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  1. Book ; Online: Electrospun Nanomaterials : Applications in Food, Environmental Remediation, and Bioengineering

    Mallavia, Ricardo / Falco, Alberto

    2020  

    Keywords Technology: general issues ; electrospinning ; curcumin ; PLA/PEG/curcumin nanofiber ; drug release ; porous nanofiber ; polycaprolactone ; nanofibers ; COOH plasma ; cell adhesion and spreading ; cell viability ; freeze-thawed platelet-rich plasma immobilization ; piezoelectricity ; scaffold ; polyvinylidene fluoride ; polyvinylidene fluoride-trifluoroethylene ; tissue engineering ; osteoblast ; neuron ; stem cell ; aligned fiber ; HDPAF ; micro-nanofibers ; β-carotene ; thermoprotection ; photoprotection ; antibacterial effect ; centella ; propolis ; hinokitiol ; biodegradable polymer ; PHBH ; nanofiber ; food packaging ; functional membrane ; biomaterials ; polymers ; PMVE/MA ; nanoparticles ; nanoencapsulation ; antibiotics ; electrospun nanofibers ; polyethylene oxide nanofibers PEO-NFs ; microbial fuel cells ; honey ; food industry ; recovered energy (Erec) ; chitosan ; chitin nanofibrils ; hemostatic material ; hemorrhage ; photoactive nanoparticles ; cadmium selenide ; cellulose acetate ; electrospun fibers ; solar thermal ; n/a
    Size 1 electronic resource (202 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046566
    ISBN 9783039432271 ; 3039432273
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents.

    Díaz-Puertas, Rocío / Adamek, Mikolaj / Mallavia, Ricardo / Falco, Alberto

    Marine drugs

    2023  Volume 21, Issue 6

    Abstract: The slow discovery of new antibiotics combined with the alarming emergence of antibiotic-resistant bacteria underscores the need for alternative treatments. In this regard, fish skin mucus has been demonstrated to contain a diverse array of bioactive ... ...

    Abstract The slow discovery of new antibiotics combined with the alarming emergence of antibiotic-resistant bacteria underscores the need for alternative treatments. In this regard, fish skin mucus has been demonstrated to contain a diverse array of bioactive molecules with antimicrobial properties, including peptides, proteins, and other metabolites. This review aims to provide an overview of the antimicrobial molecules found in fish skin mucus and its reported in vitro antimicrobial capacity against bacteria, fungi, and viruses. Additionally, the different methods of mucus extraction, which can be grouped as aqueous, organic, and acidic extractions, are presented. Finally, omic techniques (genomics, transcriptomics, proteomics, metabolomics, and multiomics) are described as key tools for the identification and isolation of new antimicrobial compounds. Overall, this study provides valuable insight into the potential of fish skin mucus as a promising source for the discovery of new antimicrobial agents.
    MeSH term(s) Animals ; Skin/metabolism ; Anti-Infective Agents/metabolism ; Anti-Bacterial Agents/chemistry ; Mucus/chemistry ; Bacteria ; Plant Extracts/analysis
    Chemical Substances Anti-Infective Agents ; Anti-Bacterial Agents ; Plant Extracts
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21060350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Electrospun Nanomaterials: Applications in Food, Environmental Remediation, and Bioengineering.

    Falco, Alberto / Mallavia, Ricardo

    Nanomaterials (Basel, Switzerland)

    2020  Volume 10, Issue 9

    Abstract: Among the large number of methods to fabricate nanofibers[…] . ...

    Abstract Among the large number of methods to fabricate nanofibers[…] .
    Language English
    Publishing date 2020-08-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano10091714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Phytochemical-Based Nanomaterials against Antibiotic-Resistant Bacteria: An Updated Review.

