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  1. Book ; Online: Sharpened Uncertainty Principle

    Fan, Yun

    2022  

    Abstract: For any finite group $G$, any finite $G$-set $X$ and any field $F$, we consider the vector space $F^X$ of all functions from $X$ to $F$. When the group algebra $FG$ is semisimple and splitting, we find a specific basis $\widehat X$ of $F^X$, construct ... ...

    Abstract For any finite group $G$, any finite $G$-set $X$ and any field $F$, we consider the vector space $F^X$ of all functions from $X$ to $F$. When the group algebra $FG$ is semisimple and splitting, we find a specific basis $\widehat X$ of $F^X$, construct the Fourier transform: $F^X\to F^{\widehat X}$, $f\mapsto\widehat f$, and define the rank support $\mbox{rk-supp}(\widehat f)$; we prove that $\mbox{rk-supp}(\widehat f)=\dim FGf$, where $FGf$ is the submodule of the permutation module $FX$ generated by the element $f=\sum_{x\in X}f(x)x$. Next, we extend a sharpened uncertainty principle for abelian finite groups by Feng, Hollmann, and Xiang [9] to the following extensive framework: for any field $F$, any transitive $G$-set $X$ and $0\neq f\in F^X$ we prove that $$ |{\rm supp}(f)|\cdot \dim FGf \geq |X|+|{\rm supp}(f)|-|X_{{\rm supp}(f)}|, $$ where ${\rm supp}(f)$ is the support of $f$, and $X_{{\rm supp}(f)}$ is a block of $X$ associated with the subset ${\rm supp}(f)$ such that ${\rm supp}(f)$ is a disjoint union of some translations of the block. Then many (sharpened or classical) versions of finite-dimensional uncertainty principle are derived as corollaries.
    Keywords Mathematics - Group Theory ; Computer Science - Discrete Mathematics ; 05E18 ; 20B05 ; 20C15 ; 43A30 ; 94B60
    Subject code 512
    Publishing date 2022-11-21
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: [Effect of auricular acupressure combined with 5α-reductase inhibitor on short-term quality of life of patients after transurethral plasmakinetic enucleation of the prostate].

    Xue, Yi-Feng / Fan, Yun-Xia / Wang, Rong

    Zhonghua nan ke xue = National journal of andrology

    2024  Volume 29, Issue 7, Page(s) 609–614

    Abstract: Objective: To evaluate the effect of combined application of Semen vaccariae seeds auricular acupressure and 5α-reductase inhibitor (finasteride tablets) on postoperative quality of life of patients after transurethral plasmakinetic enucleation of the ... ...

    Abstract Objective: To evaluate the effect of combined application of Semen vaccariae seeds auricular acupressure and 5α-reductase inhibitor (finasteride tablets) on postoperative quality of life of patients after transurethral plasmakinetic enucleation of the prostate (PKEP).
    Methods: 120 patients with benign prostatic hyperplasia (BPH) who were scheduled to undergo PKEP at the Department of Urology, Jintan People's Hospital Affiliated to Jiangsu University from January 2020 to December 2022, were randomly divided into 4 groups after voluntarily signing informed consent. Three days before the operation, 30 patients were given oryzanol tablets 5 mg orally once a night (placebo group), 31 patients were given Semen vaccariae seeds auricular acupressure (auricular acupressure group), 29 patients were given finasteride 5 mg orally once a night (finasteride group), and another 30 patients were given auricular acupressure combined with finasteride 5 mg orally once a night (combination therapy group). The above treatment was continued for 6 weeks after PKEP. The general data of the perioperative period and the 6-week postoperative follow-up results of the 4 groups were compared to observe the indicators such as the symptom score of nocturia, the self-rating depression scale, and the quality of life (QoL) after treatment among the groups.
    Results: All patients who underwent PKEP completed the 6-week postoperative follow-up and no statistical difference in the relevant data of the 4 groups was found before the operation. After 2 and 4 weeks of follow-up, the nocturia symptom scores of the auricular acupressure group and the combination therapy group were better than those of the placebo group and the finasteride group. The depression symptom scores and QoL results showed that the auricular acupressure group, finasteride group, and combination therapy group were superior to the placebo group (P<0.05). After 6 weeks of follow-up, QoL in the combination therapy group was 1.65±0.55, which was significantly different from that in the other three groups (P<0.05).
    Conclusion: Combined application of auricular acupressure and 5α-reductase inhibitor can significantly alleviate symptoms such as nocturia and depression and improve the quality of life in BPH patients after PKEP.
    MeSH term(s) Male ; Humans ; Finasteride/therapeutic use ; Prostate ; Quality of Life ; Acupressure ; Nocturia ; Prostatic Hyperplasia ; Oxidoreductases
    Chemical Substances Finasteride (57GNO57U7G) ; Oxidoreductases (EC 1.-)
    Language Chinese
    Publishing date 2024-04-15
    Publishing country China
    Document type Randomized Controlled Trial ; English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Thesis ; Online: Managing reefer logistics in cold chains

