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Article ; Online: Clinical outcomes and prognostic factors after HCV clearance with DAA in HIV/HCV-coinfected patients with advanced fibrosis/cirrhosis.

Berenguer, Juan / Aldámiz-Echevarría, Teresa / Hontañón, Víctor / Fanciulli, Chiara / Quereda, Carmen / Busca, Carmen / Domínguez, Lourdes / Hernández, Cristina / Vergas, Jorge / Gaspar, Gabriel / García-Fraile, Lucio J / Díez, Cristina / De Miguel, Marta / Bellón, José M / Bañares, Rafael / González-García, Juan

Hepatology (Baltimore, Md.)

2024

Abstract: Background and aims: We assessed long-term clinical outcomes and prognostic factors for liver disease progression after sustained viral response with direct-acting antivirals in patients coinfected with HIV/HCV with advanced fibrosis or cirrhosis.: ... ...

Abstract	Background and aims: We assessed long-term clinical outcomes and prognostic factors for liver disease progression after sustained viral response with direct-acting antivirals in patients coinfected with HIV/HCV with advanced fibrosis or cirrhosis. Approach and results: A total of 1300 patients who achieved sustained viral response with direct-acting antivirals from 2014 to 2017 in Spain were included: 1145 with compensated advanced chronic liver disease (384 advanced fibrosis and 761 compensated cirrhosis) and 155 with decompensated cirrhosis. The median follow-up was 40.9 months. Overall, 85 deaths occurred, 61 due to non-liver non-AIDS-related causes that were the leading cause of death across all stages of liver disease. The incidence (95% CI) of decompensation per 100 person-years (py) was 0 in patients with advanced fibrosis, 1.01 (0.68-1.51) in patients with compensated cirrhosis, and 8.35 (6.05-11.53) in patients with decompensated cirrhosis. The incidence (95% CI) of HCC per 100 py was 0.34 (0.13-0.91) in patients with advanced fibrosis, 0.73 (0.45-1.18) in patients with compensated cirrhosis, and 1.92 (1.00-3.70) per 100 py in patients with decompensated cirrhosis. Prognostic factors for decompensation in patients with compensated advanced chronic liver disease included serum albumin, liver stiffness measurement (LSM), and fibrosis 4. In this population, LSM and LSM-based posttreatment risk stratification models showed their predictive ability for decompensation and HCC. Conclusions: Non-liver non-AIDS-related events were the leading causes of morbidity and mortality after direct-acting antiviral cure among coinfected patients with advanced fibrosis/cirrhosis. Among those with compensated advanced chronic liver disease, baseline LSM and posttreatment LSM-based models helped to assess decompensation and HCC risk.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1097/HEP.0000000000000838
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Zs.A 1660: Show issues

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Article ; Online: Longitudinal Whole-Genome Sequence Characterization of a Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Omicron BA.5 Infection in an Immunocompromised Patient Successfully Treated With Sotrovimab 1000 mg.

Tejerina, Francisco / Palomino, Rosalía / Catalan, Pilar / Sanz, Amadeo / Marin, Mercedes / Lopez-Andujar, Felipe / Perez, Leire / Aldamiz, Teresa / Muñoz, Patricia / Rodriguez-Gonzalez, Carmen / Diez, Cristina / Fanciulli, Chiara / Lago, Laura Pérez / de Viedma, Darío García

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2023 Volume 76, Issue 10, Page(s) 1872–1874

MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2/genetics ; Immunocompromised Host
Chemical Substances	sotrovimab (1MTK0BPN8V)
Language	English
Publishing date	2023-02-13
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad090
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Diplejía facial aislada como variante atípica del síndrome de Guillain-Barré tras sospecha de infección por SARS-CoV-2.

Lavilla Olleros, Cristina / López-Rubio, Marina / Fanciulli, Chiara / González-Munera, Adriana / Millán Núñez-Cortés, Jesús

Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)

2021 Volume 78, Issue 4, Page(s) 405–407

Abstract: Introduction: Since the SARS-CoV-2 pandemics began, multiple cases of Guillain-Barre syndrome secondary to COVID-19 have been described. Its typical presentation consists of the triad of paresthesia, ascending muscle weakness and areflexia, although ... ...

