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Article ; Online: Genetic diversity of merozoite surface protein-5 (MSP-5) of Plasmodium vivax isolates from Malaria patients in Iran.

Mansouri, Sholeh / Heidari, Aliehsan / Keshavarz, Hossein / Fallah, Parviz / Bairami, Amir / Mahmoudi, Elaheh

2023 Volume 23, Issue 1, Page(s) 807

Abstract: Malaria has not yet been eradicated in Iran, and Plasmodium vivax (P. vivax) is the main cause of malaria in the country. This study aimed to investigate and analyze the amount of genetic diversity of Plasmodium vivax merozoite surface protein-5 (PvMSP-5) ...

Abstract	Malaria has not yet been eradicated in Iran, and Plasmodium vivax (P. vivax) is the main cause of malaria in the country. This study aimed to investigate and analyze the amount of genetic diversity of Plasmodium vivax merozoite surface protein-5 (PvMSP-5) exon 1 gene in the southeast of Iran.Thirty-five patients with clinical symptoms of P. vivax malaria participated. The exon 1 of PvMSP-5 was amplified by PCR, and the PCR product of all isolates was sequenced, and genetic polymorphisms were determined using various genetic software.The analysis showed that studied isolates are different from one another in the DnaSP software version. Out of the 612 sites, 477 were monomorphic and 135 were segregated. The total number of mutations was 143. The singleton variable and the parsimony informative sites were 23 and 112, respectively. There were 17 specific haplotypes with haplotype diversity equal to 0.943. Nucleotide diversity was equal to 0.06766 in the isolates. The ratio of nonsynonymous (0.06446) to synonymous (0.07909) mutations was 0.815020. Tajima's D, which expressed coding, and non-coding regions, was 0.72403, which was not deemed significant (P > 0.10).The analysis of intrapopulation diversity revealed nucleotide and haplotype diversity in the msp-5 gene of Iranian P. vivax isolates. In addition to balancing or purifying selection, intragenic recombination also contributed to the variation observed in exon 1 of PvMSP-5, according to the findings.
MeSH term(s)	Animals ; Humans ; Plasmodium vivax/genetics ; Iran/epidemiology ; Merozoites ; Merozoite Surface Protein 1/genetics ; Malaria, Vivax ; Polymorphism, Genetic ; Membrane Proteins/genetics ; Sequence Analysis, DNA ; Nucleotides ; Genetic Variation ; Protozoan Proteins/genetics ; Antigens, Protozoan/genetics
Chemical Substances	Merozoite Surface Protein 1 ; Membrane Proteins ; Nucleotides ; Protozoan Proteins ; Antigens, Protozoan
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08804-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Xanthohumol hinders invasion and cell cycle progression in cancer cells through targeting MMP2, MMP9, FAK and P53 genes in three-dimensional breast and lung cancer cells culture.

Gholizadeh Siahmazgi, Zohreh / Irani, Shiva / Ghiaseddin, Ali / Fallah, Parviz / Haghpanah, Vahid

Cancer cell international

2023 Volume 23, Issue 1, Page(s) 153

Abstract: Background: Despite recent advances in the treatment of lung and breast cancer, the mortality with these two types of cancer is high. Xanthohumol (XN) is known as a bioactive compound that shows an anticancer effect on cancer cells. Here, we intended to ...

Abstract	Background: Despite recent advances in the treatment of lung and breast cancer, the mortality with these two types of cancer is high. Xanthohumol (XN) is known as a bioactive compound that shows an anticancer effect on cancer cells. Here, we intended to investigate the anticancer effects of XN on the breast and lung cancer cell lines, using the three-dimensional (3D) cell culture. Methods: XN was isolated from Humulus lupulus using Preparative-Thin Layer Chromatography (P-TLC) method and its authenticity was documented through Fourier Transform Infrared spectroscopy (FT-IR) and Hydrogen Nuclear Magnetic Resonance (H-NMR) methods. The spheroids of the breast (MCF-7) and lung (A549) cancer cell lines were prepared by the Hanging Drop (HD) method. Subsequently, the IC Results: While the IC Conclusions: According to our results of XN treatment in 3D conditions, this bioactive compound can be introduced as an adjuvant anti-cancer agent for breast and lung cancer.
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-023-03009-2
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Article: Electroencephalograph Emotion Classification Using a Novel Adaptive Ensemble Classifier Considering Personality Traits.

