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Article ; Online: Measuring the Success of Global Sports Governance: A Deep Trust Network Model Approach.

Fan, Zhongyi / Yi, Jiandong

2024 Volume 53, Issue 2, Page(s) 17

Abstract: With the development of the economy and the improvement of living standards, people's needs have gradually changed, and sports has received increasing attention. At the same time, due to the significant efforts of all countries in sports, sports ... ...

Abstract	With the development of the economy and the improvement of living standards, people's needs have gradually changed, and sports has received increasing attention. At the same time, due to the significant efforts of all countries in sports, sports governance has also attracted considerable attention from scholars. However, the evaluation of global sports governance has rarely been discussed. This paper analyzes the principles for selecting indicators of global sports governance and develops a global sports governance evaluation indicator system consisting of 3 first-level indicators, 6 s-level indicators, and 14 third-level indicators. Additionally, this paper conducted an empirical study of the indicator system using the deep trust network model, and the results showed that the research on the evaluation index system of global sports governance based on the deep trust network model is feasible. Compared with the actual scores, the evaluation gaps for sports facility satisfaction, sports information satisfaction, and sports activity satisfaction were only 0.05, 0.09, and 0.05, respectively. Overall, this method is more accurate in analyzing the evaluation index system of global sports governance and can more directly and objectively reflect the shortcomings of current global sports governance, providing specific analysis of particular problems. The paper suggests that current global sports governance should focus on the coverage of sports facilities, attention to mass sports, satisfaction of sports activities, and promote in-depth development through both hard and soft governance measures.
MeSH term(s)	Humans ; Trust
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	124517-x
ISSN	1573-6555 ; 0090-6905
ISSN (online)	1573-6555
ISSN	0090-6905
DOI	10.1007/s10936-024-10048-x
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Article ; Online: Salmonella typhimurium targeting with monoclonal antibodies prevents infection in mice.

Li, Jie / Yang, Yang / Fan, Zhongyi / Huang, Zhiqiang / Chen, Jun / Liu, Qing

PLoS neglected tropical diseases

2023 Volume 17, Issue 12, Page(s) e0011579

Abstract: Salmonella is a prevalent foodborne and waterborne pathogens threating global public health and food safety. Given the diversity of Salmonella serotypes and the emergence of antibiotic-resistant strains, there is an urgent need for the development of ... ...

Abstract	Salmonella is a prevalent foodborne and waterborne pathogens threating global public health and food safety. Given the diversity of Salmonella serotypes and the emergence of antibiotic-resistant strains, there is an urgent need for the development of broadly protective therapies. This study aims to prepare monoclonal antibodies (Mabs) with broad reactivity against multi-serotype Salmonella strains, potentially offering cross-protection. We prepared two Mabs F1D4 and B7D4 against protein FliK and BcsZ, two potential vaccine candidates against multi-serotype Salmonella. The two Mabs belonging to IgG1 isotype exhibited high titers of 1:256,000 and 1:512,000 respectively, as well as broad cross-reactivity against 28 different serotypes of Salmonella strains with percentages of 89.29% and 92.86%, correspondingly. Neutralizing effects of the two Mabs on Salmonella growth, adhesion, invasion and motility was evaluated in vitro using bacteriostatic and bactericidal activity with and without complement and bacterial invasion inhibition assay. Additionally, cytotoxicity assays, animal toxicity analyses, and pharmacokinetic evaluations demonstrated the safety and sustained effectiveness of both Mabs. Furthermore, F1D4 or B7D4-therapy in mice challenged with S. Typhimurium LT2 exhibited milder organs damage and lower Salmonella colonization, as well as the higher relative survival of 86.67% and 93.33% respectively. This study produced two broadly reactive and potential cross protective Mabs F1D4 and B7D4, which offered new possibilities for immunotherapy of salmonellosis.
MeSH term(s)	Animals ; Mice ; Salmonella typhimurium ; Antibodies, Monoclonal ; Salmonella Infections/prevention & control ; Cross Reactions ; Immunoglobulin G ; Salmonella Infections, Animal/prevention & control ; Antibodies, Bacterial
Chemical Substances	Antibodies, Monoclonal ; Immunoglobulin G ; Antibodies, Bacterial
Language	English
Publishing date	2023-12-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011579
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Article ; Online: Optimization Design And Simulation Of Microgrid In Amdjarass Town, Chad

Wu Qing / Fan Zhongyi / Zhang Jintao / Sun Qin / Yang Junjie

E3S Web of Conferences, Vol 118, p

2019 Volume 02015

Abstract: How to supply electricity to the remote areas has become a very pressing issue for some countries which do not have the ability to connect all power grids to the whole country temporarily. At the same time, with the increase of fossil fuel costs and the ... ...

