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  1. Article: [NAFLD renaming to MAFLD, MASLD: background, similarities, differences, and countermeasures].

    Fan, J G / Li, X Y

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2023  Volume 31, Issue 8, Page(s) 789–792

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic stress liver injury due to chronic malnutrition in genetically susceptible individuals. With the prevalence of obesity, diabetes, and metabolic syndrome, NAFLD has become the world's number ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic stress liver injury due to chronic malnutrition in genetically susceptible individuals. With the prevalence of obesity, diabetes, and metabolic syndrome, NAFLD has become the world's number one chronic liver disease, and the flaws of forty years of exclusive disease diagnostic criteria and stigmatized disease terminology are becoming increasingly prominent. To this end, in the past three years, the international consensus group and the three major hepatology societies have suggested that NAFLD be renamed metabolism-associated fatty liver disease (MAFLD) and metabolism-associated steatosis liver disease (MASLD). Here is a description of the background of naming NAFLD, MAFLD, and MASLD, the similarities and differences of the three terms, the existing disputes, and our country's coping strategies.
    MeSH term(s) Humans ; Non-alcoholic Fatty Liver Disease ; Metabolic Diseases ; Metabolic Syndrome ; Consensus
    Language Chinese
    Publishing date 2023-09-18
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20230809-00042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Pregnancy management in patients with hepatolenticular degeneration].

    Xiao, Q Q / Fan, J G

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2023  Volume 30, Issue 11, Page(s) 1276–1279

    Abstract: Hepatolenticular degeneration (HLD) is an autosomal recessive genetic disease with a wide range of clinical manifestations. Women of childbearing age often present with irregular or even absent menstruation. Getting pregnant can be difficult without ... ...

    Abstract Hepatolenticular degeneration (HLD) is an autosomal recessive genetic disease with a wide range of clinical manifestations. Women of childbearing age often present with irregular or even absent menstruation. Getting pregnant can be difficult without systematic treatment, and even if someone does become pregnant, miscarriages are common. This article reviews the use of medication during pregnancy in patients with hepatolenticular degeneration and also discusses the mode of delivery, anesthetic drug selection, and breastfeeding safety.
    MeSH term(s) Humans ; Female ; Pregnancy ; Hepatolenticular Degeneration/therapy
    Language Chinese
    Publishing date 2023-02-27
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20210329-00146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Factors influencing the clinical phenotype of hepatolenticular degeneration].

    Xiao, Q Q / Wang, Z X / Fan, J G

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2023  Volume 31, Issue 2, Page(s) 207–211

    Abstract: Hepatolenticular degeneration is an autosomal recessive genetic disease caused by mutations in the ATP7B gene. More than 800 mutations have been identified in the ATP7B gene so far, with significant differences in clinical phenotypes among different ... ...

    Abstract Hepatolenticular degeneration is an autosomal recessive genetic disease caused by mutations in the ATP7B gene. More than 800 mutations have been identified in the ATP7B gene so far, with significant differences in clinical phenotypes among different mutation sites. Totally different clinical phenotypic mutations can even exist in the same gene. Although copper accumulation due to gene mutation is the basis of the pathogenesis of hepatolenticular degeneration, more and more evidence demonstrates that it is difficult to explain the diversity of clinical manifestations solely from the perspective of gene mutation. Therefore, this article reviews the research progress on the factors influencing genotype, modifier genes, epigenetics, age, gender, diet, and other factors on the phenotype of patients with hepatolenticular degeneration.
    MeSH term(s) Humans ; Hepatolenticular Degeneration/genetics ; Copper-Transporting ATPases/genetics ; Cation Transport Proteins/genetics ; Phenotype ; Genotype ; Mutation
    Chemical Substances Copper-Transporting ATPases (EC 7.2.2.8) ; Cation Transport Proteins
    Language Chinese
    Publishing date 2023-05-03
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20211124-00579
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [An interpretation of the British Association for the Study of the Liver practice guideline for the evaluation and treatment of hepatolenticular degeneration].

    Xiao, Q Q / Xu, X / Fan, J G

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2023  Volume 30, Issue 11, Page(s) 1154–1157

    Abstract: Hepatolenticular degeneration is common among rare diseases. China has a higher incidence rate than Western countries, and it is increasing year by year. The disease is easy to overlook and misdiagnose due to its complexity and non-specific clinical ... ...

    Abstract Hepatolenticular degeneration is common among rare diseases. China has a higher incidence rate than Western countries, and it is increasing year by year. The disease is easy to overlook and misdiagnose due to its complexity and non-specific clinical manifestations. Therefore, the British Association for the Study of the Liver has recently issued practice guidelines for the evaluation and treatment of hepatolenticular degeneration in order to aid clinicians in improving the clinical decision-making process regarding diagnosis, treatment, and long-term follow-up management. Herein is a brief introduction and interpretation of the content of the guideline, with aim of facilitating its application in clinical practice.
    MeSH term(s) Humans ; Hepatolenticular Degeneration/diagnosis ; Hepatolenticular Degeneration/therapy ; China ; Incidence
    Language Chinese
    Publishing date 2023-02-27
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20220511-00257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Advances in the treatment of Wilson Disease].

    Xiao, Q Q / Fan, J G

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2021  Volume 29, Issue 1, Page(s) 79–82

    Abstract: Wilson Disease is kind of an autosomal recessive genetic disease. Early diagnosis and timely treatment are very important for prognosis. This article reviews the treatment of Wilson Disease, focusing on penicillamine, sodium dimercaptopropane sulfonate, ... ...

    Abstract Wilson Disease is kind of an autosomal recessive genetic disease. Early diagnosis and timely treatment are very important for prognosis. This article reviews the treatment of Wilson Disease, focusing on penicillamine, sodium dimercaptopropane sulfonate, ammonium tetrathiomolybdate and zinc, liver transplantation and gene therapy. At the same time, the problems of medication adherence and follow-up evaluation in patients with Wilson Disease are also discussed.
    MeSH term(s) Genetic Therapy ; Hepatolenticular Degeneration/drug therapy ; Hepatolenticular Degeneration/genetics ; Humans ; Liver Transplantation ; Penicillamine/therapeutic use ; Zinc
    Chemical Substances Penicillamine (GNN1DV99GX) ; Zinc (J41CSQ7QDS)
    Language Chinese
    Publishing date 2021-02-02
    Publishing country China
    Document type Journal Article ; Review
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20201018-00559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Advances in the study of non-infectious liver diseases and precancerous lesions of hepatocellular carcinoma].

    Yan, S Y / Fan, J G

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2019  Volume 27, Issue 7, Page(s) 487–490

    Abstract: Hepatocellular carcinoma (HCC) is a major disease with a high degree of malignancy, and poor prognosis, which seriously endangers human health. Chronic viral hepatitis (HBV, HCV)-cirrhosis-liver cancer patterns of pathogenesis has been widely accepted. ... ...

    Abstract Hepatocellular carcinoma (HCC) is a major disease with a high degree of malignancy, and poor prognosis, which seriously endangers human health. Chronic viral hepatitis (HBV, HCV)-cirrhosis-liver cancer patterns of pathogenesis has been widely accepted. However, the relationship between non-infectious liver disease and HCC is not completely clear; thereby how various non-infectious liver diseases develop through precancerous lesions has attracted widespread attention to HCC. A full understanding of these precancerous lesions is likely to provide new ideas and strategies for the prevention and treatment of non-infectious liver disease-related HCC.
    MeSH term(s) Carcinoma, Hepatocellular ; Hepatitis, Chronic ; Humans ; Liver Cirrhosis ; Liver Neoplasms ; Precancerous Conditions/diagnosis
    Language Chinese
    Publishing date 2019-09-18
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.issn.1007-3418.2019.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Prevalence and harm of nonalcoholic fatty liver disease].

    Shao, Y L / Fan, J G

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2019  Volume 27, Issue 1, Page(s) 10–13

    Abstract: Worldwide increasing prevalence of obesity and lifestyle changes has put nonalcoholic fatty liver disease (NAFLD) as the most prevalent liver disease of the coming decade. NAFLD not only causes cirrhosis and hepatocellular carcinoma, but also acts as a ... ...

    Abstract Worldwide increasing prevalence of obesity and lifestyle changes has put nonalcoholic fatty liver disease (NAFLD) as the most prevalent liver disease of the coming decade. NAFLD not only causes cirrhosis and hepatocellular carcinoma, but also acts as a component of metabolic syndrome together with obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and dyslipidemia. Consequently, its mutual cause-and-effect interactions have brought a huge clinical and financial burden to patients and society.
    MeSH term(s) Carcinoma, Hepatocellular/epidemiology ; China/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Liver Cirrhosis/epidemiology ; Liver Neoplasms/epidemiology ; Metabolic Syndrome/epidemiology ; Non-alcoholic Fatty Liver Disease/epidemiology ; Obesity/epidemiology ; Prevalence ; Risk Factors
    Language Chinese
    Publishing date 2019-01-27
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.issn.1007-3418.2019.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Clinical research advances in chronic hepatitis B complicated by fatty liver disease].

