LIVIVO - Search results -

Search results

Result 1 - 10 of total 44

Search options

Article: Catalpol Regulates Oligodendrocyte Regeneration and Remyelination by Activating the GEF-Cdc42/Rac1 Signaling Pathway in EAE Mice.

Wu, Minghui / Kang, Qi / Kang, Yuezhi / Tong, Yanping / Yang, Tao / Fan, Yongping

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7074157

Abstract: The main obstacle to remyelination in demyelinating diseases, such as multiple sclerosis, is the inability of oligodendrocyte precursor cells (OPCs) to differentiate into mature oligodendrocytes (OLs) in the demyelinating region. Consequently, promoting ... ...

Abstract	The main obstacle to remyelination in demyelinating diseases, such as multiple sclerosis, is the inability of oligodendrocyte precursor cells (OPCs) to differentiate into mature oligodendrocytes (OLs) in the demyelinating region. Consequently, promoting OL differentiation and myelin remodeling is a key goal in the search for treatments. Rho GTPases play diverse and important roles throughout the development of neuronal axons and the formation of the myelin sheath. The current study aimed to investigate the direct protective effects of catalpol on demyelination damage induced by myelin oligodendrocyte glycoprotein (MOG) immunization and to explore whether the GEF-Cdc42/Rac1 signaling pathway contributes to the regeneration effect induced by catalpol. In the MOG-induced experimental autoimmune encephalomyelitis (EAE) mouse model of demyelination, we observed that catalpol significantly promoted OL development by enhancing the expression of glutathione S-transferase pi (GST-pi) in the affected brain. By Luxol fast blue staining and myelin basic protein (MBP) expression assessment, catalpol was found to increase MBP expression and promote myelin repair. Furthermore, catalpol promoted OL differentiation associated with the upregulation of Cdc42/Rac1 expression and activation in vivo. In addition, PAK1/MRCK
Language	English
Publishing date	2022-11-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7074157
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Association of Pain with Plasma C5a in Patients with Neuromyelitis Optica Spectrum Disorders During Remission.

Tong, Yanping / Liu, Jie / Yang, Tao / Wang, Jingwen / Zhao, Tianyou / Kang, Yuezhi / Fan, Yongping

Neuropsychiatric disease and treatment

2022 Volume 18, Page(s) 1039–1046

Abstract: Objective: To investigate the association of pain with plasma C5a levels and other related inflammatory cytokines in neuromyelitis optica spectrum disorders (NMOSD) patients during remission.: Participants and methods: NMOSD patients (n = 87) and ... ...

Abstract	Objective: To investigate the association of pain with plasma C5a levels and other related inflammatory cytokines in neuromyelitis optica spectrum disorders (NMOSD) patients during remission. Participants and methods: NMOSD patients (n = 87) and healthy controls (HC; n = 44) were consecutively recruited between January 2017 and April 2018. Plasma complement 5 (C5), C5a, interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β levels were detected. Visual Analogue Scale (VAS), ID pain scale, 24-item Hamilton Depression Scale (HAMD), Multiple Sclerosis Impact Scale (MSIS-29), and Kurtzke Expanded Disability Status Scale (EDSS) were used to evaluate the degree and types of pain, the existence of depression and anxiety, and the life quality and disability status of patients. Binary logistic regression equation was used to assess the association of pain with plasma C5a levels. Results: Among the 87 NMOSD patients, 40 complained of pain that in 67.5% (27/40) of cases had a neuropathic component (ID pain ≥2). Plasma C5a, IL-6, TNF-α, and IL-1β levels were significantly elevated in NMOSD patients than in HC. Plasma C5 levels were negatively correlated with the time from sampling to the last relapse or disease onset. NMOSD patients with pain had higher plasma C5a levels, and they suffered from a higher disability, more anxiety, and worse life quality compared to those patients without pain. In NMOSD patients with pain, there were not significant differences between plasma levels of C5, C5a, IL-6, TNF-α, or IL-1β, regardless of neuropathic pain or not. Binary logistic regression showed that the OR of plasma C5a level was 1.002, with gender and EDSS score were identified as independent factors associated with pain in NMOSD. Conclusion: NMOSD patients during remission had elevated C5a and related inflammatory cytokines levels in peripheral blood. Elevated C5a may have a unique role in the pathogenesis of pain in NMOSD patients.
Language	English
Publishing date	2022-05-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S359620
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6068: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Retraction Note: Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice.