Abstract	How to supply electricity to the remote areas has become a very pressing issue for some countries which do not have the ability to connect all power grids to the whole country temporarily. At the same time, with the increase of fossil fuel costs and the continuous development of renewable energy generation technology, the construction of a hybrid renewable energy microgrid system seems to become an economic and technical approach to resolve the power shortage problem in the remote areas of some countries. Based on the analysis of local natural resources and load conditions, this paper designed a microgrid system which contains the wind turbines, PV systems, a diesel generator and an energy storage module to meet the power supply needs of the small town Amdjarass in Chad. Then the authors optimized the capacity of this microgrid and estimated the cost of this system with the utilization of HOMER software. In the end, this paper set the optimal configuration scheme with the target of the lowest COE and analyzed the sensitivity of some important parameters which could affect the economic performance.
Keywords	Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SLC25A38 as a novel biomarker for metastasis and clinical outcome in uveal melanoma.

Fan, Zhongyi / Duan, Jingjing / Luo, Pu / Shao, Ling / Chen, Qiong / Tan, Xiaohua / Zhang, Lei / Xu, Xiaojie

Cell death & disease

2022 Volume 13, Issue 4, Page(s) 330

Abstract: Risk of metastasis is increased by the presence of chromosome 3 monosomy in uveal melanoma (UM). This study aimed to identify more accurate biomarker for risk of metastasis in UM. A total of 80 patients with UM from TCGA were assigned to two groups based ...

Abstract	Risk of metastasis is increased by the presence of chromosome 3 monosomy in uveal melanoma (UM). This study aimed to identify more accurate biomarker for risk of metastasis in UM. A total of 80 patients with UM from TCGA were assigned to two groups based on the metastatic status, and bioinformatic analyses were performed to search for critical genes for risk of metastasis. SLC25A38, located on chromosome 3, was the dominant downregulated gene in metastatic UM patients. Low expression of SLC25A38 was an independent predictive and prognostic factor in UM. The predictive potential of SLC25A38 expression was superior to that of pervious reported biomarkers in both TCGA cohort and GSE22138 cohort. Subsequently, its role in promoting metastasis was explored in vitro and in vivo. Knock-out of SLC25A38 could enhance the migration ability of UM cells, and promote distant metastasis in mice models. Through the inhibition of CBP/HIF-mediated pathway followed by the suppression of pro-angiogenic factors, SLC25A38 was situated upstream of metastasis-related pathways, especially angiogenesis. Low expression of SLC25A38 promotes angiogenesis and metastasis, and identifies increased metastatic risk and worse survival in UM patients. This finding may further improve the accuracy of prognostic prediction for UM.
MeSH term(s)	Animals ; Biomarkers ; Computational Biology ; Humans ; Melanoma/pathology ; Mice ; Mitochondrial Membrane Transport Proteins ; Neoplasm Metastasis ; Uveal Neoplasms/genetics ; Uveal Neoplasms/metabolism ; Uveal Neoplasms/pathology
Chemical Substances	Biomarkers ; Mitochondrial Membrane Transport Proteins ; Slc25a38 protein, human
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-022-04718-8
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Article ; Online: Hsa-LINC02418/mmu-4930573I07Rik regulated by METTL3 dictates anti-PD-L1 immunotherapeutic efficacy via enhancement of Trim21-mediated PD-L1 ubiquitination.

Sun, Zhijia / Mai, Haixing / Xue, Chunyuan / Fan, Zhongyi / Li, Jiangbo / Chen, Hairui / Huo, Nan / Kang, Xiaofeng / Tang, Chuanhao / Fang, Liaoxin / Zhao, Hui / Han, Yuchen / Sun, Chao / Peng, Huanyan / Du, Yimeng / Yang, Jing / Du, Nan / Xu, Xiaojie

Journal for immunotherapy of cancer

2023 Volume 11, Issue 12

Abstract: Background: Limited response to programmed death ligand-1 (PD-L1)/programmed death 1 (PD-1) immunotherapy is a major hindrance of checkpoint immunotherapy in non-small cell lung cancer (NSCLC). The abundance of PD-L1 on the tumor cell surface is crucial ...

