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Book ; Online ; E-Book: Public mental health

Eaton, William W. / Fallin, M. Daniele

2019

Author's details	edited by William W. Eaton and M. Daniele Fallin
Keywords	Mental Disorders ; Public Health Practice ; Mental Health Services
Language	English
Size	1 Online-Ressource (xviii, 611 Seiten), Diagramme
Edition	Second edition
Publisher	Oxford University Press
Publishing place	New York, NY
Publishing country	United States
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020063731
ISBN	978-0-19-091662-6 ; 9780190916602 ; 9780190916619 ; 0-19-091662-1 ; 0190916605 ; 0190916613
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Creating Comprehensive Crisis Response Systems: An Opportunity to Build on The Promise of 988.

Fix, Rebecca L / Bandara, Sachini / Fallin, M Daniele / Barry, Colleen L

Community mental health journal

2022 Volume 59, Issue 2, Page(s) 205–208

Abstract: The implementation of a national suicide prevention hotline is imminent and will need to be supported by comprehensive crisis systems, which are currently rarely implemented in part due to their cost. In this Commentary paper we identify three core ... ...

Abstract	The implementation of a national suicide prevention hotline is imminent and will need to be supported by comprehensive crisis systems, which are currently rarely implemented in part due to their cost. In this Commentary paper we identify three core components of a high-functioning, integrated crisis service system. We identified regional crisis call centers, mobile response teams, and crisis receiving and stabilization centers as core components of an integrated crisis service system. We then outline how this approach has been used in Arizona. Building out these systems and sustainable funding models to support these systems is necessary to ensure that 988 implementation lives up to the promise of creating a lifeline to support services for individuals in crisis.
MeSH term(s)	Humans ; Hotlines ; Suicide Prevention ; Crisis Intervention
Language	English
Publishing date	2022-08-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	215855-3
ISSN	1573-2789 ; 0010-3853
ISSN (online)	1573-2789
ISSN	0010-3853
DOI	10.1007/s10597-022-01017-6
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Article: Exploring a Role for Parental Mental Health in Perception and Reports of Pain on Behalf of Children with Autism Spectrum Disorder.

Grosvenor, Luke P / Whitney, Daniel G / Volk, Heather E / Fallin, M Daniele

Autism research and treatment

2021 Volume 2021, Page(s) 2981383

Abstract: Children with autism spectrum disorder (ASD) have a higher prevalence of pain compared to those without ASD. Pain is a leading cause of morbidity and disability worldwide and may contribute to adverse health outcomes in people with ASD, thus warranting ... ...

Abstract	Children with autism spectrum disorder (ASD) have a higher prevalence of pain compared to those without ASD. Pain is a leading cause of morbidity and disability worldwide and may contribute to adverse health outcomes in people with ASD, thus warranting further research on this special population. The present study used data from 1,423 children with ASD and 46,023 children without ASD and their mothers from the combined 2016-2017 National Survey of Children's Health. Mothers reported child pain and ASD status and their own mental health status. Mothers reporting a status of "Fair or Poor" were considered as having maternal mental health conditions (MMHCs) for the purposes of this study. Children with and without ASD who had mothers with MMHCs had higher odds of pain compared to children with mothers without MMHCs. These increased odds did not attenuate as a result of controlling for co-occurring neurological conditions, which have been associated with increased pain in children with ASD. Thus, parent mental health may alter perception and/or reports of pain on behalf of children with and without ASD. Future research should include more detailed assessments of parent mental health and clinical assessments of children in order to explore the role of parent mental health in the experiences of pain and other symptoms present in children with ASD.
Language	English
Publishing date	2021-11-15
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2626622-2
ISSN	2090-1933 ; 2090-1925
ISSN (online)	2090-1933
ISSN	2090-1925
DOI	10.1155/2021/2981383
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Article ; Online: Differential Performance of Social Communication Questionnaire Items in African American/Black vs. White Children.

