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Article ; Online: The influence of placenta microbiota of normal term pregnant women on immune regulation during pregnancy.

Yang, Ping / Lu, Tong / Liang, Xinyuan / Huang, Ting / Wu, Lulu / He, Zonglin / Xiao, Xiaomin / Fan, Shangrong

2024 Volume 24, Issue 1, Page(s) 171

Abstract: Background: The concerted regulation of placenta microbiota and the immune responses secures the occurrence and development of pregnancy, while few studies reported this correlation. This study aimed to explore the relationship between the placenta ... ...

Abstract	Background: The concerted regulation of placenta microbiota and the immune responses secures the occurrence and development of pregnancy, while few studies reported this correlation. This study aimed to explore the relationship between the placenta microbiota and immune regulation during pregnancy. Methods: Twenty-six healthy pregnant women scheduled for elective cesarean section in the First Affiliated Hospital of Jinan University who met the inclusion criteria were recruited. Placenta and peripheral venous blood samples were collected. Microbiota in placental tissue was detected using high-throughput sequencing. Flow cytometry was used to detect immune cells in placental tissue and peripheral venous blood. ELISA and Luminex liquid chip technology were used to detect the content of cytokines in placental tissue and peripheral venous blood, respectively. Results: The placental microbiota has stimulating effects on the local immunity of the placenta and mainly stimulates the placental balance ratio CD56 + CD16 + /CD56 + CD16 and the placental macrophages, that is, it plays the role of immune protection and supporting nutrition. The stimulating effect of placental microbiota on maternal systemic immunity mainly induces peripheral Treg cells and B lymphocytes. Conclusion: The placental microbiota may be an important factor mediating local immune regulation in the placenta, and placental microbiota participates in the regulatory function of the maternal immune system.
MeSH term(s)	Pregnancy ; Female ; Humans ; Placenta ; Pregnant Women ; Cesarean Section ; Cytokines ; Microbiota
Chemical Substances	Cytokines
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-024-06353-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: TAGLN2-Regulated Trophoblast Migration, Invasion and Fusion are Impaired in Preeclampsia.

Wang, Hao / Zhang, Xiaowei / Liu, Chunfeng / Chen, Shengfu / Liu, Xinyang / Fan, Shangrong

Frontiers in cell and developmental biology

2022 Volume 10, Page(s) 810633

Abstract: Preeclampsia (PE) is a serious disease during pregnancy that affects approximately eight million mothers and infants worldwide each year and is closely related to abnormal trophoblast function. However, research on placental trophoblast functional ... ...

Abstract	Preeclampsia (PE) is a serious disease during pregnancy that affects approximately eight million mothers and infants worldwide each year and is closely related to abnormal trophoblast function. However, research on placental trophoblast functional abnormalities is insufficient, and the etiology of PE is unclear. Here, we report that the expression of transgelin-2 (TAGLN2) was downregulated in the placenta of patients with PE. In addition, a lack of TAGLN2 significantly reduced the ability of trophoblasts to migrate, invade and fuse. A co-immunoprecipitation (Co-IP) and microscale thermophoresis analysis showed that TAGLN2 bound directly to E-cadherin. A decrease in TAGLN2 expression led to a reduction in cleavage of the E-cadherin extracellular domain, thereby regulating the function of trophoblasts. In addition, we found that a reduction in soluble E-cadherin may also have an effect on blood vessel formation in the placenta, which is necessary for normal placental development. What's more, the
Language	English
Publishing date	2022-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2022.810633
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Article ; Online: Correction to: Molecular identification and antifungal susceptibility profile of yeast from vulvovaginal candidiasis.

Shi, Yu / Zhu, Yuxia / Fan, Shangrong / Liu, Xiaoping / Liang, Yiheng / Shan, Yingying

BMC infectious diseases

2022 Volume 22, Issue 1, Page(s) 85

Language	English
Publishing date	2022-01-24
Publishing country	England
Document type	Published Erratum
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-021-06601-x
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Article: Maternal sepsis in pregnancy and the puerperal periods: a cross-sectional study.

Liu, Ping / Zhang, Xiaowei / Wang, Xinxin / Liang, Yiheng / Wei, Nan / Xiao, Zhansong / Li, Ting / Zhe, Ruilian / Zhao, Weihua / Fan, Shangrong

Frontiers in medicine

2023 Volume 10, Page(s) 1126807

Abstract: Maternal sepsis is a life-threatening condition and ranks among the top five causes of maternal death in pregnancy and the postpartum period. Herein, we conducted a retrospective study on sepsis cases to explain the related risk factors by comparing them ...

