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  1. Article: [Promoting implementation research and One Health approach to respond the four global health challenges: an interpretation of the Special Programme for Research and Training in Tropical Diseases (TDR) Strategy 2024-2029].

    Fang, J

    Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control

    2024  Volume 36, Issue 1, Page(s) 13–16

    Abstract: Tropical diseases, notably neglected tropical diseases and infectious diseases of poverty, remain major health problems endangering the poorest and most-marginalized people in the world. The Special Programme for Research and Training in Tropical ... ...

    Abstract Tropical diseases, notably neglected tropical diseases and infectious diseases of poverty, remain major health problems endangering the poorest and most-marginalized people in the world. The Special Programme for Research and Training in Tropical Diseases (TDR), which is co-sponsored by the World Health Organization, the United Nations Children's Fund (UNICEF), the United Nations Development Programme (UNDP) and the World Bank, is an important programme that helps facilitate, support, guide and coordinate global efforts to combat tropical diseases. On July 2023, TDR formally issued its 2024-2029 strategy, which proposed the direction and proprieties of global tropical disease prevention and control in the next six years. Based on its original focus on supporting researchers and research institutions from low and middle-income countries to conduct research on tropical diseases and building their research capabilities, this strategy proposed some new developments, which mainly included incorporating tropical disease prevention and control into the overall framework of addressing major global health challenges and achieving the health goals set by the United Nations Sustainable Development Goals (SDGs) to combat tropical diseases and contribute to achieving health goals of SDGs in a collaborative and integrated manner; supporting implementation research and encouraging practitioners and social innovators to participate in research to enable generation of solutions that may be used to solve local health problems; promoting and encouraging the One Health concept and interdisciplinary and cross-departmental collaboration; shifting gradually its focus from disease prevention and control to addressing the health needs of the poorest and most-marginalized populations. These new developments deserve the attention of personnel and institutions in China dedicated to the prevention and control of tropical diseases in order to help their future researches and activities.
    MeSH term(s) Child ; Humans ; Global Health ; One Health ; World Health Organization ; Communicable Diseases ; Poverty
    Language Chinese
    Publishing date 2024-04-11
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1005-6661
    ISSN 1005-6661
    DOI 10.16250/j.32.1374.2023146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 2-PD reporting needs detail.

    Fang, Jialiu

    Hand surgery & rehabilitation

    2024  , Page(s) 101652

    Language English
    Publishing date 2024-01-29
    Publishing country France
    Document type Letter
    ZDB-ID 2848776-X
    ISSN 2468-1210
    ISSN (online) 2468-1210
    DOI 10.1016/j.hansur.2024.101652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1791: Show issues Location:
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  3. Article ; Online: Environmental law, environmental policy stringency, and development of environmental technologies in China.

    Fang, Jun

    Environmental science and pollution research international

    2023  Volume 30, Issue 45, Page(s) 101234–101249

    Abstract: China's fast industrialization and economic expansion has led to environmental degradation, prompting the government to implement a slew of environmental regulations and laws. This article examines how China's stringent environmental policies and ... ...

    Abstract China's fast industrialization and economic expansion has led to environmental degradation, prompting the government to implement a slew of environmental regulations and laws. This article examines how China's stringent environmental policies and legislation have impacted the development of environmental technology. The study's panel of Chinese companies confirmed that more stringent regulations really spurred innovation in green technology. This research lends credence to the premise that stricter environmental regulations are helpful in inspiring the development of cleaner technology that may help mitigate environmental issues. Research also shows that tighter environmental legislation increases environmental policy's effect on technological development. According to these results, environmental law may improve the efficiency of environmental policy by providing a hospitable framework for the application of technological innovation. The findings of this research have significant implications for Chinese policymakers committed to fostering sustainable development. The need of rigorous environmental rules to support comprehensive environmental policies that promote the development of greener technology is emphasized. The results shed even more light on how crucial it is to enforce environmental laws in order to ensure that environmental policies are effectively implemented. In essence, this study contributes to the expanding body of knowledge on the link between environmental policy and technical advancement by illuminating the potential for China's environmental policy and law to work together to encourage sustainable development. China's investment in green tech research and development may mitigate the environmental damage caused by its rapid economic growth.
    MeSH term(s) Environmental Policy ; Conservation of Natural Resources ; China ; Sustainable Development ; Technology ; Economic Development
    Language English
    Publishing date 2023-08-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-29023-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The role of data imbalance bias in the prediction of protein stability change upon mutation.

    Fang, Jianwen

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0283727

    Abstract: There is a controversy over what causes the low robustness of some programs for predicting protein stability change upon mutation. Some researchers suggested that low-quality data and insufficiently informative features are the primary reasons, while ... ...

    Abstract There is a controversy over what causes the low robustness of some programs for predicting protein stability change upon mutation. Some researchers suggested that low-quality data and insufficiently informative features are the primary reasons, while others attributed the problem largely to a bias caused by data imbalance as there are more destabilizing mutations than stabilizing ones. In this study, a simple approach was developed to construct a balanced dataset that was then conjugated with a leave-one-protein-out approach to illustrate that the bias may not be the primary reason for poor performance. A balanced dataset with some seemly good conventional n-fold CV results should not be used as a proof that a model for predicting protein stability change upon mutations is robust. Thus, some of the existing algorithms need to be re-examined before any practical applications. Also, more emphasis should be put on obtaining high quality and quantity of data and features in future research.
    MeSH term(s) Mutation ; Proteins/genetics ; Algorithms ; Protein Stability
    Chemical Substances Proteins
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0283727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Predicting thermostability difference between cellular protein orthologs.

