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Article ; Online: A dual-signal fluorescent colorimetric tetracyclines sensor based on multicolor carbon dots as probes and smartphone-assisted visual assay.

Fan, Ya Jie / Wang, Zhen Guang / Su, Ming / Liu, Xiao Tong / Shen, Shi Gang / Dong, Jiang Xue

2023 Volume 1247, Page(s) 340843

Abstract: The widespread presence of tetracyclines in the environment has raised concerns about the potential risks to ecosystems and human health. The ratiometric fluorescence sensor for detecting tetracyclines was developed using europium-doped carbon dots (Eu- ... ...

Abstract	The widespread presence of tetracyclines in the environment has raised concerns about the potential risks to ecosystems and human health. The ratiometric fluorescence sensor for detecting tetracyclines was developed using europium-doped carbon dots (Eu-CDs) as probes under alkaline conditions. The sensing mechanism of sensor for tetracyclines was considered as inner filter effect (IFE), antenna effect (AE), and self-quenching effect (SQE). The sensor had a wide linear detection range than the reported europium ions-based tetracyclines sensors. The linear detection ranges of oxytetracycline (OTC), tetracycline (TC), doxycycline (DC) and chlorotetracycline (CTC) were respectively 0.00-603.75 μM, 0.00-623.82 μM, 0.00-594.61 μM and 0.00-601.54 μM, and the corresponding detection limits were respectively 9.50 nM, 15.80 nM, 10.40 nM and 90.30 nM. The smartphone with RGB Color Picker was further employed to analyze the concentration of tetracyclines, which provided a new method for visual tetracyclines detection. The application of Eu-CDs test paper was also explored, and the results showed that the Eu-CDs test paper has great potential application in the visual detection of tetracyclines. In addition, the accuracy of the established tetracyclines sensor was compared with that of the China national standard method by high-performance liquid chromatography (HPLC), and the results showed that the established method in this work has similar accuracy to the China national standard method. The sensor has been employed to detect tetracyclines in the actual samples with satisfactory results, which indicated that this method has promising applications in the real-time monitoring tetracyclines of food and environment.
MeSH term(s)	Humans ; Tetracyclines/analysis ; Carbon/chemistry ; Europium/chemistry ; Smartphone ; Colorimetry ; Ecosystem ; Quantum Dots/chemistry ; Fluorescent Dyes/chemistry ; Anti-Bacterial Agents/analysis ; Spectrometry, Fluorescence/methods ; Limit of Detection
Chemical Substances	Tetracyclines ; Carbon (7440-44-0) ; Europium (444W947O8O) ; Fluorescent Dyes ; Anti-Bacterial Agents
Language	English
Publishing date	2023-01-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2023.340843
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Article: A ratiometric fluorescent sensor for tetracyclines detection in meat based on pH-dependence of targets with lanthanum-doped carbon dots as probes

Fan, Ya Jie / Su, Ming / Shi, Yu-E. / Liu, Xiao Tong / Shen, Shi Gang / Dong, Jiang Xue

Analytical and bioanalytical chemistry. 2022 Mar., v. 414, no. 8

2022

Abstract: Although some ratiometric fluorescent sensors have been reported to detect tetracyclines, most of ratiometric fluorescent sensors were established based on europium ion with a narrow linear range. In this work, a ratiometric fluorescent sensor for ... ...

