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  1. Article ; Online: Thermodynamics-based rules of thumb to evaluate the interaction of chelators and kinetically-labile metal ions in blood serum and plasma.

    Falcone, Enrico / Faller, Peter

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 8, Page(s) 2197–2208

    Abstract: Metal ions play a very important role in nature and their homeostasis is crucial. A lot of metal-related chemical research activities are ongoing that concern metal-based drugs or tools, such as chelation therapy, metal- and metabolite sensors, metallo- ... ...

    Abstract Metal ions play a very important role in nature and their homeostasis is crucial. A lot of metal-related chemical research activities are ongoing that concern metal-based drugs or tools, such as chelation therapy, metal- and metabolite sensors, metallo-drugs and prodrugs, PET and MRI imaging agents,
    MeSH term(s) Chelating Agents/chemistry ; Serum ; Ligands ; Thumb ; Metals/metabolism ; Thermodynamics ; Coordination Complexes/chemistry ; Transferrin/metabolism ; Plasma/metabolism ; Ions/chemistry
    Chemical Substances Chelating Agents ; Ligands ; Metals ; Coordination Complexes ; Transferrin ; Ions
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d2dt03875g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Glutathione Protects other Cellular Thiols against Oxidation by Cu

    Doumi, Iman / Lang, Lukas / Vileno, Bertrand / Deponte, Marcel / Faller, Peter

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 21, Page(s) e202304212

    Abstract: Cu-thiosemicarbazones have been intensively investigated for their application in cancer therapy or as antimicrobials. Copper(II)-di-2-pyridylketone-4,4-dimethyl-thiosemicarbazone ( ... ...

    Abstract Cu-thiosemicarbazones have been intensively investigated for their application in cancer therapy or as antimicrobials. Copper(II)-di-2-pyridylketone-4,4-dimethyl-thiosemicarbazone (Cu
    MeSH term(s) Copper/metabolism ; Sulfhydryl Compounds ; Oxidation-Reduction ; Thiosemicarbazones ; Glutathione/metabolism ; Penicillamine/metabolism ; Acetylcysteine/metabolism
    Chemical Substances Copper (789U1901C5) ; di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone ; Sulfhydryl Compounds ; Thiosemicarbazones ; Glutathione (GAN16C9B8O) ; Penicillamine (GNN1DV99GX) ; Acetylcysteine (WYQ7N0BPYC)
    Language English
    Publishing date 2024-02-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202304212
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  3. Article ; Online: Impact of human serum albumin on Cu

    Martínez-Camarena, Álvaro / Sour, Angélique / Faller, Peter

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 38, Page(s) 13758–13768

    Abstract: The chelator diacetyl-bis( ...

    Abstract The chelator diacetyl-bis(
    MeSH term(s) Humans ; Coordination Complexes ; Organometallic Compounds/chemistry ; Diacetyl ; Serum Albumin, Human ; Ligands ; Zinc ; Thiosemicarbazones/chemistry ; Copper Radioisotopes ; Radiopharmaceuticals
    Chemical Substances Coordination Complexes ; Organometallic Compounds ; Diacetyl (K324J5K4HM) ; Serum Albumin, Human (ZIF514RVZR) ; Ligands ; Zinc (J41CSQ7QDS) ; Thiosemicarbazones ; Copper Radioisotopes ; Radiopharmaceuticals
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt02380j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Reproducibility Problems of Amyloid-β Self-Assembly and How to Deal With Them.

    Faller, Peter / Hureau, Christelle

    Frontiers in chemistry

    2021  Volume 8, Page(s) 611227

    Abstract: The self-assembly of peptides and proteins into amyloid fibrils and other aggregates are linked to several diseases. One of the most studied cases is the peptide amyloid-β (Aβ), found self-assembled in Alzheimer's disease patients' brains. In test tubes, ...