Title translation	Isolated facial diplegia as an atypical variant of Guillain-Barre syndrome after suspected SARS-CoV-2 infection
Abstract	Introduction: Since the SARS-CoV-2 pandemics began, multiple cases of Guillain-Barre syndrome secondary to COVID-19 have been described. Its typical presentation consists of the triad of paresthesia, ascending muscle weakness and areflexia, although there are several regional variants such as facial diplegia. Case presentation: Two weeks after a contact with a confirmed case of COVID-19, a 35-year-old woman presents with viral myopericarditis. Laboratory studies for autoimmune diseases come back negative, as well as multiple viral serologies. She presents anti-SARS-CoV-2 IgG, with negative PCR. A week after discharge she presents with palsy of both facial nerves, without other neurological abnormalities. She undergoes examination with cranial CT without findings, and an EMG which shows bilateral alteration of facial nerves. She refuses the performance of a lumbar puncture. Discussion: Facial diplegia can occur because of several illnesses, such as meningeal or brainstem tumors, infectious agents, Guillain-Barre syndrome, autoimmune diseases, trauma, metabolic causes or congenital causes. In our patient, having discarded other etiologies with imaging and analytical studies, the most probable cause is the Guillain-Barre syndrome. It is possibly secondary to SARS-CoV-2 infection given the presence of anti-SARS-CoV-2 IgG antibodies after contact with a confirmed case. Conclusion: This case supports the hypothesis that COVID-19 may trigger the Guillain-Barre syndrome, specifically as facial diplegia, which is an atypical variant that should be known to be early diagnosed and treated as part of this syndrome.
MeSH term(s)	Adult ; COVID-19 ; Female ; Guillain-Barre Syndrome/diagnosis ; Guillain-Barre Syndrome/etiology ; Humans ; Pandemics ; Paresthesia ; SARS-CoV-2
Language	Spanish
Publishing date	2021-12-28
Publishing country	Argentina
Document type	Case Reports ; Journal Article
ZDB-ID	390127-0
ISSN	1853-0605 ; 0014-6722 ; 0301-7281
ISSN (online)	1853-0605
ISSN	0014-6722 ; 0301-7281
DOI	10.31053/1853.0605.v78.n4.32392
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Zs.B 2644: Show issues

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Article ; Online: Post-COVID-19 syndrome. SARS-CoV-2 RNA detection in plasma, stool, and urine in patients with persistent symptoms after COVID-19.

Tejerina, Francisco / Catalan, Pilar / Rodriguez-Grande, Cristina / Adan, Javier / Rodriguez-Gonzalez, Carmen / Muñoz, Patricia / Aldamiz, Teresa / Diez, Cristina / Perez, Leire / Fanciulli, Chiara / Garcia de Viedma, Dario

BMC infectious diseases

2022 Volume 22, Issue 1, Page(s) 211

Abstract: Background: There is a paucity of knowledge on the long-term outcome in patients diagnosed with COVID-19. We describe a cohort of patients with a constellation of symptoms occurring four weeks after diagnosis causing different degrees of reduced ... ...

Abstract	Background: There is a paucity of knowledge on the long-term outcome in patients diagnosed with COVID-19. We describe a cohort of patients with a constellation of symptoms occurring four weeks after diagnosis causing different degrees of reduced functional capacity. Although different hypothesis have been proposed to explain this condition like persistent immune activation or immunological dysfunction, to date, no physiopathological mechanism has been identified. Consequently, there are no therapeutic options besides symptomatic treatment and rehabilitation. Methods: We evaluated patients with symptoms that persisted for at least 4 weeks after COVID-19. Epidemiological and clinical data were collected. Blood tests, including inflammatory markers, were conducted, and imaging studies made if deemed necessary. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction (RT-PCR) in plasma, stool, and urine were performed. Patients were offered antiviral treatment (compassionate use). Results: We evaluated 29 patients who reported fatigue, muscle pain, dyspnea, inappropriate tachycardia, and low-grade fever. Median number of days from COVID-19 to positive RT-PCR in extra-respiratory samples was 55 (39-67). Previous COVID-19 was mild in 55% of the cases. Thirteen patients (45%) had positive plasma RT-PCR results and 51% were positive in at least one RT-PCR sample (plasma, urine, or stool). Functional status was severely reduced in 48% of the subjects. Eighteen patients (62%) received antiviral treatment. Improvement was seen in most patients (p = 0.000) and patients in the treatment group achieved better outcomes with significant differences (p = 0.01). Conclusions: In a cohort of COVID-19 patients with persistent symptoms, 45% of them have detectable plasma SARS-CoV-2 RNA. Our results indicate possible systemic viral persistence in these patients, who may benefit of antiviral treatment strategies.
MeSH term(s)	COVID-19/complications ; COVID-19/diagnosis ; Humans ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Serologic Tests
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-022-07153-4
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Article ; Online: Cervical and Oropharyngeal Lymphogranuloma Venereum: Case Report and Literature Review.

