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  1. Book ; Thesis: Identification of distinct ischemia- versus reperfusion-specific inflammatory patterns and their regulatory network in clinical heart transplantation

    Ledwoch, Nadine / Falk, Christine Susanne

    2022  

    Institution Medizinische Hochschule Hannover
    Institut für Transplantationsimmunologie
    Author's details vorgelegt von Nadine Maria Ledwoch ; Institut für Transplantationsimmunologie der Medizinischen Hochschule Hannover ; Betreuer/in der Arbeit: Prof.´in Dr. rer. nat. Christine Falk
    Subject code 616.1 ; 610
    Language English ; German
    Size 2 ungezählte Blätter, 52 Blätter, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2022
    Note Text auf Englisch, Zusammenfassung auf Deutsch, Sonderabdrucke auf Englisch ; Enthält 1 Zeitschriftenaufsatz aus "Cytokine", Jg. 149 (2022)
    HBZ-ID HT030635149
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 199 order for loan Magazin

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  2. Book ; Thesis: Cardiac transplantation is accompanied by major changes in the T and NK cell subset composition within the first 24 hours

    Iske, Jasper / Falk, Christine Susanne

    2021  

    Institution Medizinische Hochschule Hannover
    Institut für Transplantationsimmunologie
    Author's details vorgelegt von Jasper Iske ; aus dem Institut für Transplantationsimmunologie der Medizinische Hochschule Hannover ; Betreuerin der Arbeit: Professorin Dr. rer. nat. Christine Falk
    Language English
    Size 1 ungezähltes Blatt, 72 Blätter, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2022
    HBZ-ID HT030635165
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Thesis: The influence of immunosuppressive drugs on NK cell phenotype and function in the context of kidney transplantation

    Hoffmann, Ulrike / Falk, Christine Susanne

    2018  

    Institution Medizinische Hochschule Hannover
    Institut für Transplantationsimmunologie
    Integriertes Forschungs- und Behandlungszentrum Transplantation
    Author's details vorgelegt von Ulrike Hoffmann
    Language English
    Size 2 ungezählte Blätter, 61 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2018
    Note Enthält 1 Sonderabdruck aus: PLoS One ; 10,7.2015. e0132484. 19 Seiten
    HBZ-ID HT019815373
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Online ; Thesis: Phenotypical and functional characterization of donor NK and T cells in the peripheral blood of lung transplant recipients

    Hitz, Anna-Maria [Verfasser] / Falk, Christine Susanne [Akademischer Betreuer]

    2023  

    Author's details Anna-Maria Hitz ; Akademischer Betreuer: Christine Susanne Falk ; Institut für Transplantationsimmunologie
    Keywords Technische Chemie ; Technical Chemistry
    Subject code sg660
    Language English
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Book ; Online ; Thesis: CD14highCD16+ Monocytes are the main producers of immunosuppressive interleukin-10 following heart transplantation

    Ludwig, Kristina [Verfasser] / Falk, Christine Susanne [Akademischer Betreuer]

    2023  

    Author's details Kristina Ludwig ; Akademischer Betreuer: Christine Susanne Falk ; Institut für Transplantationsimmunologie
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Book ; Online ; Thesis: Etablierung und Charakterisierung von murinen Tumormodellen des intrahepatischen Cholangiokarzinoms

    Schumann, Georgina [Verfasser] / Vogel, Arndt [Akademischer Betreuer] / Falk, Christine Susanne [Akademischer Betreuer]

    2023  

    Author's details Georgina Schumann ; Akademische Betreuer: Arndt Vogel, Christine Susanne Falk ; Klinik für Gastroenterologie, Hepatologie und Endokrinologie
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: Correction to: Efficient generation of gene-modified human natural killer cells via alpharetroviral vectors.

    Suerth, Julia D / Morgan, Michael A / Kloess, Stephan / Heckl, Dirk / Neudörfl, Christine / Falk, Christine S / Koehl, Ulrike / Schambach, Axel

    Journal of molecular medicine (Berlin, Germany)

    2023  Volume 102, Issue 1, Page(s) 143–145

    Language English
    Publishing date 2023-12-07
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-023-02404-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article ; Online: Third SARS-CoV-2 vaccination and breakthrough infections enhance humoral and cellular immunity against variants of concern.

    Ruhl, Louisa / Kühne, Jenny F / Beushausen, Kerstin / Keil, Jana / Christoph, Stella / Sauer, Jasper / Falk, Christine S

    Frontiers in immunology

    2023  Volume 14, Page(s) 1120010

    Abstract: Introduction: SARS-CoV-2 vaccination is the leading strategy to prevent severe courses after SARS-CoV-2 infection. In our study, we analyzed humoral and cellular immune responses in detail to three consecutive homologous or heterologous SARS-CoV-2 ... ...