    Yang, R X / Fan, J G

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2018  Volume 26, Issue 1, Page(s) 73–76

    Abstract: Chronic hepatitis B and fatty liver disease are two most common chronic liver diseases in China, and with the increasing prevalence of obesity, chronic hepatitis B complicated by fatty liver disease is more and more common in clinical practice. The ... ...

    Abstract Chronic hepatitis B and fatty liver disease are two most common chronic liver diseases in China, and with the increasing prevalence of obesity, chronic hepatitis B complicated by fatty liver disease is more and more common in clinical practice. The influence of chronic hepatitis B virus infection on fatty liver disease and lipid metabolism has gradually become a hot topic in clinical research, as well as the influence of fatty liver disease and metabolic factors on the course and treatment of chronic hepatitis B.
    MeSH term(s) China/epidemiology ; Fatty Liver/complications ; Fatty Liver/epidemiology ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/epidemiology ; Humans ; Obesity/epidemiology ; Prevalence ; Risk Factors
    Language Chinese
    Publishing date 2018-05-26
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.issn.1007-3418.2018.01.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Emphasis on clinical study of heterogeneity of non-alcoholic fatty liver disease].

    Huang, L J / Xu, Y H / Fan, J G

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2020  Volume 28, Issue 3, Page(s) 193–197

    Abstract: Nonalcoholic fatty liver disease is the leading cause of chronic liver disease worldwide. Non-alcoholic fatty liver disease has a wide spectrum of diseases including simple fatty liver, steatohepatitis, liver fibrosis, and cirrhosis. The clinical ... ...

    Abstract Nonalcoholic fatty liver disease is the leading cause of chronic liver disease worldwide. Non-alcoholic fatty liver disease has a wide spectrum of diseases including simple fatty liver, steatohepatitis, liver fibrosis, and cirrhosis. The clinical manifestations and disease outcomes of patients with non-alcoholic fatty liver disease vary widely, and are related to the heterogeneity of risk factors, such as heredity, epigenetics, race, gender, age, diet, exercise, alcohol drinking, intestinal microecology, coexisting diseases, and hormone and metabolic status. Emphasizing the study of pathogenesis and clinical heterogeneity of patients with non-alcoholic fatty liver disease will help to layer the management of disease and improve the effectiveness of clinical trials.
    MeSH term(s) Diet ; Exercise ; Fatty Liver/complications ; Humans ; Liver ; Liver Cirrhosis/complications ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/physiopathology ; Risk Factors
    Language Chinese
    Publishing date 2020-04-19
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn501113-20200317-00119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Introduction to the APASL clinical guidelines on the management of metabolic-associated fatty liver disease].

    Shi, Y W / Xiao, Q Q / Fan, J G

    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

    2020  Volume 28, Issue 11, Page(s) 915–917

    Abstract: Recently, metabolic-associated fatty liver disease has become the world's highest prevalence of chronic liver disease. Moreover, it is closely related to metabolic syndrome and related diseases, bringing a huge disease burden. Previously, the global ... ...

    Abstract Recently, metabolic-associated fatty liver disease has become the world's highest prevalence of chronic liver disease. Moreover, it is closely related to metabolic syndrome and related diseases, bringing a huge disease burden. Previously, the global expert consensus on renaming for non-alcoholic fatty liver disease and the diagnostic criteria for metabolic-associated fatty liver disease has increased the certainty of further clinical research and practice. Presently, the research on metabolic-associated fatty liver disease is progressing rapidly, and the opinions and data based on clinical evidence are constantly updated. Hepatology international has published the "Asian Pacific Association for the Study of liver diseases' clinical guidelines on the management of metabolic-associated fatty liver disease" , which aims to promote clinical practice and improve the efficiency of clinical research. Here, we have translated the published recommendations into Chinese language, hoping to help most health professionals make clinical decisions.
    MeSH term(s) Consensus ; Gastroenterology ; Humans ; Metabolic Syndrome ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/therapy ; Prevalence
    Language Chinese
    Publishing date 2020-11-25
    Publishing country China
    Document type Journal Article
    ISSN 1007-3418
    ISSN 1007-3418
    DOI 10.3760/cma.j.cn51113-20201102-00592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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