Abstract	Background: Limited response to programmed death ligand-1 (PD-L1)/programmed death 1 (PD-1) immunotherapy is a major hindrance of checkpoint immunotherapy in non-small cell lung cancer (NSCLC). The abundance of PD-L1 on the tumor cell surface is crucial for the responsiveness of PD-1/PD-L1 immunotherapy. However, the negative control of PD-L1 expression and the physiological significance of the PD-L1 inhibition in NSCLC immunotherapy remain obscure. Methods: Bioinformatics analysis was performed to profile and investigate the long non-coding RNAs that negatively correlated with PD-L1 expression and positively correlated with CD8+T cell infiltration in NSCLC. Immunofluorescence, Results: LINC02418 is a negative regulator of PD-L1 expression that positively correlated with CD8+T cell infiltration, predicting favorable clinical outcomes for patients with NSCLC. LINC02418 downregulates PD-L1 expression by enhancing PD-L1 ubiquitination mediated by E3 ligase Trim21. Both hsa-LINC02418 and mmu-4930573I07Rik (its homologous RNA in mice) regulate PD-L1 therapeutic efficacy in NSCLC via Trim21, inducing T cell-induced apoptosis Conclusion: LINC02418 functions as a negative regulator of PD-L1 expression in NSCLC cells by promoting the degradation of PD-L1 through the ubiquitin-proteasome pathway. The expression of LINC02418 is regulated by METTL3/YTHDF2-mediated m6A modification. This study illuminates the underlying mechanisms of PD-L1 negative regulation and presents a promising target for improving the effectiveness of anti-PD-L1 therapy in NSCLC.
MeSH term(s)	Humans ; Animals ; Mice ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; B7-H1 Antigen/metabolism ; Programmed Cell Death 1 Receptor ; Immunotherapy ; RNA/metabolism ; RNA/therapeutic use ; Ubiquitination ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Methyltransferases/therapeutic use
Chemical Substances	CD274 protein, human ; B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; RNA (63231-63-0) ; METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-)
Language	English
Publishing date	2023-12-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2023-007415
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Article: The effect of different particle sizes and HCl-modified kaolin on catalytic pyrolysis characteristics of reworked polypropylene plastics

Luo, Wei / Hu, Qing / Fan, Zhong-yi / Wan, Jun / He, Qian / Huang, Sheng-xiong / Zhou, Nan / Song, Min / Zhang, Jia-chao / Zhou, Zhi

Energy. 2020 Dec. 15, v. 213

2020

Abstract: At present, the catalysts used to produce high value products by catalytic pyrolysis of high calorific value waste plastics are expensive. In this study, the catalytic pyrolysis characteristics of reworked polypropylene (PP) plastics were studied by ... ...

Abstract	At present, the catalysts used to produce high value products by catalytic pyrolysis of high calorific value waste plastics are expensive. In this study, the catalytic pyrolysis characteristics of reworked polypropylene (PP) plastics were studied by using low-cost kaolin with different particle sizes and HCl-modified kaolin. The results show that the catalysts reduced the condensate oil yield and increased the gas yield. C6–C20 was the major components of condensate oil ranging from 90% to 97% in catalyst pyrolysis by significantly decreasing the heavy components (above C20). Kaolin has high cracking efficiency of heavy components into alkanes and alkenes (the range of diesel components). The stronger acid sites on the modified kaolin further promoted the secondary cracking of diesel components, resulting in a great increase in the C6–C11 content. Moreover, HCl-modified kaolin significantly increased the aromaticity of the condensate oil because of the aromatization and Diels-Alder reaction of alkanes and alkenes. Meanwhile, kaolin significantly increased the yield of H₂, and the H₂ yield was increased with the decrease of kaolin particle size. HCl-modified kaolin further promoted the yield and quality of gas. It is found that kaolin is a potential cheap and efficient pyrolysis catalyst.
Keywords	alkenes ; aromatization ; catalysts ; condensates ; cycloaddition reactions ; energy ; kaolin ; oils ; particle size ; polypropylenes ; pyrolysis
Language	English
Dates of publication	2020-1215
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2020.119080
Database	NAL-Catalogue (AGRICOLA)

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Article: Genomic characterization of

Zhang, Xuelin / Xiao, Saisong / Jiang, Xuege / Li, Yun / Fan, Zhongyi / Yu, Yi / Wang, Peng / Li, Diangeng / Zhao, Xian / Liu, Changting

Gut pathogens

2019 Volume 11, Page(s) 25

Abstract: Background: Multidrug resistance is a growing global public health threat with far more serious consequences than generally anticipated. In this study, we investigated the antibiotic resistance and genomic traits of a clinical strain of : Results: ... ...

Abstract	Background: Multidrug resistance is a growing global public health threat with far more serious consequences than generally anticipated. In this study, we investigated the antibiotic resistance and genomic traits of a clinical strain of Results: LCT-EC001 was resistant to 16 kinds of widely used antibiotics, including fourth-generation cephalosporins and carbapenems. In total, up to 68 determinants associated with antibiotic resistance were identified, including 8 beta-lactamase genes (notably producing ESBLs and KPCs), 31 multidrug efflux system genes, 6 outer membrane transport system genes, 4 aminoglycoside-modifying enzyme genes, 10 two-component regulatory system genes, and 9 other enzyme or transcriptional regulator genes, covering nearly all known drug-resistance mechanisms in Conclusions: Antibiotic resistance was extremely severe in
Language	English
Publishing date	2019-05-21
Publishing country	England
Document type	Case Reports
ZDB-ID	2478277-4
ISSN	1757-4749
ISSN	1757-4749
DOI	10.1186/s13099-019-0298-5
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Article: Comparison of form-deprived myopia and lens-induced myopia in guinea pigs.

Xiao, Hui / Fan, Zhong-Yi / Tian, Xiao-Dan / Xu, Yan-Chun

International journal of ophthalmology

2014 Volume 7, Issue 2, Page(s) 245–250

Abstract: Aim: To study the efficacy difference between form-deprived myopia (FDM) and lens-induced myopia (LIM), the degree of myopia, axial length and pathological changes of the posterior sclera from guinea pigs were evaluated.: Methods: Four-week pigmented ...

Abstract	Aim: To study the efficacy difference between form-deprived myopia (FDM) and lens-induced myopia (LIM), the degree of myopia, axial length and pathological changes of the posterior sclera from guinea pigs were evaluated. Methods: Four-week pigmented guinea pigs were randomly assigned into 3 groups, including normal control (n=6), FDM group with monocular cover (n=11) and LIM group with monocular -7D lens treatment (n=11). FDM group was form-deprived while LIM group was lens-induced for 14 d. Refractive error and axial length were measured prior to and post treatment, respectively. Morphological changes of sclera were examined using both light and electronic microscopes. Results: After 14d treatment, refractive errors for FDM group and LIM group were -3.05±0.71D and -2.12±1.29D, respectively, which were significantly more myopic than that of normal controls and fellow control eyes (P<0.01). As for axial length, it was 7.93±0.03 mm for FDM group and 7.89±0.06 mm for LIM group, which were significantly longer than both normal and fellow controls (P<0.01). With respect to both refractory error and axial length, the differences between FDM group and LIM group were not significant (P>0.05). Under light microscope, both FDM group and LIM group showed thinned sclera, disarrangement of fibrosis and enlarged disassociation between fibers. Consistently, ultrastructural examination showed degenerated fibroblasts and thinned fibers in posterior sclera. Conclusion: Following two weeks of myopia induction in guinea pigs, with regard to the degree of myopia, axial length and pathological alterations, there was no significant difference between FDM and LIM models. Therefore, FDM and LIM are equally effective and useful as a model of experimental myopia and guinea pigs are ideal animals for induction of experimental myopia because their high sensitivity to both form-deprivation and lens-induction.
Language	English
Publishing date	2014-04-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.3980/j.issn.2222-3959.2014.02.10
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Article ; Online: A nomogram-based immunoprofile predicts overall survival for previously untreated patients with esophageal squamous cell carcinoma after esophagectomy.

Duan, Jingjing / Xie, Yongwei / Qu, Lijuan / Wang, Lingxiong / Zhou, Shunkai / Wang, Yu / Fan, Zhongyi / Yang, Shengsheng / Jiao, Shunchang

Journal for immunotherapy of cancer

2018 Volume 6, Issue 1, Page(s) 100

Abstract: Background: Immunoscore, as a prognostic tool defined to quantify in situ immune cell infiltrates, appears to be superior to the TNM staging system. In esophageal squamous cell carcinoma (ESCC), no immunoscore has been established; however, in situ ... ...

