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Book ; Online ; E-Book: Handbook of HER2-targeted agents in breast cancer

Alvarez, Ricardo / Cortes, Javier / Falzon, Mary / Gianni, Luca / Harbeck, Nadia / Piccart, Martine

2016

Author's details	Ricardo H. Alvarez, Javier Cortés, Mary Falzon, Michael Gandy, Luca Gianni, Nadia Harbeck, Martine Piccart
Keywords	Breast Neoplasms / drug therapy ; Breast Neoplasms / genetics ; Genes, erbB-2 ; Gene Targeting ; Breast cancer ; Cancer ; HER2 ; HER2-positive ; Oncology ; Pertuzumab ; Trastuzumab
Subject code	610
Language	English
Size	1 Online-Ressource (110 Seiten), Illustrationen
Edition	Second edition
Publisher	Springer
Publishing place	Cham
Publishing country	Germany
Document type	Book ; Online ; E-Book
Note	Lizenzpflichtig
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019455877
ISBN	978-3-319-28216-9 ; 9783319282145 ; 3-319-28216-6 ; 331928214X
DOI	10.1007/978-3-319-28216-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Spindle cell tumour with thymus-like differentiation (SETTLE) on fine needle aspiration cytology: A case report highlighting diagnostic pitfalls.

Adegun, Oluyori K / Proctor, Ian / Falzon, Mary / Pomplun, Sabine

Diagnostic cytopathology

2021 Volume 49, Issue 8, Page(s) E325–E328

Abstract: A 7-year-old girl presented with a painless neck swelling localised near the left lobe of the thyroid gland, which was initially investigated by fine needle aspiration cytology. This raised a differential diagnosis of medullary thyroid carcinoma and ... ...

Abstract	A 7-year-old girl presented with a painless neck swelling localised near the left lobe of the thyroid gland, which was initially investigated by fine needle aspiration cytology. This raised a differential diagnosis of medullary thyroid carcinoma and small round blue cell tumour. Only after several additional clinical investigations and a total thyroidectomy was a definitive diagnosis of spindle cell tumour with thymus-like differentiation (SETTLE) reached. This case report highlights how contemporaneous clinical and investigation findings made arriving at a definitive diagnosis challenging, contributed to diagnostic delay, and ultimately influenced choice of treatment.
MeSH term(s)	Biopsy, Fine-Needle ; Carcinoma, Neuroendocrine/diagnosis ; Carcinoma, Neuroendocrine/pathology ; Child ; Cytodiagnosis ; Delayed Diagnosis ; Diagnosis, Differential ; Female ; Humans ; Neoplasms, Glandular and Epithelial/diagnosis ; Neoplasms, Glandular and Epithelial/pathology ; Sarcoma/diagnosis ; Sarcoma/pathology ; Thyroid Gland/pathology ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/pathology
Language	English
Publishing date	2021-04-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	632710-2
ISSN	1097-0339 ; 8755-1039
ISSN (online)	1097-0339
ISSN	8755-1039
DOI	10.1002/dc.24744
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Article ; Online: TTF-1 positive breast cancer: a cautionary tale.

Ellery, Peter / Archard, Nicholas / Saetta, Ally / Gandy, Michael / Falzon, Mary

Journal of clinical pathology

2015 Volume 68, Issue 8, Page(s) 665–666

MeSH term(s)	Aged ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biopsy ; Carcinoma, Ductal, Breast/chemistry ; Carcinoma, Ductal, Breast/genetics ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/therapy ; Carcinoma, Intraductal, Noninfiltrating/chemistry ; Carcinoma, Intraductal, Noninfiltrating/genetics ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Intraductal, Noninfiltrating/therapy ; Diagnosis, Differential ; Diagnostic Errors/prevention & control ; Female ; Humans ; Immunohistochemistry ; Neoplasm Grading ; Nuclear Proteins/analysis ; Predictive Value of Tests ; Thyroid Nuclear Factor 1 ; Transcription Factors/analysis ; Triple Negative Breast Neoplasms/chemistry ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/pathology ; Triple Negative Breast Neoplasms/therapy
Chemical Substances	Biomarkers, Tumor ; NKX2-1 protein, human ; Nuclear Proteins ; Thyroid Nuclear Factor 1 ; Transcription Factors
Language	English
Publishing date	2015-08
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80261-x
ISSN	1472-4146 ; 0021-9746
ISSN (online)	1472-4146
ISSN	0021-9746
DOI	10.1136/jclinpath-2015-202998
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Article ; Online: BAP1 and YY1 regulate expression of death receptors in malignant pleural mesothelioma.

