can lead to the development of unusual-but functional-hybrid materials. In this work, a key way of designing centimeter-scale macroporous 3D composites, using renewable marine biopolymer spongin and a model industrial solution that simulates the highly toxic copper-containing waste generated in the production of printed circuit boards worldwide, is proposed. A new spongin-atacamite composite material is developed and its structure is confirmed using neutron diffraction, X-ray diffraction, high-resolution transmission electron microscopy/selected-area electron diffraction, X-ray photoelectron spectroscopy, near-edge X-ray absorption fine structure spectroscopy, and electron paramagnetic resonance spectroscopy. The formation mechanism for this material is also proposed. This study provides experimental evidence suggesting multifunctional applicability of the designed composite in the development of 3D constructed sensors, catalysts, and antibacterial filter systems.
    MeSH term(s) Ammonia/chemistry ; Biomimetic Materials/chemistry ; Biopolymers/chemistry ; Catalysis ; Chlorides/chemistry ; Copper/chemistry ; Humans ; Molecular Conformation ; Nanocomposites/chemistry ; Oxidation-Reduction ; Porosity ; Printing, Three-Dimensional ; Structure-Activity Relationship ; Water Pollution, Chemical/prevention & control
    Chemical Substances Biopolymers ; Chlorides ; atacamite ; spongin ; Ammonia (7664-41-7) ; Copper (789U1901C5)
    Language English
    Publishing date 2021-06-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202101682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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