Abstract	Maternal sepsis is a life-threatening condition and ranks among the top five causes of maternal death in pregnancy and the postpartum period. Herein, we conducted a retrospective study on sepsis cases to explain the related risk factors by comparing them with bloodstream infection (BSI) and control maternities. In total, 76 sepsis cases were enrolled, and 31 BSI and 57 maternal cases of the same age but with neither sepsis nor BSI were set as controls. Genital tract infection (GTI) and pneumonia were the two most common infection sources in both sepsis (22 cases, 29% and 29 cases, 38%) and BSI cases (18 cases, 58% and 8 cases, 26%). Urinary tract infection (UTI)/pyelonephritis (9 cases, 12%) and digestive infection cases (11 cases, 14%) only existed in the sepsis group. Significantly different infection sources were discovered between the sepsis-death and sepsis-cure groups. A higher proportion of pneumonia and a lower proportion of GTI cases were present in the sepsis-death group (17 cases, 45% pneumonia and 9 cases, 24% GTI) than in the sepsis-cure group (12 cases, 32% pneumonia and 13 cases, 34% GTI). In addition, although gram-negative bacteria were the dominant infectious microorganisms as previously reported, lower proportion of gram-negative bacteria infectious cases in sepsis (30 cases, 50%) and even lower in sepsis-death group (14 cases, 41%) was shown in this study than previous studies. As expected, significantly greater adverse maternal and fetal outcomes, such as higher maternal mortality (26.3% vs. 0% vs. 0%), higher fetal mortality (42.2% vs. 20.8% vs. 0%), earlier gestational age at delivery (26.4 ± 9.5 vs. 32.3 ± 8.1 vs. 37.7 ± 4.0) and lower newborn weight (1,590 ± 1287.8 vs. 2859.2 ± 966.0 vs. 3214.2 ± 506.4), were observed in the sepsis group. This study offered some potential pathogenesis and mortality risk factors for sepsis, which may inspire the treatment of sepsis in the future.
Language	English
Publishing date	2023-05-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1126807
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Article ; Online: Alterations in Vaginal Microbiota and Associated Metabolome in Women with Recurrent Implantation Failure.

Fu, Min / Zhang, Xiaowei / Liang, Yiheng / Lin, Shouren / Qian, Weiping / Fan, Shangrong

mBio

2020 Volume 11, Issue 3

Abstract: Recurrent implantation failure (RIF) refers to repeated failure to become pregnant after transferring embryos with normal morphology. However, the pathogenesis of RIF remains unrevealed, especially for those without any pathological features. In this ... ...

Abstract	Recurrent implantation failure (RIF) refers to repeated failure to become pregnant after transferring embryos with normal morphology. However, the pathogenesis of RIF remains unrevealed, especially for those without any pathological features. In this study, we characterized the vaginal microbiota and metabolomes of patients with unexplained RIF, while patients who achieved clinical pregnancy in the first frozen embryo transfer (FET) cycle were used as controls. Based on 16S rRNA gene sequencing of the vaginal microbiota, the vaginal
MeSH term(s)	Adult ; Case-Control Studies ; Embryo Implantation ; Female ; Fertilization in Vitro ; Humans ; Metabolome ; Microbiota ; Pregnancy ; Pregnancy Rate ; RNA, Ribosomal, 16S/genetics ; Recurrence ; Vagina/microbiology
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2020-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.03242-19
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Article ; Online: Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt.

Liu, Chunfeng / Wang, Hao / Yang, Mo / Liang, Yiheng / Jiang, Li / Sun, Siman / Fan, Shangrong

Reproductive sciences (Thousand Oaks, Calif.)

2020 Volume 28, Issue 1, Page(s) 178–185

Abstract: Preeclampsia is a multi-system disease that is unique to human pregnancy. Impaired extravillous trophoblast migration and invasion accompanied by poor spiral vascular remodeling is thought to be the initial reason. This study investigated cAMP-dependent ... ...