Galeano-Valle, Francisco / Pérez-Latorre, Leire / Díez-Romero, Cristina / Fanciulli, Chiara / Aldamiz-Echeverria-Lois, Teresa / Tejerina-Picado, Francisco

Sexually transmitted diseases

2019 Volume 46, Issue 10, Page(s) 689–692

Abstract: Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by invasive serovars of Chlamydia trachomatis. There have been only a few case reports of oropharyngeal C. trachomatis infection complicated with cervical LGV. We report a case of ... ...

Abstract	Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by invasive serovars of Chlamydia trachomatis. There have been only a few case reports of oropharyngeal C. trachomatis infection complicated with cervical LGV. We report a case of a HIV-positive male patient with cervical LGV that presented a poor evolution despite appropriate treatment.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Cervical Atlas/microbiology ; Chlamydia Infections/complications ; Chlamydia Infections/microbiology ; Chlamydia trachomatis ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/microbiology ; HIV Seropositivity/complications ; HIV Seropositivity/microbiology ; Homosexuality, Male ; Humans ; Lymphogranuloma Venereum/diagnostic imaging ; Lymphogranuloma Venereum/drug therapy ; Male ; Middle Aged ; Oropharynx/microbiology ; Serogroup ; Tomography, X-Ray Computed
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2019-06-27
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000001036
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Zs.A 1217: Show issues

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Article ; Online: Imported and autochthonous leprosy presenting in Madrid (1989-2015): A case series and review of the literature.

Norman, Francesca F / Fanciulli, Chiara / Pérez-Molina, José-Antonio / Monge-Maillo, Begoña / López-Vélez, Rogelio

Travel medicine and infectious disease

2016 Volume 14, Issue 4, Page(s) 331–349

Abstract: Background: Leprosy remains infrequent in non-endemic areas. The objective of this study was to describe the cases of leprosy reviewed at a referral unit for imported diseases in Europe and to compare these findings with published data on imported ... ...

Abstract	Background: Leprosy remains infrequent in non-endemic areas. The objective of this study was to describe the cases of leprosy reviewed at a referral unit for imported diseases in Europe and to compare these findings with published data on imported leprosy. Methods: Cases of leprosy evaluated at a referral centre are described and salient features of autochthonous and imported cases are compared. A review of the literature on imported leprosy was performed. Results: During the study period, 25 patients with leprosy were followed-up (10 were autochthonous cases and 15 were considered to be imported). Regarding imported cases, the majority were diagnosed in Latin American immigrants (10/15, 67%), mean age was 42 years, there were no differences in gender distribution, estimated average time from arrival in Spain to first visit at the unit was 3 years and from symptom onset to diagnosis was 2 years. Over 80% of imported cases had multibacillary disease and over one third of patients had been previously diagnosed with leprosy. One third had received alternate incorrect diagnoses initially, <50% of patients with imported leprosy completed standard therapy and were considered cured and over one third were lost to follow-up. Conclusions: Leprosy remains a complex disease for healthcare professionals unfamiliar with this infection. Manifestations are polymorphic so misdiagnoses and consequent delays in diagnosis are not infrequent and may lead to resulting disabilities. Early diagnosis and management are essential to prevent sequelae and possible transmission. Improving access to health care, especially for vulnerable groups, would be necessary to advance in the control of this disease.
MeSH term(s)	Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Diagnostic Errors ; Emigrants and Immigrants ; Europe/epidemiology ; Female ; Health Personnel/education ; Humans ; Infant ; Leprosy/diagnosis ; Leprosy/epidemiology ; Leprosy/microbiology ; Leprosy/transmission ; Male ; Middle Aged ; Mycobacterium leprae/isolation & purification ; Neglected Diseases/epidemiology ; Neglected Diseases/microbiology ; Spain/epidemiology ; Time Factors ; Travel
Language	English
Publishing date	2016-07
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2170891-5
ISSN	1873-0442 ; 1477-8939
ISSN (online)	1873-0442
ISSN	1477-8939
DOI	10.1016/j.tmaid.2016.06.008
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Article ; Online: SARS-COV-2 Infection in People Living with HIV: Experience from a Tertiary Hospital in Madrid.

