LIVIVO - Search results -

Search results

Result 1 - 10 of total 10

Search options

Article ; Online: Total Synthesis of Principinol B.

Du, Qiang / Fan, Zhibo / Yang, Ming

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 17, Page(s) e202400956

Abstract: We have accomplished the first and asymmetric total synthesis of principinol B, a grayanoid possessing an oxabicyclo[3.2.1] architecture. A functionalized 5/7/6/5 tetracyclic intermediate was assembled in a convergent manner by a diastereoselective ... ...

Abstract	We have accomplished the first and asymmetric total synthesis of principinol B, a grayanoid possessing an oxabicyclo[3.2.1] architecture. A functionalized 5/7/6/5 tetracyclic intermediate was assembled in a convergent manner by a diastereoselective intermolecular aldol reaction and subsequent carbonyl-olefin metathesis of two enantiomerically enriched fragments. The oxabicyclo[3.2.1] architecture containing a 6,10-ether bridge was constructed by the Williamson ether synthesis.
Language	English
Publishing date	2024-03-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202400956
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- Full text online
- Order with fees

Article ; Online: CoCl

Fan, Zhibo / Liu, Yanru / Lan, Yuxin / Wu, Yujie / Li, Junyu / Xu, Xiaomei

Cell biology international

2024 Volume 48, Issue 6, Page(s) 808–820

Abstract: Bone defects are characterized by a hypoxic environment, which affects bone tissue repair. However, the role of hypoxia in the repair of alveolar bone defects remains unclear. Human periodontal ligament stem cells (hPDLSCs) are high-quality seed cells ... ...

Abstract	Bone defects are characterized by a hypoxic environment, which affects bone tissue repair. However, the role of hypoxia in the repair of alveolar bone defects remains unclear. Human periodontal ligament stem cells (hPDLSCs) are high-quality seed cells for repairing alveolar bone defects, whose behavior changes under hypoxia. However, their mechanism of action is not known and needs to be elucidated. We hypothesized that hypoxia might be beneficial to alveolar bone defect repair and the osteogenic differentiation of hPDLSCs. To test this hypothesis, cobalt chloride (CoCl
MeSH term(s)	Humans ; TOR Serine-Threonine Kinases/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Osteogenesis/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Cobalt/pharmacology ; Cell Differentiation/drug effects ; Periodontal Ligament/metabolism ; Periodontal Ligament/cytology ; Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Hypoxia ; Stem Cells/metabolism ; Cell Cycle Proteins/metabolism ; Cells, Cultured ; Alveolar Bone Loss/metabolism ; Phosphoproteins/metabolism ; Male ; Rabbits ; Bone Regeneration/drug effects
Language	English
Publishing date	2024-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1143453-3
ISSN	1095-8355 ; 1065-6995
ISSN (online)	1095-8355
ISSN	1065-6995
DOI	10.1002/cbin.12148
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1451: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Continuous motion estimation of lower limbs based on deep belief networks and random forest.

Wang, Fei / Lu, Jian / Fan, Zhibo / Ren, Chuanjian / Geng, Xin

The Review of scientific instruments

2022 Volume 93, Issue 4, Page(s) 44106

Abstract: Due to the lag problem of traditional sensor acquisition data, the following movement of exoskeleton robots can affect the comfort of the wearer and even the normal movement pattern of the wearer. In order to solve the problem of lag in exoskeleton ... ...

Abstract	Due to the lag problem of traditional sensor acquisition data, the following movement of exoskeleton robots can affect the comfort of the wearer and even the normal movement pattern of the wearer. In order to solve the problem of lag in exoskeleton motion control, this paper designs a continuous motion estimation method for lower limbs based on the human surface electromyographic (sEMG) signal and achieves the recognition of the motion intention of the wearer through a combination of the deep belief network (DBN) and random forest (RF) algorithm. First, the motion characteristics of human lower limbs are analyzed, and the hip-knee angle and sEMG signal related to lower limb motion are collected and extracted; then, the DBN is used in the dimensionality reduction of the sEMG signal feature values; finally, the motion intention of the wearer is predicted using the RF model optimized by the genetic algorithm. The experimental results show that the root mean square error of knee and hip prediction results of the combined algorithm proposed in this article improved by 0.2573° and 0.3375°, respectively, compared to the algorithm with dimensionality reduction by principal component analysis, and the single prediction time is 0.28 ms less than that before dimensionality reduction, provided that other conditions are exactly the same.
MeSH term(s)	Algorithms ; Electromyography ; Exoskeleton Device ; Humans ; Lower Extremity ; Motion
Language	English
Publishing date	2022-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0057478
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 46/112: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Regulation of reactive oxygen species on the mitophagy of human periodontal ligament cells through the PINK1/Parkin pathway under starvation.

