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  1. Article ; Online: Four new eudesmane-type and one new eremophilane-type sesquiterpenes from the whole plant of Carpesium abrotanoides L.

    Fan, Yu-Wen / Zhang, Wei-Jie / Ao, Zhuo-Yi / Chen, Jia-Yan / Lian, Xin / Pan, Yong-Chen / Chen, Li-Ping / Jiang, Dong-Xu / Wu, Jie-Wei

    Fitoterapia

    2023  Volume 169, Page(s) 105548

    Abstract: The extract of the whole plant of Carpesium abrotanoides L. yielded five new sesquiterpenes including four eudesmanes (1-4) and one eremophilane (5). The new compounds were characterized by spectroscopic analysis especially 1D and 2D NMR spectroscopy and ...

    Abstract The extract of the whole plant of Carpesium abrotanoides L. yielded five new sesquiterpenes including four eudesmanes (1-4) and one eremophilane (5). The new compounds were characterized by spectroscopic analysis especially 1D and 2D NMR spectroscopy and HRESIMS data. Structurally, both compounds 1 and 2 were sesquiterpene epoxides and 2 owned an epoxy group at C-4/C-15 position to form a spiro skeleton. Compounds 4 and 5 were two sesquiterpenes without lactones and 5 possessed a carboxy group in the molecule. Additionally, all the isolated compounds were preliminarily evaluated for the inhibitory activity against SARS-CoV-2 main protease. As a result, compound 2 showed moderate activity with an IC
    MeSH term(s) Molecular Structure ; Polycyclic Sesquiterpenes ; COVID-19 ; SARS-CoV-2 ; Sesquiterpenes ; Sesquiterpenes, Eudesmane/pharmacology ; Magnetic Resonance Spectroscopy ; Asteraceae/chemistry
    Chemical Substances Polycyclic Sesquiterpenes ; Sesquiterpenes ; eudesmane (473-11-0) ; Sesquiterpenes, Eudesmane
    Language English
    Publishing date 2023-05-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 412385-2
    ISSN 1873-6971 ; 0367-326X
    ISSN (online) 1873-6971
    ISSN 0367-326X
    DOI 10.1016/j.fitote.2023.105548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The sesquiterpenes with the COVID-19 M

    Fan, Yu-Wen / Ao, Zhuo-Yi / Zhang, Wei-Jie / Chen, Jia-Yan / Lian, Xin / Chen Pan, Yong- / Chen, Li-Ping / Wu, Jie-Wei / Yuan, Jie

    Natural product research

    2023  , Page(s) 1–9

    Abstract: The extract of the whole plant ... ...

    Abstract The extract of the whole plant of
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2230609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Four new stilbenes and one new flavonoid with potential antibacterial and anti-SARS-CoV-2 activity from Cajanus cajan.

    Chen, Jia-Yan / Lian, Xin / Fan, Yu-Wen / Ao, Zhuo-Yi / Zhang, Wei-Jie / Pan, Yong-Chen / Chen, Li-Ping / Yuan, Jie / Wu, Jie-Wei

    Journal of natural medicines

    2023  Volume 77, Issue 4, Page(s) 858–866

    Abstract: Four new stilbenes (1-4) and one new flavonoid (5), named cajanines D-H, together with three known stilbenes (6-8) were isolated from the leaves of Cajanus cajan (L.) Millsp. (pigeon pea). The structures of these compounds were elucidated unambiguously ... ...

    Abstract Four new stilbenes (1-4) and one new flavonoid (5), named cajanines D-H, together with three known stilbenes (6-8) were isolated from the leaves of Cajanus cajan (L.) Millsp. (pigeon pea). The structures of these compounds were elucidated unambiguously on the basis of IR, 1D, and 2D NMR, as well as HRESIMS data. Structurally, stilbenes 1-4 bore an isopentyl side chain, and further hydroxylation of compounds 1-3 generated a greater variety of structural forms. Compound 5 was a flavonoid owning an isopentyl side chain. Besides, antibacterial activity of the isolated compounds against Staphylococcus aureus, Bacillus cereus, and Escherichia coli was studied in vitro. Compounds 1-8 were endowed with profound antibacterial activity. Among them, the MIC values of compounds 4, 6, and 7 against S. aureus were 1.56, 0.78, and 0.78 µg/mL, respectively, among which 6 and 7 had better antibacterial activity than the positive control Vancomycin with the MIC values of 1.56 µg/mL. Additionally, the anti-SARS-CoV-2 main protease activity of all the isolated compounds was evaluated, and it was worth mentioning that the IC
    MeSH term(s) Flavonoids/pharmacology ; Cajanus/chemistry ; Staphylococcus aureus ; Stilbenes/chemistry ; SARS-CoV-2 ; COVID-19 ; Anti-Bacterial Agents/pharmacology
    Chemical Substances Flavonoids ; Stilbenes ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2227540-X
    ISSN 1861-0293 ; 1340-3443
    ISSN (online) 1861-0293
    ISSN 1340-3443
    DOI 10.1007/s11418-023-01727-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2692: Show issues Location:
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  4. Article ; Online: Three stilbenes from pigeon pea with promising anti-methicillin-resistant Staphylococcus aureus biofilm formation activity.