Dahl, Ethan / Moody, Eric J / Barger, Brian / Rosenberg, Steven / DiGuiseppi, Carolyn / Fallin, M Daniele / Lee, Li-Ching / Wiggins, Lisa

Journal of autism and developmental disorders

2023

Abstract: Screening for autism spectrum disorder (ASD) is an essential early step in the identification process and inaccurate screening may lead to significant delays in the onset of treatment. Past research has highlighted discrepancies in the performance of ASD ...

Abstract	Screening for autism spectrum disorder (ASD) is an essential early step in the identification process and inaccurate screening may lead to significant delays in the onset of treatment. Past research has highlighted discrepancies in the performance of ASD screening tools such as the Social Communication Questionnaire (SCQ) among certain racial and ethnic groups. The current study explored the functioning of the SCQ among African American/Black and White respondents based on item level performance on the measure. Differential Item Functioning (DIF) analyses showed that 16 (41%) items of the SCQ functioned differently for African American/Black respondents when compared to White respondents. Implications, such as the potential for delayed diagnosis and treatment, and the influence on downstream outcomes, are discussed.
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-023-05931-w
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Article: DNA methylation signatures as biomarkers of prior environmental exposures.

Ladd-Acosta, Christine / Fallin, M Daniele

Current epidemiology reports

2019 Volume 6, Issue 1, Page(s) 1–13

Abstract: Purpose of review: This review demonstrates the growing body of evidence connecting DNA methylation to prior exposure. It highlights the potential to use DNA methylation patterns as a feasible, stable, and accurate biomarker of past exposure, opening ... ...

Abstract	Purpose of review: This review demonstrates the growing body of evidence connecting DNA methylation to prior exposure. It highlights the potential to use DNA methylation patterns as a feasible, stable, and accurate biomarker of past exposure, opening new opportunities for environmental and gene-environment interaction studies among existing banked samples. Recent findings: We present the evidence for association between past exposure, including prenatal exposures, and DNA methylation measured at a later time in the life course. We demonstrate the potential utility of DNA methylation-based biomarkers of past exposure using results from multiple studies of smoking as an example. Multiple studies show the ability to accurately predict prenatal smoking exposure based on DNA methylation measured at birth, in childhood, and even adulthood. Separate sets of DNA methylation loci have been used to predict past personal smoking exposure (postnatal) as well. Further, it appears that these two types of exposures, prenatal and previous personal exposure, can be isolated from each other. There is also a suggestion that quantitative methylation scores may be useful for estimating dose. We highlight the remaining needs for rigor in methylation biomarker development including analytic challenges as well as the need for development across multiple developmental windows, multiple tissue types, and multiple ancestries. Summary: If fully developed, DNA methylation-based biomarkers can dramatically shift our ability to carry out environmental and genetic-environmental epidemiology using existing biobanks, opening up unprecedented opportunities for environmental health.
Language	English
Publishing date	2019-02-01
Publishing country	Switzerland
Document type	Journal Article
ISSN	2196-2995
ISSN	2196-2995
DOI	10.1007/s40471-019-0178-z
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Article ; Online: Exposure to air pollution is associated with DNA methylation changes in sperm.

Schrott, Rose / Feinberg, Jason I / Newschaffer, Craig J / Hertz-Picciotto, Irva / Croen, Lisa A / Fallin, M Daniele / Volk, Heather E / Ladd-Acosta, Christine / Feinberg, Andrew P

Environmental epigenetics

2024 Volume 10, Issue 1, Page(s) dvae003

Abstract: Exposure to air pollutants has been associated with adverse health outcomes in adults and children who were prenatally exposed. In addition to reducing exposure to air pollutants, it is important to identify their biologic targets in order to mitigate ... ...