Abstract	Preeclampsia is a multi-system disease that is unique to human pregnancy. Impaired extravillous trophoblast migration and invasion accompanied by poor spiral vascular remodeling is thought to be the initial reason. This study investigated cAMP-dependent protein kinase inhibitor-b(PKIB) expression in placentas and its involvement in the pathogenesis of PE. We used immunohistochemistry and western blotting to calculate PKIB levels in the placentas. Then we knocked down PKIB by siRNA and used real-time cell analysis to assess the invasion and migration ability of trophoblasts. Tube formation assay and spheroid sprouting assay were utilized to identify the ability to form vessels of trophoblasts. At last, western blotting was used to demonstrate the level of phosphorylated Akt, as well as downstream-related genes of Akt signaling pathway in trophoblasts. We first found that PKIB expression level was lower in the PE placentas than in the normal placentas. In addition, we found that downregulation of PKIB can inhibit the migration, invasion, and the ability to form vessels of HTR8/SVneo cells. Downregulation of PKIB leaded to a decrease in phosphorylated Akt, as well as downstream proteins such as matrix metalloproteinase 2, matrix metalloproteinase 9, and glycogen synthase kinase 3β, which are related to migration and invasion. Our study revealed that the downregulation of PKIB expression resulted in decreased migration, invasion, and vessel formation ability by regulating Akt signaling pathway in placental trophoblasts in PE.
MeSH term(s)	Adult ; Case-Control Studies ; Cell Line ; Cell Movement ; Down-Regulation ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Phosphorylation ; Pre-Eclampsia/diagnosis ; Pre-Eclampsia/metabolism ; Pre-Eclampsia/physiopathology ; Pregnancy ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Trophoblasts/enzymology ; Trophoblasts/pathology ; Vascular Remodeling
Chemical Substances	Intracellular Signaling Peptides and Proteins ; PKIB protein, human ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-020-00258-8
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Article ; Online: Molecular identification and antifungal susceptibility profile of yeast from vulvovaginal candidiasis.

Shi, Yu / Zhu, Yuxia / Fan, Shangrong / Liu, Xiaoping / Liang, Yiheng / Shan, Yingying

BMC infectious diseases

2020 Volume 20, Issue 1, Page(s) 287

Abstract: Background: Accurate identification Candida is important for successful therapy and epidemiology study. The aim of research is to study API 20C yeast identification system identification rate by using molecular identification as gold standard and tested ...

Abstract	Background: Accurate identification Candida is important for successful therapy and epidemiology study. The aim of research is to study API 20C yeast identification system identification rate by using molecular identification as gold standard and tested the antifungal susceptibility of Candida from patients with vulvovaginal candidiasis (VVC). Methods: In total, 3574 yeast isolates were obtained from patients with VVC. API 20C yeast identification, molecular identification and in vitro antifungal susceptibility were performed. Results: C. albicans was the predominant Candida species [2748 isolates, 76.9%] in VVC. The isolates from vaginal samples represented 22 species based on molecular identification. The API 20C system identifies only 11 of the species encountered during the study period. Based on the API 20C system, 3273 (91.78%) isolates were correctly identified to the species level. The correct identification rate of the API 20C system for rare yeast was 15.29% (26/170 isolates). Antifungal susceptibility was tested in a total of 1844 isolates of Candida from patients with VVC. C. albicans was susceptible to most of the tested antifungals. The MICs of azoles for C. glabrata were higher than those for C. albicans. The MICs of echinocandins for C. parapsilosis were higher than those for C. albicans. Conclusions: The API 20C yeast identification system can be used to reliably identify the most common Candida species while molecular methods are necessary for the identification of closely related, emerging, and rare yeast species. The results from this study suggest that much of the previous studies on the epidemiology of VVC should be re-thought. C. albicans was susceptible to most of the tested antifungals.
MeSH term(s)	Adult ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida/classification ; Candida/drug effects ; Candida/genetics ; Candida/isolation & purification ; Candidiasis, Vulvovaginal/drug therapy ; Candidiasis, Vulvovaginal/epidemiology ; Candidiasis, Vulvovaginal/microbiology ; China/epidemiology ; Drug Resistance, Multiple, Fungal ; Female ; Humans ; Microbial Sensitivity Tests ; Polymerase Chain Reaction ; Prevalence ; Prospective Studies ; Young Adult
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2020-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-020-04985-w
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Article ; Online: Human Coronavirus Infections and Pregnancy.

Fan, Shangrong / Yan, Shaomei / Liu, Xiaoping / Liu, Ping / Huang, Lei / Wang, Suhua

Maternal-fetal medicine (Wolters Kluwer Health, Inc.)

2020 Volume 3, Issue 1, Page(s) 53–65

Abstract: Human coronavirus (HCoV) causes potentially fatal respiratory disease. Pregnancy is a physiological state that predisposes women to viral infection. In this review, we aim to present advances in the pathogenesis, clinical features, diagnosis, and ... ...

