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  1. Article: [Clinical efficacy of Manlyman Spray combined with biofeedback therapy on premature ejaculation].

    Zhang, Gao-Yue / Chen, Shan-Wen / Fang, Guang-Hong / Li, Jian-Ying / Li, Jian-Hui

    Zhonghua nan ke xue = National journal of andrology

    2024  Volume 29, Issue 7, Page(s) 630–633

    Abstract: Objective： To observe the clinical effect of Manlyman Spray combined with biofeedback therapy in the treatment of premature ejaculation (PE)．Methods： A total of 60 primary premature ejaculation patients with stable sexual partners and regular sexual ... ...

    Abstract Objective： To observe the clinical effect of Manlyman Spray combined with biofeedback therapy in the treatment of premature ejaculation (PE)．Methods： A total of 60 primary premature ejaculation patients with stable sexual partners and regular sexual activity (≥１ times per week) from April 2021 to October 2022 were involved in the clinical observation, The patients' age is (34.3 ± 4.9) years old, and the course of the disease is (112.5 ± 65.5) months, and Manlyman Spray combined with biofeedback therapy was used to treat patients for 8 weeks. Manlyman Spray was sprayed 3 times on the surface of the penisqd for 4 weeks, and Biofeedback therapy is treated twice a week according to the AI setting module, for a total of 8 weeks. Before and 8 weeks after medication and at 4 weeks after drug withdrawal, the Intravaginal Ejaculation Latency Time (IELT), Premature Ejaculation Diagnostic Tool (PEDT) scores and Clinical Global Impression of Change (CGIC) scores were Obtained and compared. Results： After 8 weeks of treatment, the IELT of the patients was significantly prolonged (［351.4 ± 76.7］ vs ［87 ± 16.8］,P<0.05) and at 4 weeks after drug withdrawal, the therapeutic effect still existed (［345.9 ± 80.3］ vs ［87 ± 16.8］,P<0.05), the PEDT scores were significantly improved after treatment (［18.2 ± 1.1］ vs ［9.0 ± 1.4］,P<0.05)and at 4 weeks after drug withdrawal(［18.0 ± 1.2］ vs ［9.0 ± 1.4］,P<0.05), and so were the CGIC scores (［13.4 ± 1.3］ vs ［3.3 ± 1.4］,P<0.05, and ［12.6 ± 1.6］ vs ［3.3 ± 1.4］,P<0.05). Conclusion： The combination of Manlyman Spray and biofeedback therapy can effectively treat primary premature ejaculation, with a long duration of treatment and good safety, and the specific mechanism needs further study.
    MeSH term(s) Male ; Humans ; Adult ; Premature Ejaculation/therapy ; Biofeedback, Psychology ; Treatment Outcome ; Ejaculation ; Sexual Behavior
    Language Chinese
    Publishing date 2024-04-15
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6577: Show issues Location:
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  2. Article ; Online: Association of Maternal History of Spontaneous Abortion and Stillbirth With Risk of Congenital Heart Disease in Offspring of Women With vs Without Type 2 Diabetes.

    Ji, Honglei / Liang, Hong / Yu, Yongfu / Wang, Ziliang / Yuan, Wei / Qian, Xu / Mikkelsen, Ellen Margrethe / Laursen, Anne Sofie Dam / Fang, GuangHong / Huang, Guoying / Miao, Maohua / Li, Jiong

    JAMA network open

    2021  Volume 4, Issue 11, Page(s) e2133805

    Abstract: Importance: The associations of maternal history of spontaneous abortion (SA) and stillbirth with congenital heart disease (CHD) remain elusive.: Objective: To evaluate the associations of maternal history of pregnancy loss with CHD in offspring and ... ...

