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  1. Article ; Online: Comment on "Patients' perspectives on informational needs surrounding gender affirming vaginoplasty".

    Falcone, Marco / Cirigliano, Lorenzo

    International journal of impotence research

    2024  

    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-024-00841-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2910: Show issues Location:
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  2. Article ; Online: Education:

    Falcone, Marco

    JAC-antimicrobial resistance

    2021  Volume 3, Issue Suppl 1, Page(s) i25

    Abstract: This video is a presentation from Professor Marco Falcone from the University Hospital Pisa, Italy, originally presented at the BSAC conference 'Into clinical practice: Meeting the challenges of Gram-negative infection management' on 14 October 2020. ... ...

    Abstract This video is a presentation from Professor Marco Falcone from the University Hospital Pisa, Italy, originally presented at the BSAC conference 'Into clinical practice: Meeting the challenges of Gram-negative infection management' on 14 October 2020. Professor Falcone highlights the cefiderocol compassionate use case series that has been published in
    Language English
    Publishing date 2021-06-15
    Publishing country England
    Document type Journal Article
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlab056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Skin and soft tissue infections in the elderly.

    Falcone, Marco / Tiseo, Giusy

    Current opinion in infectious diseases

    2023  Volume 36, Issue 2, Page(s) 102–108

    Abstract: Purpose of review: To highlight the peculiarity of skin and soft tissue infections (SSTIs) in elderly patients and to provide useful elements for their optimal management.: Recent findings: In the COVID-19 era, early discharge from the hospital and ... ...

    Abstract Purpose of review: To highlight the peculiarity of skin and soft tissue infections (SSTIs) in elderly patients and to provide useful elements for their optimal management.
    Recent findings: In the COVID-19 era, early discharge from the hospital and implementation of outpatient management is of key importance.
    Summary: Elderly patients are at high risk of SSTIs due to several factors, including presence of multiple comorbidities and skin factors predisposing to infections. Clinical presentation may be atypical and some signs of severity, such as fever and increase in C-reactive protein, may be absent or aspecific in this patients population. An appropriate diagnosis of SSTIs in the elderly is crucial to avoid antibiotic overtreatment. Further studies should explore factors associated with bacterial superinfections in patients with pressure ulcers or lower limb erythema. Since several risk factors for methicillin-resistant Staphylococcus aureus (MRSA) may coexist in elderly patients, these subjects should be carefully screened for MRSA risk factors and those with high risk of resistant etiology should receive early antibiotic therapy active against MRSA. Physicians should aim to several objectives, including clinical cure, patient safety, early discharge and return to community. SSTIs in the elderly may be managed using long-acting antibiotics, but clinical follow-up is needed.
    MeSH term(s) Humans ; Aged ; Soft Tissue Infections/drug therapy ; Soft Tissue Infections/epidemiology ; Soft Tissue Infections/diagnosis ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Skin Infections/drug therapy ; Community-Acquired Infections/drug therapy ; COVID-19 ; Anti-Bacterial Agents/therapeutic use ; Staphylococcal Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2462: Show issues Location:
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  4. Article ; Online: Cefiderocol for the Treatment of Metallo-β-Lactamases Producing Gram-Negative Bacilli: Lights and Shadows From the Literature.

    Falcone, Marco / Tiseo, Giusy

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue 6, Page(s) 1085–1087

    MeSH term(s) Cephalosporins/therapeutic use ; Gram-Negative Bacteria ; Humans ; beta-Lactamases ; Cefiderocol
    Chemical Substances Cephalosporins ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 480: Show issues

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  5. Article ; Online: Reply to Epling and Powers, "Cefiderocol and the Need for Higher-Quality Evidence: Methods Matter for Patients".

    Falcone, Marco / Tiseo, Giusy

    Antimicrobial agents and chemotherapy

    2022  Volume 66, Issue 8, Page(s) e0079522

    MeSH term(s) Cephalosporins ; Humans ; Microbial Sensitivity Tests ; Cefiderocol
    Chemical Substances Cephalosporins
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.00795-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 809: Show issues Location:
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    Einzelsignatur: Show issues

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  6. Article ; Online: Neglected tropical diseases in Europe: an emerging problem for health professionals.

    Falcone, Marco

    Internal and emergency medicine

    2017  Volume 12, Issue 4, Page(s) 423–424

    Language English
    Publishing date 2017
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-017-1648-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6673: Show issues Location:
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  7. Article ; Online: What is the clinical significance of 'heteroresistance' in nonfermenting Gram-negative strains?