Ishii, Yuki / Kolluri, Krishna K / Pennycuick, Adam / Zhang, Xidan / Nigro, Ersilia / Alrifai, Doraid / Borg, Elaine / Falzon, Mary / Shah, Khalid / Kumar, Neelam / Janes, Sam M

The Journal of biological chemistry

2021 Volume 297, Issue 5, Page(s) 101223

Abstract: Malignant pleural mesothelioma (MPM) is a rare, aggressive, and incurable cancer arising from the mesothelial lining of the pleura, with few available treatment options. We recently reported that loss of function of the nuclear deubiquitinase BRCA1- ... ...

Abstract	Malignant pleural mesothelioma (MPM) is a rare, aggressive, and incurable cancer arising from the mesothelial lining of the pleura, with few available treatment options. We recently reported that loss of function of the nuclear deubiquitinase BRCA1-associated protein 1 (BAP1), a frequent event in MPM, is associated with sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. As a potential underlying mechanism, here we report that BAP1 negatively regulates the expression of TRAIL receptors: death receptor 4 (DR4) and death receptor 5 (DR5). Using tissue microarrays of tumor samples from MPM patients, we found a strong inverse correlation between BAP1 and TRAIL receptor expression. BAP1 knockdown increased DR4 and DR5 expression, whereas overexpression of BAP1 had the opposite effect. Reporter assays confirmed wt-BAP1, but not catalytically inactive BAP1 mutant, reduced promoter activities of DR4 and DR5, suggesting deubiquitinase activity is required for the regulation of gene expression. Co-immunoprecipitation studies demonstrated direct binding of BAP1 to the transcription factor Ying Yang 1 (YY1), and chromatin immunoprecipitation assays revealed BAP1 and YY1 to be enriched in the promoter regions of DR4 and DR5. Knockdown of YY1 also increased DR4 and DR5 expression and sensitivity to TRAIL. These results suggest that BAP1 and YY1 cooperatively repress transcription of TRAIL receptors. Our finding that BAP1 directly regulates the extrinsic apoptotic pathway will provide new insights into the role of BAP1 in the development of MPM and other cancers with frequent BAP1 mutations.
MeSH term(s)	Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Humans ; Mesothelioma, Malignant/genetics ; Mesothelioma, Malignant/metabolism ; Mutation ; Receptors, TNF-Related Apoptosis-Inducing Ligand/biosynthesis ; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics ; TNF-Related Apoptosis-Inducing Ligand/biosynthesis ; TNF-Related Apoptosis-Inducing Ligand/genetics ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; Ubiquitin Thiolesterase/genetics ; Ubiquitin Thiolesterase/metabolism ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/metabolism
Chemical Substances	BAP1 protein, human ; Receptors, TNF-Related Apoptosis-Inducing Ligand ; TNF-Related Apoptosis-Inducing Ligand ; TNFRSF10A protein, human ; TNFRSF10B protein, human ; TNFSF10 protein, human ; Tumor Suppressor Proteins ; YY1 Transcription Factor ; YY1 protein, human ; Ubiquitin Thiolesterase (EC 3.4.19.12)
Language	English
Publishing date	2021-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.101223
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Article ; Online: Diagnosis of Combined Adenocarcinoma Small Cell Lung Cancer By Endobronchial Ultrasound Transbronchial Needle Aspiration.

Perrotta, Fabio / Khiroya, Reena / Russell, Peter / Ekeowa, Ugo / Saleem, Amer / Borg, Elaine / Ahmad, Tanya / Falzon, Mary / Forster, Martin / Navani, Neal

Journal of bronchology & interventional pulmonology

2019 Volume 26, Issue 2, Page(s) e20–e22

MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/pathology ; Aged ; Bronchoscopy ; Diagnosis, Differential ; Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Male ; Neoplasms, Multiple Primary/diagnosis ; Neoplasms, Multiple Primary/diagnostic imaging ; Neoplasms, Multiple Primary/pathology ; Small Cell Lung Carcinoma/diagnosis ; Small Cell Lung Carcinoma/diagnostic imaging ; Small Cell Lung Carcinoma/pathology
Language	English
Publishing date	2019-03-21
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2478320-1
ISSN	1948-8270 ; 1944-6586
ISSN (online)	1948-8270
ISSN	1944-6586
DOI	10.1097/LBR.0000000000000573
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Article: Polarized localization of epithelial CXCL11 in chronic obstructive pulmonary disease and mechanisms of T cell egression.