Yang, Tao / Zheng, Qi / Wang, Su / Fang, Ling / Liu, Lei / Zhao, Hui / Wang, Lei / Fan, Yongping

BMC complementary medicine and therapies

2023 Volume 23, Issue 1, Page(s) 355

Language	English
Publishing date	2023-10-07
Publishing country	England
Document type	Retraction of Publication
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-023-04196-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Abnormalcortical thickness in relapsing-remitting multiple sclerosis, correlations with cognition impairment, and effect of modified Bushenyisui decoction on cognitive function of multiple sclerosis.

Zhao, Xuesong / Yang, Tao / Cheng, Fang / Yang, Song / Zhu, Wanlin / Li, Shaowu / Fan, Yongping

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2021 Volume 41, Issue 2, Page(s) 316–325

Abstract: Objective: To investigate the changes of subcortical gray matter volume and cortical thickness, andexplorethe correlations between regional abnormalities of cortical thickness and cognitive impairment and the effect of modified Bushenyisui decoction ( ... ...

Abstract	Objective: To investigate the changes of subcortical gray matter volume and cortical thickness, andexplorethe correlations between regional abnormalities of cortical thickness and cognitive impairment and the effect of modified Bushenyisui decoction ( BSYSD) on the cognitive function of multiple sclerosis (MS). Methods: This prospective study was approved by the institutional review board. 92 subjects were recruited, including 46 relapsing-remitting multiple sclerosis (RRMS) patients and 46 healthy controls (HC). Of the 46 patients, 22 patients experienced the treatment of BSYSD for half a year. A conventional three-dimensional T1-weighted sequence were acquired for all participants on a 3.0 tesla magnetic resonance system. Basic information, detailed cognitive scales Montreal Cognitive Assessment (MoCA), symbol digit modalities test (SDMT), immediate memory, delayed recall, and long-term recognition were evaluated. Subcortical gray matter volume and cortical thickness weremeasured by FreeSurfer. The correlations between cortical thickness which MS patients showed reduced with respect to HC and cognitive scales wereanalyzed by Pearson correlation in RRMS patients. The influence of modified BSYSD on MS patients' cognition was analyzed by paired T Test. Results: MoCA, immediate memory, delayed recall, and long-term delayed recognition in RRMS were significantly decreased than those of HC. Gray matter atrophy measured by FreeSurfer showed mainly in thalamus and hippocampus of RRMS patients. Compared with HC, the cortical thickness of several regions in frontal lobe, parietal lobe, temporal lobe, hippocampal, cingulate gyrus, and fusiform gyrus of RRMS patients were decreased with significant difference. The regions of cortical thickness thinning related to MoCA, immediate memory, delayed recall, and long-term delayed recognition were temporal lobe and fusiform gyrus. Modified BSYSD could improve MoCA, SDMT, immediate memory, delayed recall, and long-term delayed recognition of MS patients, and it could promote the recovery of cognitive function in MS patients. Conclusions: Gray matter atrophy and cortical thickness thinning were validated in RRMS. Cortical thickness thinning of temporal lobe and fusiform gyrus strongly related to cognitive deficits in RRMS. The modified BSYSD could promote the recovery of cognitive function in MS.
MeSH term(s)	Adult ; Aged ; Brain/diagnostic imaging ; Brain/physiopathology ; Cognition/drug effects ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/psychology ; Drugs, Chinese Herbal/administration & dosage ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/complications ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/psychology ; Neuropsychological Tests ; Prospective Studies ; Young Adult
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-04-06
Publishing country	China
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603186-9
ISSN	2589-451X ; 0254-6272 ; 0255-2922
ISSN (online)	2589-451X ; 0254-6272
ISSN	0255-2922
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2564: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Randomized trial of erhuangfang for relapsing multiple sclerosis.

Zhou, Li / Fan, Yongping

Neurological research

2015 Volume 37, Issue 7, Page(s) 633–637

Abstract: Objectives: The purpose of this study is to reveal the effect of Erhaungfang on relapsing multiple sclerosis (MS) and investigate the underlying mechanism.: Methods: In our 2-year, randomized study, a total of 67 patients (diagnosed as MS) with age ... ...