Khajeh Hosseini, Mohammad Saleh / Pourmir Firoozabadi, Mohammad / Badie, Kambiz / Azad Fallah, Parviz

Basic and clinical neuroscience

2023 Volume 14, Issue 5, Page(s) 687–700

Abstract: Introduction: The study explores the use of Electroencephalograph (EEG) signals as a means to uncover various states of the human brain, with a specific focus on emotion classification. Despite the potential of EEG signals in this domain, existing ... ...

Abstract	Introduction: The study explores the use of Electroencephalograph (EEG) signals as a means to uncover various states of the human brain, with a specific focus on emotion classification. Despite the potential of EEG signals in this domain, existing methods face challenges. Features extracted from EEG signals may not accurately represent an individual's emotional patterns due to interference from time-varying factors and noise. Additionally, higher-level cognitive factors, such as personality, mood, and past experiences, further complicate emotion recognition. The dynamic nature of EEG data in terms of time series introduces variability in feature distribution and interclass discrimination across different time stages. Methods: To address these challenges, the paper proposes a novel adaptive ensemble classification method. The study introduces a new method for providing emotional stimuli, categorizing them into three groups (sadness, neutral, and happiness) based on their valence-arousal (VA) scores. The experiment involved 60 participants aged 19-30 years, and the proposed method aimed to mitigate the limitations associated with conventional classifiers. Results: The results demonstrate a significant improvement in the performance of emotion classifiers compared to conventional methods. The classification accuracy achieved by the proposed adaptive ensemble classification method is reported at 87.96%. This suggests a promising advancement in the ability to accurately classify emotions using EEG signals, overcoming the limitations outlined in the introduction. Conclusion: In conclusion, the paper introduces an innovative approach to emotion classification based on EEG signals, addressing key challenges associated with existing methods. By employing a new adaptive ensemble classification method and refining the process of providing emotional stimuli, the study achieves a noteworthy improvement in classification accuracy. This advancement is crucial for enhancing our understanding of the complexities of emotion recognition through EEG signals, paving the way for more effective applications in fields such as neuroinformatics and affective computing.
Language	English
Publishing date	2023-09-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2652444-2
ISSN	2228-7442 ; 2008-126X
ISSN (online)	2228-7442
ISSN	2008-126X
DOI	10.32598/bcn.2022.3830.2
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Article ; Online: Molecular imprinting of miR-559 on a peptide-immobilized poly L-DOPA/silica core-shell and in vitro investigating its effects on HER2-positive breast cancer cells.

Mohammadzade, Hadi / Hashemi-Moghaddam, Hamid / Beikzadeh, Leila / Ahmadieh-Yazdi, Amirhossein / Madanchi, Hamid / Fallah, Parviz

Drug delivery and translational research

2023 Volume 13, Issue 10, Page(s) 2487–2502

Abstract: In a significant percentage of breast cancers, increased expression of the HER2 receptor is seen and is associated with the spread and worsening of the disease. This research aims to investigate the effect of miR-559 (which targets HER2 mRNA) on SKBR3 ... ...

Abstract	In a significant percentage of breast cancers, increased expression of the HER2 receptor is seen and is associated with the spread and worsening of the disease. This research aims to investigate the effect of miR-559 (which targets HER2 mRNA) on SKBR3 breast cancer cells and the possibility of their effective delivery with polymeric nanoparticles and tumor-targeting peptides. L-DOPA monomers were polymerized on the surface of silica nanoparticles in the presence of miR-559 (as a molecular template for molecular imprinting) then an anti-HER2 peptide coupled to the surface of these polymeric nanocomposites (miR-NC-NL2), and the effects of this construct against a HER2-positive breast cancer cells (SKBR3 cells) investigated in vitro conditions. The results showed that miR-NC-NL2 is selective for HER2-positive cells and delivers the miR-559 to them in a targeted manner. miR-NC-NL2 decreased the proliferation of SKBR3 cells and reduced the expression and production of HER2 protein in these cells. Effective and targeted delivery of miR-559 to HER2-positive cancer cells by the miR-NC-NL2 promises the therapeutic potential of this nascent structure based on its inhibitory effect on cancer growth and progression. Of course, animal experiments require a better understanding of this structure's anti-tumor effects.
MeSH term(s)	Animals ; Levodopa/pharmacology ; Silicon Dioxide ; Molecular Imprinting ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Cell Proliferation ; Cell Line, Tumor ; Peptide Fragments/pharmacology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasms
Chemical Substances	Levodopa (46627O600J) ; Silicon Dioxide (7631-86-9) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Peptide Fragments ; MicroRNAs
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2590155-2
ISSN	2190-3948 ; 2190-393X
ISSN (online)	2190-3948
ISSN	2190-393X
DOI	10.1007/s13346-023-01330-x
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Article: Key plasma microRNAs variations in patients with Plasmodium vivax malaria in Iran