González Guembe, Maria / Tisner Pensado, Yago / Tejerina Picado, Francisco / Diez, Cristina / Pérez Latorre, Leire / Fanciulli, Chiara / Parras Vázquez, Francisco / López Bernaldo de Quirós, Juan Carlos / Berenguer, Juan / Padilla Ortega, Belen / Machado, Marina / Valerio Minero, Maricela / Muñoz Garcia, Patricia / Bouza Santiago, Emilio / Galar, Alicia / Catalan, Pilar / Alonso, Roberto / Bellón, Jose M / Aldámiz-Echevarría Lois, Teresa

AIDS research and human retroviruses

2022 Volume 38, Issue 5, Page(s) 394–398

Abstract: Since SAR-COV-2 infection emerged and spread worldwide, little is known about its impact on people living with human immunodeficiency virus (HIV). We performed a single-center retrospective study to describe the potential particularities and risk factors ...

Abstract	Since SAR-COV-2 infection emerged and spread worldwide, little is known about its impact on people living with human immunodeficiency virus (HIV). We performed a single-center retrospective study to describe the potential particularities and risk factors for respiratory failure (RF) in that population. This single-center retrospective study included patients infected with HIV, whose current follow-up is run in this center, above18 years of age, with diagnosis of SARS-CoV-2 infection between March 5, 2020 and April 15, 2021. We collected data regarding HIV immunological and virological status, main epidemiological characteristics, as well as those conditions considered to potentially influence in SARS-CoV-2 evolution; and clinical, microbiological, radiological, respiratory status, and survival concerning coronavirus disease 2019 (COVID-19). We compared all that, for patients with and without RF and performed a logistic regression for suspected risk factors for RF. One hundred seventy-seven HIV patients were diagnosed from COVID-19 (mean age 53.8 years, 81.3% male). At diagnosis, 95.5% were receiving ART and 91.3% had undetectable viral load, with median CD4 count of 569 cells/μL. One hundred thirty-eight patients (78.4%) had symptoms, 44 (25%) developed RF and 53 (31%) developed bilateral pneumonia. The most commonly used treatments were: steroids (26.7%) and hydroxychloroquine (13.1%). When comparing patients with and without RF, we found statistically significant differences for 20 of the analyzed variables such as age (
MeSH term(s)	COVID-19/epidemiology ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Tertiary Care Centers
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	639130-8
ISSN	1931-8405 ; 0889-2229
ISSN (online)	1931-8405
ISSN	0889-2229
DOI	10.1089/AID.2021.0159
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Zs.A 1928: Show issues

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Article ; Online: Stroke in HIV-infected individuals with and without HCV coinfection in Spain in the combination antiretroviral therapy era.

Alvaro-Meca, Alejandro / Berenguer, Juan / Díaz, Asunción / Micheloud, Dariela / Aldámiz-Echevarría, Teresa / Fanciulli, Chiara / Resino, Salvador

PloS one

2017 Volume 12, Issue 6, Page(s) e0179493

Abstract: The incidence of stroke in human immunodeficiency virus (HIV)-infected individuals has been well analyzed in recent epidemiological studies. However, little is known about the specific contribution of hepatitis C virus (HCV) infection to stroke among HIV- ...

