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  1. Article ; Online: COVID19: potential cardiovascular issues in pediatric patients.

    Bertoncelli, Deborah / Guidarini, Marta / Della Greca, Anna / Ratti, Chiara / Falcinella, Francesca / Iovane, Brunella / Dutto, Mauro Luigi / Caffarelli, Carlo / Tchana, Bertrand

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 2, Page(s) 177–183

    Abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) has rapidly spread worldwide with increasing hospitalization and mortality rate. Ongoing studies and accumulated data are de- tailing the features and the effects of the new ... ...

    Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) has rapidly spread worldwide with increasing hospitalization and mortality rate. Ongoing studies and accumulated data are de- tailing the features and the effects of the new coronavirus disease 19 (COVID 19) in the adult population, and cardiovascular involvement is emerging as the most significant and life-threatening complication, with an in- creased risk of morbidity and mortality in patients with underlying cardiovascular disease. At present, though the limited data on the effects of COVID 19 in pediatric patients, children seem to count for a little proportion of SARS-COV 2 infection, and present with less severe disease and effects However infants and toddlers are at risk of developing critical course. The disease has a range of clinical presentations in children, for which the potential need for further investigation of myocardial injury and cardiovascular issues should be kept in mind to avoid misdiagnosing severe clinical entities. Overlapping with Kawasaki disease is a concern, particularly the incomplete and atypical form. We aim to summarize the initial considerations and potential cardiovascular implications of COVID-19 for children and patients with congenital heart disease.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Cardiovascular Diseases/virology ; Child ; Coronavirus Infections/diagnosis ; Diagnostic Errors ; Humans ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i2.9655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: COVID19: potential cardiovascular issues in pediatric patients

    Bertoncelli, Deborah / Guidarini, Marta / Della Greca, Anna / Ratti, Chiara / Falcinella, Francesca / Iovane, Brunella / Dutto, Mauro Luigi / Caffarelli, Carlo / Tchana, Bertrand

    Acta Biomed

    Abstract: The novel severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) has rapidly spread worldwide with increasing hospitalization and mortality rate. Ongoing studies and accumulated data are de- tailing the features and the effects of the new ... ...

    Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) has rapidly spread worldwide with increasing hospitalization and mortality rate. Ongoing studies and accumulated data are de- tailing the features and the effects of the new coronavirus disease 19 (COVID 19) in the adult population, and cardiovascular involvement is emerging as the most significant and life-threatening complication, with an in- creased risk of morbidity and mortality in patients with underlying cardiovascular disease. At present, though the limited data on the effects of COVID 19 in pediatric patients, children seem to count for a little proportion of SARS-COV 2 infection, and present with less severe disease and effects However infants and toddlers are at risk of developing critical course. The disease has a range of clinical presentations in children, for which the potential need for further investigation of myocardial injury and cardiovascular issues should be kept in mind to avoid misdiagnosing severe clinical entities. Overlapping with Kawasaki disease is a concern, particularly the incomplete and atypical form. We aim to summarize the initial considerations and potential cardiovascular implications of COVID-19 for children and patients with congenital heart disease.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #315970
    Database COVID19

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  3. Article ; Online: Comparison of Outcomes of Staged Complete Revascularization Versus Culprit Lesion-Only Revascularization for ST-Elevation Myocardial Infarction and Multivessel Coronary Artery Disease.

    Marino, Marcello / Crimi, Gabriele / Leonardi, Sergio / Ferlini, Marco / Repetto, Alessandra / Camporotondo, Rita / Demarchi, Andrea / De Pascali, Ilaria / Falcinella, Francesca / Oltrona Visconti, Luigi / De Servi, Stefano / Ferrario, Maurizio / De Ferrari, Gaetano Maria / Gnecchi, Massimiliano

    The American journal of cardiology

    2017  Volume 119, Issue 4, Page(s) 508–514

    Abstract: The management of noninfarct-related arteries in patients with ST-elevation myocardial infarction (STEMI) and multivessel coronary disease (MVD) is still debated. We evaluated the prognostic impact of staged complete revascularization with percutaneous ... ...

    Abstract The management of noninfarct-related arteries in patients with ST-elevation myocardial infarction (STEMI) and multivessel coronary disease (MVD) is still debated. We evaluated the prognostic impact of staged complete revascularization with percutaneous coronary intervention (PCI) in STEMI patients with MVD admitted to our hospital from 2005 to 2013. Patients undergoing staged complete revascularization (n = 300) were compared with 1:1 propensity score-matched patients with culprit lesion-only treatment (n = 300). We considered a composite primary end point of all-cause death, myocardial infarction, and urgent PCI. Secondary end points included components of the primary, cardiovascular death, any PCI excluding staged PCI. We also performed an analysis including only patients surviving at least 5 days. The median follow-up was 553 days. The primary end point occurred in 10.3% of patients in the staged complete revascularization group and in 16.3% of patients in the culprit lesion-only group (hazard ratio 0.61, 95% CI 0.38 to 0.95, p = 0.031). Although this difference was no longer significant when considering only the survivors at day 5, all-cause and cardiovascular mortalities were still reduced in the staged complete revascularization group. Complete revascularization was associated with a better outcome (hazard ratio 0.35, 95% CI 0.17 to 0.63, p = 0.005) if performed within 30 days of STEMI. In conclusion, compared with culprit lesion-only revascularization, in STEMI patients with MVD undergoing primary PCI, an approach of staged complete revascularization was associated with a better outcome.
    MeSH term(s) Aged ; Cause of Death ; Coronary Artery Disease/surgery ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Mortality ; Percutaneous Coronary Intervention/methods ; Propensity Score ; Proportional Hazards Models ; Retrospective Studies ; ST Elevation Myocardial Infarction/surgery
    Language English
    Publishing date 2017-02-15
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2016.10.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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