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  1. Book ; Thesis: Die molekulare Genetik einer Insertions-Mutation bei transgenen Ratten der Linie TgN1273

    Falter, Claudia

    2000  

    Language German
    Size 163 Bl., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2000 (Nicht für den Austausch)
    HBZ-ID HT013067631
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 E 2016 order for loan Magazin

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  2. Article ; Online: A resource of human coronavirus protein-coding sequences in a flexible, multipurpose Gateway Entry clone collection.

    Weller, Benjamin / Lin, Chung-Wen / Pogoutse, Oxana / Sauer, Mayra / Marin-de la Rosa, Nora / Strobel, Alexandra / Young, Veronika / Knapp, Jennifer J / Rayhan, Ashyad / Falter, Claudia / Kim, Dae-Kyum / Roth, Frederick P / Falter-Braun, Pascal

    G3 (Bethesda, Md.)

    2023  Volume 13, Issue 7

    Abstract: The COVID-19 pandemic has catalyzed unprecedented scientific data and reagent sharing and collaboration, which enabled understanding the virology of the SARS-CoV-2 virus and vaccine development at record speed. The pandemic, however, has also raised ... ...

    Abstract The COVID-19 pandemic has catalyzed unprecedented scientific data and reagent sharing and collaboration, which enabled understanding the virology of the SARS-CoV-2 virus and vaccine development at record speed. The pandemic, however, has also raised awareness of the danger posed by the family of coronaviruses, of which 7 are known to infect humans and dozens have been identified in reservoir species, such as bats, rodents, or livestock. To facilitate understanding the commonalities and specifics of coronavirus infections and aspects of viral biology that determine their level of lethality to the human host, we have generated a collection of freely available clones encoding nearly all human coronavirus proteins known to date. We hope that this flexible, Gateway-compatible vector collection will encourage further research into the interactions of coronaviruses with their human host, to increase preparedness for future zoonotic viral outbreaks.
    MeSH term(s) Humans ; COVID-19/epidemiology ; SARS-CoV-2/genetics ; Pandemics
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkad105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High-Quality Yeast-2-Hybrid Interaction Network Mapping.

    Altmann, Melina / Altmann, Stefan / Falter, Claudia / Falter-Braun, Pascal

    Current protocols in plant biology

    2018  Volume 3, Issue 3, Page(s) e20067

    Abstract: In this article, we describe a Y2H interaction mapping protocol for systematically screening medium-to-large collections of open reading frames (ORFs) against each other. The protocol is well suited for analysis of focused networks, for modules of ... ...

    Abstract In this article, we describe a Y2H interaction mapping protocol for systematically screening medium-to-large collections of open reading frames (ORFs) against each other. The protocol is well suited for analysis of focused networks, for modules of interest, assembling genome-scale interactome maps, and investigating host-microbe interactions. The four-step high-throughput protocol has a demonstrated low false-discovery rate that is essential for producing meaningful network maps. Following the assembly of yeast expression clones from an existing ORFeome collection, we describe in detail the four-step procedure that begins with the primary screen using minipools, followed by secondary verification of primary positives, identification of candidate interaction pairs by sequencing, and a final verification step using fresh inoculants. In addition to this core protocol, aspects of network mapping and quality control will be discussed briefly. © 2018 by John Wiley & Sons, Inc.
    MeSH term(s) Open Reading Frames ; Saccharomyces cerevisiae ; Two-Hybrid System Techniques
    Language English
    Publishing date 2018-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2379-8068
    ISSN (online) 2379-8068
    DOI 10.1002/cppb.20067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Conference proceedings: German Conference on Bioinformatics, GCB 2007

    Falter, Claudia / Schliep, Alexander / Selbig, Joachim / Vingron, Martin / Walther, Dirk

    26.-28.09.2007 in Potsdam, Germany

    (GI-Edition : Proceedings ; 115)

    2007  

    Institution German Conference on Bioinformatics
    Event/congress GCB (2007.09.26-28, Potsdam) ; German Conference on Bioinformatics (2007.09.26-28, Potsdam)
    Author's details Claudia Falter, Alexander Schliep, Joachim Selbig, Martin Vingron, Dirk Walther (eds.)
    Series title GI-Edition : Proceedings ; 115
    Language English
    Size 199 S., Ill., graph. Darst.
    Publisher Ges. für Informatik
    Publishing place Bonn
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 3885792095 ; 9783885792093
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article: Sicherung der Qualität von Beratungsprozessen in kleinen und mittleren Unternehmen