Abstract	Although some ratiometric fluorescent sensors have been reported to detect tetracyclines, most of ratiometric fluorescent sensors were established based on europium ion with a narrow linear range. In this work, a ratiometric fluorescent sensor for tetracyclines detection was established based on the dual-emission lanthanum-doped carbon dots (La-CDs) as probes combining with the characteristic pH-response of tetracyclines. The fluorescence intensity of tetracyclines will be enhanced in high pH, and the emission peak of tetracyclines overlapped with the peak of probes. The superposition effect of tetracyclines and probes at 515 nm greatly improved the sensitivity of the ratiometric fluorescent sensor and widened the detection range, and linear ranges for oxytetracycline (OTC) and tetracycline (TC) were respectively 0.00–805.20 μM and 0.00–1039.50 μM. Moreover, the preparation procedure of the La-CDs was simple and time saving and the coupling agent was not required. A comparison of La-CDs with undoped carbon dots (un-CDs) showed that the optical performance and sensing performance of La-CDs were improved. In addition, a portable paper sensor with La-CDs as probes was preliminarily explored in this work, and the sensor has been applied to detect OTC and TC in pork and fish with satisfactory results.
Keywords	analytical chemistry ; europium ; fish ; fluorescence ; oxytetracycline ; pH ; paper ; pork ; tetracycline
Language	English
Dates of publication	2022-03
Size	p. 2597-2606.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ISSN	1618-2642
DOI	10.1007/s00216-022-03895-x
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Article ; Online: DNA Tile and Invading Stacking Primer-Assisted CRISPR–Cas12a Multiple Amplification System for Entropy-Driven Electrochemical Detection of MicroRNA with Tunable Sensitivity

Wang, Huan / Li, Yan Lei / Fan, Ya Jie / Dong, Jiang Xue / Ren, Xiang / Ma, Hongmin / Wu, Dan / Gao, Zhong Feng / Wei, Qin / Xia, Fan

Analytical Chemistry. 2023 Aug. 25, v. 95, no. 36 p.13659-13667

2023

Abstract: Conventional electrochemical detection of microRNA (miRNA) encounters issues of poor sensitivity and fixed dynamic range. Here, we report a DNA tile and invading stacking primer-assisted CRISPR–Cas12a multiple amplification strategy to construct an ... ...

Abstract	Conventional electrochemical detection of microRNA (miRNA) encounters issues of poor sensitivity and fixed dynamic range. Here, we report a DNA tile and invading stacking primer-assisted CRISPR–Cas12a multiple amplification strategy to construct an entropy-controlled electrochemical biosensor for the detection of miRNA with tunable sensitivity and dynamic range. To amplify the signal, a cascade amplification of the CRISPR–Cas12a system along with invading stacking primer signal amplification (ISPSA) was designed to detect trace amounts of miRNA-31 (miR-31). The target miR-31 could activate ISPSA and produce numerous DNAs, triggering the cleavage of the single-stranded linker probe (LP) that connects a methylene blue-labeled DNA tile with a DNA tetrahedron to form a Y-shaped DNA scaffold on the electrode. Based on the decrease of current, miR-31 can be accurately and efficiently detected. Impressively, by changing the loop length of the LP, it is possible to finely tune the entropic contribution while keeping the enthalpic contribution constant. This strategy has shown a tunable limit of detection for miRNA from 0.31 fM to 0.56 pM, as well as a dynamic range from ∼2200-fold to ∼270,000-fold. Moreover, it demonstrated satisfactory results in identifying cancer cells with a high expression of miR-31. Our strategy broadens the application of conventional electrochemical biosensing and provides a tunable strategy for detecting miRNAs at varying concentrations.
Keywords	DNA ; analytical chemistry ; biosensors ; detection limit ; electrochemistry ; electrodes ; microRNA
Language	English
Dates of publication	2023-0825
Size	p. 13659-13667.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c02603
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Article ; Online: Photocleavable DNA Nanotube-Based Dual-Amplified Resonance Rayleigh Scattering System for MicroRNA Detection Incorporating Molecular Computing-Cascaded Keypad Lock Functionality.

Li, Yan Lei / Min, Xue Hong / Fan, Ya Jie / Dong, Jiang Xue / Wu, Dan / Ren, Xiang / Ma, Hong Min / Gao, Zhong Feng / Wei, Qin / Xia, Fan / Ju, Huangxian

Analytical chemistry

2024

Abstract: Cascade molecular events in complex systems are of vital importance for enhancing molecular diagnosis and information processing. However, the conversion of a cascaded biosensing system into a multilayer encrypted molecular keypad lock remains a ... ...

