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Article: [Evaluation of safety and clinical efficacy of bilateral percutaneous kyphoplasty in treatment of osteoporotic thoraco-lumbar burst fractures].

Pang, D M / Yang, J C / Gao, H F / Fan, Z X / Yin, P

2022 Volume 102, Issue 35, Page(s) 2793–2798

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Aged ; Aged, 80 and over ; Bone Cements/therapeutic use ; Female ; Fractures, Compression/surgery ; Humans ; Kyphoplasty/methods ; Kyphosis ; Male ; Middle Aged ; Osteoporotic Fractures/surgery ; Prospective Studies ; Spinal Puncture ; Treatment Outcome
Chemical Substances	Bone Cements
Language	Chinese
Publishing date	2022-09-13
Publishing country	China
Document type	Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20220408-00758
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Article ; Online: Circ_NCKAP1 promotes skin basal cell carcinoma progression by sponging the miR-148b-5p/HSP90 axis.

Fan, Z-X / Xi, W / Miao, X-Y / Li, L-Y / Miao, G-Y

European review for medical and pharmacological sciences

2021 Volume 25, Issue 17, Page(s) 5355–5364

Abstract: Objective: Skin basal cell carcinoma (BCC) is the most common malignant skin tumor. Recent studies demonstrated that circular RNAs (circRNAs) are implicated in tumorigenesis and may represent potential therapeutic targets. The aim of the present study ... ...

Abstract	Objective: Skin basal cell carcinoma (BCC) is the most common malignant skin tumor. Recent studies demonstrated that circular RNAs (circRNAs) are implicated in tumorigenesis and may represent potential therapeutic targets. The aim of the present study was to explore the expression profiles of circRNAs and their role in skin BCC. Materials and methods: Three pairs of skin BCC tissues and adjacent tissues were used to perform a circRNA microarray for screening of circRNA expression profiles. Circ_NCKAP1 was selected as a target circRNA by RT-qPCR verification and bioinformatics analysis. The effect of circ_NCKAP1 knockdown on cell proliferation and apoptosis was assessed using CCK8 and Annexin V-FITC/PI assays, and its regulation over the miR-148b-5p/HSP90 axis was assessed by dual-luciferase reporter assay. Results: Circ_NCKAP1 was found to be significantly upregulated in skin BCC tissues (p<0.05). In vitro loss-of-function assays demonstrated that circ_NCKAP1 knockdown markedly inhibited cell proliferation and promoted cell apoptosis (p<0.05). Moreover, Dual-Luciferase reporter assay identified that circ_NCKAP1 could bind to miR-148b-5p directly, and HSP90 was targeted by miR-148b-5p. Conclusions: Circ_NCKAP1 can promote skin BCC progression by sponging the miR-148b-5p/HSP90 axis, and circ_NCKAP1 may be a potential target for skin BCC therapy.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Aged ; Apoptosis/genetics ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knockdown Techniques ; HSP90 Heat-Shock Proteins/genetics ; Humans ; Male ; MicroRNAs/genetics ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Up-Regulation
Chemical Substances	Adaptor Proteins, Signal Transducing ; HSP90 Heat-Shock Proteins ; MIRN148 microRNA, human ; MicroRNAs ; NCKAP1 protein, human
Language	English
Publishing date	2021-09-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202109_26642
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Article: Tree-ring evidence for the historical cyclic defoliator outbreaks on Larix potaninii in the central Hengduan Mountains, SW China

Fan, Z.-X. / Bräuning, A.

Ecological indicators

2017 Volume 74, Issue -, Page(s) 160

Language	English
Document type	Article
ZDB-ID	2036774-0
ISSN	1470-160x
Database	Current Contents Nutrition, Environment, Agriculture

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Article: [Using structured decision-making to identify the appropriate type of entity for the centers for disease control and prevention of China].

Zhang, Q / Cao, M / Fan, Z X / Xiang, L / Zhang, J

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

2020 Volume 54, Issue 11, Page(s) 1243–1248

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Centers for Disease Control and Prevention, U.S. ; China ; Public Health ; Surveys and Questionnaires ; United States
Language	Chinese
Publishing date	2020-11-02
Publishing country	China
Document type	Journal Article
ZDB-ID	604575-3
ISSN	0253-9624
ISSN	0253-9624
DOI	10.3760/cma.j.cn112150-20200713-00999
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Article ; Online: Expression of water-soluble nucleocapsid protein of SARS-CoV-2 and analysis of its immunogenicity.