    Díaz-Puertas, Rocío / Álvarez-Martínez, Francisco Javier / Falco, Alberto / Barrajón-Catalán, Enrique / Mallavia, Ricardo

    Polymers

    2023  Volume 15, Issue 6

    Abstract: Antibiotic-resistant bacteria (ARB) is a growing global health threat, leading to the search for alternative strategies to combat bacterial infections. Phytochemicals, which are naturally occurring compounds found in plants, have shown potential as ... ...

    Abstract Antibiotic-resistant bacteria (ARB) is a growing global health threat, leading to the search for alternative strategies to combat bacterial infections. Phytochemicals, which are naturally occurring compounds found in plants, have shown potential as antimicrobial agents; however, therapy with these agents has certain limitations. The use of nanotechnology combined with antibacterial phytochemicals could help achieve greater antibacterial capacity against ARB by providing improved mechanical, physicochemical, biopharmaceutical, bioavailability, morphological or release properties. This review aims to provide an updated overview of the current state of research on the use of phytochemical-based nanomaterials for the treatment against ARB, with a special focus on polymeric nanofibers and nanoparticles. The review discusses the various types of phytochemicals that have been incorporated into different nanomaterials, the methods used to synthesize these materials, and the results of studies evaluating their antimicrobial activity. The challenges and limitations of using phytochemical-based nanomaterials, as well as future directions for research in this field, are also considered here. Overall, this review highlights the potential of phytochemical-based nanomaterials as a promising strategy for the treatment against ARB, but also stresses the need for further studies to fully understand their mechanisms of action and optimize their use in clinical settings.
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15061392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Viricidal Activity of Thermoplastic Polyurethane Materials with Silver Nanoparticles.

    Díaz-Puertas, Rocío / Rodríguez-Cañas, Enrique / Bello-Perez, Melissa / Fernández-Oliver, Marta / Mallavia, Ricardo / Falco, Alberto

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 9

    Abstract: The use of diverse Ag-based nanoparticulated forms has shown promising results in controlling viral propagation. In this study, a commercial nanomaterial consisting of ceramic-coated silver nanoparticles (AgNPs) was incorporated into thermoplastic ... ...

    Abstract The use of diverse Ag-based nanoparticulated forms has shown promising results in controlling viral propagation. In this study, a commercial nanomaterial consisting of ceramic-coated silver nanoparticles (AgNPs) was incorporated into thermoplastic polyurethane (TPU) plates using an industrial protocol, and the surface composition, ion-release dynamics and viricidal properties were studied. The surface characterization by FESEM-EDX revealed that the molar composition of the ceramic material was 5.5 P:3.3 Mg:Al and facilitated the identification of the embedded AgNPs (54.4 ± 24.9 nm). As determined by ICPMS, the release rates from the AgNP-TPU into aqueous solvents were 4 ppm/h for Ag and Al, and 28.4 ppm/h for Mg ions. Regarding the biological assays, the AgNP-TPU material did not induce significant cytotoxicity in the cell lines employed. Its viricidal activity was characterized, based on ISO 21702:2019, using the Spring viraemia of carp virus (SVCV), and then tested against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The results demonstrated that AgNP-TPU materials exhibited significant (75%) and direct antiviral activity against SVCV virions in a time- and temperature-dependent manner. Similar inhibition levels were found against SARS-CoV-2. These findings show the potential of AgNP-TPU-based materials as a supporting strategy to control viral spread.
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13091467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases

    Falco, Alberto / Adamek, Mikolaj / Pereiro, Patricia / Hoole, David / Encinar, José Antonio / Novoa, Beatriz / Mallavia, Ricardo

    Marine drugs. 2022 May 28, v. 20, no. 6

    2022  

    Abstract: The high proliferation of microorganisms in aquatic environments has allowed their coevolution for billions of years with other living beings that also inhabit these niches. Among the different existing types of interaction, the eternal competition for ... ...