Abstract	Human coronavirus (HCoV) causes potentially fatal respiratory disease. Pregnancy is a physiological state that predisposes women to viral infection. In this review, we aim to present advances in the pathogenesis, clinical features, diagnosis, and treatment in HCoV in pregnancy. We retrieved information from the Pubmed database up to June 2020, using various search terms and relevant words, including coronaviruses, severe acute respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus, 2019 coronavirus disease, and pregnancy. Both basic and clinical studies were selected. We found no evidence that pregnant women are more susceptible to HCoV infection or that those with HCoV infection are more prone to developing severe pneumonia. There is also no confirmed evidence of vertical mother-to-child transmission of HcoV infection during maternal HCoV infection. Those diagnosed with infection should be promptly admitted to a negative-pressure isolation ward, preferably in a designated hospital with adequate facilities and multi-disciplinary expertise to manage critically ill obstetric patients. Antiviral treatment has been routinely used to treat pregnant women with HCoV infection. The timing and mode of delivery should be individualized, depending mainly on the clinical status of the patient, gestational age, and fetal condition. Early cord clamping and temporary separation of the newborn for at least 2 weeks is recommended. All medical staff caring for patients with HCoV infection should use personal protective equipment. This review highlights the advances in pathogenesis, maternal-fetal outcome, maternal-fetal transmission, diagnosis and treatment in HCoV including severe acute respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus, and coronavirus disease 2019 in pregnancy.
Language	English
Publishing date	2020-09-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3026863-1
ISSN	2641-5895 ; 2096-6954
ISSN (online)	2641-5895
ISSN	2096-6954
DOI	10.1097/FM9.0000000000000071
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Article ; Online: Orally administrated

Qi, Fengyuan / Fan, Shangrong / Fang, Chao / Ge, Lan / Lyu, Jinli / Huang, Zhuoqi / Zhao, Shaowei / Zou, Yuanqiang / Huang, Liting / Liu, Xinyang / Liang, Yiheng / Zhang, Yongke / Zhong, Yiyi / Zhang, Haifeng / Xiao, Liang / Zhang, Xiaowei

Frontiers in immunology

2023 Volume 14, Page(s) 1125239

Abstract: Bacterial vaginosis (BV) is a common infection of the lower genital tract with a vaginal microbiome dysbiosis caused by decreasing of lactobacilli. Previous studies suggested that supplementation with live : Clinical trial registration: https:// ... ...

Abstract	Bacterial vaginosis (BV) is a common infection of the lower genital tract with a vaginal microbiome dysbiosis caused by decreasing of lactobacilli. Previous studies suggested that supplementation with live Clinical trial registration: https://classic.clinicaltrials.gov/ct2/show/, identifier NCT04771728.
MeSH term(s)	Female ; Humans ; Adjuvants, Immunologic/therapeutic use ; Adjuvants, Pharmaceutic ; Lactobacillus/physiology ; Lactobacillus crispatus ; Lactobacillus gasseri ; Metronidazole/therapeutic use ; Treatment Outcome ; Vagina/microbiology ; Vaginosis, Bacterial/microbiology
Chemical Substances	Adjuvants, Immunologic ; Adjuvants, Pharmaceutic ; Metronidazole (140QMO216E)
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1125239
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Article ; Online: Prevalence of and risk factors for chlamydia in female outpatients with genital tract infections: a nationwide multi-center, cross-sectional study in China.

Li, Ting / Liu, Zhaohui / Zhang, Dai / Liao, Qinping / Fan, Shangrong / Hao, Min / Hong, Ying / Huang, Xiufeng / Wang, Huilan / Xiong, Zhengai / Xu, Hong / Xue, Fengxia / Xue, Min / Yang, Xingsheng / Zhang, Jianqing

Frontiers in public health

2023 Volume 11, Page(s) 1182108

Abstract: Introduction: Chlamydia trachomatis: Methods: A prospective, multicenter epidemiological study of genital chlamydia prevalence in 3008 patients with genital tract infections in 13 hospitals in 12 provinces of China was performed between May 2017 and ... ...

Abstract	Introduction: Chlamydia trachomatis Methods: A prospective, multicenter epidemiological study of genital chlamydia prevalence in 3008 patients with genital tract infections in 13 hospitals in 12 provinces of China was performed between May 2017 and November 2018. Vaginal secretion specimens were collected for the clinical diagnosis of vaginitis, whereas cervical secretion specimens were tested for Results: Totally 2,908 participants were included. The prevalence rates of chlamydia and gonococcal infections in women with genital tract infections were 6.33% (184/2908) and 0.01% (20/2908), respectively. Multivariate analysis showed high risk factors for chlamydia were premarital sex behavior, first sexual intercourse before the age of 20 and bacterial vaginosis. Discussion: Given that most chlamydia cases are asymptomatic and no vaccine is currently available, chlamydia prevention strategies should include behavioral interventions as well as early screening programs to identify and treat individuals with genital tract infections, especially those with the above identified risk factors.
MeSH term(s)	Humans ; Female ; Cross-Sectional Studies ; Reproductive Tract Infections/epidemiology ; Chlamydia Infections/epidemiology ; Chlamydia Infections/diagnosis ; Prospective Studies ; Prevalence ; Outpatients ; Risk Factors ; Chlamydia trachomatis
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Multicenter Study ; Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1182108
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