Porter, Joanna C / Falzon, Mary / Hall, Alan

Journal of immunology (Baltimore, Md. : 1950)

2008 Volume 180, Issue 3, Page(s) 1866–1877

Abstract: The exit of lymphocytes from the interstitium of the lung, across the bronchial epithelium and into the airway lumen, is known as egression, or luminal clearance. Egression is important for immune surveillance and the resolution of inflammation, but the ... ...

Abstract	The exit of lymphocytes from the interstitium of the lung, across the bronchial epithelium and into the airway lumen, is known as egression, or luminal clearance. Egression is important for immune surveillance and the resolution of inflammation, but the mechanisms involved are unknown. We show that egression of human T cells across the bronchial epithelium is a multistep process, driven in part by a polarized transepithelial gradient of CXCL11 that is up-regulated in patients with chronic obstructive airways disease. Previous studies have shown that T cells can migrate across a disrupted bronchial epithelium, but we provide evidence that egression does not require epithelial injury, and can take place across an intact epithelial barrier. After negotiating the extracellular matrix, the T cell adheres to the basal surface of the bronchial epithelial cell using alpha(4) and leukocyte function associated-1 integrins before crossing the epithelium in an leukocyte function associated-1-dependent way. We demonstrate an egression-dependent decrease in transepithelial resistance across the epithelium without gross alteration in tight-junction proteins. The process of egression has been relatively overlooked when considering the control of leukocyte trafficking in the lung and other epithelial organs. This study highlights the role of the respiratory epithelium in the trafficking of T lymphocytes from the pulmonary interstitium and into the large airways, during the onset and resolution of pulmonary inflammation.
MeSH term(s)	Actins/antagonists & inhibitors ; Actins/metabolism ; Antibodies, Monoclonal/pharmacology ; Bronchi/immunology ; Bronchi/pathology ; Cell Adhesion ; Cell Movement ; Cell Polarity ; Cells, Cultured ; Chemokine CXCL11/analysis ; Chemokine CXCL11/metabolism ; Humans ; Integrins/metabolism ; Lymphocyte Function-Associated Antigen-1/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Pulmonary Disease, Chronic Obstructive/immunology ; Pulmonary Disease, Chronic Obstructive/pathology ; Receptors, CXCR3/immunology ; Respiratory Mucosa/immunology ; Respiratory Mucosa/pathology ; T-Lymphocytes/immunology ; Zonula Occludens-1 Protein ; beta Catenin/genetics ; beta Catenin/metabolism
Chemical Substances	Actins ; Antibodies, Monoclonal ; CXCL11 protein, human ; CXCR3 protein, human ; Chemokine CXCL11 ; Integrins ; Lymphocyte Function-Associated Antigen-1 ; Membrane Proteins ; Phosphoproteins ; Receptors, CXCR3 ; TJP1 protein, human ; Zonula Occludens-1 Protein ; beta Catenin
Language	English
Publishing date	2008-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.180.3.1866
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Article ; Online: Retrospective response analysis of BAP1 expression to predict the clinical activity of systemic cytotoxic chemotherapy in mesothelioma.

Kumar, Neelam / Alrifai, Doraid / Kolluri, Krishna K / Sage, Elizabeth K / Ishii, Yuki / Guppy, Naomi / Borg, Elaine / Falzon, Mary / Nankivell, Matthew / Nicholson, Andrew G / Janes, Sam M

Lung cancer (Amsterdam, Netherlands)

2018 Volume 127, Page(s) 164–166

Abstract: Introduction BRCA1 associated protein-1 (BAP1) is a key tumor driver in mesothelioma and a potential biomarker predicting response to several targeted therapies in clinical testing. Whether it also modulates response to cytotoxic chemotherapy is ... ...