Fan, Zhibo / Jin, Ke / Li, Shenghong / Xu, Jie / Xu, Xiaomei

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology

2022 Volume 40, Issue 6, Page(s) 645–653

Abstract: Objectives: This study aimed to explore the specific mechanism, mediated by the reactive oxygen species (ROS) and PINK1/Parkin pathway, of the mitochondrial autophagy of human periodontal ligament cells (hPDLCs) under starvation conditions.: Methods: ...

Abstract	Objectives: This study aimed to explore the specific mechanism, mediated by the reactive oxygen species (ROS) and PINK1/Parkin pathway, of the mitochondrial autophagy of human periodontal ligament cells (hPDLCs) under starvation conditions. Methods: hPDLCs were isolated and cultured from normal periodontal tissues. Earle's balanced salt solution (EBSS) was used to simulated a starvation environment and thus stimulate hPDLCs mitochondrial autophagy. N-Acetyl-L-cysteine (NAC) was used to inhibit ROS production to explore the role of ROS in hPDLC mitochondrial autophagy. Cyclosporin A was used to inhibit the PINK1/Parkin pathway to study the role of ROS and the PINK1/Parkin pathway in hPDLCs activation under starvation. The mitochondrial membrane potential was detected by flow cytometry with a JC-1 mitochondrial membrane potential detection kit. The morphological structure of mitochondria and the formation of mitochondrial autophagosome were observed by transmission electron microscopy. Mito tracker red cmxros and lyso tracker green staining were used to observe the localization of mitochondria and lysosomes. The formation intensity of ROS was detected with a DCFH-DA ROS fluorescent probe. The expression levels of mitochondrial autophagy genes (Tomm20 and Timm23) and the PINK1/Parkin pathway were detected by real-time quantitative polymerase chain reaction (RT-qPCR). The expression levels of mitochondrial autophagy proteins (Tomm20 and Timm23) and PINK1/Parkin protein were detected by Western blot. Results: EBSS starvation for 30 min induced the strongest activation of hPDLCs mitochondrial autophagy, increased the expression of ROS, downregulated the expression of mitochondrial autophagy-related genes (Tomm20 and Timm23) ( Conclusions: ROS enhanced the mitochondrial autophagy of hPDLCs primarily through the PINK1/Parkin pathway under starvation conditions.
MeSH term(s)	Humans ; Mitophagy/genetics ; Reactive Oxygen Species/metabolism ; Periodontal Ligament/metabolism ; Cyclosporine ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Reactive Oxygen Species ; parkin protein (EC 2.3.2.27) ; Cyclosporine (83HN0GTJ6D) ; Protein Kinases (EC 2.7.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	Chinese
Publishing date	2022-11-23
Publishing country	China
Document type	Journal Article
ZDB-ID	1202342-5
ISSN	2618-0456 ; 1000-1182
ISSN (online)	2618-0456
ISSN	1000-1182
DOI	10.7518/hxkq.2022.06.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4073: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Gold-Catalyzed Formal Hexadehydro-Diels–Alder/Carboalkoxylation Reaction Cascades

Wang, Hong-Fa / Guo, Lin-Na / Fan, Zhi-Bo / Tang, Tian-Hua / Zi, Weiwei

Organic letters. 2021 Mar. 15, v. 23, no. 7

2021

Abstract: A dual gold-catalyzed hexadehydro-Diels–Alder/carboalkoxylation cascade reaction is reported. In this transformation, the gold catalyst participated in the hexadehydro-Diels–Alder step, switching the mechanism from a radical type to a cationic one, and ... ...

Abstract	A dual gold-catalyzed hexadehydro-Diels–Alder/carboalkoxylation cascade reaction is reported. In this transformation, the gold catalyst participated in the hexadehydro-Diels–Alder step, switching the mechanism from a radical type to a cationic one, and then the catalyst activated the resulting aryne to form an ortho-Au phenyl cation species, which underwent a carboalkoxylation rearrangement rather than the expected aryne–ene reaction.
Keywords	catalysts ; cations ; gold
Language	English
Dates of publication	2021-0315
Size	p. 2676-2681.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1523-7052
DOI	10.1021/acs.orglett.1c00581
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Gold-Catalyzed Formal Hexadehydro-Diels-Alder/Carboalkoxylation Reaction Cascades.