Abstract	Exposure to air pollutants has been associated with adverse health outcomes in adults and children who were prenatally exposed. In addition to reducing exposure to air pollutants, it is important to identify their biologic targets in order to mitigate the health consequences of exposure. One molecular change associated with prenatal exposure to air pollutants is DNA methylation (DNAm), which has been associated with changes in placenta and cord blood tissues at birth. However, little is known about how air pollution exposure impacts the sperm epigenome, which could provide important insights into the mechanism of transmission to offspring. In the present study, we explored whether exposure to particulate matter less than 2.5 microns in diameter, particulate matter less than 10 microns in diameter, nitrogen dioxide (NO
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2831217-X
ISSN	2058-5888 ; 2058-5888
ISSN (online)	2058-5888
ISSN	2058-5888
DOI	10.1093/eep/dvae003
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Article ; Online: Invited Commentary: Is DNA Methylation an Actionable Mediator of Prenatal Exposure Effects on Child Health?

Ladd-Acosta, Christine / Fallin, M Daniele

American journal of epidemiology

2019 Volume 188, Issue 11, Page(s) 1887–1889

Abstract: A substantial body of literature has shown robust associations between prenatal smoking exposure and DNA methylation levels. The pattern of DNA methylation can be used as a molecular signature of past prenatal smoking exposure and might also provide ... ...

Abstract	A substantial body of literature has shown robust associations between prenatal smoking exposure and DNA methylation levels. The pattern of DNA methylation can be used as a molecular signature of past prenatal smoking exposure and might also provide mechanistic insights into associations between prenatal smoking exposure and adverse health outcomes. In this issue of the Journal, Cardenas et al. (Am J Epidemiol. 2019;188(11):1878-1886) evaluated whether DNA methylation mediates the association between prenatal smoking and low birth weight in a tissue that is mechanistically relevant to birth weight-the placenta-using formal mediation analyses. They found that methylation levels, at 5 loci, mediated smoking exposure effects on birth weight but only among children whose mothers smoked during pregnancy. Given the use of formal mediation methods and measurement in a mechanistically relevant tissue, this work has the potential to inform novel directions for intervention. Replication of these findings in larger and more racially and ethnically diverse samples, repeated measures to better tease apart the timing of DNA methylation changes with respect to exposure and birth weight, and continued use of intervention-focused mediation methods are needed before the impact of these findings will be fully realized.
MeSH term(s)	Birth Weight/genetics ; Child ; Child Health ; DNA Methylation ; Female ; Humans ; Placenta ; Pregnancy ; Prenatal Exposure Delayed Effects ; Smoking
Language	English
Publishing date	2019-10-23
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/aje/kwz182
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Article ; Online: Gestational thyroid hormones and autism-related traits in the EARLI and HOME studies.

Zhong, Caichen / Rando, Juliette / Patti, Marisa A / Braun, Joseph M / Chen, Aimin / Xu, Yingying / Lanphear, Bruce P / Yolton, Kimberly / Croen, Lisa A / Fallin, M Daniele / Hertz-Picciotto, Irva / Newschaffer, Craig J / Lyall, Kristen

Autism research : official journal of the International Society for Autism Research

2024 Volume 17, Issue 4, Page(s) 716–727

Abstract: Thyroid hormones are essential for neurodevelopment. Few studies have considered associations with quantitatively measured autism spectrum disorder (ASD)-related traits, which may help elucidate associations for a broader population. Participants were ... ...