Abstract	Introduction BRCA1 associated protein-1 (BAP1) is a key tumor driver in mesothelioma and a potential biomarker predicting response to several targeted therapies in clinical testing. Whether it also modulates response to cytotoxic chemotherapy is undetermined. This study used retrospective response analysis of BAP1 expression in archival tumor biopsies taken from patients in the MS01 trial (NCT00075699). We aimed to determine if BAP1 expression correlated with overall survival within the three treatment arms in this trial, namely active symptom control (ASC); ASC plus mitomycin, vinblastine and cisplatin (MVP); and ASC plus vinorelbine. Materials and methods We used immunohistochemical analysis of tumor samples from the MS01 trial to identify subgroups with and without nuclear BAP1 expression. We performed correlative analysis of clinical characteristics (age at diagnosis, sex and histological subtype) and overall survival within treatment arms with nuclear BAP1 expression. Results 89 tumor samples from the 409 patients originally in the trial were available for analysis. Of these, 60 samples harbored a positive internal control, in the form of positive staining of inflammatory cells for BAP1, and were carried forward for analysis. Correlative analysis suggested no significant association between loss of nuclear BAP1 expression and age at diagnosis, sex and histological subtype. Kaplan Meier survival analysis revealed a small, though non-significant, overall survival disadvantage associated with BAP1 expression in tumors from patients treated with vinorelbine. Discussion This exploratory analysis suggests BAP1 expression may modify response to vinorelbine in MPM, possibly due to prevention of mitotic microtubule formation. We suggest ongoing and planned clinical studies of vinorelbine in MPM assess BAP1 expression as a predictive biomarker of response.
MeSH term(s)	Aged ; Biomarkers, Tumor/metabolism ; Cisplatin/therapeutic use ; Female ; Humans ; Male ; Mesothelioma/diagnosis ; Mesothelioma/drug therapy ; Mesothelioma/mortality ; Microtubules/metabolism ; Pleural Neoplasms/diagnosis ; Pleural Neoplasms/drug therapy ; Pleural Neoplasms/mortality ; Prognosis ; Retrospective Studies ; Survival Analysis ; Tumor Suppressor Proteins/metabolism ; Ubiquitin Thiolesterase/metabolism ; Vinblastine/therapeutic use
Chemical Substances	BAP1 protein, human ; Biomarkers, Tumor ; Tumor Suppressor Proteins ; Vinblastine (5V9KLZ54CY) ; Ubiquitin Thiolesterase (EC 3.4.19.12) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2018-12-05
Publishing country	Ireland
Document type	Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2018.12.004
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Zs.A 2135: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Central airway obstruction caused by a peripheral hamartoma.

Goodman, Anna / Falzon, Mary / Gelder, Colin / George, Jeremy

Lung cancer (Amsterdam, Netherlands)

2007 Volume 57, Issue 3, Page(s) 395–398

Abstract: We report the first case of a hamartoma, arising from peripheral lung tissue, which extended proximally over several decades to occlude the large airways. The patient's symptoms were originally attributed to asthma and the correct diagnosis was only made ...

Abstract	We report the first case of a hamartoma, arising from peripheral lung tissue, which extended proximally over several decades to occlude the large airways. The patient's symptoms were originally attributed to asthma and the correct diagnosis was only made when she developed life-threatening airway obstruction. The endobronchial component of the hamartoma was debulked with urgent laser therapy, while the peripheral base of the tumour was resected by elective right middle lobectomy.
MeSH term(s)	Airway Obstruction/diagnosis ; Airway Obstruction/etiology ; Female ; Hamartoma/complications ; Hamartoma/diagnosis ; Hamartoma/pathology ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Lung Neoplasms/pathology ; Middle Aged
Language	English
Publishing date	2007-09
Publishing country	Ireland
Document type	Case Reports ; Journal Article
ZDB-ID	632771-0
ISSN	0169-5002
ISSN	0169-5002
DOI	10.1016/j.lungcan.2007.03.008
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Article: Primary synovial sarcoma of the lung: can haemothorax be the first manifestation?

Woo, Wen Ling / Panagiotopoulos, Nikolaos / Gvinianidze, Lasha / Fhadil, Sadeer / Borg, Elaine / Falzon, Mary / Lawrence, David

Journal of thoracic disease

2015 Volume 6, Issue 12, Page(s) E249–51

Abstract: Primary pulmonary synovial sarcomas represent a rare clinical entity and account for approximately 0.5% of lung malignancies. We report the case of a 30-year-old male who presented clinically with haemothorax. Imaging revealed a complex collection ... ...

