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Article ; Online: Nrf2-mediated macrophage function in benign prostatic hyperplasia: Novel molecular insights and implications.

Song, Guanhui / Tong, Jinlin / Wang, Yuhe / Li, Yuanyuan / Liao, Zeqi / Fan, Danping / Fan, Xinrong

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 167, Page(s) 115566

Abstract: One of the most common urological diseases is benign prostatic hyperplasia (BPH), with a high prevalence in the middle-aged and elderly male population. Patient's mental and physical health is affected significantly by this condition, causing them ... ...

Abstract	One of the most common urological diseases is benign prostatic hyperplasia (BPH), with a high prevalence in the middle-aged and elderly male population. Patient's mental and physical health is affected significantly by this condition, causing them considerable discomfort. During the development of BPH, a synergistic effect occurs in response to inflammation, oxidative stress, and apoptosis induced by the activation of macrophages. The nuclear factor erythroid2-related factor 2 (Nrf2) signaling pathway can mediate macrophage activation and inhibit prostate hyperplasia by suppressing pro-inflammatory factors, anti-oxidative stress disorder, and initiating apoptosis. The purpose of this study was to review the mechanism of action of Nrf2 signaling pathway-mediated macrophage activation on the immune microenvironment of BPH and to summarize the Chinese medicine based on Nrf2 to provide an overview of BPH treatment options.
MeSH term(s)	Aged ; Humans ; Male ; Middle Aged ; Inflammation/metabolism ; Macrophages/metabolism ; NF-E2-Related Factor 2/metabolism ; Prostatic Hyperplasia/metabolism ; Signal Transduction
Chemical Substances	NF-E2-Related Factor 2 ; NFE2L2 protein, human
Language	English
Publishing date	2023-09-29
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115566
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Article: The Role of Reactive Oxygen Species in the Rheumatoid Arthritis-Associated Synovial Microenvironment

Wang, Xing / Fan, Danping / Cao, Xiaoxue / Ye, Qinbin / Wang, Qiong / Zhang, Mengxiao / Xiao, Cheng

Antioxidants. 2022 June 13, v. 11, no. 6

2022

Abstract: Rheumatoid arthritis (RA) is an inflammatory disease that begins with a loss of tolerance to modified self-antigens and immune system abnormalities, eventually leading to synovitis and bone and cartilage degradation. Reactive oxygen species (ROS) are ... ...

Abstract	Rheumatoid arthritis (RA) is an inflammatory disease that begins with a loss of tolerance to modified self-antigens and immune system abnormalities, eventually leading to synovitis and bone and cartilage degradation. Reactive oxygen species (ROS) are commonly used as destructive or modifying agents of cellular components or they act as signaling molecules in the immune system. During the development of RA, a hypoxic and inflammatory situation in the synovium maintains ROS generation, which can be sustained by increased DNA damage and malfunctioning mitochondria in a feedback loop. Oxidative stress caused by abundant ROS production has also been shown to be associated with synovitis in RA. The goal of this review is to examine the functions of ROS and related molecular mechanisms in diverse cells in the synovial microenvironment of RA. The strategies relying on regulating ROS to treat RA are also reviewed.
Keywords	DNA damage ; cartilage ; immune system ; mitochondria ; oxidative stress ; reactive oxygen species ; rheumatoid arthritis ; synovitis
Language	English
Dates of publication	2022-0613
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11061153
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Pain Mechanism in Rheumatoid Arthritis: From Cytokines to Central Sensitization.

Cao, Yanting / Fan, Danping / Yin, Yiqing

Mediators of inflammation

2020 Volume 2020, Page(s) 2076328

Abstract: Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in recent years, through the implementation of targeted treatment and the introduction of disease-modifying antirheumatic drugs (DMARDs), the treatment of RA patients ... ...