Abstract	The incidence of stroke in human immunodeficiency virus (HIV)-infected individuals has been well analyzed in recent epidemiological studies. However, little is known about the specific contribution of hepatitis C virus (HCV) infection to stroke among HIV-infected individuals. The aims of this study were to analyze trends in the incidence rates of stroke in HIV-infected individuals during the combination antiretroviral (cART) era in Spain and to categorize them by the presence or absence of HCV coinfection. We analyzed hospital discharges with a diagnosis of stroke in Spain according to ICD-9-CM during 1997-2013. The study period was divided into four calendar periods (1997-1999, 2000-2003, 2004-2007, and 2008-2013). Patients were classified according to HCV serology. The number of HIV-infected patients was estimated based on data from the National Centre of Epidemiology. We calculated incidence rates (events per 10,000 patient-years) and in-hospital case fatality rates (CFR). The incidence of hemorrhagic stroke (HS) decreased in HIV-monoinfected patients (15.8 [1997-1999] to 6.5 [2008-2013]; P<0.001) and increased in HIV/HCV-coinfected patients (1.3 [1997-1999] to 5.5 [2008-2013]; P<0.001). The incidence of ischemic stroke (IS) decreased in HIV-monoinfected patients (27.4 [1997-1999] to 21.7 [2008-2013]; P = 0.005) and increased in HIV/HCV-coinfected patients (1.8 [1997-1999] to 11.9 [2008-2013]; P<0.001). The CFR was 3.3 times higher for HS than for IS for the whole study period. The CFR of HS in HIV-monoinfected patients decreased significantly (47.4% [1997-1999] to 30.6% [2008-2013]; P = 0.010) but did not change significantly among HIV/HCV-coinfected patients (41.4% [1997-1999] to 44.7% [2008-2013]; P = 0.784). The CFR of IS in the whole HIV-infected population decreased significantly (14.6% [1997-1999] to 10.9% [2008-2013]; P = 0.034), although no significant differences were found when each group was analyzed separately. In conclusion, after the introduction of cART, HS and IS rates decreased in HIV-monoinfected individuals, but increased steadily in HIV/HCV-coinfected individuals.
MeSH term(s)	Adult ; Aged ; Anti-Retroviral Agents/administration & dosage ; Brain Ischemia/drug therapy ; Brain Ischemia/epidemiology ; Brain Ischemia/etiology ; Coinfection/complications ; Coinfection/epidemiology ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV-1 ; Hepacivirus ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Humans ; Incidence ; Intracranial Hemorrhages/drug therapy ; Intracranial Hemorrhages/epidemiology ; Intracranial Hemorrhages/etiology ; Male ; Middle Aged ; Retrospective Studies ; Spain/epidemiology ; Stroke/epidemiology ; Stroke/etiology
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2017
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0179493
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Article ; Online: Switching to bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat in heavily antiretroviral-experienced, virologically suppressed HIV-infected adults receiving complex regimens.

Podzamczer, Daniel / Imaz, Arkaitz / Lopez-Lirola, Ana / Knobel, Hernando / Masiá, Mar / Fanciulli, Chiara / Hernández, Cristina / Lagarde, María / Gutierrez, Angela / Curran, Adrià / Morano, Luis / Montero-Alonso, Marta / Troya, Jesús / Rigo, Raúl / Casadellà, María / Navarro-Alcaraz, Antonio / Ardila, Fernando / Parera, Mariona / Bernal, Enrique /

Echeverria, Patricia / Estrada, Vicente / Hidalgo-Tenorio, Carmen / Macias, Juan / Prieto, Paula / Portilla, Joaquín / Valencia, Eulalia / Vivancos, María Jesús / Rivero, Antonio

The Journal of antimicrobial chemotherapy

2023 Volume 78, Issue 11, Page(s) 2696–2701

Abstract: Objectives: To evaluate the efficacy and safety of the two-pill regimen bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat as a switching strategy in heavily treatment-experienced people living with HIV (PLWH).: ... ...

Abstract	Objectives: To evaluate the efficacy and safety of the two-pill regimen bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) plus darunavir/cobicistat as a switching strategy in heavily treatment-experienced people living with HIV (PLWH). Methods: Multicentre, prospective, single-arm pilot clinical trial. Participants were virologically suppressed adults receiving a stable antiretroviral regimen of at least three pills from at least three drug families due to previous virological failures and/or toxicities with no documented resistance to integrase strand transfer inhibitors or darunavir (≥15 points, Stanford). Clinical and laboratory assessments were performed at 0, 4, 12, 24, 36 and 48 weeks. HIV-1 proviral DNA was amplified and sequenced by Illumina at baseline. Plasma bictegravir concentrations were determined in 22 patients using UHPLC-MS/MS. The primary study endpoint was viral load (VL)< 50 copies/mL at Week 48 (ITT). Results: We enrolled 63 participants (92% men) with median baseline CD4 count of 515 cells/mm3 (IQR: 334.5-734.5), 24 years on ART (IQR: 15.9-27.8). The median number of pills was 4 (range: 3-10). At baseline, proviral DNA was amplified in 39 participants: 33/39 had resistance mutations. Three participants discontinued owing to toxicity. At 48 weeks, 95% had VL < 50 copies/mL by ITT and 100% by PP analysis. A modest increase was observed in the bictegravir plasma concentration, and a significant decrease in estimated glomerular filtration rate was observed only at Week 4, probably related to interaction with renal transporters. Conclusions: Our data suggest that BIC/FTC/TAF + darunavir/cobicistat is an effective, well-tolerated regimen that may improve convenience and, potentially, long-term success in stable heavily pre-treated PLWH.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Adenine/therapeutic use ; Alanine/therapeutic use ; Anti-HIV Agents/adverse effects ; Anti-Retroviral Agents/therapeutic use ; Cobicistat/therapeutic use ; Darunavir/therapeutic use ; DNA/therapeutic use ; Emtricitabine/therapeutic use ; HIV Infections/drug therapy ; Prospective Studies ; Tandem Mass Spectrometry
Chemical Substances	Adenine (JAC85A2161) ; Alanine (OF5P57N2ZX) ; Anti-HIV Agents ; Anti-Retroviral Agents ; bictegravir (8GB79LOJ07) ; Cobicistat (LW2E03M5PG) ; Darunavir (YO603Y8113) ; DNA (9007-49-2) ; Emtricitabine (G70B4ETF4S) ; tenofovir alafenamide (EL9943AG5J)
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad285
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: European mitochondrial haplogroups predict liver-related outcomes in patients coinfected with HIV and HCV: a retrospective study.

