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  1. Article: A Bibliometric and Visual Analysis of the Current Status and Trends of Forensic Mixed Stain Research.

    Fan, Qing-Wei / Li, Ling / Yang, Hui-Ling / Deng, Ting-Ting / Xu, Dong-Dong / Wang, Yun / DU, Bing / Yan, Jiang-Wei

    Fa yi xue za zhi

    2024  Volume 40, Issue 1, Page(s) 20–29

    Abstract: Objectives: To explore the context and hotspot changes of forensic mixed stain research through bibliometric approach.: Methods: The literature of forensic mixed stain included in the core collection of Web of Science database from 2011 to 2022 were ... ...

    Abstract Objectives: To explore the context and hotspot changes of forensic mixed stain research through bibliometric approach.
    Methods: The literature of forensic mixed stain included in the core collection of Web of Science database from 2011 to 2022 were collected as the study object, and the annual publication number, countrie (region), institution, journal, keywords, etc. were bibliometrically and visually analyzed using the R-based Bibliometrix 1.1.6 package and VOSviewer 1.6.18 software.
    Results: A total of 732 articles on forensic mixed stain were included from 2011 to 2022, with the annual number of articles published and the annual citation frequency showing a steady increase year by year. Among the 59 countries (regions) with the most published articles, the United States ranked first with 246 articles, followed by China with 153 articles. The literature came from 104 journals, and the total number of articles published in the top 10 journals was 633. FORENSIC SCI INT GENET ranked first with 307 articles. Visual analysis using VOSviewer software showed that keywords could be divided into four research clusters, namely the genetic marker development group (blue), the mixed stain typing analysis theory group (red), the sequencing analysis group (yellow), and the case sample research group (green). It can be divided into four development stages in terms of different time periods: early development (2011-2013), middle development (2014-2016), rapid development (2017-2020) and latest development (2021-2022).
    Conclusions: The number of publications by domestic and foreign scholars in the study of mixed stain in forensic science is showing a relatively stable trend. Machine learning, next generation sequencing and other research have been the hottest topics that have attracted the most attention in recent years, which is expected to further develop the theory of mixed stain typing and sequencing analysis in forensic mixed stain research.
    MeSH term(s) Bibliometrics ; China ; Coloring Agents ; Forensic Sciences ; High-Throughput Nucleotide Sequencing
    Chemical Substances Coloring Agents
    Language Chinese
    Publishing date 2024-03-08
    Publishing country China
    Document type Journal Article
    ISSN 1004-5619
    ISSN 1004-5619
    DOI 10.12116/j.issn.1004-5619.2022.521010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Analysis of Genetic Polymorphism and Population Genetic Structure of 57 Autosomal InDel Loci in Beichuan Qiang Population.

    Jiang, Chun-Yue / Ma, Hao / Fan, Qing-Wei / Yang, Hui-Ling / Xu, Dong-Dong / Wang, Yun / DU, Bing

    Fa yi xue za zhi

    2023  Volume 38, Issue 6, Page(s) 739–746

    Abstract: Objectives: To investigate the genetic information of 57 autosomal InDel loci (A-InDels) included in AGCU InDel 60 fluorescence detection kit in the Beichuan Qiang population of Sichuan Province and evaluate its application value in forensic medicine.!## ...

    Abstract Objectives: To investigate the genetic information of 57 autosomal InDel loci (A-InDels) included in AGCU InDel 60 fluorescence detection kit in the Beichuan Qiang population of Sichuan Province and evaluate its application value in forensic medicine.
    Methods: A total of 200 unrelated healthy individuals from Beichuan Qiang population of Sichuan Province were typing detected by AGCU InDel 60 fluorescence detection kit. Allele frequencies and population genetic parameters of the 57 A-InDels were statistically analyzed and compared with the available data of 26 populations.
    Results: After Bonferroni correction, there was no linkage disequilibrium between the 57 A-InDels, and all loci were in Hardy-Weinberg equilibrium. Except for rs66595817 and rs72085595, the minor allele frequencies of 55 A-InDels were above 0.3. PIC ranged from 0.298 3 to 0.375 0, CDP was 1-2.974 8×10
    Conclusions: The 57 A-InDels in AGCU InDel 60 fluorescence detection kit have a good genetic polymorphism in Beichuan Qiang population of Sichuan Province, which can be used as effective supplemental for individual identification and paternity identification in forensic medicine.
    MeSH term(s) Humans ; Genetics, Population ; Asian People/genetics ; Polymorphism, Genetic ; Gene Frequency ; INDEL Mutation ; China ; Microsatellite Repeats ; Genetic Loci
    Language Chinese
    Publishing date 2023-02-02
    Publishing country China
    Document type Journal Article
    ISSN 1004-5619
    ISSN 1004-5619
    DOI 10.12116/j.issn.1004-5619.2021.511102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Beating of grafted chains induced by active Brownian particles.