    Li, Bai-Lin / Chen, Jia-Yan / Hu, Juan-Juan / Fan, Yu-Wen / Ao, Zhuo-Yi / Zhang, Wei-Jie / Lian, Xin / Liang, Hui-Jun / Li, Qian-Ran / Guan, Xiao-Xian / Wu, Jie-Wei / Yuan, Jie / Jiang, Dong-Xu

    International microbiology : the official journal of the Spanish Society for Microbiology

    2023  Volume 27, Issue 2, Page(s) 535–544

    Abstract: Cajaninstilbene acid (CSA), longistylin A (LLA), and longistylin C (LLC) are three characteristic stilbenes isolated from pigeon pea. The objective of this study was to evaluate the antibacterial activity of these stilbenes against Staphylococcus aureus ... ...

    Abstract Cajaninstilbene acid (CSA), longistylin A (LLA), and longistylin C (LLC) are three characteristic stilbenes isolated from pigeon pea. The objective of this study was to evaluate the antibacterial activity of these stilbenes against Staphylococcus aureus and even methicillin-resistant Staphylococcus aureus (MRSA) and test the possibility of inhibiting biofilm formation. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of these stilbenes were evaluated. And the results showed that LLA was most effective against tested strains with MIC and MBC values of 1.56 μg/mL followed by LLC with MIC and MBC values of 3.12 μg/mL and 6.25 μg/mL as well as CSA with MIC and MBC values of 6.25 μg/mL and 6.25-12.5 μg/mL. Through growth curve and cytotoxicity analysis, the concentrations of these stilbenes were determined to be set at their respective 1/4 MIC in the follow-up research. In an anti-biofilm formation assay, these stilbenes were found to be effectively inhibited bacterial proliferation, biofilm formation, and key gene expressions related to the adhesion and virulence of MRSA. It is the first time that the anti-S. aureus and MRSA activities of the three stilbenes have been systematically reported. Conclusively, these findings provide insight into the anti-MRSA mechanism of stilbenes from pigeon pea, indicating these compounds may be used as antimicrobial agents or additives for food with health functions, and contribute to the development as well as application of pigeon pea in food science.
    MeSH term(s) Methicillin-Resistant Staphylococcus aureus ; Cajanus ; Anti-Bacterial Agents/pharmacology ; Stilbenes/pharmacology ; Microbial Sensitivity Tests ; Antibodies/pharmacology ; Biofilms
    Chemical Substances Anti-Bacterial Agents ; Stilbenes ; Antibodies
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1454951-7
    ISSN 1618-1905 ; 1139-6709
    ISSN (online) 1618-1905
    ISSN 1139-6709
    DOI 10.1007/s10123-023-00413-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4964: Show issues Location:
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  5. Article ; Online: Investigation of the material basis and mechanism of Lizhong decoction in ameliorating ulcerative colitis based on spectrum-effect relationship and network pharmacology.

    Zhang, Yun / Li, Wen-Wen / Wang, Yu / Fan, Yu-Wen / Wang, Qu-Yi / Liu, Chen / Jiang, Shu / Shang, Er-Xin / Duan, Jin-Ao

    Journal of ethnopharmacology

    2023  Volume 323, Page(s) 117666

    Abstract: Ethnopharmacological relevance: Lizhong decoction (LZD), a classical herbal prescription recorded by Zhang Zhongjing in Treatise on Febrile and Miscellaneous Diseases, has been extensively used to treat ulcerative colitis (UC) in clinical practice for ... ...