    Tiseo, Giusy / Galfo, Valentina / Falcone, Marco

    Current opinion in infectious diseases

    2023  Volume 36, Issue 6, Page(s) 555–563

    Abstract: Purpose of review: The aim of this study was to discuss the potential clinical significance of heteroresistance in nonfermenting Gram-negative bacilli (GNB).: Recent findings: Recently, heteroresistance has been considered potentially responsible for ...

    Abstract Purpose of review: The aim of this study was to discuss the potential clinical significance of heteroresistance in nonfermenting Gram-negative bacilli (GNB).
    Recent findings: Recently, heteroresistance has been considered potentially responsible for clinical failure in Acinetobacter baumannii infections. This raised a scientific debate, still open, about the potential clinical significance of heteroresistance in nonfermenting GNB.
    Summary: We reviewed the literature of last 20 years and found a limited number of studies evaluating the relationship between heteroresistance and clinical outcome in nonfermenting GNB. Unlike Gram-positive bacteria, heteroresistance is reported in a significant proportion of nonfermenting GNB with some studies describing it in all tested strains and for several antibiotics (including tigecycline, carbapenems, levofloxacin, cefiderocol, colistin). One important issue is the need for validated detection method since the population analysis profile test, that is considered the gold standard, requires high costs and time. Studies evaluating the correlation between heteroresistance and clinical outcome are contrasting and have several limitations. Although in-vitro detection of heteroresistance in nonfermenting GNB has not been associated with in-vivo treatment failure, its presence may suggest to prefer combination regimens instead monotherapy when treating infections by nonfermenters. Further studies are needed to clarify the clinical significance of heteroresistance.
    MeSH term(s) Humans ; Clinical Relevance ; Drug Resistance, Multiple, Bacterial ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Colistin ; Gram-Negative Bacteria ; Acinetobacter Infections
    Chemical Substances Anti-Bacterial Agents ; Colistin (Z67X93HJG1)
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2462: Show issues Location:
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  8. Article ; Online: Unveiling the molecular Hallmarks of Peyronie's disease: a comprehensive narrative review.

    Şahin, Ali / Babayev, Huseyn / Cirigliano, Lorenzo / Preto, Mirko / Falcone, Marco / Altıntas, Emre / Gül, Murat

    International journal of impotence research

    2024  

    Abstract: Peyronie's disease, a fibroinflammatory disorder, detrimentally impacts the sexual well-being of men and their partners. The manifestation of fibrotic plaques within penile tissue, attributed to dysregulated fibrogenesis, is pathognomonic for this ... ...

    Abstract Peyronie's disease, a fibroinflammatory disorder, detrimentally impacts the sexual well-being of men and their partners. The manifestation of fibrotic plaques within penile tissue, attributed to dysregulated fibrogenesis, is pathognomonic for this condition. The onset of fibrosis hinges on the perturbation of the equilibrium between matrix metalloproteinases (MMPs), crucial enzymes governing the extracellular matrix, and tissue inhibitors of MMPs (TIMPs). In the context of Peyronie's disease, there is an elevation in TIMP levels coupled with a decline in MMP levels, culminating in fibrogenesis. Despite the scant molecular insights into fibrotic pathologies, particularly in the context of Peyronie's disease, a comprehensive literature search spanning 1995 to 2023, utilizing PubMed Library, was conducted to elucidate these mechanisms. The findings underscore the involvement of growth factors such as FGF and PDGF, and cytokines like IL-1 and IL-6, alongside PAI-1, PTX-3, HIF, and IgG4 in the fibrotic cascade. Given the tissue-specific modulation of fibrosis, comprehending the molecular underpinnings of penile fibrosis becomes imperative for the innovation of novel and efficacious therapies targeting Peyronie's disease. This review stands as a valuable resource for researchers and clinicians engaged in investigating the molecular basis of fibrotic diseases, offering guidance for advancements in understanding Peyronie's disease.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-024-00845-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Steroid-dependent ocular pain.

    Testa, Davide / Falcone, Marco / Ragone, Maria Cristina / Posarelli, Chiara / Migliorini, Paola

    International journal of rheumatic diseases

    2024  Volume 27, Issue 4, Page(s) e15148

    MeSH term(s) Humans ; Eye Pain/diagnosis ; Eye Pain/etiology ; Glucocorticoids/adverse effects ; Glucocorticoids/therapeutic use ; Treatment Outcome ; Female ; Male
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.15148
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    Zs.A 6098: Show issues Location:
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  10. Article ; Online: Paradigm Shift:

    Franconi, Iacopo / Rizzato, Cosmeri / Tavanti, Arianna / Falcone, Marco / Lupetti, Antonella

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 10

    Abstract: Candidemia is the fourth most common healthcare-related bloodstream infection. In recent years, incidence rates ... ...

    Abstract Candidemia is the fourth most common healthcare-related bloodstream infection. In recent years, incidence rates of
    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9101012
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