Abstract	Thyroid hormones are essential for neurodevelopment. Few studies have considered associations with quantitatively measured autism spectrum disorder (ASD)-related traits, which may help elucidate associations for a broader population. Participants were drawn from two prospective pregnancy cohorts: the Early Autism Risk Longitudinal Investigation (EARLI), enrolling pregnant women who already had a child with ASD, and the Health Outcomes and Measures of the Environment (HOME) Study, following pregnant women from the greater Cincinnati, OH area. Gestational thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured in mid-pregnancy 16 (±3) weeks gestation serum samples. ASD-related traits were measured using the Social Responsiveness Scale (SRS) at ages 3-8 years. The association was examined using quantile regression, adjusting for maternal and sociodemographic factors. 278 participants (132 from EARLI, 146 from HOME) were included. TSH distributions were similar across cohorts, while FT4 levels were higher in EARLI compared to HOME. In pooled analyses, particularly for those in the highest SRS quantile (95th percentile), higher FT4 levels were associated with increasing SRS scores (β = 5.21, 95% CI = 0.93, 9.48), and higher TSH levels were associated with decreasing SRS scores (β = -6.94, 95% CI = -11.04, -2.83). The association between TSH and SRS remained significant in HOME for the 95% percentile of SRS scores (β = -6.48, 95% CI = -12.16, -0.80), but not EARLI. Results for FT4 were attenuated when examined in the individual cohorts. Our results add to evidence that gestational thyroid hormones may be associated with ASD-related outcomes by suggesting that relationships may differ across the distribution of ASD-related traits and by familial likelihood of ASD.
MeSH term(s)	Child ; Humans ; Female ; Pregnancy ; Autism Spectrum Disorder ; Prospective Studies ; Autistic Disorder ; Thyroid Hormones ; Thyrotropin
Chemical Substances	Thyroid Hormones ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2481338-2
ISSN	1939-3806 ; 1939-3792
ISSN (online)	1939-3806
ISSN	1939-3792
DOI	10.1002/aur.3115
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Article ; Online: Gastrointestinal concerns in children with autism spectrum disorder: A qualitative study of family experiences.

Holingue, Calliope / Poku, Ohemaa / Pfeiffer, Danika / Murray, Sarah / Fallin, M Daniele

Autism : the international journal of research and practice

2021 Volume 26, Issue 7, Page(s) 1698–1711

Abstract: Lay abstract: Gastrointestinal problems are common in the autism spectrum disorder community and may affect both the person with autism spectrum disorder and their families. However, little research is available on the experiences of families who have a ...

Abstract	Lay abstract: Gastrointestinal problems are common in the autism spectrum disorder community and may affect both the person with autism spectrum disorder and their families. However, little research is available on the experiences of families who have a child with both autism spectrum disorder and gastrointestinal symptoms. We held one-on-one interviews with 12 parents of children who had both autism spectrum disorder and gastrointestinal symptoms. We analyzed the raw text responses from these interviews and identified four main themes. First, parents shared that their children had trouble verbally communicating when they were experiencing gastrointestinal symptoms (Theme 1). This led parents to use bodily signs, such as changes in the stool, and non-verbal behaviors, such as irritability, to recognize when their child was having gastrointestinal symptoms. Next, gastrointestinal issues affected both the child's well-being and their ability to attend class and extracurricular or social activities (Theme 2). The gastrointestinal issues also affected the family's routines, overall well-being, and their ability to go out and do activities together as a family (Theme 3). Finally, parents often had challenges receiving accessible and quality healthcare for their child's gastrointestinal problems (Theme 4). Together, these findings highlight the enormous burden that gastrointestinal symptoms have on the wellness of children with autism spectrum disorder and their families.
MeSH term(s)	Autism Spectrum Disorder/complications ; Child ; Family ; Gastrointestinal Diseases ; Humans ; Parents ; Qualitative Research
Language	English
Publishing date	2021-12-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1338513-6
ISSN	1461-7005 ; 1362-3613
ISSN (online)	1461-7005
ISSN	1362-3613
DOI	10.1177/13623613211062667
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Article ; Online: Genetics in epidemiology.

Fallin, M Daniele

Epidemiology (Cambridge, Mass.)

2010 Volume 21, Issue 5, Page(s) 595–596

MeSH term(s)	Genetic Predisposition to Disease/epidemiology ; Genetics, Population ; Humans
Language	English
Publishing date	2010-09
Publishing country	United States
Document type	Editorial
ZDB-ID	1053263-8
ISSN	1531-5487 ; 1044-3983
ISSN (online)	1531-5487
ISSN	1044-3983
DOI	10.1097/EDE.0b013e3181ea5f9d
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