    Abstract Introduction: SARS-CoV-2 vaccination is the leading strategy to prevent severe courses after SARS-CoV-2 infection. In our study, we analyzed humoral and cellular immune responses in detail to three consecutive homologous or heterologous SARS-CoV-2 vaccinations and breakthrough infections.
    Methods: Peripheral blood samples of n=20 individuals were analyzed in the time course of three SARS-CoV-2 vaccinations and/or breakthrough infection. S1-, RBD-, S2- and N-specific IgG antibodies were quantified using Luminex-based multiplex assays and electrochemiluminescence multiplex assays for surrogate neutralization in plasma. Changes in cellular immune components were determined via flow cytometry of whole blood samples.
    Results: All individuals (n=20) responded to vaccination with increasing S1-/RBD-/S2-specific IgG levels, whereas specific plasma IgA displayed individual variability. The third dose increased antibody inhibitory capacity (AIC) against immune-escape variants Beta and Omicron BA.1 independently of age. The mRNA-primed vaccination induced IgG and IgA immunity more efficiently, whereas vector-primed individuals displayed higher levels of memory T and B cells. Vaccinees showed SARS-CoV-2-specific T cell responses, which were further improved and specified after Omicron breakthrough infections in parallel to the appearance of new variant-specific antibodies.
    Discussion: In conclusion, the third vaccination was essential to increase IgG levels, mandatory to boost AIC against immune-escape variants, and induced SARS-CoV-2-specific T cells. Breakthrough infection with Omicron generates additional spike specificities covering all known variants.
    MeSH term(s) Humans ; COVID-19 Vaccines ; SARS-CoV-2 ; Breakthrough Infections ; COVID-19/prevention & control ; Immunity, Cellular ; Immunoglobulin G ; Vaccination ; Immunoglobulin A
    Chemical Substances COVID-19 Vaccines ; Immunoglobulin G ; Immunoglobulin A
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1120010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Impaired T and "memory-like" NK-cell reconstitution is linked to late-onset HCMV reactivation after letermovir cessation.

    Lauruschkat, Chris David / Muchsin, Ihsan / Rein, Alice Felicitas / Erhard, Florian / Grathwohl, Denise / Dölken, Lars / Köchel, Carolin / Nehmer, Anne / Falk, Christine S / Grigoleit, Götz Ulrich / Einsele, Hermann / Wurster, Sebastian / Kraus, Sabrina

    Blood advances

    2024  

    Abstract: Allogeneic hematopoietic stem cell transplantation (alloSCT) is the only cure for many hematologic malignancies. However, alloSCT recipients are susceptible to opportunistic pathogens such as human cytomegalovirus (HCMV). Letermovir prophylaxis has ... ...

    Abstract Allogeneic hematopoietic stem cell transplantation (alloSCT) is the only cure for many hematologic malignancies. However, alloSCT recipients are susceptible to opportunistic pathogens such as human cytomegalovirus (HCMV). Letermovir prophylaxis has revolutionized HCMV management, but the challenge of late HCMV reactivations has emerged. Immunological surrogates of clinically significant HCMV reactivations (csCMVi) after discontinuation of letermovir remain to be defined. Therefore, we studied NK-cell reconstitution along with the global and HCMV pp65-specific T-cell repertoire of 24 alloSCT recipients at seven timepoints before (day +90) and after (days +120-270) cessation of letermovir prophylaxis. Patients who experienced csCMVi had lower counts of IFNγ+ HCMV-specific CD4+ and CD8+ T cells than HCMV controllers. Furthermore, csCMVi patients displayed late impairment of NK-cell reconstitution, especially suppression of "memory-like" CD159c+CD56dim NK-cell counts that preceded csCMVi events in most patients. Moreover, several surrogates of immune reconstitution were associated with the severity of HCMV manifestation, with patients suffering from HCMV end-organ disease and/or refractory HCMV infection harboring least HCMV-specific T cells and "memory-like" NK cells. Altogether, our findings establish an association of delayed or insufficient proliferation of both HCMV-specific T cells and "memory-like" NK cells with csCMVi and the severity of HCMV manifestations following discontinuation of letermovir prophylaxis.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023012008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7153: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Book ; Online ; Thesis: Delineating the relevance of phenotypic identity in normal and malignant hematopoiesis by fluorescent genetic barcoding

    Lieske, Anna [Verfasser] / Schambach, Axel [Akademischer Betreuer] / Falk, Christine Susanne [Akademischer Betreuer]

    2022  

    Author's details Anna Lieske ; Akademische Betreuer: Axel Schambach, Christine Susanne Falk ; Institut Experimentelle Hämatologie
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Bibliothek der Medizinischen Hochschule Hannover
    Publishing place Hannover
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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