    Abstract The self-assembly of peptides and proteins into amyloid fibrils and other aggregates are linked to several diseases. One of the most studied cases is the peptide amyloid-β (Aβ), found self-assembled in Alzheimer's disease patients' brains. In test tubes, assays with chemically synthesized or recombinant Aβ are widely investigated to understand the aggregation process and to find modulators, which could be of therapeutic interest. Experience over more than a decade in our laboratory through discussions with colleagues, expertly studying the literature, and as reviewers revealed to us the widely encountered difficulty to control the aggregation and obtain reproducible results in the test tube. However, this issue is scarcely reported and discussed in the publications, which we think hampers strongly the progress in this field and can deceive newcomers. Here, we describe the difficulty and potential reasons to obtain reproducible aggregation data and propose some guidelines for working with it.
    Language English
    Publishing date 2021-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2020.611227
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  5. Article ; Online: Why the Ala-His-His Peptide Is an Appropriate Scaffold to Remove and Redox Silence Copper Ions from the Alzheimer's-Related Aβ Peptide.

    Gonzalez, Paulina / Sabater, Laurent / Mathieu, Emilie / Faller, Peter / Hureau, Christelle

    Biomolecules

    2022  Volume 12, Issue 10

    Abstract: The progressive, neurodegenerative Alzheimer's disease (AD) is the most widespread dementia. Due to the ageing of the population and the current lack of molecules able to prevent or stop the disease, AD will be even more impactful for society in the ... ...

    Abstract The progressive, neurodegenerative Alzheimer's disease (AD) is the most widespread dementia. Due to the ageing of the population and the current lack of molecules able to prevent or stop the disease, AD will be even more impactful for society in the future. AD is a multifactorial disease, and, among other factors, metal ions have been regarded as potential therapeutic targets. This is the case for the redox-competent Cu ions involved in the production of reactive oxygen species (ROS) when bound to the Alzheimer-related Aβ peptide, a process that contributes to the overall oxidative stress and inflammation observed in AD. Here, we made use of peptide ligands to stop the Cu(Aβ)-induced ROS production and we showed why the AHH sequence is fully appropriate, while the two parents, AH and AAH, are not. The AHH peptide keeps its beneficial ability against Cu(Aβ)-induced ROS, even in the presence of Zn<sup>II</sup>-competing ions and other biologically relevant ions. The detailed kinetic mechanism by which AHH could exert its action against Cu(Aβ)-induced ROS is also proposed.
    MeSH term(s) Humans ; Copper/chemistry ; Amyloid beta-Peptides/metabolism ; Reactive Oxygen Species/metabolism ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Ligands ; Oxidation-Reduction ; Ions
    Chemical Substances Copper (789U1901C5) ; Amyloid beta-Peptides ; Reactive Oxygen Species ; peptide I (141039-76-1) ; Ligands ; Ala-His-His ; Ions
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12101327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Derivatization of the Peptidic Xxx-Zzz-His Motif toward a Ligand with Attomolar Cu

    Zimmeter, Katharina / Vileno, Bertrand / Platas-Iglesias, Carlos / Vinjamuri, Bharath / Sour, Angélique / Faller, Peter

    Inorganic chemistry

    2023  Volume 62, Issue 24, Page(s) 9429–9439

    Abstract: Cu chelation in biological systems is of interest as a tool to study the metabolism of this essential metal or for applications in the case of diseases with a systemic or local Cu overload, such as Wilson's or Alzheimer's disease. The choice of the ... ...

    Abstract Cu chelation in biological systems is of interest as a tool to study the metabolism of this essential metal or for applications in the case of diseases with a systemic or local Cu overload, such as Wilson's or Alzheimer's disease. The choice of the chelating agent must meet several criteria. Among others, affinities and kinetics of metal binding and related metal selectivity are important parameters of the chelators to consider. Here, we report on the synthesis and characterization of Cu-binding properties of two ligands, L1 and L2, derivatives of the well-known peptidic Cu
    MeSH term(s) Humans ; Ligands ; Peptides/metabolism ; Oxidation-Reduction ; Chelating Agents/chemistry ; Amines ; Copper/chemistry
    Chemical Substances Ligands ; Peptides ; Chelating Agents ; Amines ; Copper (789U1901C5)
    Language English
    Publishing date 2023-06-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c00480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dual Role of Glutathione as a Reducing Agent and Cu-Ligand Governs the ROS Production by Anticancer Cu-Thiosemicarbazone Complexes.