    Fan, Yun

    Decision support in a multi-actor setting

    2021  

    Abstract: Global agriculture trade stimulates a transformation of traditional cold chains to global cold chains with long-haul intercontinental transportation. Sea transportation by reefer containers will be the dominant modality in the future for global cold ... ...

    Abstract Global agriculture trade stimulates a transformation of traditional cold chains to global cold chains with long-haul intercontinental transportation. Sea transportation by reefer containers will be the dominant modality in the future for global cold chains. Reefer logistics plans and controls the forward and backward logistics of reefer containers and perishable products. Reefer logistics is challenging due to its distinctive features that include (1) high asset value, (2) food quality/waste issue, (3) energy requirements for refrigeration, (4) extra emissions, and (5) reefer maintenance and PTI. Thus, reefer logistics is a complex system with specific technical challenges, which deals with cost-efficiency, timeliness, product quality, and sustainability requirements.One of the biggest challenges in reefer logistics is to find solutions balancing cost, quality, and sustainability since improving product quality and sustainability may come at a cost. Additionally, multiple stakeholders are involved in reefer logistics, who have different perceptions of the product quality, economic aspect, and sustainability. There can be a conflict of interests between stakeholders. Therefore, it is necessary to manage the potentially conflicting objectives in a multi-actor setting for reefer logistics. The main research question that this thesis aims to answer is: How to manage reefer logistics considering its distinctive characteristics and trading off conflicting objectives of multiple stakeholders?In this thesis, we firstly provide an overall understanding of reefer logistics by analysing its technical characteristics and stakeholders. After the qualitative analysis, we propose a generic agent-oriented modelling framework to manage reefer logistics, which considers the identified features and the multiple stakeholders' objectives. We further evaluate two (re)designs of reefer logistics using the overall understanding of reefer logistics and the generic modelling framework.In Chapter 2, we explore the characteristics of ...
    Keywords Life Science
    Subject code 380
    Language English
    Publisher Wageningen University
    Publishing country nl
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Immune checkpoint inhibitors in the treatment of oesophageal squamous cell carcinoma: where are we and where are we going?

    Chen, Ning / Xu, Xiaoling / Fan, Yun

    Therapeutic advances in medical oncology

    2023  Volume 15, Page(s) 17588359231189420

    Abstract: Oesophageal squamous cell carcinoma (ESCC) is a kind of malignant tumour with high invasiveness and a poor prognosis. Immunotherapy, especially immune checkpoint inhibitors (ICIs), is a rapidly growing therapeutic method that activates and enhances anti- ... ...