    Kailer, Norbert / Falter, Claudia

    Personalwirtschaft und Organisationskonzepte moderner Betriebe : IAB-Kontaktseminar vom 11. bis 15.12.2000 am Institut für Arbeitswissenschaft der Ruhr-Universität Bochum , p. 185-209

    2001  , Page(s) 185–209

    Author's details Norbert Kailer; Claudia Falter
    Keywords KMU ; Unternehmensberatung ; Organisationsberatung ; Dienstleistungsqualität ; Beziehungsmarketing ; Qualitätsmanagement ; Deutschland
    Language German
    Size graph. Darst
    Publisher Inst. für Arbeitsmarkt- und Berufsforschung der Bundesanst. für Arbeit
    Publishing place Nürnberg
    Document type Article
    Note Literaturangaben
    Database ECONomics Information System

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  6. Book: Betriebliche Kompetenzentwicklung in Kooperation von Hochschulen und Wirtschaft

    Falter, Claudia / Gahleitner, Claudia / Stockinger, Alexander / Thum-Kraft, Monika / Wöss, Lydia

    Erhebung von Kooperationsfeldern und -formen, Analyse der Angebots- und Nachfragestruktur, Defizitanalyse und Gestaltungsempfehlungen

    (Ibw-Schriftenreihe ; 136)

    2007  

    Author's details Monika Thum-Kraft; Claudia Falter; Claudia Gahleitner; Alexander Stockinger; Lydia Wöss. [Hrsg.: ibw, Institut für Bildungsforschung der Wirtschaft]
    Series title Ibw-Schriftenreihe ; 136
    Keywords Kooperation ; Unternehmen ; Hochschule ; Humanvermögen ; Personalentwicklung ; Betriebliche Fortbildung ; Betriebliches Bildungsmanagement ; Österreich
    Language German
    Size 159 S., graph. Darst., 24 cm
    Document type Book
    ISBN 3902358408 ; 9783902358400
    Database ECONomics Information System

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  7. Article ; Online: A proteome-scale map of the SARS-CoV-2-human contactome.

    Kim, Dae-Kyum / Weller, Benjamin / Lin, Chung-Wen / Sheykhkarimli, Dayag / Knapp, Jennifer J / Dugied, Guillaume / Zanzoni, Andreas / Pons, Carles / Tofaute, Marie J / Maseko, Sibusiso B / Spirohn, Kerstin / Laval, Florent / Lambourne, Luke / Kishore, Nishka / Rayhan, Ashyad / Sauer, Mayra / Young, Veronika / Halder, Hridi / la Rosa, Nora Marín-de /
    Pogoutse, Oxana / Strobel, Alexandra / Schwehn, Patrick / Li, Roujia / Rothballer, Simin T / Altmann, Melina / Cassonnet, Patricia / Coté, Atina G / Vergara, Lena Elorduy / Hazelwood, Isaiah / Liu, Betty B / Nguyen, Maria / Pandiarajan, Ramakrishnan / Dohai, Bushra / Coloma, Patricia A Rodriguez / Poirson, Juline / Giuliana, Paolo / Willems, Luc / Taipale, Mikko / Jacob, Yves / Hao, Tong / Hill, David E / Brun, Christine / Twizere, Jean-Claude / Krappmann, Daniel / Heinig, Matthias / Falter, Claudia / Aloy, Patrick / Demeret, Caroline / Vidal, Marc / Calderwood, Michael A / Roth, Frederick P / Falter-Braun, Pascal

    Nature biotechnology

    2022  Volume 41, Issue 1, Page(s) 140–149

    Abstract: Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity to efficiently design therapies for emerging virus variants remains an urgent challenge of the ongoing pandemic. Infection and immune reactions are mediated by direct ... ...