Abstract	Cascade molecular events in complex systems are of vital importance for enhancing molecular diagnosis and information processing. However, the conversion of a cascaded biosensing system into a multilayer encrypted molecular keypad lock remains a significant challenge in the development of molecular logic devices. In this study, we present a photocleavable DNA nanotube-based dual-amplified resonance Rayleigh scattering (RRS) system for detecting microRNA-126 (miR-126). The cascading dual-amplification biosensing system provides a multilayer-encrypted prototype with the functionality of a molecular computing cascade keypad lock. RRS signals were greatly amplified by using photocleavable DNA nanotubes and enzyme-assisted strand displacement amplification (SDA). In the presence of miR-126, enzyme-assisted SDA produced numerous identical nucleotide fragments as the target, which were then specifically attached to magnetic beads through the DNA nanotube by using a Y-shaped DNA scaffold. Upon ultraviolet irradiation, the DNA nanotube was released into the solution, resulting in an increase in the intensity of the RRS signal. This strategy demonstrated a low limit of detection (0.16 fM) and a wide dynamic range (1 fM to 1 nM) for miR-126. Impressively, the enzyme-assisted SDA offers a molecular computing model for generating the target pool, which serves as the input element for unlocking the system. By cascading the molecular computing process, we successfully constructed a molecular keypad lock with a multilevel authentication technique. The proposed system holds great potential for applications in molecular diagnosis and information security, indicating significant value in integrating molecular circuits for intelligent sensing.
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c04718
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Article: Urotensin II activates the ferroptosis pathway through circ0004372/miR-124/SERTAD4 to promote the activation of vascular adventitial fibroblasts.

Hu, Yan-Chao / Han, Tuo / Fan, Ya-Jie / Zhang, Chun-Yan / Zhang, Yan / Ma, Wei-Dong / Wang, Cong-Xia

General physiology and biophysics

2022 Volume 41, Issue 5, Page(s) 381–392

Abstract: Both vascular adventitial fibroblasts (VAFs) and urotensin II (UII) play important roles in vascular remodeling diseases, but the mechanism of UII in VAFs is still unclear. UII inhibited miR-124 expression through up-regulating circ0004372 expression, ... ...

Abstract	Both vascular adventitial fibroblasts (VAFs) and urotensin II (UII) play important roles in vascular remodeling diseases, but the mechanism of UII in VAFs is still unclear. UII inhibited miR-124 expression through up-regulating circ0004372 expression, thereby promoting SERTAD4 expression. UII significantly promoted the generation of ROS, MDA and 4-HNE, reduced the activities of SOD, GST and GR, increased Fe2+ concentration and inhibited GPX4 expression through circ0004372/miR-124/SERTAD4. Both UII and ferroptosis inducer Erastin significantly promoted the expression of α-SMA, Collagen I and TGF-β1 in VAFs, but circ0004372 siRNA, miR-124 mimics, SERTAD4 siRNA or Ferrostatin-1 significantly inhibited the effect of UII and Erastin on cell activation. When co-transfected with circ0004372 siRNA and miR-124 inhibitors or miR-124 mimics and SERTAD4 overexpression vector, UII still significantly increased the expression of α-SMA, Collagen I and TGF-β1. After transfection with circ0004372 overexpression vector, miR-124 inhibitors or SERTAD4 overexpression vector and then treating with UII and Ferrostatin-1, the expression of α-SMA, Collagen I and TGF-β1 was still significant; when the circ0004372 overexpression vector and miR-124 mimics or miR-124 inhibitors and SERTAD4 siRNA were co-transfected and then UII and Ferrostatin-1 were added, the expression of α-SMA, Collagen I and TGF-β1 was not significantly increased. Therefore, these results indicate that UII promotes the activation of VAFs through the circ0004372/miR-124/SERTAD4/ferroptosis pathway.
MeSH term(s)	Collagen ; Cyclohexylamines ; Ferroptosis ; Fibroblasts ; MicroRNAs/metabolism ; Phenylenediamines ; RNA, Small Interfering/metabolism ; RNA, Small Interfering/pharmacology ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase/metabolism ; Urotensins
Chemical Substances	Cyclohexylamines ; MicroRNAs ; Phenylenediamines ; RNA, Small Interfering ; Reactive Oxygen Species ; Urotensins ; ferrostatin-1 ; Collagen (9007-34-5) ; urotensin II (9047-55-6) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2022-10-12
Publishing country	Slovakia
Document type	Journal Article
ZDB-ID	791184-1
ISSN	0231-5882
ISSN	0231-5882
DOI	10.4149/gpb_2022027
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Article ; Online: A ratiometric fluorescent sensor for tetracyclines detection in meat based on pH-dependence of targets with lanthanum-doped carbon dots as probes.