    Fang, Jianwen

    Bioinformatics (Oxford, England)

    2023  Volume 39, Issue 8

    Abstract: Motivation: Protein thermostability is of great interest, both in theory and in practice.: Results: This study compared orthologous proteins with different cellular thermostability. A large number of physicochemical properties of protein were ... ...

    Abstract Motivation: Protein thermostability is of great interest, both in theory and in practice.
    Results: This study compared orthologous proteins with different cellular thermostability. A large number of physicochemical properties of protein were calculated and used to develop a series of machine learning models for predicting cellular thermostability differences between orthologous proteins. Most of the important features in these models are also highly correlated to relative cellular thermostability. A comparison between the present study with previous comparison of orthologous proteins from thermophilic and mesophilic organisms found that most highly correlated features are consistent in these studies, suggesting they may be important to protein thermostability.
    Availability and implementation: Data freely available for download at https://github.com/fangj3/cellular-protein-thermostability-dataset.
    MeSH term(s) Amino Acid Sequence ; Proteins/chemistry
    Chemical Substances Proteins
    Language English
    Publishing date 2023-08-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1422668-6
    ISSN 1367-4811 ; 1367-4803
    ISSN (online) 1367-4811
    ISSN 1367-4803
    DOI 10.1093/bioinformatics/btad504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2374: Show issues Location:
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  6. Article ; Online: Re: Tobler-Ammann B, Beckmann-Fries V, Calcagni M, Kämpfen A, Schrepfer L, Vögelin E. Outcomes of 218 primary single-finger flexor tendon repairs up to 1 year after surgery: a multicentre cohort study. J Hand Surg Eur Vol. 2023 Jul 3: 17531934231184737. doi: 10.1177/17531934231184737.

    Fang, Jialiu

    The Journal of hand surgery, European volume

    2023  Volume 49, Issue 2, Page(s) 279–283

    MeSH term(s) Humans ; Fingers ; Tendons/surgery ; Upper Extremity ; Cohort Studies ; Finger Injuries/surgery
    Language English
    Publishing date 2023-09-20
    Publishing country England
    Document type Multicenter Study ; Letter
    ZDB-ID 2272801-6
    ISSN 2043-6289 ; 1753-1934
    ISSN (online) 2043-6289
    ISSN 1753-1934
    DOI 10.1177/17531934231200159
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1940: Show issues Location:
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  7. Article: [Standardized and individualized treatment improves survival rate and quality of life for advanced thyroid cancer].

    Fang, J G

    Zhonghua yi xue za zhi

    2023  Volume 103, Issue 40, Page(s) 3152–3154

    Abstract: The overall prognosis of differentiated thyroid carcinoma is favorable, but some patients still progress to a locally advanced stage. At present, there are still some problems in the diagnosis and treatment of locally advanced thyroid cancer, which have ... ...

    Abstract The overall prognosis of differentiated thyroid carcinoma is favorable, but some patients still progress to a locally advanced stage. At present, there are still some problems in the diagnosis and treatment of locally advanced thyroid cancer, which have not been completely clarified, and have caused some problems to the clinical treatment. This article provides a comprehensive analysis and elaboration on the selection of surgical methods for local advanced thyroid cancer, management of recurrent laryngeal nerve and trachea, timing selection of staging surgery, and targeted therapy, aiming at promoting standardized and individualized treatment for advanced thyroid cancer and improving the survival rate and quality of life.
    MeSH term(s) Humans ; Survival Rate ; Quality of Life ; Thyroid Neoplasms/therapy ; Prognosis ; Trachea/pathology
    Language Chinese
    Publishing date 2023-09-28
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 132513-9
    ISSN 0376-2491
    ISSN 0376-2491
    DOI 10.3760/cma.j.cn112137-20230605-00939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2011: Show issues Location:
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  8. Article: EPR Effect-Based Tumor Targeted Nanomedicine: A Promising Approach for Controlling Cancer.

    Fang, Jun

    Journal of personalized medicine

    2022  Volume 12, Issue 1

    Abstract: Cancer remains the major threat to human health in most advanced countries in the world [ ... ]. ...

    Abstract Cancer remains the major threat to human health in most advanced countries in the world [...].
    Language English
    Publishing date 2022-01-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12010095
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  9. Thesis ; Online: Use of new approach methodologies to study the developmental toxicity of polycyclic aromatic hydrocarbons

    Fang, Jing

    2023  

    Keywords Life Science
    Language English
    Publisher Wageningen University
    Publishing country nl
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: [Surgical management of local advanced differentiated thyroid carcinoma].

    Fang, J G

    Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

    2022  Volume 57, Issue 9, Page(s) 1140–1144

    MeSH term(s) Adenocarcinoma, Follicular/surgery ; Humans ; Neoplasm Recurrence, Local/surgery ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyroidectomy
    Language Chinese
    Publishing date 2022-09-20
    Publishing country China
    Document type Journal Article
    ZDB-ID 2195655-8
    ISSN 1673-0860
    ISSN 1673-0860
    DOI 10.3760/cma.j.cn115330-20220218-00073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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