Abstract	Pain is the most common symptom in patients with rheumatoid arthritis (RA). Although in recent years, through the implementation of targeted treatment and the introduction of disease-modifying antirheumatic drugs (DMARDs), the treatment of RA patients has made a significant progress, a large proportion of patients still feel pain. Finding appropriate treatment to alleviate the pain is very important for RA patients. Current research showed that, in addition to inflammation, RA pain involves peripheral sensitization and abnormalities in the central nervous system (CNS) pain regulatory mechanisms. This review summarized the literature on pain mechanisms of RA published in recent years. A better understanding of pain mechanisms will help to develop new analgesic targets and deploy new and existing therapies.
MeSH term(s)	Animals ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/drug therapy ; Central Nervous System/metabolism ; Central Nervous System Sensitization/physiology ; Cytokines/blood ; Humans ; Pain/blood ; Pain/drug therapy
Chemical Substances	Antirheumatic Agents ; Cytokines
Language	English
Publishing date	2020-09-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1137605-3
ISSN	1466-1861 ; 0962-9351
ISSN (online)	1466-1861
ISSN	0962-9351
DOI	10.1155/2020/2076328
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Article: The Role of Reactive Oxygen Species in the Rheumatoid Arthritis-Associated Synovial Microenvironment.

Wang, Xing / Fan, Danping / Cao, Xiaoxue / Ye, Qinbin / Wang, Qiong / Zhang, Mengxiao / Xiao, Cheng

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 6

Abstract	Rheumatoid arthritis (RA) is an inflammatory disease that begins with a loss of tolerance to modified self-antigens and immune system abnormalities, eventually leading to synovitis and bone and cartilage degradation. Reactive oxygen species (ROS) are commonly used as destructive or modifying agents of cellular components or they act as signaling molecules in the immune system. During the development of RA, a hypoxic and inflammatory situation in the synovium maintains ROS generation, which can be sustained by increased DNA damage and malfunctioning mitochondria in a feedback loop. Oxidative stress caused by abundant ROS production has also been shown to be associated with synovitis in RA. The goal of this review is to examine the functions of ROS and related molecular mechanisms in diverse cells in the synovial microenvironment of RA. The strategies relying on regulating ROS to treat RA are also reviewed.
Language	English
Publishing date	2022-06-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11061153
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Article ; Online: Xiong Fu Powder Regulates the Intestinal Microenvironment to Protect Bones Against Destruction in Collagen-Induced Arthritis Rat Models.

Xi, Xiaoyu / Ye, Qinbin / Li, Xiaoya / Lu, Xiangchen / Fan, Danping / Xia, Ya / Xiao, Cheng

Frontiers in cellular and infection microbiology

2022 Volume 12, Page(s) 854940

Abstract: Background: Changes in the intestinal microenvironment affected bone destruction in rheumatoid arthritis (RA), and spleen deficiency (SD) was closely related to the intestinal microenvironment. In this study, we aimed to explore the aggravation of SD on ...

Abstract	Background: Changes in the intestinal microenvironment affected bone destruction in rheumatoid arthritis (RA), and spleen deficiency (SD) was closely related to the intestinal microenvironment. In this study, we aimed to explore the aggravation of SD on collagen-induced arthritis (CIA) and the bone protection of compound Xiong Fu powder (XFP) on CIA with SD (SD-CIA) based on the intestinal microenvironment. Method: An SD-CIA rat model was established using Results: Compared with that in CIA rats, bone destruction in SD-CIA rats was aggravated, as manifested by increased AI scores, more severe joint pathological changes and radiological damage, and increased number of osteoclasts (OCs) in the ankle joint. Meanwhile, the proportion of Tregs/Th17 cells was biased toward Th17 cells in Peyer's patches. Furthermore, the gene levels of Conclusion: SD can aggravate bone destruction in CIA rats. Compound XFP may attenuate bone destruction in SD-CIA rats by regulating the intestinal microenvironment. One of the mechanisms is the cross-talk between sIgA secretion regulated by intestinal mucosal Tregs and Th17 cells and adhesion of
MeSH term(s)	Animals ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/drug therapy ; Arthritis, Rheumatoid ; Cytokines/metabolism ; Immunoglobulin A, Secretory ; Powders/adverse effects ; Rats ; Th17 Cells
Chemical Substances	Cytokines ; Immunoglobulin A, Secretory ; Powders
Language	English
Publishing date	2022-07-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2022.854940
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Article ; Online: Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H.