    Abstract Importance: The associations of maternal history of spontaneous abortion (SA) and stillbirth with congenital heart disease (CHD) remain elusive.
    Objective: To evaluate the associations of maternal history of pregnancy loss with CHD in offspring and the role of maternal type 2 diabetes.
    Design, setting, and participants: This population-based cohort study included singleton live offspring born between January 1, 1977, and December 31, 2016, identified through Danish national health registries. Statistical analysis was performed from October 1, 2019, through September 1, 2021.
    Exposures: Maternal history of SA, with frequency varying from 1 or 2 to 3 or more episodes, and maternal history of single and multiple stillbirths.
    Main outcomes and measures: Overall CHD identified by hospital diagnosis. Cox proportional hazard regression was used to estimate the hazard ratio (HR) of CHD. Diabetes was evaluated as a potential confounder and a potential effect modifier.
    Results: Among 1 642 534 included offspring (mean [SD] age, 14.11 [8.39] years; 843 265 male [51.35%]), 246 669 (15.02%) were born to mothers with a history of SA and 9750 (0.59%) were born to mothers with a history of stillbirth. The HRs of CHD were 1.16 (95% CI, 1.13-1.20) for offspring with a maternal history of SA and 1.49 (95% CI, 1.32-1.68) for offspring with a maternal history of stillbirth. Significant dose-response associations were observed among offspring with a maternal history of 3 or more episodes of SA (HR, 1.60; 95% CI, 1.39-1.84) and those with maternal history of multiple stillbirths (HR, 2.75; 95% CI, 1.63-4.65). If only inpatient CHD cases were included, the risk of CHD was higher than that found in the main analysis, with HRs of 1.24 (95% CI, 1.19-1.30) for maternal history of SA and 1.78 (95% CI, 1.51-2.11) for maternal history of stillbirth. The observed associations were strengthened by maternal prepregnancy type 2 diabetes (HR for maternal history of SA, 1.65 [95% CI, 1.37-1.97]; HR for maternal history of stillbirth, 1.74 [95% CI, 1.06-2.85]).
    Conclusions and relevance: These findings suggest that offspring born to mothers with a previous SA or stillbirth, especially multiple episodes, or with prepregnancy type 2 diabetes were at a higher risk of being diagnosed with CHD. These findings may help identify women at increased risk in whom detailed fetal heart assessment may be cost-effective and highlight the importance of screening for type 2 diabetes in women of reproductive age.
    MeSH term(s) Abortion, Spontaneous/epidemiology ; Adolescent ; Cohort Studies ; Denmark/epidemiology ; Diabetes Mellitus, Type 2/complications ; Female ; Heart Defects, Congenital/epidemiology ; Heart Defects, Congenital/etiology ; Humans ; Infant, Newborn ; Male ; Pregnancy ; Pregnancy in Diabetics/epidemiology ; Pregnancy in Diabetics/etiology ; Proportional Hazards Models ; Registries ; Reproductive History ; Stillbirth
    Language English
    Publishing date 2021-11-01
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.33805
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Identification of herbal tea ingredient Plumeria rubra and its adulterants using DNA barcoding].

    Shi, Yu-Hua / Sun, Wei / Fang, Guang-Hong / Zheng, Rong-Bo / Xu, Wen-Liu / Huang, Xiao-Dan / Weng, Shao-Quan / Li, Chu-Yuan / Chen, Shi-Lin

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2014  Volume 39, Issue 12, Page(s) 2199–2203

    Abstract: ITS2 sequence was used as a barcode to identify herbal tea ingredient Plumeria rubra and its adulterants. Genomic DNAs from forty eight samples were extracted, the ITS2 sequences were amplified and sequenced bi-direstionlly, and then assembled and ... ...

    Abstract ITS2 sequence was used as a barcode to identify herbal tea ingredient Plumeria rubra and its adulterants. Genomic DNAs from forty eight samples were extracted, the ITS2 sequences were amplified and sequenced bi-direstionlly, and then assembled and obtained using CodonCode Aligner. The sequences were aligned using ClustalW, the genetic distances were computed by kimura 2-parameter (K2P) model and the Neighbor-joining (NJ) phylogenetic trees were constructed using MEGA5.0. Results showed that the length of ITS2 sequence of P. rubra were 244 bp. The intra-specific genetic distances (0-0. 016 6) were much smaller than inter-specific ones between P. rubra and its adulterants(0.320 8-0.650 4). The NJ tree indicated that P. rubra and its adulterants could be distinguished clearly. Therefore, Using ITS2 barcode can accurately andeffectively distinguish herbal tea ingredient P. rubra from its adulterants, which providesa new molecular method to identify P. rubra and ensure its safety in use.
    MeSH term(s) Apocynaceae/classification ; Apocynaceae/genetics ; DNA Barcoding, Taxonomic/methods ; DNA, Plant/genetics ; DNA, Ribosomal Spacer/genetics ; Drug Contamination/prevention & control ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/classification ; Flowers/chemistry ; Flowers/classification ; Molecular Sequence Data ; Phylogeny ; Quality Control
    Chemical Substances DNA, Plant ; DNA, Ribosomal Spacer ; Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2014-06
    Publishing country China
    Document type English Abstract ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3056: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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