Fan, Ya Jie / Su, Ming / Shi, Yu-E / Liu, Xiao Tong / Shen, Shi Gang / Dong, Jiang Xue

Analytical and bioanalytical chemistry

2022 Volume 414, Issue 8, Page(s) 2597–2606

Abstract	Although some ratiometric fluorescent sensors have been reported to detect tetracyclines, most of ratiometric fluorescent sensors were established based on europium ion with a narrow linear range. In this work, a ratiometric fluorescent sensor for tetracyclines detection was established based on the dual-emission lanthanum-doped carbon dots (La-CDs) as probes combining with the characteristic pH-response of tetracyclines. The fluorescence intensity of tetracyclines will be enhanced in high pH, and the emission peak of tetracyclines overlapped with the peak of probes. The superposition effect of tetracyclines and probes at 515 nm greatly improved the sensitivity of the ratiometric fluorescent sensor and widened the detection range, and linear ranges for oxytetracycline (OTC) and tetracycline (TC) were respectively 0.00-805.20 μM and 0.00-1039.50 μM. Moreover, the preparation procedure of the La-CDs was simple and time saving and the coupling agent was not required. A comparison of La-CDs with undoped carbon dots (un-CDs) showed that the optical performance and sensing performance of La-CDs were improved. In addition, a portable paper sensor with La-CDs as probes was preliminarily explored in this work, and the sensor has been applied to detect OTC and TC in pork and fish with satisfactory results.
MeSH term(s)	Animals ; Carbon ; Fluorescent Dyes ; Hydrogen-Ion Concentration ; Lanthanum ; Meat ; Quantum Dots ; Tetracyclines
Chemical Substances	Fluorescent Dyes ; Tetracyclines ; Lanthanum (6I3K30563S) ; Carbon (7440-44-0)
Language	English
Publishing date	2022-02-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201093-8
ISSN	1618-2650 ; 0016-1152 ; 0372-7920
ISSN (online)	1618-2650
ISSN	0016-1152 ; 0372-7920
DOI	10.1007/s00216-022-03895-x
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Article ; Online: Photocontrollable DNA Walker-Based Molecular Circuit for the Tunable Detection of MicroRNA-21 Using Metal–Organic Frameworks as Label-Free Fluorescence Tags

Dong, Jiang Xue / Zhang, Sai Mei / Li, Yan Lei / Zhang, Xu / Fan, Ya Jie / Su, Ming / Wang, Zhen Guang / Li, Hui / Shen, Shi Gang / Gao, Zhong Feng / Wei, Qin / Xia, Fan

Analytical Chemistry. 2023 Nov. 06, v. 95, no. 45 p.16744-16753

2023

Abstract: Tunable detection of microRNA is crucial to meet the desired demand for sample species with varying concentrations in clinical settings. Herein, we present a DNA walker-based molecular circuit for the detection of miRNA-21 (miR-21) with tunable dynamic ... ...

