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  1. Article ; Online: A supramolecular injectable hydrogel based on

    Fallahi, Hooman / Daemi, Hamed / Bagheri, Fatemeh / Baghaban Eslaminejad, Mohamadreza

    Biomedical materials (Bristol, England)

    2022  Volume 17, Issue 6

    Abstract: Owing to the similarity of hydrogels to cartilage extracellular matrix, they have been extensively utilized in the chondral lesions. Moreover, their tunable administration properties are desirable for reducing injuries in lesion sites. Generally, ... ...

    Abstract Owing to the similarity of hydrogels to cartilage extracellular matrix, they have been extensively utilized in the chondral lesions. Moreover, their tunable administration properties are desirable for reducing injuries in lesion sites. Generally, injectable hydrogels are mechanically weak, requiring some modifications for being used as a cell carrier in place of articular cartilage. In this study, a combination of
    MeSH term(s) Alginates ; Amines ; Anilides ; Cartilage, Articular ; Cyclodextrins/metabolism ; Cyclodextrins/pharmacology ; Hydrogels/chemistry ; Mesenchymal Stem Cells ; Phthalic Acids ; Poloxamer/metabolism ; Poloxamer/pharmacology
    Chemical Substances Alginates ; Amines ; Anilides ; Cyclodextrins ; Hydrogels ; Phthalic Acids ; Poloxamer (106392-12-5) ; kartogenin (Q93BBN11CP)
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2265222-X
    ISSN 1748-605X ; 1748-6041
    ISSN (online) 1748-605X
    ISSN 1748-6041
    DOI 10.1088/1748-605X/ac8bbd
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6626: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Influence of Microgel and Interstitial Matrix Compositions on Granular Hydrogel Composite Properties.

    Muir, Victoria G / Weintraub, Shoshana / Dhand, Abhishek P / Fallahi, Hooman / Han, Lin / Burdick, Jason A

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 10, Page(s) e2206117

    Abstract: Granular hydrogels are an emerging class of biomaterials formed by jamming hydrogel microparticles (i.e., microgels). These materials have many advantageous properties that can be tailored through microgel design and extent of packing. To enhance the ... ...

    Abstract Granular hydrogels are an emerging class of biomaterials formed by jamming hydrogel microparticles (i.e., microgels). These materials have many advantageous properties that can be tailored through microgel design and extent of packing. To enhance the range of properties, granular composites can be formed with a hydrogel interstitial matrix between the packed microgels, allowing for material flow and then stabilization after crosslinking. This approach allows for distinct compartments (i.e., microgels and interstitial space) with varied properties to engineer complex material behaviors. However, a thorough investigation of how the compositions and ratios of microgels and interstitial matrices influence material properties has not been performed. Herein, granular hydrogel composites are fabricated by combining fragmented hyaluronic acid (HA) microgels with interstitial matrices consisting of photocrosslinkable HA. Microgels of varying compressive moduli (10-70 kPa) are combined with interstitial matrices (0-30 vol.%) with compressive moduli varying from 2-120 kPa. Granular composite structure (confocal imaging), mechanics (local and bulk), flow behavior (rheology), and printability are thoroughly assessed. Lastly, variations in the interstitial matrix chemistry (covalent vs guest-host) and microgel degradability are investigated. Overall, this study describes the influence of granular composite composition on structure and mechanical properties of granular hydrogels towards informed designs for future applications.
    Language English
    Publishing date 2023-01-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202206117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration.

    Xu, Karen L / Di Caprio, Nikolas / Fallahi, Hooman / Dehghany, Mohammad / Davidson, Matthew D / Laforest, Lorielle / Cheung, Brian C H / Zhang, Yuqi / Wu, Mingming / Shenoy, Vivek / Han, Lin / Mauck, Robert L / Burdick, Jason A

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2766

    Abstract: Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their environments or instead utilize ...

    Abstract Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their environments or instead utilize existing extracellular matrix microstructures or microtracks as innate pathways for migration. While hydrogels in general are valuable tools for probing the extracellular regulators of 3-dimensional migration, few recapitulate these natural migration paths. Here, we develop a biopolymer-based bicontinuous hydrogel system that comprises a covalent hydrogel of enzymatically crosslinked gelatin and a physical hydrogel of guest and host moieties bonded to hyaluronic acid. Bicontinuous hydrogels form through controlled solution immiscibility, and their continuous subdomains and high micro-interfacial surface area enable rapid 3D migration, particularly when compared to homogeneous hydrogels. Migratory behavior is mesenchymal in nature and regulated by biochemical and biophysical signals from the hydrogel, which is shown across various cell types and physiologically relevant contexts (e.g., cell spheroids, ex vivo tissues, in vivo tissues). Our findings introduce a design that leverages important local interfaces to guide rapid cell migration.
    MeSH term(s) Hydrogels/chemistry ; Cell Movement ; Extracellular Matrix/metabolism ; Spheroids, Cellular ; Biopolymers/metabolism
    Chemical Substances Hydrogels ; Biopolymers
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46774-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Microinterfaces in bicontinuous hydrogels guide rapid 3D cell migration.

    Xu, Karen L / Caprio, Nikolas di / Fallahi, Hooman / Dehgany, Mohammad / Davidson, Matthew D / Cheung, Brian Ch / Laforest, Lorielle / Wu, Mingming / Shenoy, Vivek / Han, Lin / Mauck, Robert L / Burdick, Jason A

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their environments or may instead ... ...

    Abstract Cell migration is critical for tissue development and regeneration but requires extracellular environments that are conducive to motion. Cells may actively generate migratory routes in vivo by degrading or remodeling their environments or may instead utilize existing ECM microstructures or microtracks as innate pathways for migration. While hydrogels in general are valuable tools for probing the extracellular regulators of 3D migration, few have recapitulated these natural migration paths. Here, we developed a biopolymer-based (i.e., gelatin and hyaluronic acid) bicontinuous hydrogel system formed through controlled solution immiscibility whose continuous subdomains and high micro-interfacial surface area enabled rapid 3D migration, particularly when compared to homogeneous hydrogels. Migratory behavior was mesenchymal in nature and regulated by biochemical and biophysical signals from the hydrogel, which was shown across various cell types and physiologically relevant contexts (e.g., cell spheroids, ex vivo tissues, in vivo tissues). Our findings introduce a new design that leverages important local interfaces to guide rapid cell migration.
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.28.559609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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