Wang, Y B / Wang, S W / Jin, Q Y / Chen, L P / Zhang, F Q / Shi, J J / Yin, Y / Fan, Z X / Liu, X Y / Wang, L P / Li, P

Polish journal of veterinary sciences

2023 Volume 26, Issue 4, Page(s) 571–579

Abstract: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a major public health concern. Nucleocapsid (N) protein is the most abundant structural protein on SARS-CoV-2 virions and induces ... ...

Abstract	Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a major public health concern. Nucleocapsid (N) protein is the most abundant structural protein on SARS-CoV-2 virions and induces the production of antibodies at the early stage of infection. Large-scale preparation of N protein is essential for the development of immunoassays to detect antibodies to SARS-CoV-2 and the control of virus transmission. In this study, expression of water-soluble N protein was achieved through inducing protein expression at 25°C with 0.5 mM IPTG for 12 h. Western blot and ELISA showed that recombinant N protein could be recognized by sera collected from subjects immunized with Sinovac inactivated SARS-CoV-2 vaccine. Four monoclonal antibodies namely 2B1B1, 4D3A3, 5G1F8, and 7C6F5 were produced using hybridoma technology. Titers of all four monoclonal antibodies in ELISA reached more than 1.28×10 6.0. Moreover, all monoclonal antibodies could react specifically with N protein expressed by transfection of pcDNA3.1-N into BHK-21 cells in IPMA and IFA. These results indicated that water-soluble N protein retained high immunogenicity and possessed the same epitopes as that of native N protein on virions. In addition, the preparation of water-soluble N protein and its monoclonal antibodies laid the basis for the development of immunoassays for COVID-19 detection.
MeSH term(s)	Animals ; Nucleocapsid Proteins ; SARS-CoV-2 ; COVID-19 Vaccines ; COVID-19/veterinary ; Antibodies, Monoclonal ; Recombinant Proteins ; Antibodies, Viral
Chemical Substances	Nucleocapsid Proteins ; COVID-19 Vaccines ; Antibodies, Monoclonal ; Recombinant Proteins ; Antibodies, Viral
Language	English
Publishing date	2023-12-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2860634-6
ISSN	2300-2557 ; 1505-1773
ISSN (online)	2300-2557
ISSN	1505-1773
DOI	10.24425/pjvs.2023.148277
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Article: [Clinical features, risk factors and prognosis of idiopathic dilated cardiomyopathy complicated by ischemic stroke].

Fan, Z X / Wang, C B / Fang, L L / Cai, B / Yuan, P / Niu, T T / Ma, L / Yuan, G B / Liu, G Z

Zhonghua yi xue za zhi

2022 Volume 102, Issue 45, Page(s) 3592–3597

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Ischemic Stroke ; Cardiomyopathy, Dilated ; Stroke, Lacunar ; Retrospective Studies ; Risk Factors ; Heart Failure ; Hypertension
Language	Chinese
Publishing date	2022-12-08
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20220427-00949
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Article ; Online: Biotransformation of insecticide flonicamid by Aminobacter sp. CGMCC 1.17253 via nitrile hydratase catalysed hydration pathway.

Yang, W L / Dai, Z L / Cheng, X / Fan, Z X / Jiang, H Y / Dai, Y J

Journal of applied microbiology

2020 Volume 130, Issue 5, Page(s) 1571–1581

Abstract: Aims: This study evaluates flonicamid biotransformation ability of Aminobacter sp. CGMCC 1.17253 and the enzyme catalytic mechanism involved.: Methods and results: Flonicamid transformed by resting cells of Aminobacter sp. CGMCC 1.17253 was carried ... ...