    Abstract The high proliferation of microorganisms in aquatic environments has allowed their coevolution for billions of years with other living beings that also inhabit these niches. Among the different existing types of interaction, the eternal competition for supremacy between the susceptible species and their pathogens has selected, as part of the effector division of the immune system of the former ones, a vast and varied arsenal of efficient antimicrobial molecules, which is highly amplified by the broad biodiversity radiated, above any others, at the marine habitats. At present, the great recent scientific and technological advances already allow the massive discovery and exploitation of these defense compounds for therapeutic purposes against infectious diseases of our interest. Among them, antimicrobial peptides and antimicrobial metabolites stand out because of the wide dimensions of their structural diversities, mechanisms of action, and target pathogen ranges. This revision work contextualizes the research in this field and serves as a presentation and scope identification of the Special Issue from Marine Drugs journal “The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases”.
    Keywords antimicrobial peptides ; biodiversity ; coevolution ; immune system ; metabolites ; pathogens ; therapeutics
    Language English
    Dates of publication 2022-0528
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2175190-0
    ISSN 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md20060363
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Modulation of the Tissue Expression Pattern of Zebrafish CRP-Like Molecules Suggests a Relevant Antiviral Role in Fish Skin

    Bello-Perez, Melissa / Adamek, Mikolaj / Coll, Julio / Figueras, Antonio / Novoa, Beatriz / Falco, Alberto

    Biology. 2021 Jan. 22, v. 10, no. 2

    2021  

    Abstract: Recent studies suggest that short pentraxins in fish might serve as biomarkers for not only bacterial infections, as in higher vertebrates including humans, but also for viral ones. These fish orthologs of mammalian short pentraxins are currently ... ...

    Abstract Recent studies suggest that short pentraxins in fish might serve as biomarkers for not only bacterial infections, as in higher vertebrates including humans, but also for viral ones. These fish orthologs of mammalian short pentraxins are currently attracting interest because of their newly discovered antiviral activity. In the present work, the modulation of the gene expression of all zebrafish short pentraxins (CRP-like proteins, CRP1-7) was extensively analyzed by quantitative polymerase chain reaction. Initially, the tissue distribution of crp1-7 transcripts and how the transcripts varied in response to a bath infection with the spring viremia of carp virus, were determined. The expression of crp1-7 was widely distributed and generally increased after infection (mostly at 5 days post infection), except for crp1 (downregulated). Interestingly, several crp transcription levels significantly increased in skin. Further assays in mutant zebrafish of recombinant activation gene 1 (rag1) showed that all crps (except for crp2, downregulated) were already constitutively highly expressed in skin from rag1 knockouts and only increased moderately after viral infection. Similar results were obtained for most mx isoforms (a reporter gene of the interferon response), suggesting a general overcompensation of the innate immunity in the absence of the adaptive one.
    Keywords Carp sprivivirus ; Danio rerio ; antiviral properties ; biomarkers ; fish ; fish skin ; gene expression ; innate immunity ; interferons ; mutants ; quantitative polymerase chain reaction ; reporter genes ; tissue distribution
    Language English
    Dates of publication 2021-0122
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10020078
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: An N-terminal half fragment of the histidine phosphocarrier protein, HPr, is disordered but binds to HPr partners and shows antibacterial properties

    Neira, José L. / Palomino-Schätzlein, Martina / Hurtado-Gómez, Estefanía / Ortore, María G. / Falcó, Alberto

    Biochimica et biophysica acta. 2021 Dec., v. 1865, no. 12

    2021  

    Abstract: The phosphotransferase system (PTS) modulates the preferential use of sugars in bacteria. It is formed by a protein cascade in which the first two proteins are general (namely enzyme I, EI, and the histidine phosphocarrier protein, HPr) and the others ... ...