    Abstract Oesophageal squamous cell carcinoma (ESCC) is a kind of malignant tumour with high invasiveness and a poor prognosis. Immunotherapy, especially immune checkpoint inhibitors (ICIs), is a rapidly growing therapeutic method that activates and enhances anti-tumour immunity to treat patients with malignancy. Several clinical trials have confirmed the efficacy of ICIs in the treatment of ESCC. ICIs have been approved for the treatment of patients with ESCC. However, only a subset of patients can obtain excellent benefits from ICI therapy. In recent years, there has been a growing interest in exploring predictive biomarkers of immunotherapy response. In this review, we highlighted the predictive biomarkers for the prognosis of ESCC patients treated with ICIs and pointed out the existing problems and the direction of future research in this field.
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2503443-1
    ISSN 1758-8359 ; 1758-8340
    ISSN (online) 1758-8359
    ISSN 1758-8340
    DOI 10.1177/17588359231189420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting HER2 alterations in non-small cell lung cancer: Therapeutic breakthrough and challenges.

    Yu, Ying / Yang, Yehao / Li, Hui / Fan, Yun

    Cancer treatment reviews

    2023  Volume 114, Page(s) 102520

    Abstract: In non-small cell lung cancer (NSCLC) with human epidermal growth factor receptor 2 (HER2) alterations, chemotherapy remains the standard treatment over a decade, due to the minor efficacy of traditional pan-HER tyrosine kinase inhibitors (TKIs) and HER2- ...

    Abstract In non-small cell lung cancer (NSCLC) with human epidermal growth factor receptor 2 (HER2) alterations, chemotherapy remains the standard treatment over a decade, due to the minor efficacy of traditional pan-HER tyrosine kinase inhibitors (TKIs) and HER2-targeted monoclonal antibodies. In recent years, novel selective HER2 TKIs have been developed for pretreated HER2-mutant patients. In particular, pyrotinib has shown moderate efficacy as well as a manageable safety profile, and it is now being further evaluated as monotherapy or combined with other existing therapies; by contrast, while poziotinib has demonstrated promising preliminary results, the high rates of toxicity has hampered subsequent studies. Most notably, trastuzumab deruxtecan (T-DXd, DS-8201) has led to a significant breakthrough, with the most encouraging efficacy data (response rate of 55 %, median progression-free survival of 8.2 months and median overall survival of 17.8 months) among all the anti-HER2 agents. This is certainly remarkable progress, and T-DXd is undoubtedly the key drug for the treatment of this disease. Future developments regarding T-DXd are favourable, including shifting from monotherapy to combination strategies, improving structural design to optimise antitumour activity and minimise toxicity, identifying the potential resistance mechanisms and developing therapeutic strategies to overcome them. Several other challenges need to be addressed, such as the intracranial activity of anti-HER2 agents and the optimal sequencing of therapies. Here, we summarise recent therapeutic advances in targeting HER2 alterations in NSCLC and highlight the future perspectives of these patient populations.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Lung Neoplasms/drug therapy ; Trastuzumab/therapeutic use ; Receptor, ErbB-2/metabolism ; Immunoconjugates/therapeutic use ; Progression-Free Survival
    Chemical Substances Antibodies, Monoclonal, Humanized ; Trastuzumab (P188ANX8CK) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Immunoconjugates
    Language English
    Publishing date 2023-01-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2023.102520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Shaping the tumor immune microenvironment of SCLC: Mechanisms, and opportunities for immunotherapy.

    Chen, Yunfei / Li, Hui / Fan, Yun

    Cancer treatment reviews

    2023  Volume 120, Page(s) 102606

    Abstract: Small-cell lung cancer (SCLC) is a very aggressive neuroendocrine tumor with a poor prognosis. Whereas immunotherapy has emerged as a promising approach for treating SCLC, its unique tumor immune microenvironment (TIME) might limit patient responses. To ... ...