Wang, Hong-Fa / Guo, Lin-Na / Fan, Zhi-Bo / Tang, Tian-Hua / Zi, Weiwei

Organic letters

2021 Volume 23, Issue 7, Page(s) 2676–2681

Abstract: A dual gold-catalyzed hexadehydro-Diels-Alder/carboalkoxylation cascade reaction is reported. In this transformation, the gold catalyst participated in the hexadehydro-Diels-Alder step, switching the mechanism from a radical type to a cationic one, and ... ...

Abstract	A dual gold-catalyzed hexadehydro-Diels-Alder/carboalkoxylation cascade reaction is reported. In this transformation, the gold catalyst participated in the hexadehydro-Diels-Alder step, switching the mechanism from a radical type to a cationic one, and then the catalyst activated the resulting aryne to form an ortho-Au phenyl cation species, which underwent a carboalkoxylation rearrangement rather than the expected aryne-ene reaction.
Language	English
Publishing date	2021-03-15
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.1c00581
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Improved Target Signal Source Tracking and Extraction Method Based on Outdoor Visible Light Communication Using a Cam-Shift Algorithm and Kalman Filter.

Huang, Mouxiao / Guan, Weipeng / Fan, Zhibo / Chen, Zenghong / Li, Jingyi / Chen, Bangdong

Sensors (Basel, Switzerland)

2018 Volume 18, Issue 12

Abstract: An improved Cam-Shift algorithm with a Kalman filter applied to image-sensor based on outdoor visible light communication (OVLC) is presented in this paper. The proposed optimized tracking algorithm is used to track and extract the region of the target ... ...

Abstract	An improved Cam-Shift algorithm with a Kalman filter applied to image-sensor based on outdoor visible light communication (OVLC) is presented in this paper. The proposed optimized tracking algorithm is used to track and extract the region of the target signal source Light Emitting Diode (LED) that carries modulated information for data transmission. Extracting the target signal source LED area is the premise of an image-sensor-based VLC system, especially in outdoor dynamic scenes. However, most of the existing VLC studies focus on data transmission rate, visible light positioning, etc. While the actual first step of realizing communication is usually ignored in the field of VLC, especially when the transmitter (signal source LED) or the receiver (image sensor) is moving in a more complex outdoor environment. Therefore, an improved tracking algorithm is proposed in this paper, aiming at solving the problem of extracting the region of the target signal source LED accurately in dynamic scenes with different interferences so as to promote the feasibility of VLC applications in outdoor scenes. The proposed algorithm considers color characteristics and special distribution characteristics of the moving target at the same time. The image is converted to a color probability distribution map based on the color histogram of the target and adaptively adjusts the location and size of the search window based on the results obtained from the previous frame. Meanwhile, it predicts the motion state of the target in the next frame according to the position and velocity information of the current frame to enhance accuracy and robustness of tracking. Experimental results show that the tracking error of the proposed algorithm is 0.85 cm and the computational time of processing one frame is 0.042 s. Besides, results also show that the improved algorithm can track and extract the target signal source LED area completely and accurately in an environment of many interference factors. This study confirms that the proposed algorithm can be applied to an OVLC system with many interferences to realize the actual first step of communication in an image-sensor-based VLC system, laying foundations for subsequent data transmission and other steps.
Language	English
Publishing date	2018-11-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s18124173
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Book ; Online: FGN

Fan, Zhibo / Yu, Jin-Gang / Liang, Zhihao / Ou, Jiarong / Gao, Changxin / Xia, Gui-Song / Li, Yuanqing

Fully Guided Network for Few-Shot Instance Segmentation

2020

Abstract: Few-shot instance segmentation (FSIS) conjoins the few-shot learning paradigm with general instance segmentation, which provides a possible way of tackling instance segmentation in the lack of abundant labeled data for training. This paper presents a ... ...

Abstract	Few-shot instance segmentation (FSIS) conjoins the few-shot learning paradigm with general instance segmentation, which provides a possible way of tackling instance segmentation in the lack of abundant labeled data for training. This paper presents a Fully Guided Network (FGN) for few-shot instance segmentation. FGN perceives FSIS as a guided model where a so-called support set is encoded and utilized to guide the predictions of a base instance segmentation network (i.e., Mask R-CNN), critical to which is the guidance mechanism. In this view, FGN introduces different guidance mechanisms into the various key components in Mask R-CNN, including Attention-Guided RPN, Relation-Guided Detector, and Attention-Guided FCN, in order to make full use of the guidance effect from the support set and adapt better to the inter-class generalization. Experiments on public datasets demonstrate that our proposed FGN can outperform the state-of-the-art methods. Comment: Accepted by CVPR 2020, 10 pages, 6 figures
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	004
Publishing date	2020-03-31
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Pd-CuFe Catalyst for Transfer Hydrogenation of Nitriles: Controllable Selectivity to Primary Amines and Secondary Amines.