Abstract	Tunable detection of microRNA is crucial to meet the desired demand for sample species with varying concentrations in clinical settings. Herein, we present a DNA walker-based molecular circuit for the detection of miRNA-21 (miR-21) with tunable dynamic ranges and sensitivity levels ranging from fM to pM. The phosphate-activated fluorescence of UiO-66-NH₂ metal–organic framework nanoparticles was used as label-free fluorescence tags due to their competitive coordination effect with the Zr atom, which significantly inhibited the ligand-to-metal charge transfer. To achieve a tunable detection performance for miR-21, the ultraviolet sensitive o-nitrobenzyl was induced as a photocleavable linker, which was inserted at various sites between the loop and the stem of the hairpin probe to regulate the DNA strand displacement reaction. The dynamic range can be precisely regulated from 700- to 67,000-fold with tunable limits of detection ranging from 2.5 fM to 36.7 pM. Impressively, a Boolean logic tree and complex molecular circuit were constructed for logic computation and cancer diagnosis in clinical blood samples. This intelligent biosensing method presents a powerful solution for converting complex biosensing systems into actionable healthcare decisions and will facilitate early disease diagnosis.
Keywords	DNA ; analytical chemistry ; blood ; coordination polymers ; disease diagnosis ; fluorescence ; health services ; microRNA ; nanoparticles
Language	English
Dates of publication	2023-1106
Size	p. 16744-16753.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03913
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Article ; Online: d‑Penicillamine@Ag/Cu Nanocluster-Based Fluorescent Nanoneuron for Logic Screening Phosphonate-Type Organophosphate Pesticides and Steganographically Encrypting Information

Fan, Ya Jie / Dong, Jiang Xue / Li, Yan Lei / Wang, Zhen Guang / Chang, Yan Qing / Ren, Li Fang / Su, Ming / Guan, Li / Shen, Shi Gang / Gao, Zhong Feng / Wei, Qin / Xia, Fan

Analytical Chemistry. 2023 July 10, v. 95, no. 29 p.11113-11123

2023

Abstract: Organophosphate pesticides are used in agriculture due to their high effectiveness and low persistence in eradicating insects and pests. However, conventional detection methods encounter the limitation of undesired detection specificity. Thus, screening ... ...

Abstract	Organophosphate pesticides are used in agriculture due to their high effectiveness and low persistence in eradicating insects and pests. However, conventional detection methods encounter the limitation of undesired detection specificity. Thus, screening phosphonate-type organophosphate pesticides (OOPs) from their analogues, phosphorothioate organophosphate pesticides (SOPs), remains a challenge. Here, we reported a d-penicillamine@Ag/Cu nanocluster (DPA@Ag/Cu NCs)-based fluorescence assay to screen OOPs from 21 kinds of organophosphate pesticides, which can be used for logic sensing and information encryption. Acetylthiocholine chloride was enzymatically split by acetylcholinesterase (AChE) to produce thiocholine, which reduced the fluorescence of DPA@Ag/Cu NCs due to the transmission of electrons from DPA@Ag/Cu NCs donor to the thiol group acceptor. Impressively, OOPs acted as an AChE inhibitor and retained the high fluorescence of DPA@Ag/Cu NCs due to the stronger positive electricity of the phosphorus atom. Conversely, SOPs possessed weak toxicity to AChE, which led to low fluorescence intensity. By setting 21 kinds of organophosphate pesticides as the inputs and the fluorescence of the resulting products as the outputs, DPA@Ag/Cu NCs could serve as a fluorescent nanoneuron to construct Boolean logic tree and complex logic circuit for molecular computing. As a proof of concept, by converting the selective response patterns of DPA@Ag/Cu NCs into binary strings, molecular crypto-steganography for encoding, storing, and concealing information was successfully achieved. This study is expected to advance the progress and practical application of nanoclusters in the area of logic detection and information security while also enhancing the relationship between molecular sensors and the world of information.
Keywords	acetylcholinesterase ; analytical chemistry ; chlorides ; electricity ; fluorescence ; nanoparticles ; organophosphorus compounds ; phosphorus ; thiols ; toxicity
Language	English
Dates of publication	2023-0710
Size	p. 11113-11123.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c02030
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Article ; Online: d-Penicillamine@Ag/Cu Nanocluster-Based Fluorescent Nanoneuron for Logic Screening Phosphonate-Type Organophosphate Pesticides and Steganographically Encrypting Information.