Hadighi, Ramtin / Heidari, Aliehsan / Fallah, Parviz / Keshavarz, Hossein / Tavakoli, Ziba / sholeh Mansouri / Sadrkhanloo, Mehrdokht

Heliyon. 2022 Mar., v. 8, no. 3

2022

Abstract: As the cause of RBC infection and splenomegaly, malaria remains a major parasitic disease in the world. New specific biomarkers such as MicroRNAs (miRNAs) are developed to accurately diagnose malaria and clarify its pathologic changes. This study aimed ... ...

Abstract	As the cause of RBC infection and splenomegaly, malaria remains a major parasitic disease in the world. New specific biomarkers such as MicroRNAs (miRNAs) are developed to accurately diagnose malaria and clarify its pathologic changes. This study aimed at evaluating changes in the plasma miRNAs markers of Plasmodium vivax in patients with malaria in Chabahar, Iran. For the present descriptive-analytical study conducted in 2018, we collected blood samples from 20 individuals. Real-time quantitative Polymerase Chain Reaction (RT-qPCR) was used to measure the plasma levels of miR-145, miR-155, miR-191 and miR-223-3p. The 2-ΔΔCT method of Real-time PCR showed the plasma levels of miR-223, miR-145 and miR-155 to respectively be 5.6, 16.9 and 1.7 times higher in patients with P. vivax compared to those in healthy individuals. The expressions of all the three miRNAs significantly increased in patients with malaria compared to in the controls (P < 0.05). The expression of miR-191 was 1.405 times higher in patients with malaria compared to that in the controls, although the difference was statistically insignificant. The present study found P. vivax to change host miRNAs such as miR-223, miR-145 and miR-155. These small molecules thus appeared to constitute biomarkers for P. vivax malaria assessment.
Keywords	Plasmodium vivax ; biomarkers ; malaria ; microRNA ; quantitative polymerase chain reaction ; splenomegaly ; Iran
Language	English
Dates of publication	2022-03
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e09018
Database	NAL-Catalogue (AGRICOLA)

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Article: Key plasma microRNAs variations in patients with

Hadighi, Ramtin / Heidari, Aliehsan / Fallah, Parviz / Keshavarz, Hossein / Tavakoli, Ziba / Sholeh Mansouri / Sadrkhanloo, Mehrdokht

Heliyon

2022 Volume 8, Issue 3, Page(s) e09018

Abstract: Introduction: As the cause of RBC infection and splenomegaly, malaria remains a major parasitic disease in the world. New specific biomarkers such as MicroRNAs (miRNAs) are developed to accurately diagnose malaria and clarify its pathologic changes. ... ...

Abstract	Introduction: As the cause of RBC infection and splenomegaly, malaria remains a major parasitic disease in the world. New specific biomarkers such as MicroRNAs (miRNAs) are developed to accurately diagnose malaria and clarify its pathologic changes. This study aimed at evaluating changes in the plasma miRNAs markers of Materials and methods: For the present descriptive-analytical study conducted in 2018, we collected blood samples from 20 individuals. Real-time quantitative Polymerase Chain Reaction (RT-qPCR) was used to measure the plasma levels of miR-145, miR-155, miR-191 and miR-223-3p. Results: The 2-ΔΔCT method of Real-time PCR showed the plasma levels of miR-223, miR-145 and miR-155 to respectively be 5.6, 16.9 and 1.7 times higher in patients with Conclusion: The present study found
Language	English
Publishing date	2022-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e09018
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Article: Circulating miRNAs can serve as potential diagnostic biomarkers in chronic myelogenous leukemia patients.

Keramati, Farid / Jafarian, Arefeh / Soltani, Adele / Javandoost, Ehsan / Mollaei, Mojtaba / Fallah, Parviz

Leukemia research reports

2021 Volume 16, Page(s) 100257

Abstract: Introduction: Chronic Myelogenous Leukemia (CML) is a myeloproliferative disorder described as a malignant blood disorder by accounts for 15-20% of all adult leukemia. MicroRNAs (miRNAs) play an important role in post-transcriptional regulation of gene ... ...