    Abstract Ethnopharmacological relevance: Lizhong decoction (LZD), a classical herbal prescription recorded by Zhang Zhongjing in Treatise on Febrile and Miscellaneous Diseases, has been extensively used to treat ulcerative colitis (UC) in clinical practice for thousands of years. However, its material basis and underlying mechanism are not yet clear.
    Aim of the study: This study aims to explore the material basis and potential mechanism of LZD against UC based on the spectrum-effect relationship and network pharmacology.
    Materials and methods: First, LZD was extracted by a systematic solvent extraction method into four parts. Ultra-high performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) technique was used to identify the compounds from different polar parts, and dextran sulfate sodium (DSS)-induced colitis model was used to evaluate the efficacy of each fraction. Then, the spectrum-effect analyses of compounds and efficacy indicators were established via grey relational analysis (GRA), bivariate correlation analysis (BCA) and partial least squares regression (PLSR). Finally, the potential mechanism of LZD for UC therapy was explored by network pharmacology, and the results were further verified by molecular docking and reverse transcription quantitative polymerase chain reaction (RT-qPCR).
    Results: 66 chemical components of LZD were identified by UPLC-Q-TOF-MS/MS technology. The pharmacodynamic results showed that extraction parts of LZD had different therapeutic effects on UC, among which ethyl acetate and n-butanol extracts had significant anti-colitis effects, which might be the main effective fractions of LZD. Furthermore, the spectrum-effect analyses indicated that 21 active ingredients such as liquiritin apioside, neolicuroside, formononetin, ginsenoside Rg1, 6-gingesulfonic acid, licoricesaponin A3, liquiritin, glycyrrhizic acid were the main material basis for LZD improving UC. Based on the above results, network pharmacology suggested that the amelioration of LZD on UC might be closely related to the PI3K-Akt signaling pathway. Additionally, molecular docking technology and RT-qPCR further verified that LZD could markedly inhibit the PI3K-Akt signaling pathway.
    Conclusion: Overall, our study first identified the chemical compositions of LZD by using UPLC-Q-TOF-MS/MS. Furthermore, the material basis and potential mechanism of LZD in improving UC were comprehensively elucidated via spectrum-effect relationships, network pharmacology, molecular docking and experimental verification. The proposed strategy provided a systematic approach for exploring how herbal medicines worked. More importantly, it laid the solid foundation for further clinical application and rational development of LZD.
    MeSH term(s) Humans ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Molecular Docking Simulation ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Tandem Mass Spectrometry ; Colitis ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-12-28
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1494: Show issues Location:
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  6. Article ; Online: Two new withanolides from the whole plants of Physalis peruviana

    Li, Qian-Ran / Liang, Hui-Jun / Li, Bai-Lin / Ao, Zhuo-Yi / Fan, Yu-Wen / Zhang, Wei-Jie / Lian, Xin / Chen, Jia-Yan / Hu, Juan-Juan / Yuan, Jie / Wu, Jie-Wei

    Journal of Asian Natural Products Research. 2023 Apr. 3, v. 25, no. 4 p.349-356

    2023  

    Abstract: Two new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C, 1 and 2), along with twelve known withanolides (3–14), were purified and identified from Physalis peruviana L. The chemical structures of these new isolates ... ...

    Abstract Two new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C, 1 and 2), along with twelve known withanolides (3–14), were purified and identified from Physalis peruviana L. The chemical structures of these new isolates were elucidated through analyzing spectroscopic and HRESIMS data. All the obtained metabolites were appraised for their potential antiproliferative activity against the human breast cancer cell line MCF-7. Compound 7 was discovered to exhibit potent activity with an IC₅₀ value of 3.51 µM and compounds 2, 6 and 14 showed weak cytotoxic effect.
    Keywords Physalis peruviana ; breast neoplasms ; cell lines ; cytotoxicity ; humans ; metabolites ; neoplasm cells ; research ; spectroscopy ; Solanaceae ; withanolides ; Physalis ; structure elucidation ; antiproliferative activity
    Language English
    Dates of publication 2023-0403
    Size p. 349-356.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2022.2095263
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Peruranolides A-D, four new withanolides with potential antibacterial and cytotoxic activity from

    Li, Qian-Ran / Liang, Hui-Jun / Li, Bai-Lin / Yuan, Jie / Ao, Zhuo-Yi / Fan, Yu-Wen / Zhang, Wei-Jie / Lian, Xin / Chen, Jia-Yan / Wang, Jian-Zhong / Wu, Jie-Wei

    Frontiers in bioscience (Landmark edition)

    2022  Volume 27, Issue 3, Page(s) 98

    Abstract: Background: Many drugs for anti-tumour have been developed, nevertheless, seeking new anticancer drug is the focus of ongoing investigation. Withanolides have been reported to possess potent antiproliferative activity. Literature findings revealed that ... ...