Aldámiz-Echevarría, Teresa / Resino, Salvador / Bellón, José M / Jiménez-Sousa, María A / Miralles, Pilar / Medrano, Luz M / Carrero, Ana / Díez, Cristina / Pérez-Latorre, Leire / Fanciulli, Chiara / Garcia-Broncano, Pilar / Berenguer, Juan

Journal of translational medicine

2019 Volume 17, Issue 1, Page(s) 244

Abstract: Background: Mitochondrial DNA (mtDNA) haplogroups have been associated with advanced liver fibrosis and cirrhosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Our aim was to determine whether mtDNA ... ...

Abstract	Background: Mitochondrial DNA (mtDNA) haplogroups have been associated with advanced liver fibrosis and cirrhosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Our aim was to determine whether mtDNA haplogroups are associated with liver-related events (LREs) in HIV/HCV-coinfected patients. Methods: We carried out a retrospective cohort study in HIV/HCV-coinfected patients who were potential candidates for therapy with interferon and ribavirin (IFN/Rib) between 2000 and 2009. The primary endpoint was the occurrence of LREs (decompensation or hepatocellular carcinoma). mtDNA genotyping was performed using the Sequenom MassARRAY platform. We used Fine and Gray proportional hazards model to test the association between mtDNA haplogroups and LREs, considering death as a competitive risk. Results: The study population comprised 243 patients, of whom 40 had advanced fibrosis or cirrhosis. After a median follow-up of 7.7 years, 90 patients treated with IFN/Rib achieved sustained viral response (SVR), 18 patients had LREs, and 11 patients died. Patients with haplogroup H had lower cumulative incidence than patients with other haplogroups (p = 0.012). However, patients with haplogroup T had higher cumulative incidence than patients with other haplogroups (p = 0.074). In the multivariate analysis, haplogroup T was associated with an increased hazard of developing LREs [adjusted subhazard ratio (aSHR) = 3.56 (95% CI 1.13;11.30); p = 0.030]; whereas haplogroup H was not associated with lower hazard of LREs [aSHR = 0.36 (95% CI 0.10;1.25); p = 0.105]. When we excluded patients who achieved SVR during follow-up, we obtained similar SHR values. Conclusions: European mitochondrial haplogroups may influence the natural history of chronic hepatitis C.
MeSH term(s)	Adult ; Antiviral Agents/therapeutic use ; Biopsy ; Carcinoma, Hepatocellular/diagnosis ; Coinfection ; DNA, Mitochondrial/genetics ; Disease Progression ; Europe ; Female ; Genotype ; HIV Infections/complications ; HIV Infections/genetics ; HIV Infections/virology ; Haplotypes ; Hepacivirus/genetics ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/genetics ; Hepatitis C, Chronic/virology ; Humans ; Interferons/administration & dosage ; Liver/virology ; Liver Failure/diagnosis ; Liver Neoplasms/diagnosis ; Male ; Middle Aged ; Proportional Hazards Models ; Retrospective Studies ; Ribavirin/administration & dosage ; Risk
Chemical Substances	Antiviral Agents ; DNA, Mitochondrial ; Ribavirin (49717AWG6K) ; Interferons (9008-11-1)
Language	English
Publishing date	2019-07-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1479-5876
ISSN (online)	1479-5876
DOI	10.1186/s12967-019-1997-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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