Abstract	Introduction: Chronic Myelogenous Leukemia (CML) is a myeloproliferative disorder described as a malignant blood disorder by accounts for 15-20% of all adult leukemia. MicroRNAs (miRNAs) play an important role in post-transcriptional regulation of gene expressions. Expression level of tumor suppressor-miRNAs, described as miRNAs that target the oncogens, can contribute to diagnosis and prognosis of some malignant disorders including CML. We theorized that according to the excessive proliferation and alteration in miRNA expressions, there could be a change in the expression of miRNAs in plasma carried by exosomes. Methods: We consequently decided to detect the differences between normal and aberrant miRNA expression in human plasma sample to find out the possibility of diagnosis by these alterations. The expression of candidate miRNAs were compared using RNA extracted from the plasma of 50 patients, as well as 30 healthy individuals. We analysed the plasma miR-16-1, miR-20, miR-106, miR-126, miR-155, miR-222, and miR-451 expression levels in CML patients by individual real-time quantitative RT-PCR. Results: All selected miRNAs were found to be upregulated in newly diagnosed CML patients compared to the control, while upregulation of only three (miR-20, 106 and 222) were significant (17.4, 19 and 74.95 fold change, respectively; In conclusion: microRNAs have a potential use in treatment of CML, as they can target the genes involved in cell cycle, MAPK, growth inhibition, TGF beta, and p53 signaling pathways. Therefore, these miRNA signatures provide the basis for their utilization as biomarkers in CML.
Language	English
Publishing date	2021-07-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2706248-X
ISSN	2213-0489
ISSN	2213-0489
DOI	10.1016/j.lrr.2021.100257
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Article: BI-847325, a selective dual MEK and Aurora kinases inhibitor, reduces aggressive behavior of anaplastic thyroid carcinoma on an in vitro three-dimensional culture.

Samimi, Hilda / Tavakoli, Rezvan / Fallah, Parviz / Naderi Sohi, Alireza / Amini Shirkouhi, Maryam / Naderi, Mahmood / Haghpanah, Vahid

Cancer cell international

2022 Volume 22, Issue 1, Page(s) 388

Abstract: Background: Anaplastic thyroid carcinoma (ATC) is the most aggressive subtype of thyroid cancer. In this study, we used a three-dimensional in vitro system to evaluate the effect of a dual MEK/Aurora kinase inhibitor, BI-847325 anticancer drug, on ... ...

Abstract	Background: Anaplastic thyroid carcinoma (ATC) is the most aggressive subtype of thyroid cancer. In this study, we used a three-dimensional in vitro system to evaluate the effect of a dual MEK/Aurora kinase inhibitor, BI-847325 anticancer drug, on several cellular and molecular processes involved in cancer progression. Methods: Human ATC cell lines, C643 and SW1736, were grown in alginate hydrogel and treated with IC Results: Western blot results showed that BI-847325 inhibits MEK1/2 and AURKB functions by decreasing phospho-ERK1/2 and phospho-Histone H3 levels. BI-847325 induced thyroid differentiation markers and apoptosis in ATC cell lines. Inversely, BI-847325 intervention decreased multidrug resistance, cell cycle progression, proliferation, angiogenesis, and invasion at the molecular and/or cellular levels. Conclusion: The results of the present study suggest that BI-857,325 might be an effective multi-targeted anticancer drug for ATC treatment.
Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2091573-1
ISSN	1475-2867
ISSN	1475-2867
DOI	10.1186/s12935-022-02813-6
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Article: Biliary cirrhosis-induced cardiac abnormality in rats: Interaction between Farnesoid-X-activated receptors and the cardiac uncoupling proteins 2 and 3.

Bayat, Gholamreza / Hashemi, Seyed Ali / Karim, Hosein / Fallah, Parviz / Hedayatyanfard, Keshvad / Bayat, Mahnaz / Khalili, Azadeh

Iranian journal of basic medical sciences

2022 Volume 25, Issue 1, Page(s) 126–133

Abstract: Objectives: This study aimed to evaluate the relationship between Farnesoid-X-activated receptors (FXR) as nuclear regulators of the antioxidant defense system as well as cardiac mitochondrial carrier proteins of UCP2 and UCP3 in cardiac damage induced ... ...

