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  1. Article ; Online: The patterns of growth of cervical cancer: a challenge to personalized radical surgery.

    Buda, Alessandro / Fanfani, Francesco

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2023  Volume 33, Issue 7, Page(s) 1162–1163

    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/surgery ; Uterine Cervical Neoplasms/pathology ; Hysterectomy ; Neoplasm Staging ; Laparoscopy ; Retrospective Studies
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-004556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3198: Show issues Location:
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  2. Article: Editorial: Lymph node assessment in cervical cancer.

    Guani, Benedetta / Chacon, Enrique / Fanfani, Francesco / Bizzarri, Nicolò

    Frontiers in oncology

    2023  Volume 13, Page(s) 1324654

    Language English
    Publishing date 2023-11-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1324654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Uterine fundus indocyanine green injection for sentinel lymph node biopsy in endometrial cancer patients with limited access to cervical injection.

    Bizzarri, Nicolò / Parisi, Giuseppe / Di Berardino, Stefano / Naccarato, Laura / Scambia, Giovanni / Fanfani, Francesco

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2024  

    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-005086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Therapeutic role of para-aortic lymphadenectomy in patients with intermediate- and high-risk endometrial cancer: a systematic review and meta-analysis.

    Pavone, Matteo / Jochum, Floriane / Lecointre, Lise / Fanfani, Francesco / Scambia, Giovanni / Querleu, Denis / Akladios, Chérif

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2024  Volume 34, Issue 4, Page(s) 519–527

    Abstract: Objective: Lymph nodal involvement is a prognostic factor in endometrial cancer. The added value of para-aortic lymphadenectomy compared with pelvic nodal evaluation alone remains a matter of debate in the management of patients with intermediate- and ... ...

    Abstract Objective: Lymph nodal involvement is a prognostic factor in endometrial cancer. The added value of para-aortic lymphadenectomy compared with pelvic nodal evaluation alone remains a matter of debate in the management of patients with intermediate- and high-risk endometrial cancer. A systematic review and meta-analysis was conducted to assess the prognostic value of para-aortic lymphadenectomy in terms of overall survival and disease-free survival in patients with intermediate- and high-risk endometrial cancer.
    Methods: The study adhered to the PRISMA guidelines. PubMed, Google Scholar and ClinicalTrials.gov were searched from January 2000 to April 2023. Studies on intermediate- and high-risk patients who underwent pelvic versus pelvic and para-aortic dissection were included in the analysis. The Methodological Index for Nonrandomized Studies (MINORS) and the Quality Assessment of Diagnostic Accuracy Studies 2 tool (QUADAS-2) were used for quality assessment of the selected articles.
    Results: Fourteen studies were identified, encompassing 9415 patients with a median age of 62 years (IQR 56.5-66.5). The majority had International Federation of Gynecology and Obstetrics stage I-II disease (76%) and endometrioid histology (89%). The 72% of patients who underwent only pelvic nodal evaluation and the 87% who underwent pelvic and para-aortic lymphadenectomy received adjuvant treatment (p=0.44). Pelvic and para-aortic lymphadenectomy was associated with a significant improvement in 5-year overall survival (RR=0.71, 95% CI 0.57 to 0.88, p<0.01), translating to a 41% reduction in the risk of overall death. However, no significant differences were observed in the 5-year risk of recurrence (RR=1.12, 95% CI 0.94 to 1.34, p=0.15). Additionally, patients undergoing pelvic and para-aortic lymphadenectomy experienced a 26% increased risk of post-operative complications (RR=1.26, 95% CI 1.04 to 1.53, p=0.03) and prolonged operative times (MD=56.27, 95% CI 15.94 to 96.60, p<0.01).
    Conclusion: Pelvic and para-aortic lymphadenectomy appears to confer a prognostic benefit in patients with intermediate- and high-risk endometrial cancer. Robust prospective studies are needed to further validate these findings and elucidate the precise role of para-aortic lymphadenectomy in the optimal management of these patients.
    MeSH term(s) Female ; Humans ; Middle Aged ; Aged ; Lymph Node Excision/adverse effects ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Endometrial Neoplasms/pathology ; Endometrium/pathology ; Disease-Free Survival ; Neoplasm Staging ; Retrospective Studies
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-005134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Minimally invasive adrenalectomy: a personalized surgical approach in recurrent cervical cancer.

    Rosati, Andrea / Certelli, Camilla / Ferrandina, Gabriella / Fanfani, Francesco / Scambia, Giovanni / Gallotta, Valerio

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2024  

    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-005241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: New Development of Tracers Uses in Gynecologic Surgery.

    Cianci, Stefano / Gueli Alletti, Salvatore / Fanfani, Francesco

    Frontiers in oncology

    2022  Volume 12, Page(s) 912267

    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.912267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Simplified anatomical nomenclature of lateral female pelvic spaces.

    Querleu, Denis / Bizzarri, Nicolò / Fanfani, Francesco / Fagotti, Anna / Scambia, Giovanni

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2022  

    Abstract: Objectives: The surgical management of gynecological malignancies involves the development of spaces and division of structures attaching the genital tract to other pelvic organs and to the pelvic sidewall. Definition, description, and denomination of ... ...