Abstract	Primary pulmonary synovial sarcomas represent a rare clinical entity and account for approximately 0.5% of lung malignancies. We report the case of a 30-year-old male who presented clinically with haemothorax. Imaging revealed a complex collection obscuring a multi-lobulated mass in the right lower lobe of the lung. He underwent a right thoracotomy for evacuation of collection and surgical resection of his pulmonary mass. Histological analysis confirmed a grade 3 monophasic fibrous synovial sarcoma of the lung with infiltration to adjacent pleura, causing his initial haemothorax. Postoperative period was uneventful and patient was referred to the oncology team for further management. Primary pulmonary synovial sarcoma, though rare, should remain an important differential when considering lung malignancies, as complete surgical resection is the mainstay of treatment.
Language	English
Publishing date	2015-01-14
Publishing country	China
Document type	Case Reports
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.3978/j.issn.2072-1439.2014.11.01
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Article ; Online: Immunohistochemical Performance of Estrogen and Progesterone Receptor Antibodies on the Dako Omnis Staining Platform: Evaluation in Multicenter Studies.

Hicks, David / Dell'Orto, Patrizia / Falzon, Mary / Hoff, Kirsten D / Levy, Yaron Y / McMahon, Loralee / Miller, Keith / Russo, Leila / Viale, Giuseppe

Applied immunohistochemistry & molecular morphology : AIMM

2017 Volume 25, Issue 5, Page(s) 313–319

Abstract: The analysis of estrogen receptor (ER) and progesterone receptor (PR) expression levels by immunohistochemistry is an important part of the initial evaluation of breast cancer and critically important in treatment planning. Anti-ERα (clone EP1) and anti- ... ...

Abstract	The analysis of estrogen receptor (ER) and progesterone receptor (PR) expression levels by immunohistochemistry is an important part of the initial evaluation of breast cancer and critically important in treatment planning. Anti-ERα (clone EP1) and anti-PR (clone PgR 1294) antibodies are in development for the Dako Omnis automated staining platform. These antibodies are not yet commercially available and are in performance evaluation, including the 4 international, multicenter studies reported here. For each antibody, a reproducibility study and a method comparison study was done in a randomized manner in order to test the antibodies under conditions closest to real-world user conditions. The reproducibility studies included 5 staining runs on the Dako Omnis with 20 formalin-fixed and paraffin-embedded human breast carcinoma specimens in 3 independent laboratories, and the method comparison studies included several hundred specimens stained on the Dako Omnis and on the Autostainer Link 48 platforms. Stained slides were evaluated for nuclear ER or PR expression according to American Society of Clinical Oncology/College of American Pathologists guidelines (≥1% cut-off for positive) by pathologists who were blinded from the staining method and specimen ID. For both anti-ERα (clone EP1) and anti-PR (clone PgR 1294) on the Dako Omnis, high reproducibility agreement rates were obtained on the interrun, interlaboratory, and interobserver endpoints. High concordance rates were observed between the specimens stained on the Dako Omnis platform and the Autostainer Link 48 platform. Staining quality was excellent for both anti-ERα (clone EP1) and anti-PR (clone PgR 1294) on the Dako Omnis. These results suggest that these antibodies are reliable and reproducible tools for immunohistochemistry analysis of ER and PR expression levels in formalin-fixed and paraffin-embedded breast carcinoma tissues on the Dako Omnis platform.
MeSH term(s)	Antibodies/analysis ; Antibodies/metabolism ; Breast Neoplasms/diagnosis ; Female ; Gene Expression Profiling/methods ; Humans ; Immunohistochemistry/methods ; Immunohistochemistry/standards ; Immunohistochemistry/trends ; Random Allocation ; Receptors, Estrogen/immunology ; Receptors, Progesterone/immunology ; Reproducibility of Results ; Staining and Labeling/instrumentation ; Staining and Labeling/standards
Chemical Substances	Antibodies ; Receptors, Estrogen ; Receptors, Progesterone
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	1473273-7
ISSN	1533-4058 ; 1062-3345 ; 1541-2016
ISSN (online)	1533-4058
ISSN	1062-3345 ; 1541-2016
DOI	10.1097/PAI.0000000000000311
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