Abstract	Objectives: This study aimed to evaluate the relationship between Farnesoid-X-activated receptors (FXR) as nuclear regulators of the antioxidant defense system as well as cardiac mitochondrial carrier proteins of UCP2 and UCP3 in cardiac damage induced by cirrhosis. Materials and methods: Twenty-two male Wistar rats (200-250 g) were randomly divided into 3 experimental groups, including a control group (n=6), a sham-operated group (n=8), and a bile duct ligated (BDL) group (n=8). Four weeks after surgical intervention, biochemical assessment (AST, ALT, GGT, LDH, and ALP), histological observation, and molecular evaluation (FXR, UCP2, UCP3, BNP, Caspase3, and GAPDH) using real-time RT-PCR were performed. Results: Compared with the sham-operation group, the BDL group showed a significant rise in liver enzymes of AST, ALT, GGT, LDH, and ALP. Defined fibrotic and necrotic bundles and thick reticulin fibers were also found in BDL liver tissue. Besides liver morphological alterations, left ventricles of BDL ones were also associated with defined cardiomyocyte hypertrophy, myofiber vacuolization, and clear pigmentation. Findings showed a significant up-regulation of cardiac Brain Natriuretic Peptide (BNP) along with marked down-regulation in hepatic FXR, cardiac FXR, and cardiac UCP2 and UCP3. However, the expression of caspase 3 in the cardiac tissue was not affected by BDL operation during 4 weeks. Conclusion: Expression of FXR as an upstream regulator of cellular redox status, besides the non-enzymatic ROS buffering defense system of cardiac UCPs, has a pivotal role in the pathogenesis of cirrhotic-induced cardiac abnormality in rats.
Language	English
Publishing date	2022-05-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
DOI	10.22038/IJBMS.2022.60888.13485
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Article ; Online: Silymarin Administration Attenuates Cirrhotic-induced Cardiac Abnormality in the Rats: A Possible Role of β

Bayat, Gholamreza / Mazloom, Roham / Hashemi, Seyed Ali / Pourkhalili, Khalil / Fallah, Parviz / Shams, Alireza / Esmaeili, Parvaneh / Khalili, Azadeh

Iranian journal of medical sciences

2022 Volume 47, Issue 4, Page(s) 367–378

Abstract: Background: Cirrhotic cardiomyopathy is a well-recognized cardiac dysfunction in cirrhotic patients. Studies have confirmed the protective effects of silymarin in different types of cardiac injury. This study aimed to examine the effectiveness and ... ...

Abstract	Background: Cirrhotic cardiomyopathy is a well-recognized cardiac dysfunction in cirrhotic patients. Studies have confirmed the protective effects of silymarin in different types of cardiac injury. This study aimed to examine the effectiveness and molecular mechanism of silymarin against myocardial dysfunction and hypertrophy in a rat model of cirrhosis. Methods: The experiment was performed at Alborz University of Medical Sciences (Karaj, Iran) during 2020-2021. Thirty-two male Wistar rats were randomly divided into four groups of Sham-operated (control group for surgical procedures), Bile Duct Ligated (BDL), and two Silymarin extract (SE)-treated groups of 300 and 600 mg/Kg/day. After 28 days, serum levels of AST, ALT, GGT, and ALP, liver histopathological status, as well as cardiac mechanical function, were assessed. Cardiac β Results: BDL was associated with a significant elevation in serum AST, ALT, GGT, and ALP, development of necrosis and fibrosis of the liver texture, increased Heart Weight and Heart Weight to Body Weight ratio, enhanced cardiac mechanical function as well as a significant up-regulation of ventricular β Conclusion: Silymarin treatment in higher dose attenuated cirrhosis-associated cardiac remodeling and reduced cardiac mechanical dysfunctions.
MeSH term(s)	Animals ; Calcium Channels, L-Type ; Cardiomyopathies/drug therapy ; Cardiomyopathies/metabolism ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Male ; Necrosis/drug therapy ; Rats ; Rats, Wistar ; Receptors, Adrenergic, beta-1/metabolism ; Silymarin/pharmacology ; Silymarin/therapeutic use
Chemical Substances	Calcium Channels, L-Type ; Receptors, Adrenergic, beta-1 ; Silymarin
Language	English
Publishing date	2022-08-02
Publishing country	Iran
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603872-4
ISSN	1735-3688 ; 0253-0716
ISSN (online)	1735-3688
ISSN	0253-0716
DOI	10.30476/IJMS.2021.90750.2172
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