    Ritacca, Alessandra G / Falcone, Enrico / Doumi, Iman / Vileno, Bertrand / Faller, Peter / Sicilia, Emilia

    Inorganic chemistry

    2023  Volume 62, Issue 9, Page(s) 3957–3964

    Abstract: α-Pyridyl thiosemicarbazones (TSC) such as Triapine (3AP) and Dp44mT are a promising class of anticancer agents. Contrary to Triapine, Dp44mT showed a pronounced synergism with ... ...

    Abstract α-Pyridyl thiosemicarbazones (TSC) such as Triapine (3AP) and Dp44mT are a promising class of anticancer agents. Contrary to Triapine, Dp44mT showed a pronounced synergism with Cu
    MeSH term(s) Reducing Agents ; Reactive Oxygen Species ; Ligands ; Thiosemicarbazones ; Antineoplastic Agents ; Glutathione ; Copper ; Cell Line, Tumor
    Chemical Substances Reducing Agents ; di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone ; 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (143621-35-6) ; Reactive Oxygen Species ; Ligands ; Thiosemicarbazones ; Antineoplastic Agents ; Glutathione (GAN16C9B8O) ; Copper (789U1901C5)
    Language English
    Publishing date 2023-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c04392
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  8. Article ; Online: Copper in Alzheimer disease: too much, too little, or misplaced?

    Faller, Peter

    Free radical biology & medicine

    2012  Volume 52, Issue 4, Page(s) 747–748

    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Animals ; Brain/metabolism ; Clioquinol/analogs & derivatives ; Clioquinol/pharmacology ; Clioquinol/therapeutic use ; Copper/deficiency ; Copper/metabolism ; Hepatolenticular Degeneration/metabolism ; Humans ; Menkes Kinky Hair Syndrome/metabolism
    Chemical Substances PBT2 compound ; Copper (789U1901C5) ; Clioquinol (7BHQ856EJ5)
    Language English
    Publishing date 2012-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2011.11.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: A luminescent ATCUN peptide variant with enhanced properties for copper(II) sensing in biological media.

    Falcone, Enrico / Vileno, Bertrand / Hoang, Mai / Raibaut, Laurent / Faller, Peter

    Journal of inorganic biochemistry

    2021  Volume 221, Page(s) 111478

    Abstract: The measurement of labile ... ...

    Abstract The measurement of labile Cu
    MeSH term(s) Amino Acid Motifs ; Chelating Agents/chemistry ; Copper/analysis ; Copper/chemistry ; Hydrogen-Ion Concentration ; Kinetics ; Limit of Detection ; Luminescence ; Luminescent Measurements ; Luminescent Proteins/chemistry ; Peptides/chemistry
    Chemical Substances Chelating Agents ; Luminescent Proteins ; Peptides ; Copper (789U1901C5)
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2021.111478
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    Zs.B 1730: Show issues Location:
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  10. Article ; Online: Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal-thiolate clusters.

    Faller, Peter

    The FEBS journal

    2010  Volume 277, Issue 14, Page(s) 2921–2930

    Abstract: Metallothionein-3, also called neuronal growth-inhibitory factor, is one of the four members of the mammalian metallothionein family, which in turn belongs to the metallothionein, a class of ubiquitously occurring low-molecular-weight cysteine- and metal- ...

    Abstract Metallothionein-3, also called neuronal growth-inhibitory factor, is one of the four members of the mammalian metallothionein family, which in turn belongs to the metallothionein, a class of ubiquitously occurring low-molecular-weight cysteine- and metal-rich proteins containing metal-thiolate clusters. Mammalian metallothioneins contain two metal-thiolate clusters of the type M(II)(3)-Cys(9) and M(II)(4)-Cys(11) [or Cu(I)(4)-CysS(6-9)]. Although metallothionein-3 shares these metal clusters with the well-characterized metallothionein-1 and metallothionein-2, it shows distinct biological, structural and chemical properties. This short review focuses on the recent developments regarding the chemistry of the metal clusters in metallothionein-3, in comparison to those in metallothionein-1 and metallothionein-2, and discusses the possible biological and functional implications.
    MeSH term(s) Animals ; Coordination Complexes/chemistry ; Humans ; Metals, Heavy/chemistry ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/metabolism
    Chemical Substances Coordination Complexes ; Metals, Heavy ; Nerve Tissue Proteins ; growth inhibitory factor
    Language English
    Publishing date 2010-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/j.1742-4658.2010.07717.x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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