    Abstract The phosphotransferase system (PTS) modulates the preferential use of sugars in bacteria. It is formed by a protein cascade in which the first two proteins are general (namely enzyme I, EI, and the histidine phosphocarrier protein, HPr) and the others are sugar-specific permeases; the active site of HPr is His15. The HPr kinase/phosphorylase (HPrK/P), involved in the use of carbon sources in Gram-positive, phopshorylates HPr at a serine. The regulator of sigma D protein (Rsd) also binds to HPr. We are designing specific fragments of HPr, which can be used to interfere with those protein-protein interactions (PPIs), where the intact HPr intervenes.We obtained a fragment (HPr48) comprising the first forty-eight residues of HPr. HPr48 was disordered as shown by fluorescence, far-ultraviolet (UV) circular dichroism (CD), small angle X-ray scattering (SAXS) and nuclear magnetic resonance (NMR).Secondary structure propensities, from the assigned backbone nuclei, further support the unfolded nature of the fragment. However, HPr48 was capable of binding to: (i) the N-terminal region of EI, EIN; (ii) the intact Rsd; and, (iii) HPrK/P, as shown by fluorescence, far-UV CD, NMR and biolayer interferometry (BLI). The association constants for each protein, as measured by fluorescence and BLI, were in the order of the low micromolar range, similar to those measured between the intact HPr and each of the other macromolecules.Although HPr48 is forty-eight-residue long, it assisted antibiotics to exert antimicrobial activity.HPr48 could be used as a lead compound in the development of new antibiotics, or, alternatively, to improve the efficiency of existing ones.
    Keywords active sites ; carbon ; circular dichroism spectroscopy ; fluorescence ; histidine ; interferometry ; nuclear magnetic resonance spectroscopy ; phosphorylase ; serine ; small-angle X-ray scattering ; ultraviolet radiation
    Language English
    Dates of publication 2021-12
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 840755-1
    ISSN 0304-4165
    ISSN 0304-4165
    DOI 10.1016/j.bbagen.2021.130015
    Database NAL-Catalogue (AGRICOLA)

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Update on the Inactivation Procedures for the Vaccine Development Prospects of a New Highly Virulent RGNNV Isolate.

    Falco, Alberto / Bello-Perez, Melissa / Díaz-Puertas, Rocío / Mold, Matthew / Adamek, Mikolaj

    Vaccines

    2021  Volume 9, Issue 12

    Abstract: Viral nervous necrosis (VNN) caused by the nervous necrosis virus (NNV) affects a broad range of primarily marine fish species, with mass mortality rates often seen among larvae and juveniles. Its genetic diversification may hinder the effective ... ...

    Abstract Viral nervous necrosis (VNN) caused by the nervous necrosis virus (NNV) affects a broad range of primarily marine fish species, with mass mortality rates often seen among larvae and juveniles. Its genetic diversification may hinder the effective implementation of preventive measures such as vaccines. The present study describes different inactivation procedures for developing an inactivated vaccine against a new NNV isolate confirmed to possess deadly effects upon the European seabass (
    Language English
    Publishing date 2021-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9121441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Modulation of the Tissue Expression Pattern of Zebrafish CRP-Like Molecules Suggests a Relevant Antiviral Role in Fish Skin.

    Bello-Perez, Melissa / Adamek, Mikolaj / Coll, Julio / Figueras, Antonio / Novoa, Beatriz / Falco, Alberto

    Biology

    2021  Volume 10, Issue 2

    Abstract: Recent studies suggest that short pentraxins in fish might serve as biomarkers for not only bacterial infections, as in higher vertebrates including humans, but also for viral ones. These fish orthologs of mammalian short pentraxins are currently ... ...

    Abstract Recent studies suggest that short pentraxins in fish might serve as biomarkers for not only bacterial infections, as in higher vertebrates including humans, but also for viral ones. These fish orthologs of mammalian short pentraxins are currently attracting interest because of their newly discovered antiviral activity. In the present work, the modulation of the gene expression of all zebrafish short pentraxins (CRP-like proteins, CRP1-7) was extensively analyzed by quantitative polymerase chain reaction. Initially, the tissue distribution of
    Language English
    Publishing date 2021-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10020078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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