    Yang, Qiu-Song / Fan, Qing-Wei / Shen, Zhuang-Lin / Xia, Yi-Qi / Tian, Wen-de / Chen, Kang

    The Journal of chemical physics

    2018  Volume 148, Issue 21, Page(s) 214904

    Abstract: We study the interplay between active Brownian particles (ABPs) and a "hairy" surface in two-dimensional geometry. We find that the increase of propelling force leads to and enhances inhomogeneous accumulation of ABPs inside the brush region. Oscillation ...

    Abstract We study the interplay between active Brownian particles (ABPs) and a "hairy" surface in two-dimensional geometry. We find that the increase of propelling force leads to and enhances inhomogeneous accumulation of ABPs inside the brush region. Oscillation of chain bundles (beating like cilia) is found in company with the formation and disassembly of a dynamic cluster of ABPs at large propelling forces. Meanwhile chains are stretched and pushed down due to the effective shear force by ABPs. The decrease of the average brush thickness with propelling force reflects the growth of the beating amplitude of chain bundles. Furthermore, the beating phenomenon is investigated in a simple single-chain system. We find that the chain swings regularly with a major oscillatory period, which increases with chain length and decreases with the increase of propelling force. We build a theory to describe the phenomenon and the predictions on the relationship between the period and amplitude for various chain lengths, and propelling forces agree very well with simulation data.
    Language English
    Publishing date 2018-06-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/1.5029967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Actual mutational research of 19 autosomal STRs based on restricted mutation model and big data.

    Liu, Zhi-Yong / Ren, He / Chen, Chong / Zhang, Jing-Jing / Zhang, Xiao-Meng / Shi, Yan / Shi, Lin-Yu / Chen, Ying / Cheng, Feng / Jia, Li / Chen, Man / Fan, Qing-Wei / Zhang, Jia-Rong / Li, Wan-Ting / Wang, Meng-Chun / Ren, Zi-Lin / Liu, Ya-Cheng / Ni, Ming / Sun, Hong-Yu /
    Yan, Jiang-Wei

    Yi chuan = Hereditas

    2021  Volume 43, Issue 10, Page(s) 949–961

    Abstract: Short tandem repeat (STR) markers have been widely used in forensic paternity testing and individual identification, but the STR mutation might impact on the forensic result interpretation. Importantly, the STR mutation rate was underestimated due to ... ...

    Abstract Short tandem repeat (STR) markers have been widely used in forensic paternity testing and individual identification, but the STR mutation might impact on the forensic result interpretation. Importantly, the STR mutation rate was underestimated due to ignoring the "hidden" mutation phenomenon in most similar studies. Considering this, we use Slooten and Ricciardi's restricted mutation model based on big data to obtain more accurate mutation rates for each marker. In this paper, the mutations of 20 autosomal STRs loci (D3S1358, D1S1656, D13S317, Penta E, D16S539, D18S51, D2S1338, CSF1PO, Penta D, TH01, vWA, D21S11, D6S1043, D7S820, D5S818, TPOX, D8S1179, D12S391, D19S433, and FGA; The restricted model does not include the correction factor of D6S1043, this paper calculates remaining 19 STR loci mutation rates) were investigated in 28,313 (Total: 78,739 individuals) confirmed parentage-testing cases in Chinese Han population. As a result, total 1665 mutations were found in all loci, including 1614 one-steps, 34 two-steps, 8 three-steps, and 9 nonintegral mutations. The loci-specific average mutation rates ranged from 0.00007700 (TPOX) to 0.00459050 (FGA) in trio's and 0.00000000 (TPOX) to 0.00344850 (FGA) in duo's. We analyzed the relationship between mutation rates of the apparent and actual, the trio's and duo's, the paternal and maternal, respectively. The results demonstrated that the actual mutation rates are more than the apparent mostly, and the values of μ1"/μ2"(apparent) are also greater than μ1/μ2 (actual) commonly (μ1", μ1; μ2", μ2 are the mutation rates of one-step and two-step). Therefore, the "hidden" mutations are identified. In addition, the mutations rates of trio's and duo's, the paternal and maternal, exhibit significant difference. Next, those mutation data are used to do a comparison with the studies of other Han populations in China, which present the temporal and regional disparities. Due to the large sample size, some rare mutation events, such as monozygotic (MZ) mutation and "fake four-step mutation", are also reported in this study. In conclusion, the estimation values of actual mutations are obtained based on big data, they can not only provide basic data for the Chinese forensic DNA and population genetics databases, but also have important significance for the development of forensic individual identification, paternity testing and genetics research.
    MeSH term(s) Big Data ; Gene Frequency ; Genetics, Population ; Humans ; Microsatellite Repeats/genetics ; Mutation ; Mutation Rate
    Language English
    Publishing date 2021-10-20
    Publishing country China
    Document type Journal Article
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.16288/j.yczz.21-197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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