    Abstract Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity to efficiently design therapies for emerging virus variants remains an urgent challenge of the ongoing pandemic. Infection and immune reactions are mediated by direct contacts between viral molecules and the host proteome, and the vast majority of these virus-host contacts (the 'contactome') have not been identified. Here, we present a systematic contactome map of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with the human host encompassing more than 200 binary virus-host and intraviral protein-protein interactions. We find that host proteins genetically associated with comorbidities of severe illness and long COVID are enriched in SARS-CoV-2 targeted network communities. Evaluating contactome-derived hypotheses, we demonstrate that viral NSP14 activates nuclear factor κB (NF-κB)-dependent transcription, even in the presence of cytokine signaling. Moreover, for several tested host proteins, genetic knock-down substantially reduces viral replication. Additionally, we show for USP25 that this effect is phenocopied by the small-molecule inhibitor AZ1. Our results connect viral proteins to human genetic architecture for COVID-19 severity and offer potential therapeutic targets.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19/genetics ; Proteome/genetics ; Post-Acute COVID-19 Syndrome ; Virus Replication/genetics ; Ubiquitin Thiolesterase/pharmacology
    Chemical Substances Proteome ; USP25 protein, human ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-022-01475-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2167: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Publisher Correction: Extensive signal integration by the phytohormone protein network.

    Altmann, Melina / Altmann, Stefan / Rodriguez, Patricia A / Weller, Benjamin / Vergara, Lena Elorduy / Palme, Julius / la Rosa, Nora Marín-de / Sauer, Mayra / Wenig, Marion / Villaécija-Aguilar, José Antonio / Sales, Jennifer / Lin, Chung-Wen / Pandiarajan, Ramakrishnan / Young, Veronika / Strobel, Alexandra / Gross, Lisa / Carbonnel, Samy / Kugler, Karl G / Garcia-Molina, Antoni /
    Bassel, George W / Falter, Claudia / Mayer, Klaus F X / Gutjahr, Caroline / Vlot, A Corina / Grill, Erwin / Falter-Braun, Pascal

    Nature

    2020  Volume 584, Issue 7821, Page(s) E34

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-020-2585-1
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    Zs.A 26: Show issues Location:
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  9. Article ; Online: Extensive signal integration by the phytohormone protein network.

    Altmann, Melina / Altmann, Stefan / Rodriguez, Patricia A / Weller, Benjamin / Elorduy Vergara, Lena / Palme, Julius / Marín-de la Rosa, Nora / Sauer, Mayra / Wenig, Marion / Villaécija-Aguilar, José Antonio / Sales, Jennifer / Lin, Chung-Wen / Pandiarajan, Ramakrishnan / Young, Veronika / Strobel, Alexandra / Gross, Lisa / Carbonnel, Samy / Kugler, Karl G / Garcia-Molina, Antoni /
    Bassel, George W / Falter, Claudia / Mayer, Klaus F X / Gutjahr, Caroline / Vlot, A Corina / Grill, Erwin / Falter-Braun, Pascal

    Nature

    2020  Volume 583, Issue 7815, Page(s) 271–276

    Abstract: Plant hormones coordinate responses to environmental cues with developmental ... ...

    Abstract Plant hormones coordinate responses to environmental cues with developmental programs
    MeSH term(s) Arabidopsis/genetics ; Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Plant Growth Regulators/metabolism ; Protein Binding ; Protein Interaction Mapping ; Protein Interaction Maps ; Reproducibility of Results ; Signal Transduction ; Transcription, Genetic
    Chemical Substances Arabidopsis Proteins ; Plant Growth Regulators
    Language English
    Publishing date 2020-07-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-020-2460-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Publisher Correction: Extensive signal integration by the phytohormone protein network

    Altmann, Melina / Altmann, Stefan / Rodriguez, Patricia A / Weller, Benjamin / Vergara, Lena Elorduy / Palme, Julius / la Rosa, Nora Marín-de / Sauer, Mayra / Wenig, Marion / Villaécija-Aguilar, José Antonio / Sales, Jennifer / Lin, Chung-Wen / Pandiarajan, Ramakrishnan / Young, Veronika / Strobel, Alexandra / Gross, Lisa / Carbonnel, Samy / Kugler, Karl G / Garcia-Molina, Antoni /
    Bassel, George W / Falter, Claudia / Mayer, Klaus F X / Gutjahr, Caroline / Vlot, A Corina / Grill, Erwin / Falter-Braun, Pascal

    Nature (Lond.)

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32724209
    Database COVID19

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