Abstract	Aims: This study evaluates flonicamid biotransformation ability of Aminobacter sp. CGMCC 1.17253 and the enzyme catalytic mechanism involved. Methods and results: Flonicamid transformed by resting cells of Aminobacter sp. CGMCC 1.17253 was carried out. Aminobacter sp. CGMCC 1.17253 converts flonicamid into N-(4-trifluoromethylnicotinoyl) glycinamide (TFNG-AM). Aminobacter sp. CGMCC 1.17253 transforms 31·1% of the flonicamid in a 200 mg l Conclusions: Aminobacter sp. CGMCC 1.17253 transforms flonicamid into TFNG-AM via hydration pathway mediated by cobalt-containing NHase. Significance and impact of the study: This is the first report that bacteria of genus Aminobacter has flonicamid-transforming ability. This study enhances our understanding of flonicamid-degrading mechanism. Aminobacter sp. CGMCC 1.17253 has the potential for bioremediation of flonicamid pollution.
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/isolation & purification ; Bacterial Proteins/metabolism ; Biodegradation, Environmental ; Biotransformation ; Hydro-Lyases/genetics ; Hydro-Lyases/isolation & purification ; Hydro-Lyases/metabolism ; Insecticides/metabolism ; Niacinamide/analogs & derivatives ; Niacinamide/metabolism ; Phyllobacteriaceae/enzymology ; Phyllobacteriaceae/genetics ; Phyllobacteriaceae/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Soil Pollutants/metabolism
Chemical Substances	Bacterial Proteins ; Insecticides ; Recombinant Proteins ; Soil Pollutants ; Niacinamide (25X51I8RD4) ; flonicamid (9500W2Z53J) ; Hydro-Lyases (EC 4.2.1.-) ; nitrile hydratase (EC 4.2.1.-)
Language	English
Publishing date	2020-10-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/jam.14880
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Article ; Online: Icariin promotes mouse hair follicle growth by increasing insulin-like growth factor 1 expression in dermal papillary cells.

Su, Y-S / Fan, Z-X / Xiao, S-E / Lin, B-J / Miao, Y / Hu, Z-Q / Liu, H

Clinical and experimental dermatology

2017 Volume 42, Issue 3, Page(s) 287–294

Abstract: Background: Icariin is a major flavonoid isolated from Epimedium spp. leaves (Epimedium Herba), and has multiple pharmacological functions, including anti-angiogenesis, anti-oxidant, anti-inflammatory and immunoprotective effects.: Aim: To ... ...

Abstract	Background: Icariin is a major flavonoid isolated from Epimedium spp. leaves (Epimedium Herba), and has multiple pharmacological functions, including anti-angiogenesis, anti-oxidant, anti-inflammatory and immunoprotective effects. Aim: To investigate whether icariin can stimulate growth of hair follicles in mice and the underlying mechanism. Methods: In vitro, the effect of icariin on hair growth was assessed by using a vibrissae hair follicle (VHF) organ-culture model. The proliferation of hair matrix keratinocytes and the expression of insulin-like growth factor (IGF)-1 in follicles were examined by double immunostaining for 5-bromo-2'-deoxyuridine and IGF-1, in the presence or absence of icariin. Dermal papilla cells (DPCs) were cultured and IGF-1 level was measured by reverse transcription-PCR and ELISA after icariin treatment. In vivo, the effect of icariin on hair growth was examined by gavage feeding of icariin to mice whose backs had been depilated, and the conversion of telogen to anagen hair was observed. Results: Treatment with icariin promoted hair shaft elongation, prolonged the hair cycle growth phase (anagen) in cultured VHFs, and accelerated transition of hair cycle from telogen to anagen phase in the dorsal skin of mice. There was significant proliferation of matrix keratinocytes and an increased level of IGF-1 in cultured VHFs. Moreover, icariin treatment upregulated IGF-1 mRNA expression in DPCs and increased IGF-1 protein content in the conditioned medium of DPCs. Conclusions: These results suggest that icariin can promote mouse hair follicle growth via stimulation of IGF-1 expression in DPCs.
MeSH term(s)	Animals ; Bromodeoxyuridine/metabolism ; Cell Proliferation/drug effects ; Dermis/cytology ; Drugs, Chinese Herbal/pharmacology ; Enzyme-Linked Immunosorbent Assay ; Epimedium/chemistry ; Flavonoids/pharmacology ; Hair Follicle/drug effects ; Hair Follicle/growth & development ; Hair Follicle/metabolism ; Immunohistochemistry ; Insulin-Like Growth Factor I/metabolism ; Keratinocytes/drug effects ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Organ Culture Techniques
Chemical Substances	Drugs, Chinese Herbal ; Flavonoids ; Insulin-Like Growth Factor I (67763-96-6) ; Bromodeoxyuridine (G34N38R2N1) ; icariin (VNM47R2QSQ)
Language	English
Publishing date	2017-04
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.13043
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Article ; Online: Effects of extracellular matrix on the growth characteristics of human dermal papillae cells in vitro.