Abstract	Objectives: The purpose of this study is to reveal the effect of Erhaungfang on relapsing multiple sclerosis (MS) and investigate the underlying mechanism. Methods: In our 2-year, randomized study, a total of 67 patients (diagnosed as MS) with age from 15 to 60 years were enrolled in this study. All patients in the acute phase were treated with methylprednisolone pulse therapy and then were randomly divided into treatment group (n = 50) administrated with erhuangfang, and control group (n = 43) without nothing. Magnetic resonance spectroscopy (MRS) was used to detect N-acetylaspartate (NAA)/creatine (CR) levels. At the end of a 2-year follow-up period, relapse rate, annual relapse rate, expanded disability status scale (EDSS) scores, and NAA/CR levels were compared between groups. Results: Relapse rate and annual relapse rate in the treatment group were significantly reduced after erhuangfang treatment (P < 0.05). There was no significant difference in terms of EDSS score between treatment group and control group and between after treatment and before treatment (P > 0.05). N-acetylaspartate/CR level was significantly correlated with the disease course (P < 0.05). There was no significant difference for NAA/CR levels in the treatment group before and after treatment (P > 0.05). Conclusions: Erhuangfang significantly reduced relapse rate and prevented progression of MS, which is an effective therapy for relapsing MS.
MeSH term(s)	Adolescent ; Adult ; Anti-Inflammatory Agents/therapeutic use ; Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Brain/drug effects ; Brain/metabolism ; Creatine/metabolism ; Disability Evaluation ; Disease Progression ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/metabolism ; Prospective Studies ; Young Adult
Chemical Substances	Anti-Inflammatory Agents ; Drugs, Chinese Herbal ; Aspartic Acid (30KYC7MIAI) ; N-acetylaspartate (997-55-7) ; Creatine (MU72812GK0)
Language	English
Publishing date	2015-07
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	424428-x
ISSN	1743-1328 ; 0161-6412
ISSN (online)	1743-1328
ISSN	0161-6412
DOI	10.1179/1743132815Y.0000000011
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1491: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Protective effects of catalpol and rhein in murine experimental autoimmune encephalomyelitis via regulation of T helper (Th) 1, Th2, Th17, and regulatory T cell responses.

Wei, Mingyan / Yang, Tao / Li, Qian / Zhou, Dongdong / Du, Zongpan / Fan, Yongping

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2020 Volume 39, Issue 6, Page(s) 809–817

Abstract: Objective: To examine the effects of catalpol and rhein on pro- and anti-inflammatory responses in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.: Methods: Female C57BL/6 mice were randomly divided ... ...

Abstract	Objective: To examine the effects of catalpol and rhein on pro- and anti-inflammatory responses in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis. Methods: Female C57BL/6 mice were randomly divided into four groups (n = 30): (a) normal saline control, (b) EAE control, (c) EAE + prednisone acetate (PA, 6 mg/kg), and (d) EAE + catalpol (40 mg/kg) and rhein (5 mg/kg). EAE was induced by injection of myelin oligodendrocyte glycoprotein 35-55 plus pertussis toxin. Treatments were orally administered daily for 40 d. Disease progression and neurological function were assessed using a semi-quantitative scale of tail and limb paralysis. Brains and spinal cords were collected on Days 6, 20, and 40 and assessed for histopathological changes by hematoxylin and eosin staining. Production of interleukin (IL)-2, IL-4, IL-10, and IL-17A protein was measured by enzyme-linked immunosorbent assay. Expression of the T helper (Th)1-, Th2-, Th17-, and regulatory T cell (Treg)-specific transcription factors T-bet, GATA3, ROR-γt, and Foxp3, respectively, were analyzed by quantitative reverse-transcription polymerase chain reaction and western blot analysis. Results: Combination treatment with catalpol and rhein significantly alleviated the clinical disability and neurological dysfunction of mice with EAE. Catalpol and rhein treatment also reduced the infiltration of pro-inflammatory T cells into pathological lesions; significantly increased the expression of the anti-inflammatory factors GATA3, Foxp3, IL-4, and IL-10; and significantly decreased the expression of the pro-inflammatory factors T-bet, ROR-γt, IL-2, and IL-17A. Conclusion: Catalpol and rhein reduced the neurological disabilities of mice with EAE, at least in part by rebalancing the pro- and anti-inflammatory environment in the brains and spinal cords.
MeSH term(s)	Animals ; Anthraquinones/therapeutic use ; Autoimmunity/drug effects ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Encephalomyelitis, Autoimmune, Experimental/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Iridoid Glucosides/therapeutic use ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/metabolism ; Th1 Cells/drug effects ; Th1 Cells/metabolism ; Th17 Cells/drug effects ; Th17 Cells/metabolism ; Th2 Cells/drug effects ; Th2 Cells/metabolism
Chemical Substances	Anthraquinones ; Iridoid Glucosides ; catalpol (2415-24-9) ; rhein (YM64C2P6UX)
Language	English
Publishing date	2020-03-10
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603186-9
ISSN	2589-451X ; 0254-6272 ; 0255-2922
ISSN (online)	2589-451X ; 0254-6272
ISSN	0255-2922
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2564: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Role of catalpol in ameliorating the pathogenesis of experimental autoimmune encephalomyelitis by increasing the level of noradrenaline in the locus coeruleus.