Liu, Lei / Liu, Yuhong / Ai, Yongjian / Li, Jifan / Zhou, Junjie / Fan, Zhibo / Bao, Hongjie / Jiang, Ruihang / Hu, Zenan / Wang, Jingting / Jing, Ke / Wang, Yue / Liang, Qionglin / Sun, Hongbin

iScience

2018 Volume 8, Page(s) 61–73

Abstract: A multicomponent nanocatalyst system was fabricated for the transfer hydrogenation of nitrile compounds. This catalyst system contains palladium, copper, and iron, which are supported on the magnetite nanospheres, and the loading of palladium could be at ...

Abstract	A multicomponent nanocatalyst system was fabricated for the transfer hydrogenation of nitrile compounds. This catalyst system contains palladium, copper, and iron, which are supported on the magnetite nanospheres, and the loading of palladium could be at the parts per million level. Palladium and copper contribute to the transformation of nitrile, and the product distribution highly depends on the alloying of Fe to Cu. The nitriles could be converted to primary amine by the Pd-Cu catalyst in the absence of Fe, whereas in the presence of Fe the products are secondary amines with high selectivity. This could be attributed to the electronic modulation of iron to copper. A variety of nitriles have been transformed to the corresponding primary or secondary amines with high selectivity, and the TOF reaches 2,929 hr
Language	English
Publishing date	2018-09-19
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2018.09.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Analysis of the complementarity determining regions β-chain genomic rearrangement using high-throughput sequencing in periphery cytotoxic T lymphocytes of patients with chronic hepatitis B.

Huang, Yinuo / Ma, Hong / Wei, Shutang / Luo, Gang / Sun, Ruimin / Fan, Zhibo / Wu, Liping / Yang, Wenyi / Fu, Lin / Wang, Junhui / Han, Dazheng / Lu, Jun

Molecular medicine reports

2016 Volume 14, Issue 1, Page(s) 762–768

Abstract: Cytotoxic T lymphocytes (CTLs) are important for the recognition of the hepatitis B virus (HBV), mediating immunoprotective mechanisms and determining the clinical outcome following HBV infection. CTLs recognize the invading virus via the T cell receptor ...

Abstract	Cytotoxic T lymphocytes (CTLs) are important for the recognition of the hepatitis B virus (HBV), mediating immunoprotective mechanisms and determining the clinical outcome following HBV infection. CTLs recognize the invading virus via the T cell receptor (TCR). The aim of the current study was to investigate the variability of TCR in lymphocytes from patients with chronic hepatitis B and whether TCR genomic recombination is regulated by the current treatment strategies. Peripheral blood mononuclear cells (PBMCs) were isolated from patients with chronic hepatitis B and high‑throughput sequencing was performed to analyze the gene expression diversity of β chain complementarity determining region. High‑throughput sequencing produced ~380,000 reads. The sequences of V and J family mRNAs of the β chain V area were analyzed and databases were created for all 30 V family and J family genes. Using the Basic Local Alignment Search Tool, 15 genes were identified to be upregulated in the samples following treatment. Among them, the expression of T cell receptor β variable 28 (TRBV28)_T cell receptor β joining 1‑5 (TRBJ1.5) and TRBV6_TRBJ2.10 were significantly different in the treated samples compared with samples taken prior to treatment. Genomic recombination patterns of TRBV and TRBJ of the β chain V area were observed to be different in the samples following treatment. The data of the current study demonstrated that the genomic rearrangement of the V and J segments of TCR β chain V area may be associated with the chronic progression of HBV and impact on treatment efficacy.
MeSH term(s)	Complementarity Determining Regions/genetics ; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor ; Hepatitis B virus/immunology ; Hepatitis B, Chronic/genetics ; Hepatitis B, Chronic/immunology ; Hepatitis B, Chronic/virology ; High-Throughput Nucleotide Sequencing ; Humans ; Polymerase Chain Reaction ; Sequence Analysis, DNA ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism
Chemical Substances	Complementarity Determining Regions
Language	English
Publishing date	2016-07
Publishing country	Greece
Document type	Journal Article
ISSN	1791-3004
ISSN (online)	1791-3004
DOI	10.3892/mmr.2016.5329
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

To top

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED