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  1. Article: Retrospective Comparison of Appropriate Statin Use Between Patients With Diabetes in the Primary Care Setting Managed by Pharmacists or Internal Medicine Providers.

    Huff, Jamie M / Falter, Rebecca A / Scheinberg, Nataliya

    Diabetes spectrum : a publication of the American Diabetes Association

    2019  Volume 32, Issue 4, Page(s) 349–354

    Abstract: Objective: The purpose of this study was to compare statin prescribing practices according to the American Diabetes Association's : Design and methods: A retrospective observational study was completed using the electronic health record of a ... ...

    Abstract Objective: The purpose of this study was to compare statin prescribing practices according to the American Diabetes Association's
    Design and methods: A retrospective observational study was completed using the electronic health record of a multispecialty private practice. A total of 176 patients were included in the study, with 88 each in the pharmacy and internal medicine groups. Patients were ≥40 years of age with diabetes and managed by an internal medicine provider or a pharmacist between January and December 2017. Descriptive statistics, χ
    Results: More pharmacy than internal medicine patients were prescribed appropriate statin therapy (47.7 vs. 34.1%,
    Conclusion: Although there were no overall significant differences in statin prescribing between the pharmacy and internal medicine groups, patients needing high-intensity statins, those who were female, and those who were younger were more likely to receive appropriate therapy when managed by a pharmacist. Appropriate statin prescribing remains low among diabetes patients, and optimization of this therapy should be prioritized.
    Language English
    Publishing date 2019-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211544-4
    ISSN 1040-9165
    ISSN 1040-9165
    DOI 10.2337/ds18-0067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of modified team-based learning activities on student performance on therapeutic assessments.

    Falter, Rebecca A / Ealey, Megan R / Carroll, Kacey A

    Currents in pharmacy teaching & learning

    2018  Volume 10, Issue 8, Page(s) 1097–1103

    Abstract: Background and purpose: To determine if changing the focus of team-based learning (TBL) grading from written to verbal responses impacted students' exam performance in those subjects and to assess student perception of utilization of course time.: ... ...

    Abstract Background and purpose: To determine if changing the focus of team-based learning (TBL) grading from written to verbal responses impacted students' exam performance in those subjects and to assess student perception of utilization of course time.
    Educational activity and setting: Assessment data from two consecutive respiratory therapeutics semesters was analyzed. These were the classes immediately before and after the TBL structural change. All data were de-identified, and student performance was assessed based on exam scores in each major subject that was covered by a TBL activity. Letter grades and student course evaluations were also compared.
    Findings: One hundred fifty-two students were assessed. There was no significant difference in overall course grades between semesters. There was improvement in exam scores for allergic rhinitis and chronic obstructive pulmonary disease (p = 0.001) and a decrease in exam scores for respiratory devices (p = 0.03). Total exam scores and other therapeutic topic scores demonstrated no differences. Student satisfaction in regard to having sufficient course time improved (p = 0.016).
    Discussion: Overall, students performed equally well in the class when removing the graded written portion of the TBL activity. There was also a trend towards improved student satisfaction after this modification.
    Summary: The change in TBL grading was successful in improving students' perceptions of the course without impacting their overall course grades, demonstrating that the TBL structure can be altered without losing the positive learning outcomes.
    MeSH term(s) Curriculum/standards ; Educational Measurement/methods ; Educational Status ; Humans ; Needs Assessment/standards ; Patient Care Team/standards ; Program Evaluation/methods ; Students, Pharmacy/statistics & numerical data
    Language English
    Publishing date 2018-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2515217-8
    ISSN 1877-1300 ; 1877-1297
    ISSN (online) 1877-1300
    ISSN 1877-1297
    DOI 10.1016/j.cptl.2018.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Benefits of a teaching certificate program for pharmacy residents.

    Falter, Rebecca A / Arrendale, Justin R

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2009  Volume 66, Issue 21, Page(s) 1905–1906

    MeSH term(s) Certification ; Education, Pharmacy, Graduate/organization & administration ; Education, Pharmacy, Graduate/standards ; Humans ; Internship, Nonmedical/organization & administration ; Internship, Nonmedical/standards ; Program Evaluation ; Teaching/standards
    Language English
    Publishing date 2009-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.2146/ajhp080649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Boosting NAD

    Gardell, Stephen J / Hopf, Meghan / Khan, Asima / Dispagna, Mauro / Hampton Sessions, E / Falter, Rebecca / Kapoor, Nidhi / Brooks, Jeanne / Culver, Jeffrey / Petucci, Chris / Ma, Chen-Ting / Cohen, Steven E / Tanaka, Jun / Burgos, Emmanuel S / Hirschi, Jennifer S / Smith, Steven R / Sergienko, Eduard / Pinkerton, Anthony B

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 3241

    Abstract: Pharmacological strategies that boost intracellular ... ...

    Abstract Pharmacological strategies that boost intracellular NAD
    MeSH term(s) A549 Cells ; Animals ; Biocatalysis/drug effects ; Enzyme Activators/administration & dosage ; Enzyme Activators/chemistry ; Enzyme Activators/pharmacology ; Humans ; Intracellular Space/drug effects ; Intracellular Space/metabolism ; Liver/drug effects ; Liver/metabolism ; Mice ; Molecular Structure ; NAD/metabolism ; Nicotinamide Mononucleotide/metabolism ; Nicotinamide Phosphoribosyltransferase/metabolism ; Phosphorylation/drug effects ; Small Molecule Libraries/administration & dosage ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology
    Chemical Substances Enzyme Activators ; Small Molecule Libraries ; NAD (0U46U6E8UK) ; Nicotinamide Mononucleotide (1094-61-7) ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12)
    Language English
    Publishing date 2019-07-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-11078-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A service learning program in providing nutrition education to children.