Li, Qian / Yang, Tao / Guo, An-Chen / Fan, Yong-Ping

Molecular medicine reports

2018 Volume 17, Issue 3, Page(s) 4163–4172

Abstract: The endogenous neurotransmitter, noradrenaline, exerts anti-inflammatory and neuroprotective effects in vivo and in vitro. Reduced noradrenaline levels results in increased inflammation and neuronal damage. The primary source of noradrenaline in the ... ...

Abstract	The endogenous neurotransmitter, noradrenaline, exerts anti-inflammatory and neuroprotective effects in vivo and in vitro. Reduced noradrenaline levels results in increased inflammation and neuronal damage. The primary source of noradrenaline in the central nervous system is tyrosine hydroxylase (TH)‑positive neurons, located in the locus coeruleus (LC). TH is the rate‑limiting enzyme for noradrenaline synthesis; therefore, regulation of TH protein expression and intrinsic enzyme activity represents the central means for controlling the synthesis of noradrenaline. Catalpol is an iridoid glycoside purified from Rehmannia glutinosa Libosch, which exerts a neuroprotective effect in multiple sclerosis (MS). The present study used an experimental mouse model of autoimmune encephalomyelitis to verify the neuroprotective effects of catalpol. Significant improvements in the clinical scores were observed in catalpol‑treated mice. Furthermore, catalpol increased TH expression and increased noradrenaline levels in the spinal cord. In primary cultures, catalpol exerted a neuroprotective effect in rat LC neurons by increasing the noradrenaline output. These results suggested that drugs targeting LC survival and function, including catalpol, may be able to benefit patients with MS.
MeSH term(s)	Amidines/antagonists & inhibitors ; Amidines/pharmacology ; Animals ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/pharmacology ; Benzylamines/administration & dosage ; Encephalomyelitis, Autoimmune, Experimental/chemically induced ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Female ; Gene Expression Regulation ; Immunization ; Injections, Intraperitoneal ; Iridoid Glucosides/isolation & purification ; Iridoid Glucosides/pharmacology ; Locus Coeruleus/drug effects ; Locus Coeruleus/immunology ; Locus Coeruleus/pathology ; Mice ; Mice, Inbred C57BL ; Myelin-Oligodendrocyte Glycoprotein/administration & dosage ; Neurons/drug effects ; Neurons/immunology ; Neurons/pathology ; Neuroprotective Agents/isolation & purification ; Neuroprotective Agents/pharmacology ; Neurotransmitter Agents/agonists ; Neurotransmitter Agents/biosynthesis ; Norepinephrine/agonists ; Norepinephrine/biosynthesis ; Oxidants/antagonists & inhibitors ; Oxidants/pharmacology ; Peptide Fragments/administration & dosage ; Primary Cell Culture ; Rehmannia/chemistry ; Spinal Cord/drug effects ; Spinal Cord/immunology ; Spinal Cord/pathology ; Tyrosine 3-Monooxygenase/genetics ; Tyrosine 3-Monooxygenase/immunology
Chemical Substances	Amidines ; Anti-Inflammatory Agents ; Benzylamines ; Iridoid Glucosides ; Myelin-Oligodendrocyte Glycoprotein ; Neuroprotective Agents ; Neurotransmitter Agents ; Oxidants ; Peptide Fragments ; myelin oligodendrocyte glycoprotein (35-55) ; catalpol (2415-24-9) ; 2,2'-azobis(2-amidinopropane) (7381JDR72F) ; Tyrosine 3-Monooxygenase (EC 1.14.16.2) ; DSP 4 (PQ1P7JP5C1) ; Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2018-01-05
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2018.8378
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Neuroprotective Effects of Fingolimod Supplement on the Retina and Optic Nerve in the Mouse Model of Experimental Autoimmune Encephalomyelitis.

Yang, Tao / Zha, Zheng / Yang, Xiao / Kang, YueZhi / Wang, Xin / Tong, Yanping / Zhao, XueSong / Wang, Lei / Fan, YongPing

Frontiers in neuroscience

2021 Volume 15, Page(s) 663541

Abstract: Favorable effects exerted by long-term administration of fingolimod therapy in multiple sclerosis (MS) patients have been reported, but sporadic side effects, such as reversible macular edema, also have been recorded. The present study aimed to determine ...

