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  1. Article ; Online: Pericapsular nerve group (PENG) block for shoulder manipulation: It may not be a real pericapsular block.

    Xiao, Su-Jun / Fan, Chen-Lu

    Journal of clinical anesthesia

    2023  Volume 88, Page(s) 111123

    MeSH term(s) Humans ; Femoral Nerve ; Shoulder/surgery
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1011618-7
    ISSN 1873-4529 ; 0952-8180
    ISSN (online) 1873-4529
    ISSN 0952-8180
    DOI 10.1016/j.jclinane.2023.111123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2622: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Lidocaine induces neurotoxicity in spinal cord neurons in Goto-Kakizaki rats via AMPK-mediated mitophagy.

    Chen, Ling / Fan, ChenLu / Zhang, Xuekang / Chen, Shibiao / Ye, Lingling / Zheng, Xiaolan

    The Journal of toxicological sciences

    2023  Volume 48, Issue 11, Page(s) 585–595

    Abstract: Objective: Lidocaine has been reported to induce neurotoxicity, which is further enhanced by high glucose levels. This study is aimed to explore the underlying mechanisms of lidocaine neurotoxicity in spinal cord neurons of diabetes.: Methods: Take ... ...

    Abstract Objective: Lidocaine has been reported to induce neurotoxicity, which is further enhanced by high glucose levels. This study is aimed to explore the underlying mechanisms of lidocaine neurotoxicity in spinal cord neurons of diabetes.
    Methods: Take thirty specific pathogen-free (SPF) healthy Sprague-Dawley (SD) rats and thirty Goto-Kakizaki (GK) rats, aged 12 weeks, weighing 180-200 g. The spinal cord neurons of rats were isolated and cultured in vitro. Cell Counting Kit-8 was used to detect cell proliferation to determine the appropriate concentration and duration of lidocaine. Mitochondrial function was assessed using ATP content, cellular oxygen consumption rate, mitochondrial membrane potential, ROS production, and mitochondrial ultrastructure. Western blot was applied to detect the expression of autophagy- and mitophagy-related molecules PINK1, p-AMPK, LC-3II/LC3-I ratio and mTORC1. Immunofluorescent staining was used to detect the expression of PINK1 and LC3.
    Results: Lidocaine decreased cell viability of spinal cord neurons in concentration- and time-dependent manners. And lidocaine treatment aggravated mitochondrial dysfunction in GK rats. Furthermore, mitophagy was activated in diabetes, and lidocaine exposure up-regulated mitophagy. AMPK activator MK8722 aggravated mitochondrial damage, increased the expression of PINK1, p-AMPK, LC-3II/LC3-I ratio, and decreased the expression of mTORC1, while AMPK inhibitor Compound C and autophagy inhibitor Bafilomycin A1 reduced mitochondrial damage and decreased the expression of PINK1, p-AMPK, LC-3II/LC3-I ratio, and increased the expression of mTORC1.
    Conclusions: Lidocaine induced neurotoxicity of spinal cord neurons in GK rats via AMPK-mediated mitophagy.
    MeSH term(s) Rats ; Animals ; Mitophagy/physiology ; AMP-Activated Protein Kinases ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Neurotoxicity Syndromes ; Neurons/metabolism ; Diabetes Mellitus ; Mechanistic Target of Rapamycin Complex 1 ; Ubiquitin-Protein Ligases/metabolism
    Chemical Substances AMP-Activated Protein Kinases (EC 2.7.11.31) ; Reactive Oxygen Species ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
    Language English
    Publishing date 2023-11-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 770623-6
    ISSN 1880-3989 ; 0388-1350
    ISSN (online) 1880-3989
    ISSN 0388-1350
    DOI 10.2131/jts.48.585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1682: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: [Seroepidemiology of varicella among the healthy population aged 1-19 years in Harbin, China].

    Li, Xi-Kun / Gao, Xiao-Li / Li, Yan / Xu, Hong / Fan, Chen-Lu

    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

    2019  Volume 21, Issue 3, Page(s) 203–207

    Abstract: Objective: To investigate the level of IgG antibody to varicella in the healthy population aged 1-19 years in Harbin, China.: Methods: Random sampling was performed to select 1 203 healthy individuals aged 1-19 years in Harbin. According to age, they ...

    Abstract Objective: To investigate the level of IgG antibody to varicella in the healthy population aged 1-19 years in Harbin, China.
    Methods: Random sampling was performed to select 1 203 healthy individuals aged 1-19 years in Harbin. According to age, they were divided into ≥1 years group (n=240), ≥4 years group (n=396), ≥7 years group (n=364) and 14-19 years group (n=203). Enzyme-linked immunosorbent assay was used to measure the concentration of varicella-zoster virus (VZV)-IgG antibody in serum, and a concentration of VZV-IgG antibody of ≥100 mIU/mL was considered positive, suggesting that the subject had the ability to resist VZV infection.
    Results: The overall positive rate of VZV-IgG antibody was 71.49% (860/1 203), and the concentration of VZV-IgG antibody was 447±17 mIU/mL. The concentration of VZV-IgG antibody tended to increase with age (P<0.05). The positive rate of VZV-IgG antibody in the urban population was significantly higher than that in the rural population (P<0.05). There was significant difference in the positive rate of VZV-IgG antibody between the populations with different doses of varicella vaccination (P<0.05), and the population with 2 doses of vaccination had the highest positive rate of VZV-IgG antibody. There was a significant difference in the concentration of VZV-IgG antibody between the populations with different medical histories (P<0.05), and the population with a past history of varicella had the highest concentration.
    Conclusions: Among the healthy population aged 1-19 years in Harbin, there is a significant difference in the level of VZV-IgG antibody between the urban and rural populations, as well as between different age groups. Varicella vaccination should be strengthened in areas with a low vaccination rate and the population aged <14 years.
    MeSH term(s) Adolescent ; Adult ; Antibodies, Viral ; Chickenpox/epidemiology ; Child ; Child, Preschool ; China/epidemiology ; Herpesvirus 3, Human ; Humans ; Immunoglobulin G ; Infant ; Seroepidemiologic Studies ; Young Adult
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language Chinese
    Publishing date 2019-03-21
    Publishing country China
    Document type Journal Article
    ISSN 1008-8830
    ISSN 1008-8830
    Database MEDical Literature Analysis and Retrieval System OnLINE

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