    Abstract Background: Many drugs for anti-tumour have been developed, nevertheless, seeking new anticancer drug is the focus of ongoing investigation. Withanolides have been reported to possess potent antiproliferative activity. Literature findings revealed that a diversity of withanolides were obtained from
    Methods: The EtOAc fraction of
    Conclusions: Our findings might offer valuable clues for the utilization of withanolides as lead compounds for antineoplastic or antibacterial drug development.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Escherichia coli ; Humans ; Molecular Structure ; Physalis/chemistry ; Staphylococcus aureus ; Withanolides/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Antineoplastic Agents ; Withanolides
    Language English
    Publishing date 2022-03-28
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2703098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Three new glycosides from the stems of

    Liang, Hui-Jun / Li, Qian-Ran / Li, Bai-Lin / Ni, Chen / Zhang, Wei-Jie / Fan, Yu-Wen / Ao, Zhuo-Yi / Hu, Juan-Juan / Yuan, Jie / Wu, Jie-Wei

    Natural product research

    2022  Volume 38, Issue 1, Page(s) 28–36

    Abstract: Two new phenolic glycosides ( ...

    Abstract Two new phenolic glycosides (
    MeSH term(s) Humans ; Glycosides/pharmacology ; Glycosides/chemistry ; Molecular Structure ; Caco-2 Cells ; Glucosides ; Diterpenes/chemistry ; Ericales
    Chemical Substances Glycosides ; Glucosides ; Diterpenes
    Language English
    Publishing date 2022-07-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2103122
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Two new withanolides from the whole plants of

    Li, Qian-Ran / Liang, Hui-Jun / Li, Bai-Lin / Ao, Zhuo-Yi / Fan, Yu-Wen / Zhang, Wei-Jie / Lian, Xin / Chen, Jia-Yan / Hu, Juan-Juan / Yuan, Jie / Wu, Jie-Wei

    Journal of Asian natural products research

    2022  Volume 25, Issue 4, Page(s) 349–356

    Abstract: Two new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C, ...

    Abstract Two new withaphysalin-type withanolides (18-O-ethylwithaphysalin R and 5-O-ethylphysaminimin C,
    MeSH term(s) Humans ; Physalis/chemistry ; Withanolides/chemistry ; Plant Extracts/chemistry ; Antineoplastic Agents
    Chemical Substances Withanolides ; Plant Extracts ; Antineoplastic Agents
    Language English
    Publishing date 2022-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2022.2095263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Euryachincoside, a Novel Phenolic Glycoside with Anti-Hepatic Fibrosis Activity from Eurya chinensis.

    Li, Bai-Lin / Liang, Hui-Jun / Li, Qian-Ran / Wang, Qian / Ao, Zhuo-Yi / Fan, Yu-Wen / Zhang, Wei-Jie / Lian, Xin / Chen, Jia-Yan / Yuan, Jie / Wu, Jie-Wei

    Planta medica

    2022  Volume 89, Issue 5, Page(s) 516–525

    Abstract: ... Eurya ... ...

    Abstract Eurya chinensis
    MeSH term(s) Rats ; Mice ; Animals ; NF-kappa B/metabolism ; Glycosides/pharmacology ; Glycosides/metabolism ; NF-E2-Related Factor 2/metabolism ; Transforming Growth Factor beta ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Liver ; Transforming Growth Factor beta1/metabolism ; Carbon Tetrachloride/adverse effects ; Carbon Tetrachloride/metabolism ; Collagen/metabolism ; Hepatic Stellate Cells
    Chemical Substances NF-kappa B ; Glycosides ; NF-E2-Related Factor 2 ; Transforming Growth Factor beta ; Transforming Growth Factor beta1 ; Carbon Tetrachloride (CL2T97X0V0) ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-04-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/a-1828-2671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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