Abstract	Favorable effects exerted by long-term administration of fingolimod therapy in multiple sclerosis (MS) patients have been reported, but sporadic side effects, such as reversible macular edema, also have been recorded. The present study aimed to determine whether fingolimod therapy is beneficial to the visual system in experimental autoimmune encephalomyelitis (EAE) mice. A decrease in demyelination and axon loss in the optic nerve as well as cellular infiltration, especially the recruited macrophages, was observed in EAE with fingolimod treatment. Fingolimod administration diminished hypergliosis of macroglia, including astrocytes and Müller cells in the retina and optic nerve in EAE. Microglia were hyperactivated in the retina and optic nerve in the EAE mice compared to controls, which could be alleviated by fingolimod treatment. Moreover, apoptosis of retinal ganglion cells (RGC) and oligodendrocytes in the optic nerve was significantly reduced with fingolimod treatment compared to that in the untreated EAE mice. These results suggested that fingolimod exerts neuroprotective and anti-inflammatory effects on the retina and optic nerve in a mouse model of EAE. Considering the paradox of favorable and side effects of fingolimod on visual system, we speculate that side effects including macular oedema caused by fingolimod during MS treatment is tendency to be vasogenic rather than hypergliosis in optic nerve and retina which warrants further neuroophthalmological investigation.
Language	English
Publishing date	2021-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2021.663541
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Identification and Quantification of Bu Shen Yi Sui Capsule by UPLC-LTQ-Orbitrap-MSn and UPLC-QTOF-MS/MS.

Liu, Haolong / Zhao, Yiyi / Zheng, Qi / Yang, Tao / Zhao, Hui / Zou, Haiyan / Fan, Yongping / Guo, Hongzhu / Wang, Lei

Journal of chromatographic science

2021 Volume 60, Issue 5, Page(s) 450–457

Abstract: Traditional Chinese medicines (TCMs) have been considered as important alternative therapeutics because of their significant medicinal benefits in specific diseases. Chinese herb formula is characterized by a vast molecule that differs in routine ... ...

Abstract	Traditional Chinese medicines (TCMs) have been considered as important alternative therapeutics because of their significant medicinal benefits in specific diseases. Chinese herb formula is characterized by a vast molecule that differs in routine medicines. Due to TCMs chemical complexity, proper quality control has been a great challenge. Choosing the appropriate method to identify and qualify these compounds is an important work to ensure its safety, efficacy and quality control. Thus, this study aimed at providing novel information on high-resolution LTQ-Orbitrap mass spectrometer (UPLC-LTQ-Orbitrap-MSn) based identification of Bu Shen Yi Sui capsule (BSYSC), which is used in treating multiple sclerosis as a kind of TCMs. Under the proposed chromatographic conditions, 80 chemical components classified as anthraquinone, phenolic acid and phenylethanoid glycosides were separated and identified from BSYSC. Coupled with the high-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) method, eight of them were regarded as marker compounds for the quantitative evaluation of BSYSC. The identification and quantification with precision of UPLC-LTQ-Orbitrap-MSn and UPLC-QTOF-MS/MS could facilitate essential data for further pharmacokinetic studies of BSYSC.
MeSH term(s)	Busulfan ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal ; Quality Control ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal ; Busulfan (G1LN9045DK)
Language	English
Publishing date	2021-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	80141-0
ISSN	1945-239X ; 0021-9665
ISSN (online)	1945-239X
ISSN	0021-9665
DOI	10.1093/chromsci/bmab091
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 895: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Corrigendum to "Bu Shen Yi Sui capsule promotes remyelination correlating with Sema3A/ NRP-1, LIF/LIFR and Nkx6.2 in mice with experimental autoimmune encephalomyelitis" [J. Ethnopharmacol. 217 (2018) 36-48].

Zhao, Pei-Yuan / Wang, Yong-Qiang / Liu, Xi-Hong / Zhu, Ying-Jun / Zhao, Hui / Zhang, Qiu-Xia / Qi, Fang / Li, Jun-Ling / Zhang, Nan / Fan, Yong-Ping / Li, Kang-Ning / Zhao, Yuan-Yuan / Lei, Jian-Feng / Wang, Lei

Journal of ethnopharmacology

2023 Volume 318, Issue Pt A, Page(s) 116853

Language	English
Publishing date	2023-06-29
Publishing country	Ireland
Document type	Published Erratum
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116853
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito