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  1. Article ; Online: Composition templating for heterogeneous nucleation of intermetallic compounds.

    Que, Zhongping / Wang, Yun / Fan, Zhongyun / Hashimoto, T / Zhou, X R

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8968

    Abstract: Refinement of intermetallic compounds (IMCs) through enhancing heterogeneous nucleation during casting process is an important approach to improve the properties of aluminium alloys, which greatly increases the economy value of recycled Al-alloys. ... ...

    Abstract Refinement of intermetallic compounds (IMCs) through enhancing heterogeneous nucleation during casting process is an important approach to improve the properties of aluminium alloys, which greatly increases the economy value of recycled Al-alloys. However, heterogeneous nucleation of IMCs is inherently more difficult than that of a pure metal or a solid solution. It requires not only creation of a crystal structure but also the positioning of 2 or more different types of atoms in the lattice with specific composition close to that of the nucleated IMCs. Previous understanding on heterogeneous nucleation is based on structural templating, usually considering the small lattice misfit at the interface between the nucleating solid and substrate. In this work, we proposed a hypothesis and demonstrated that composition templating plays a critical role in heterogeneous nucleation of IMCs. The experimental results revealed that segregation of Fe atoms on the AlB
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59709-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impeding Nucleation for More Significant Grain Refinement.

    Fan, Zhongyun / Gao, Feng / Jiang, Bo / Que, Zhongping

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 9448

    Abstract: Grain refinement has been a topic of extensive research due to its scientific and technological importance as a common industrial practice for over seven decades. The traditional approach to grain refinement has been to reduce nucleation undercooling by ... ...

    Abstract Grain refinement has been a topic of extensive research due to its scientific and technological importance as a common industrial practice for over seven decades. The traditional approach to grain refinement has been to reduce nucleation undercooling by the addition of potent nucleant particles. Here we show both theoretically and experimentally that more significant grain refinement can be achieved through increasing nucleation undercooling by using impotent nucleant particles. Based on the concept of explosive grain initiation, this new approach is illustrated by grain initiation maps and grain refinement maps and validated by experiments. It is anticipated that this new approach may lead to a profound change in both nucleation research and industrial practice well beyond metal casting.
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-66190-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Melt Conditioned Direct Chill (MC-DC) Casting and Extrusion of AA5754 Aluminium Alloy Formulated from Recycled Taint Tabor Scrap.

    Al-Helal, Kawther / Patel, Jayesh B / Scamans, Geoff M / Fan, Zhongyun

    Materials (Basel, Switzerland)

    2020  Volume 13, Issue 12

    Abstract: The melt conditioned direct chill (MC-DC) casting process has been used to produce billets and extruded planks of AA5754 alloy formulated from 100% recycled Taint Tabor scrap aluminum. The billets were homogenized and then extruded into flat planks. ... ...

    Abstract The melt conditioned direct chill (MC-DC) casting process has been used to produce billets and extruded planks of AA5754 alloy formulated from 100% recycled Taint Tabor scrap aluminum. The billets were homogenized and then extruded into flat planks. Optical metallography of the MC-DC cast billets showed equiaxed refined grains in comparison to conventional direct chill (DC) cast and direct chill grain refined (DC-GR) cast billets formulated from the same Taint Tabor scrap. Microstructural evaluation of the extruded planks showed extensive peripheral coarse grain (PCG) for the DC, DC-GR and MC-DC cast planks. The 2 mm and 1 mm MC-DC cast planks produced after cold rolling and heat treatment showed a fully recrystallized microstructure at 380 °C and 300 °C for 10 min respectively with an improvement in mechanical properties over DC-GR cast and similarly processed planks. The as-extruded MC-DC cast planks tensile tested in the transverse direction showed 34% elongation and 213 MPa ultimate tensile strength. These tensile results showed 5.8% higher elongation and 1.2% higher ultimate tensile strength compared with the DC-GR planks after applying high shear melt conditioning.
    Language English
    Publishing date 2020-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13122711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Direct Chill Casting and Extrusion of AA6111 Aluminum Alloy Formulated from Taint Tabor Scrap.

    Al-Helal, Kawther / Patel, Jayesh B / Scamans, Geoff M / Fan, Zhongyun

    Materials (Basel, Switzerland)

    2020  Volume 13, Issue 24

    Abstract: AA6111 aluminum automotive body-sheet alloy has been formulated from 100% Taint Tabor scrap aluminum. Direct chill casting with and without high shear melt conditioning (HSMC) was used to produce the AA6111 alloy billets. Both homogenized and non- ... ...

    Abstract AA6111 aluminum automotive body-sheet alloy has been formulated from 100% Taint Tabor scrap aluminum. Direct chill casting with and without high shear melt conditioning (HSMC) was used to produce the AA6111 alloy billets. Both homogenized and non-homogenized billets were extruded into sheets. The optical micrographs of the melt conditioned direct chill (MC-DC) samples showed refined equiaxed grains in comparison to direct chill (DC) cast and direct chill grain refined (DC-GR) samples. Optical metallography showed extensive peripheral coarse grain (PCG) for the DC, DC-GR and MC-DC planks extruded from the homogenized standard AA6111 billets while planks extruded from modified AA6111 billets (with recrystallization inhibitors) showed thin PCG band. The co-addition of recrystallization inhibitors Mn, Zr, and Cr with elimination of the billet homogenization step had a favorable impact on the microstructure of the AA6111 alloy following the extrusion process where a fibrous grain structure was retained across the whole section of the planks. The mechanical properties of as-cast planks extruded from non-homogenized billets were similar to those extruded from homogenized billets. Eliminating the homogenization heat treatment step prior to extrusion has important ramifications in terms of processing cost reduction.
    Language English
    Publishing date 2020-12-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13245740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Conference proceedings ; Online: Light metals technology 2013

    Fan, Zhongyun / McKay, Brian / Stone, Ian

    selected, peer reviewed papers from the Sixth International Light Metals Technology Conference (LMT2013), July 24-26, 2013, Old Windsor, United Kingdom

    (Materials science forum ; 765)

    2013  

    Abstract: The special collection focuses on recent advances in the science and technologies associated with aluminium, magnesium and titanium alloys. Topics span the full light metals field from the development of new alloys, through processing and material ... ...

    Institution International Light Metals Technology Conference
    Event/congress International Light Metals Technology Conference (6th, 2013, OldWindsorEngland)
    Author's details edited by Ian Stone, Brian McKay and Zhongyun Fan
    Series title Materials science forum ; 765
    Abstract The special collection focuses on recent advances in the science and technologies associated with aluminium, magnesium and titanium alloys. Topics span the full light metals field from the development of new alloys, through processing and material behaviour, to final application, and increasingly the issues of sustainability and end-of-life. The papers are arranged in the following chapters: 1. Alloy Development; 2. Casting & Solidification; 3. Forming; 4. Heat Treatment & Phase Transformations; 5. Mechanical Behaviour, 6. Corrosion & Surface Modification; 7. Joining; and 8. Applications. This
    Keywords Light metals ; Metals
    Language English
    Size Online-Ressource (848 pages), illustrations
    Publisher Trans Tech Publications
    Publishing place Durnten-Zurich, Switzerland
    Document type Book ; Conference proceedings ; Online
    Note Includes bibliographical references and indexes
    ISBN 9783037857663 ; 3037857668
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Article: Melt Conditioning of Light Metals by Application of High Shear for Improved Microstructure and Defect Control.

    Patel, Jayesh B / Yang, Xinliang / Mendis, Chamini L / Fan, Zhongyun

    JOM (Warrendale, Pa. : 1989)

    2017  Volume 69, Issue 6, Page(s) 1071–1076

    Abstract: Casting is the first step toward the production of majority of metal products whether the final processing step is casting or other thermomechanical processes such as extrusion or forging. The high shear melt conditioning provides an easily adopted ... ...

    Abstract Casting is the first step toward the production of majority of metal products whether the final processing step is casting or other thermomechanical processes such as extrusion or forging. The high shear melt conditioning provides an easily adopted pathway to producing castings with a more uniform fine-grained microstructure along with a more uniform distribution of the chemical composition leading to fewer defects as a result of reduced shrinkage porosities and the presence of large oxide films through the microstructure. The effectiveness of high shear melt conditioning in improving the microstructure of processes used in industry illustrates the versatility of the high shear melt conditioning technology. The application of high shear process to direct chill and twin roll casting process is demonstrated with examples from magnesium melts.
    Language English
    Publishing date 2017-04-07
    Publishing country United States
    Document type Journal Article
    ISSN 1047-4838
    ISSN 1047-4838
    DOI 10.1007/s11837-017-2335-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Enhanced production of polyhydroxybutyrate by multiple dividing E. coli.

    Wu, Hong / Fan, Zhongyun / Jiang, Xiaoran / Chen, Jinchun / Chen, Guo-Qiang

    Microbial cell factories

    2016  Volume 15, Issue 1, Page(s) 128

    Abstract: Background: Most bacteria are grown in a binary fission way meaning a bacterial cell is equally divided into two. Polyhydroxyalkanoates (PHA) can be accumulated as inclusion bodies by bacteria. The cell division way and morphology have been shown to ... ...

    Abstract Background: Most bacteria are grown in a binary fission way meaning a bacterial cell is equally divided into two. Polyhydroxyalkanoates (PHA) can be accumulated as inclusion bodies by bacteria. The cell division way and morphology have been shown to play an important role in regulating the bacterial growth and PHA storages.
    Results: The common growth pattern of Escherichia coli was changed to multiple fission patterns by deleting fission related genes minC and minD together, allowing the formation of multiple fission rings (Z-rings) in several positions of an elongated cell, thus a bacterial cell was observed to be divided into more than two daughter cells at same time. To further improve cell growth and PHA production, some genes related with division process including ftsQ, ftsL, ftsW, ftsN and ftsZ, together with the cell shape control gene mreB, were all overexpressed in E. coli JM109 ∆minCD. The changing pattern of E. coli cell growth and morphology resulted in more cell dry weights (CDW) and more than 80 % polyhydroxybutyrate (PHB) accumulation increases compared to its binary fission control grown under the same conditions.
    Conclusions: This study clearly demonstrated that combined over-expression genes ftsQ, ftsW, ftsN, ftsL and ftsZ together with shape control gene mreB in multiple division bacterial E. coli JM109 ∆minCD benefited PHA accumulation. Our study provides useful information on increasing the yield of PHA by changing the cell division pattern and cell morphology of E. coli.
    MeSH term(s) Cell Division ; Escherichia coli/cytology ; Escherichia coli/genetics ; Escherichia coli/growth & development ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Hydroxybutyrates/metabolism
    Chemical Substances Escherichia coli Proteins ; Hydroxybutyrates
    Language English
    Publishing date 2016-07-27
    Publishing country England
    Document type Journal Article
    ISSN 1475-2859
    ISSN (online) 1475-2859
    DOI 10.1186/s12934-016-0531-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: DNA damage induces the accumulation of Tiam1 by blocking β-TrCP-dependent degradation.

    Zhu, Guixin / Fan, Zhongyun / Ding, Miao / Mu, Libing / Liang, Juan / Ding, Yajie / Fu, Yu / Huang, Binlu / Wu, Wei

    The Journal of biological chemistry

    2014  Volume 289, Issue 22, Page(s) 15482–15494

    Abstract: The Rac1/JNK cascade plays important roles in DNA damage-induced apoptosis. However, how this cascade is activated upon DNA damage remains to be fully understood. We show here that, in untreated cells, Tiam1, a Rac1-specific guanine nucleotide exchange ... ...

    Abstract The Rac1/JNK cascade plays important roles in DNA damage-induced apoptosis. However, how this cascade is activated upon DNA damage remains to be fully understood. We show here that, in untreated cells, Tiam1, a Rac1-specific guanine nucleotide exchange factor, is phosphorylated by casein kinase 1 (CK1) at its C terminus, leading to Skp, Cullin, F-box-containing(β-TrCP) recognition, ubiquitination, and proteasome-mediated degradation. Upon DNA-damaging anticancer drug treatment, CK1/β-TrCP-mediated Tiam1 degradation is abolished, and the accumulated Tiam1 contributes to downstream activation of Rac1/JNK. Consistently, tumor cells overexpressing Tiam1 are hypersensitive to DNA-damaging drug treatment. In xenograft mice, Tiam1-high cells are more susceptible to doxorubicin treatment. Thus, our results uncover that inhibition of proteasome-mediated Tiam1 degradation is an upstream event leading to Rac1/JNK activation and cell apoptosis in response to DNA-damaging drug treatment.
    MeSH term(s) Animals ; Antibiotics, Antineoplastic/toxicity ; Apoptosis/genetics ; Apoptosis/physiology ; Casein Kinase I/metabolism ; DNA Damage/drug effects ; DNA Damage/physiology ; Doxorubicin/toxicity ; Female ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; JNK Mitogen-Activated Protein Kinases/metabolism ; Mice ; Mice, Nude ; Signal Transduction/genetics ; Signal Transduction/physiology ; T-Lymphoma Invasion and Metastasis-inducing Protein 1 ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination/physiology ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism ; Xenograft Model Antitumor Assays ; beta-Transducin Repeat-Containing Proteins/genetics ; beta-Transducin Repeat-Containing Proteins/metabolism ; rac1 GTP-Binding Protein/metabolism
    Chemical Substances Antibiotics, Antineoplastic ; BTRC protein, human ; Guanine Nucleotide Exchange Factors ; RAC1 protein, human ; T-Lymphoma Invasion and Metastasis-inducing Protein 1 ; TIAM1 protein, human ; beta-Transducin Repeat-Containing Proteins ; Doxorubicin (80168379AG) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Casein Kinase I (EC 2.7.11.1) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; rac1 GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2014-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M114.553388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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