Fan, Danping / Geng, Qishun / Wang, Bailiang / Wang, Xing / Xia, Ya / Yang, Liwen / Zhang, Qian / Deng, Tingting / Xu, Yuan / Zhao, Hongyan / Liu, Bin / Lu, Cheng / Gu, Xiaofeng / Xiao, Cheng

Clinical immunology (Orlando, Fla.)

2024 Volume 261, Page(s) 109929

Abstract: Previous studies have shown that epigenetic factors are involved in the occurrence and development of rheumatoid arthritis (RA). However, the role of ... ...

Abstract	Previous studies have shown that epigenetic factors are involved in the occurrence and development of rheumatoid arthritis (RA). However, the role of N
MeSH term(s)	Humans ; Rats ; Animals ; Aggression ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/metabolism ; Inflammation/metabolism ; Hypoxia ; Fibroblasts/metabolism ; Cell Proliferation ; Cells, Cultured ; AlkB Homolog 5, RNA Demethylase/genetics ; AlkB Homolog 5, RNA Demethylase/metabolism ; Adenine/analogs & derivatives
Chemical Substances	6-methyladenine (W7IBY2BGAX) ; ALKBH5 protein, human (EC 1.14.11.-) ; AlkB Homolog 5, RNA Demethylase (EC 1.14.11.-) ; Adenine (JAC85A2161)
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2024.109929
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Article ; Online: A dual dynamically cross-linked hydrogel promotes rheumatoid arthritis repair through ROS initiative regulation and microenvironment modulation-independent triptolide release.

Wang, Tianyang / Huang, Cheng / Fang, Ziyuan / Bahatibieke, Abudureheman / Fan, Danping / Wang, Xing / Zhao, Hongyan / Xie, Yajie / Qiao, Kun / Xiao, Cheng / Zheng, Yudong

Materials today. Bio

2024 Volume 26, Page(s) 101042

Abstract: High oxidative stress and inflammatory cell infiltration are major causes of the persistent bone erosion and difficult tissue regeneration in rheumatoid arthritis (RA). Triptolide (TPL) has become a highly anticipated anti-rheumatic drug due to its ... ...

Abstract	High oxidative stress and inflammatory cell infiltration are major causes of the persistent bone erosion and difficult tissue regeneration in rheumatoid arthritis (RA). Triptolide (TPL) has become a highly anticipated anti-rheumatic drug due to its excellent immunomodulatory and anti-inflammatory effects. However, the sudden drug accumulation caused by the binding of "stimulus-response" and "drug release" in a general smart delivery system is difficult to meet the shortcoming of extreme toxicity and the demand for long-term administration of TPL. Herein, we developed a dual dynamically cross-linked hydrogel (SPT@TPL), which demonstrated sensitive RA microenvironment regulation and microenvironment modulation-independent TPL release for 30 days. The abundant borate ester/tea polyphenol units in SPT@TPL possessed the capability to respond and regulate high reactive oxygen species (ROS) levels on-demand. Meanwhile, based on its dense dual crosslinked structure as well as the spontaneous healing behavior of numerous intermolecular hydrogen bonds formed after the breakage of borate ester, TPL could remain stable and slowly release under high ROS environments of RA, which dramatically reduced the risk of TPL exerting toxicity while maximized its long-term efficacy. Through the dual effects of ROS regulation and TPL sustained-release, SPT@TPL alleviated oxidative stress and reprogrammed macrophages into M2 phenotype, showing marked inhibition of inflammation and optimal regeneration of articular cartilage in RA rat model. In conclusion, this hydrogel platform with both microenvironment initiative regulation and TPL long-term sustained release provides a potential scheme for rheumatoid arthritis.
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ISSN	2590-0064
ISSN (online)	2590-0064
DOI	10.1016/j.mtbio.2024.101042
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Article ; Online: The latest information on the RIPK1 post-translational modifications and functions.

Wang, Qiong / Fan, Danping / Xia, Ya / Ye, Qinbin / Xi, Xiaoyu / Zhang, Guoqiang / Xiao, Cheng

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2021 Volume 142, Page(s) 112082

Abstract: RIPK1 is a protein kinase that simultaneously regulates inflammation, apoptosis, and necroptosis. It is thought that RIPK1 has separate functions through its scaffold structure and kinase domains. Moreover, different post-translational modifications in ... ...

Abstract	RIPK1 is a protein kinase that simultaneously regulates inflammation, apoptosis, and necroptosis. It is thought that RIPK1 has separate functions through its scaffold structure and kinase domains. Moreover, different post-translational modifications in RIPK1 play distinct or even opposing roles. Under different conditions, in different cells and species, and/or upon exposure to different stimuli, infections, and substrates, RIPK1 activation can lead to diverse results. Despite continuous research, many of the conclusions that have been drawn regarding the complex interactions of RIPK1 are controversial. This review is based on an examination and analysis of recent studies on the RIPK1 structure, post-translational modifications, and activation conditions, which can affect its functions. Finally, because of the diverse functions of RIPK1 and their relevance to the pathogenesis of many diseases, we briefly introduce the roles of RIPK1 in inflammatory and autoimmune diseases and the prospects of its use in future diagnostics and treatments.
MeSH term(s)	Animals ; Apoptosis/physiology ; Autoimmune Diseases/physiopathology ; Humans ; Inflammation/pathology ; Necroptosis/physiology ; Protein Processing, Post-Translational ; Receptor-Interacting Protein Serine-Threonine Kinases/chemistry ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism
Chemical Substances	RIPK1 protein, human (EC 2.7.11.1) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2021-08-24
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2021.112082
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Article ; Online: Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis

Xi, Xiaoyu / Ye, Qinbin / Fan, Danping / Cao, Xiaoxue / Wang, Qiong / Wang, Xing / Zhang, Mengxiao / Xu, Yuan / Xiao, Cheng

Frontiers in immunology

2022 Volume 13, Page(s) 797815

Abstract: Rheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels. In the past few years, ... ...

Abstract	Rheumatoid arthritis (RA), the most common autoimmune disease, is characterized by symmetrical synovial inflammation of multiple joints with the infiltration of pro-inflammatory immune cells and increased cytokines (CKs) levels. In the past few years, numerous studies have indicated that several factors could affect RA, such as mutations in susceptibility genes, epigenetic modifications, age, and race. Recently, environmental factors, particularly polycyclic aromatic hydrocarbons (PAHs), have attracted increasing attention in RA pathogenesis. Therefore, exploring the specific mechanisms of PAHs in RA is vitally critical. In this review, we summarize the recent progress in understanding the mechanisms of PAHs and aryl hydrocarbon receptors (AHRs) in RA. Additionally, the development of therapeutic drugs that target AHR is also reviewed. Finally, we discuss the challenges and perspectives on AHR application in the future.
MeSH term(s)	Arthritis, Rheumatoid/etiology ; Humans ; Polycyclic Aromatic Hydrocarbons ; Receptors, Aryl Hydrocarbon/genetics
Chemical Substances	Polycyclic Aromatic Hydrocarbons ; Receptors, Aryl Hydrocarbon
Language	English
Publishing date	2022-03-22
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.797815
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Article ; Online: Potential medicinal value of N6-methyladenosine in autoimmune diseases and tumours.

Geng, Qishun / Cao, Xiaoxue / Fan, Danping / Wang, Qiong / Wang, Xing / Zhang, Mengxiao / Zhao, Lu / Jiao, Yi / Deng, Tingting / Liu, Honglin / Zhou, Jing / Lou, Yanni / Liang, Jing / Xiao, Cheng

British journal of pharmacology

2023

Abstract: Autoimmune diseases (ADs) are closely related to malignant tumours. On the one hand, ADs can increase the incidence of tumours; on the other hand, malignant tumours can cause rheumatic disease-like manifestations. With the increasing depth of analysis ... ...

Abstract	Autoimmune diseases (ADs) are closely related to malignant tumours. On the one hand, ADs can increase the incidence of tumours; on the other hand, malignant tumours can cause rheumatic disease-like manifestations. With the increasing depth of analysis into the mechanism of N
Language	English
Publishing date	2023-01-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.16030
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