    Falter, Rebecca A / Pignotti-Dumas, Karla / Popish, Sarah J / Petrelli, Heather M W / Best, Mark A / Wilkinson, Julie J

    American journal of pharmaceutical education

    2011  Volume 75, Issue 5, Page(s) 85

    Abstract: Objective: To implement a service learning program in nutrition and assess its impact on pharmacy students' communication skills and professionalism and elementary school children's knowledge of nutrition concepts.: Design: First-year pharmacy ... ...

    Abstract Objective: To implement a service learning program in nutrition and assess its impact on pharmacy students' communication skills and professionalism and elementary school children's knowledge of nutrition concepts.
    Design: First-year pharmacy students completed 4 nutrition education sessions led by a registered dietitian and then presented the material to pre-selected classes of at-risk elementary school children in kindergarten through third grade.
    Assessment: Ninety-six pharmacy students completed the pre- and post-experience survey and more than 90% rated achievement of course objectives as strongly agree or agree. Four hundred sixty-eight elementary students completed a pre- and posttest on nutrition knowledge. Significant improvement was found in all grade levels on the knowledge test.
    Conclusion: This service learning experience was beneficial for the elementary school children and pharmacy students, enhancing the knowledge of both groups and establishing a positive relationship between the pharmacy school and the community.
    MeSH term(s) Child ; Child Nutrition Sciences/education ; Clinical Competence ; Communication ; Curriculum ; Dietetics/methods ; Education, Pharmacy/methods ; Health Education/methods ; Health Knowledge, Attitudes, Practice ; Humans ; Program Development ; Program Evaluation ; Students, Pharmacy
    Language English
    Publishing date 2011-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603807-4
    ISSN 1553-6467 ; 0002-9459
    ISSN (online) 1553-6467
    ISSN 0002-9459
    DOI 10.5688/ajpe75585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization.

    McAnally, Danielle / Siddiquee, Khandaker / Gomaa, Ahmed / Szabo, Andras / Vasile, Stefan / Maloney, Patrick R / Divlianska, Daniela B / Peddibhotla, Satyamaheshwar / Morfa, Camilo J / Hershberger, Paul / Falter, Rebecca / Williamson, Robert / Terry, David B / Farjo, Rafal / Pinkerton, Anthony B / Qi, Xiaping / Quigley, Judith / Boulton, Michael E / Grant, Maria B /
    Smith, Layton H

    PloS one

    2018  Volume 13, Issue 9, Page(s) e0202436

    Abstract: Neovascularization is the pathological driver of blinding eye diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and wet age-related macular degeneration. The loss of vision resulting from these diseases significantly ... ...

    Abstract Neovascularization is the pathological driver of blinding eye diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and wet age-related macular degeneration. The loss of vision resulting from these diseases significantly impacts the productivity and quality of life of patients, and represents a substantial burden on the health care system. Current standard of care includes biologics that target vascular endothelial growth factor (VEGF), a key mediator of neovascularization. While anti-VGEF therapies have been successful, up to 30% of patients are non-responsive. Therefore, there is a need for new therapeutic targets, and small molecule inhibitors of angiogenesis to complement existing treatments. Apelin and its receptor have recently been shown to play a key role in both developmental and pathological angiogenesis in the eye. Through a cell-based high-throughput screen, we identified 4-aminoquinoline antimalarial drugs as potent selective antagonists of APJ. The prototypical 4-aminoquinoline, amodiaquine was found to be a selective, non-competitive APJ antagonist that inhibited apelin signaling in a concentration-dependent manner. Additionally, amodiaquine suppressed both apelin-and VGEF-induced endothelial tube formation. Intravitreal amodaiquine significantly reduced choroidal neovascularization (CNV) lesion volume in the laser-induced CNV mouse model, and showed no signs of ocular toxicity at the highest doses tested. This work firmly establishes APJ as a novel, chemically tractable therapeutic target for the treatment of ocular neovascularization, and that amodiaquine is a potential candidate for repurposing and further toxicological, and pharmacokinetic evaluation in the clinic.
    MeSH term(s) Aminoquinolines/chemistry ; Aminoquinolines/pharmacokinetics ; Aminoquinolines/therapeutic use ; Angiogenesis Inhibitors/chemistry ; Angiogenesis Inhibitors/pharmacology ; Angiogenesis Inhibitors/therapeutic use ; Animals ; Antimalarials/chemistry ; Antimalarials/pharmacokinetics ; Antimalarials/therapeutic use ; Apelin/metabolism ; Apelin Receptors/antagonists & inhibitors ; Apelin Receptors/metabolism ; Cell Line ; Cell Proliferation/drug effects ; Choroidal Neovascularization/drug therapy ; Choroidal Neovascularization/pathology ; Disease Models, Animal ; Drug Repositioning ; Female ; Humans ; Lasers ; Mice ; Mice, Inbred C57BL ; Retinal Neovascularization/drug therapy ; Retinal Neovascularization/pathology ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/therapeutic use ; Tissue Distribution ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Aminoquinolines ; Angiogenesis Inhibitors ; Antimalarials ; Apelin ; Apelin Receptors ; Small Molecule Libraries ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2018-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0202436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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