    Abstract Objectives: The surgical management of gynecological malignancies involves the development of spaces and division of structures attaching the genital tract to other pelvic organs and to the pelvic sidewall. Definition, description, and denomination of these components are heterogeneous and may not be consistent with the anatomical nomenclature. The purpose of this article is to propose a simplified nomenclature of surgical anatomy of the female pelvis.
    Methods: We performed dissection of fresh cadavers at the anatomy laboratory of the University of the Sacred Heart, Rome, Italy. Dissections were designed to illustrate surgical concepts developed by the first author. All authors agreed a consensus on the description and denomination of the nomenclature.
    Results: The nomenclature system results in a simplified nomenclature, purely descriptive, avoiding eponyms, designed to be used by surgeons, teachers, staff members, and trainees.
    Conclusions: Simplification of the anatomical description of the female pelvis is crucial to standardize operative reports in clinical practice.
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2022-003531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Author's reply to: What is the prognostic importance of lymphovascular space invasion in the absence of lymph node metastasis for early-stage endometrial cancer?

    Tortorella, Lucia / Scambia, Giovanni / Fanfani, Francesco

    Journal of gynecologic oncology

    2021  Volume 32, Issue 5, Page(s) e89

    MeSH term(s) Endometrial Neoplasms/surgery ; Female ; Humans ; Lymph Node Excision ; Lymphatic Metastasis ; Prognosis
    Language English
    Publishing date 2021-08-11
    Publishing country Korea (South)
    Document type Letter ; Comment
    ZDB-ID 2478405-9
    ISSN 2005-0399 ; 2005-0380
    ISSN (online) 2005-0399
    ISSN 2005-0380
    DOI 10.3802/jgo.2021.32.e89
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6484: Show issues Location:
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  9. Article ; Online: ASO Author Reflections: Minimally Invasive Surgical Staging in Endometrial Cancer Diagnosed After Supracervical Hysterectomy - The Role of Cervical Injection to Detect Sentinel Lymph Node with Indocyanine Green.

    Bizzarri, Nicolò / Rosati, Andrea / Scambia, Giovanni / Fanfani, Francesco

    Annals of surgical oncology

    2021  Volume 29, Issue 1, Page(s) 684–685

    MeSH term(s) Endometrial Neoplasms/surgery ; Female ; Humans ; Hysterectomy ; Indocyanine Green ; Sentinel Lymph Node/diagnostic imaging ; Sentinel Lymph Node/surgery
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2021-08-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10694-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4042: Show issues Location:
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  10. Article ; Online: Sentinel Lymph Node Mapping in Endometrial Cancer after Supracervical Hysterectomy.

    Bizzarri, Nicolò / Rosati, Andrea / Scambia, Giovanni / Fanfani, Francesco

    Annals of surgical oncology

    2021  Volume 29, Issue 1, Page(s) 683

    Abstract: Background: Occult endometrial cancer after supracervical hysterectomy is uncommon. Even if optimal management of those rare cases is still unproven, to guide the need for adjuvant treatment, restaging should be recommended in this situation.: Methods! ...

    Abstract Background: Occult endometrial cancer after supracervical hysterectomy is uncommon. Even if optimal management of those rare cases is still unproven, to guide the need for adjuvant treatment, restaging should be recommended in this situation.
    Methods: The study was approved by institutional review board (DIPUSVSP-27-07-20107). We report the case of a 52-year-old woman with occult grade 2 endometrioid endometrial adenocarcinoma (pT1a) with negative surgical margin and smooth uterine muscle of uncertain malignant potential after supracervical hysterectomy and bilateral salpingo-oophorectomy performed for pelvic pain and uterine fibroids in a local hospital. Preoperative CT scan of chest-abdomen-pelvis did not show any lymphadenopathy or distant metastasis. Pelvic US scan revealed a normal cervical stump and a hypoechoic 18-mm right parametrial nodule. We describe the feasibility of laparoscopic sentinel lymph node identification with cervical stump injection of indocyanine green.
    Results: The patient underwent laparoscopic radical trachelectomy, left pelvic sentinel lymph node biopsy, right pelvic lymphadenectomy, peritoneal washing. Patient did not report any intraoperative or postoperative complication. At final histology cervix, SLN (ultrastaging) and pelvic lymph nodes were negative, while parametrial nodule was reported as metastasis from endometrial adenocarcinoma. Surgical margins were clear. Patient was staged as FIGO IIIB and underwent adjuvant chemo-radiation. She is now alive and disease-free, 12 months after the surgery.
    Conclusions: This video (Video 1) underlines the fact that SLN mapping with cervical injection is a feasible and safe technique also without the uterine corpus after supracervical hysterectomy. The unilateral mapping could be due to the presence of metastatic parametrium on the right side.
    MeSH term(s) Endometrial Neoplasms/surgery ; Female ; Humans ; Hysterectomy ; Lymph Node Excision ; Middle Aged ; Sentinel Lymph Node/diagnostic imaging ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node Biopsy
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10559-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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