    Abstract Small-cell lung cancer (SCLC) is a very aggressive neuroendocrine tumor with a poor prognosis. Whereas immunotherapy has emerged as a promising approach for treating SCLC, its unique tumor immune microenvironment (TIME) might limit patient responses. To fully characterize the TIME and understand the mechanism of its formation with respect to SCLC is crucial. The recent rapid development of multi-omics technologies has rapidly advanced knowledge of TIME features and the regulatory mechanisms associated with SCLC. This review summarizes the TIME features of SCLC as well as shaping the TIME according to the genomics, epigenomics, and metabolomics of tumors. Future opportunities and challenges for immunotherapy are also discussed.
    Language English
    Publishing date 2023-08-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2023.102606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Electrocatalytic oxidation of biomass derived molecules.

    Fan, Yun / Zou, Yuqin / Wang, Shuangyin

    Science bulletin

    2023  Volume 68, Issue 22, Page(s) 2695–2699

    MeSH term(s) Biomass ; Oxidation-Reduction ; Electrodes
    Language English
    Publishing date 2023-09-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2816140-3
    ISSN 2095-9281 ; 2095-9273
    ISSN (online) 2095-9281
    ISSN 2095-9273
    DOI 10.1016/j.scib.2023.09.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Consta-dihedral Codes over Finite Fields

    Fan, Yun / Leng, Yue

    2023  

    Abstract: It is proved in a reference (Fan, Lin, IEEE TIT, vol.67, pp.5016-5025) that the self-dual (LCD respectively) dihedral codes over a finite field~$F$ with ${|F|=q}$ are asymptotically good if $q$ is even (odd respectively). In this paper, we investigate ... ...

    Abstract It is proved in a reference (Fan, Lin, IEEE TIT, vol.67, pp.5016-5025) that the self-dual (LCD respectively) dihedral codes over a finite field~$F$ with ${|F|=q}$ are asymptotically good if $q$ is even (odd respectively). In this paper, we investigate the algebraic property and the asymptotic property of conta-dihedral codes over $F$, and show that: if $q$ is even or $4\,|\,(q-1)$, then the self-dual consta-dihedral codes are asymptotically good; otherwise, the LCD consta-dihedral codes are asymptotically good. And, with the help of a technique developed in this paper, some errors in the reference mentioned above are corrected.
    Keywords Computer Science - Information Theory ; 12E20 ; 13M10 ; 20C05 ; 94B60
    Publishing date 2023-03-01
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Numerical Experiments on Tibetan Plateau

    Fan Yun

    Proceedings of Indian National Science Academy, Vol 60, Iss 1A (2015)

    2015  

    Abstract: Numerical Experiments on Tibetan ... ...

    Abstract Numerical Experiments on Tibetan Plateau
    Keywords Science ; Q
    Language English
    Publishing date 2015-02-01T00:00:00Z
    Publisher Indian National Science Academy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The Duality of Caspases in Cancer, as Told through the Fly.

    Hounsell, Caitlin / Fan, Yun

    International journal of molecular sciences

    2021  Volume 22, Issue 16

    Abstract: Caspases, a family of cysteine-aspartic proteases, have an established role as critical components in the activation and initiation of apoptosis. Alongside this a variety of non-apoptotic caspase functions in proliferation, differentiation, cellular ... ...

    Abstract Caspases, a family of cysteine-aspartic proteases, have an established role as critical components in the activation and initiation of apoptosis. Alongside this a variety of non-apoptotic caspase functions in proliferation, differentiation, cellular plasticity and cell migration have been reported. The activity level and context are important factors in determining caspase function. As a consequence of their critical role in apoptosis and beyond, caspases are uniquely situated to have pathological roles, including in cancer. Altered caspase function is a common trait in a variety of cancers, with apoptotic evasion defined as a "hallmark of cancer". However, the role that caspases play in cancer is much more complex, acting both to prevent and to promote tumourigenesis. This review focuses on the major findings in
    MeSH term(s) Animals ; Apoptosis ; Carcinogenesis ; Caspases/metabolism ; Drosophila ; Humans ; Neoplasms/enzymology ; Neoplasms/etiology ; Neoplasms/pathology ; Neoplasms/prevention & control
    Chemical Substances Caspases (EC 3.4.22.-)
    Language English
    Publishing date 2021-08-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22168927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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