Fan, Ya Jie / Dong, Jiang Xue / Li, Yan Lei / Wang, Zhen Guang / Chang, Yan Qing / Ren, Li Fang / Su, Ming / Guan, Li / Shen, Shi Gang / Gao, Zhong Feng / Wei, Qin / Xia, Fan

Analytical chemistry

2023 Volume 95, Issue 29, Page(s) 11113–11123

Abstract	Organophosphate pesticides are used in agriculture due to their high effectiveness and low persistence in eradicating insects and pests. However, conventional detection methods encounter the limitation of undesired detection specificity. Thus, screening phosphonate-type organophosphate pesticides (OOPs) from their analogues, phosphorothioate organophosphate pesticides (SOPs), remains a challenge. Here, we reported a d-penicillamine@Ag/Cu nanocluster (DPA@Ag/Cu NCs)-based fluorescence assay to screen OOPs from 21 kinds of organophosphate pesticides, which can be used for logic sensing and information encryption. Acetylthiocholine chloride was enzymatically split by acetylcholinesterase (AChE) to produce thiocholine, which reduced the fluorescence of DPA@Ag/Cu NCs due to the transmission of electrons from DPA@Ag/Cu NCs donor to the thiol group acceptor. Impressively, OOPs acted as an AChE inhibitor and retained the high fluorescence of DPA@Ag/Cu NCs due to the stronger positive electricity of the phosphorus atom. Conversely, SOPs possessed weak toxicity to AChE, which led to low fluorescence intensity. By setting 21 kinds of organophosphate pesticides as the inputs and the fluorescence of the resulting products as the outputs, DPA@Ag/Cu NCs could serve as a fluorescent nanoneuron to construct Boolean logic tree and complex logic circuit for molecular computing. As a proof of concept, by converting the selective response patterns of DPA@Ag/Cu NCs into binary strings, molecular crypto-steganography for encoding, storing, and concealing information was successfully achieved. This study is expected to advance the progress and practical application of nanoclusters in the area of logic detection and information security while also enhancing the relationship between molecular sensors and the world of information.
MeSH term(s)	Penicillamine ; Organophosphonates ; Acetylcholinesterase ; Organophosphorus Compounds ; Insecticides ; Coloring Agents ; Blood Group Antigens ; Organophosphates ; Logic ; Copper ; Metal Nanoparticles ; Pesticides/analysis
Chemical Substances	Penicillamine (GNN1DV99GX) ; Organophosphonates ; Acetylcholinesterase (EC 3.1.1.7) ; Organophosphorus Compounds ; Insecticides ; Coloring Agents ; Blood Group Antigens ; Organophosphates ; Copper (789U1901C5) ; Pesticides
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c02030
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Article ; Online: Photocontrollable DNA Walker-Based Molecular Circuit for the Tunable Detection of MicroRNA-21 Using Metal-Organic Frameworks as Label-Free Fluorescence Tags.

Dong, Jiang Xue / Zhang, Sai Mei / Li, Yan Lei / Zhang, Xu / Fan, Ya Jie / Su, Ming / Wang, Zhen Guang / Li, Hui / Shen, Shi Gang / Gao, Zhong Feng / Wei, Qin / Xia, Fan

Analytical chemistry

2023 Volume 95, Issue 45, Page(s) 16744–16753

Abstract	Tunable detection of microRNA is crucial to meet the desired demand for sample species with varying concentrations in clinical settings. Herein, we present a DNA walker-based molecular circuit for the detection of miRNA-21 (miR-21) with tunable dynamic ranges and sensitivity levels ranging from fM to pM. The phosphate-activated fluorescence of UiO-66-NH
MeSH term(s)	Metal-Organic Frameworks ; DNA ; MicroRNAs/genetics ; Biosensing Techniques/methods ; Nanoparticles ; Limit of Detection ; Metal Nanoparticles
Chemical Substances	Metal-Organic Frameworks ; DNA (9007-49-2) ; MicroRNAs
Language	English
Publishing date	2023-11-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03913
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