Abstract	Background: Immunoscore, as a prognostic tool defined to quantify in situ immune cell infiltrates, appears to be superior to the TNM staging system. In esophageal squamous cell carcinoma (ESCC), no immunoscore has been established; however, in situ tumor immunology is recognized as highly important. Our study aimed to construct a comprehensive immunoprofile for ESCC. Methods: The infiltration of four immune cell types (CD8+/CD4+/Foxp3+/CD33+ cells), the expression of both inhibitory (PD-1/PD-L1/Tim-3/LAG-3) and stimulatory checkpoints (OX-40/ICOS), and IDO1 were evaluated by IHC staining and multi-color immunofluorescence in two independent cohorts (95 patients in the primary cohort and 55 patients in the validation cohort). The association with patients' overall survival was analyzed by the Kaplan-Meier method and the Cox model. Nomogram-based immunoprofile was established using the independent prognostic variables. To determine its predictive accuracy and discriminatory capacity, the C-index and calibration curve were calculated. Results: Significant correlation of PD-L1 expression in tumor cells with PD-1+ T cell infiltration was found (P = 0.035), indicating the activation of the inhibitory PD-1/PD-L1 pathway in ESCC cases. More PD-L1+ ICs, Tim-3+ ICs and LAG-3+ ICs were found in the CD8-rich tumor microenvironment, which is in accordance with the feedback nature of immune system. After adjustment by TNM stage, four immune variables including the infiltration of CD8+/Foxp3+/CD33+ cells and the PD-L1 expression by tumor cells were selected to construct a prognostic nomogram. The calibration curves showed good accuracy of the nomogram for survival prediction. To overcome the complexity of applying a nomogram in a clinical setting, a simple immunoprofile was then established according to the points of each factor from the nomogram. Our immunoprofile model could separate same-stage patients into different risk subgroups, and showed superior accuracy for survival prediction than the TNM staging system based on the C-index calculation and ROC analysis. Conclusions: Our nomogram-based immunoprofile can provide more accurate prognosis prediction and is an important complement to the TNM staging system for operable ESCC patients.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Esophageal Squamous Cell Carcinoma/immunology ; Esophageal Squamous Cell Carcinoma/mortality ; Esophageal Squamous Cell Carcinoma/pathology ; Esophagectomy/methods ; Female ; Humans ; Male ; Middle Aged ; Nomograms ; Prognosis ; Survival Analysis
Language	English
Publishing date	2018-10-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1186/s40425-018-0418-7
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Article ; Online: Preference of cancer patients and family members regarding delivery of bad news and differences in clinical practice among medical staff.

Fan, Zhongyi / Chen, Liyan / Meng, Limin / Jiang, Haihua / Zhao, Qianqian / Zhang, Lili / Fang, Chun-Kai

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2018 Volume 27, Issue 2, Page(s) 583–589

Abstract: Objectives: To study the preferences of cancer patients and their families in way of being informed of their condition and, by comparing their preferences with the medical staff's clinical practices, explore the factors underlying the latter's ... ...

Abstract	Objectives: To study the preferences of cancer patients and their families in way of being informed of their condition and, by comparing their preferences with the medical staff's clinical practices, explore the factors underlying the latter's preferences. Methods: A survey was conducted with 216 cancer patients, 242 families, and 176 clinical staff members with the Medical Status Communication questionnaire (Simplified Chinese edition). Results: The clinical staff scored lower than the cancer patients and their families in terms of the total score, way of communication, emotional support, and additional information (F = 16.134, p < .001; F = 28.604, p < .001; F = 13.839, p < .001; F = 16.745, p < .001). Factors underlying the medical staff's clinical practices included, as revealed by the multiple linear regression analysis, gender (p = .03), and willingness to improve the way of communication about cancer (p = .006). Conclusions: A gap existed between the medical staff's clinical practice and the preferences of the cancer patients and their families. The medical staff should receive adequate training in cancer communication skills and techniques for improvement in this respect. When designing training for skills in delivering bad news to cancer patients, the well-being of cancer patients and their families must be thoroughly considered, and patient demands for information should be satisfied in the context of the information explosion of the current age.
MeSH term(s)	Communication ; Family/psychology ; Female ; Humans ; Male ; Medical Staff/ethics ; Neoplasms/psychology ; Physician-Patient Relations/ethics ; Surveys and Questionnaires ; Truth Disclosure
Language	English
Publishing date	2018-07-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-018-4348-1
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