Miao, Y / Fan, Z X / Du, L J / Su, Y S / Sun, Y B / Jiang, W / Hu, Z Q

Clinical and experimental dermatology

2016 Volume 41, Issue 7, Page(s) 792–797

Abstract: Background: In humans, dermal papillae cells (DPCs) are surrounded by basal membranes. However, conventional in vitro culture conditions for DPCs do not include extracellular matrix (ECM).: Aim: To investigate the effects of different ECM types on ... ...

Abstract	Background: In humans, dermal papillae cells (DPCs) are surrounded by basal membranes. However, conventional in vitro culture conditions for DPCs do not include extracellular matrix (ECM). Aim: To investigate the effects of different ECM types on the characteristics of cultured human DPCs. Methods: Freshly isolated human DPCs were inoculated onto plates precoated with type IV collagen, fibronectin, Matrigel or hyaluronate. Cell migration, growth and viability were measured. Real-time quantitative (q)PCR and western blotting were used to detect the influence of different ECM types on the expression of DPC-specific biomarkers. Results: In planar culture, type IV collagen and fibronectin had a beneficial effect on the migration, aggregation and viability of DPCs, in contrast to Matrigel and hyaluronate. Real-time qPCR revealed that significantly increased expression of mRNA was seen only for neural cell adhesion molecule (NCAM) and α-smooth muscle actin (α-SMA) in the Matrigel group, whereas versican, NCAM and α-SMA all decreased significantly in the hyaluronate group. In the type IV collagen and fibronectin groups, mRNA expression of the above genes did not change significantly. Western blotting indicated that there were no significant differences in expression of the above proteins between the four groups and the control group. Conclusion: In planar culture, exogenous ECM types (Matrigel, type IV collagen, hyaluronate and fibronectin) changed the growth characteristics of DPCs, but they did not affect the characteristics associated with the biological functions of DPCs.
Language	English
Publishing date	2016-10
Publishing country	England
Document type	Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.12888
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Article: Analysis of influencing factors related to elevated serum troponin I level for COVID-19 patients in Yichang, China

Fan, Z. X. / Yang, J. / Zhang, J. / He, C. / Wu, H. / Yang, C. J. / Zheng, T. / Ma, C. / Xiang, Z. J. / Zhai, Y. H. / Jiang, J. / Qiu, S. Q.

Cardiovasc Diagn Ther

Abstract: BACKGROUND: Cardiac injury is a common condition among hospitalized coronavirus disease 2019 (COVID-19) patients, and is associated with a higher risk of mortality However, the mechanism of myocardial injury in COVID-19 remains unclear In this ... ...

Abstract	BACKGROUND: Cardiac injury is a common condition among hospitalized coronavirus disease 2019 (COVID-19) patients, and is associated with a higher risk of mortality However, the mechanism of myocardial injury in COVID-19 remains unclear In this retrospective study, we compared the clinical characteristics of COVID-19 patients with different troponin I (TnI) levels during hospitalization to provide a clinical reference for the identification of those at high-risk METHODS: In total, 218 patients diagnosed with COVID-19 in Yichang Central People's Hospital and Yichang Third People's Hospital between January 23 and February 19, 2020 were initially included Of these patients, 89 underwent TnI testing during hospitalization and were finally included in the study The medical history, clinical signs and symptoms at the time of admission, and laboratory test results were recorded The patients were assigned to the normal TnI group (TnI 0 01 µg/L;n=22) RESULTS: The incidence of elevated TnI in our patient cohort was 24 7% There were significant differences between the two groups in the following factors: history of coronary heart disease (CHD), age, lymphocyte count, prothrombin time (PT), activated partial thromboplastin time (APTT), and levels of interleukin (IL)-6, C-reactive protein (CRP), myoglobin (MYO), lactate dehydrogenase (LDH), and albumin (all P<0 05) Binary logistic analysis showed that a history of CHD, age, lymphocyte count, IL-6, APTT, and MYO were influencing factors of elevated serum TnI CONCLUSIONS: A history of CHD, advanced age, decreased lymphocyte count, increased IL-6, increased MYO, and prolonged APTT were independent influencing factors of elevated TnI in COVID-19 patients COVID-19 patients with these characteristics are prone to myocardial injury
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #792021
Database	COVID19

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