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  1. Article ; Online: B(C

    Xiao, Qian / Fang, Sixian / Ao, Jiaming / Zhao, Xiaoya / Huang, Cai / Liu, Yuhua / Nie, Yichu / Ishiwata, Akihiro / Tanaka, Katsunori / Deng, Wenbin / Ding, Feiqing

    ACS omega

    2024  Volume 9, Issue 10, Page(s) 11969–11975

    Abstract: Compared with stereoselective glycosylation methods mainly addressed on the preparation of pyranose glycosides, the furanosylation has been more limited, especially for the 1,2- ...

    Abstract Compared with stereoselective glycosylation methods mainly addressed on the preparation of pyranose glycosides, the furanosylation has been more limited, especially for the 1,2-
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c09761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Immunomodulatory Effect and Biological Significance of β-Glucans.

    Zhong, Xuemei / Wang, Guoqing / Li, Fu / Fang, Sixian / Zhou, Siai / Ishiwata, Akihiro / Tonevitsky, Alexander G / Shkurnikov, Maxim / Cai, Hui / Ding, Feiqing

    Pharmaceutics

    2023  Volume 15, Issue 6

    Abstract: β-glucan, one of the homopolysaccharides composed of D-glucose, exists widely in cereals and microorganisms and possesses various biological activities, including anti-inflammatory, antioxidant, and anti-tumor properties. More recently, there has been ... ...

    Abstract β-glucan, one of the homopolysaccharides composed of D-glucose, exists widely in cereals and microorganisms and possesses various biological activities, including anti-inflammatory, antioxidant, and anti-tumor properties. More recently, there has been mounting proof that β-glucan functions as a physiologically active "biological response modulator (BRM)", promoting dendritic cell maturation, cytokine secretion, and regulating adaptive immune responses-all of which are directly connected with β-glucan-regulated glucan receptors. This review focuses on the sources, structures, immune regulation, and receptor recognition mechanisms of β-glucan.
    Language English
    Publishing date 2023-05-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15061615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease.

    Wang, Xiao-Qin / Zhou, Lu-Yi / Tan, Ren-Xian / Liang, Guo-Peng / Fang, Si-Xian / Li, Wei / Xie, Mei / Wen, Yu-Hao / Wu, Jia-Qiang / Chen, Yi-Ping

    Chemistry & biodiversity

    2021  Volume 18, Issue 11, Page(s) e2100341

    Abstract: Fifteen chalcone derivatives 3a-3o were synthesized, and evaluated as multifunctional agents against Alzheimer's disease. In vitro studies revealed that these compounds inhibited self-induced ... ...

    Abstract Fifteen chalcone derivatives 3a-3o were synthesized, and evaluated as multifunctional agents against Alzheimer's disease. In vitro studies revealed that these compounds inhibited self-induced Aβ
    MeSH term(s) Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Animals ; Cell Survival/drug effects ; Chalcones/chemical synthesis ; Chalcones/chemistry ; Chalcones/pharmacology ; Copper/pharmacology ; Drug Design ; Humans ; Memory Disorders/chemically induced ; Memory Disorders/drug therapy ; Mice ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; Peptide Fragments/antagonists & inhibitors ; Peptide Fragments/metabolism ; Protein Aggregates/drug effects ; Scopolamine ; Tumor Cells, Cultured
    Chemical Substances Amyloid beta-Peptides ; Chalcones ; Neuroprotective Agents ; Peptide Fragments ; Protein Aggregates ; amyloid beta-protein (1-42) ; Copper (789U1901C5) ; Scopolamine (DL48G20X8X)
    Language English
    Publishing date 2021-10-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202100341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: miR-216a-5p inhibits malignant progression in small cell lung cancer: involvement of the Bcl-2 family proteins.

    Sun, Yanqin / Hu, Bingshuang / Wang, Yanhong / Li, Zhen / Wu, Jingfang / Yang, Yunchu / Wei, Yue / Peng, Xiaofeng / Chen, Hongling / Chen, Rongqi / Jiang, Pingyan / Fang, Sixian / Yu, Zhiwu / Guo, Linlang

    Cancer management and research

    2018  Volume 10, Page(s) 4735–4745

    Abstract: Objective: microRNAs are regulatory molecules regarded as important in the pathogenesis of different types of tumors. microRNA-216a (miR-216a-5p) has been identified as a tumor suppressor in multiple malignancies. However, the role of miR-216a-5p in the ...

    Abstract Objective: microRNAs are regulatory molecules regarded as important in the pathogenesis of different types of tumors. microRNA-216a (miR-216a-5p) has been identified as a tumor suppressor in multiple malignancies. However, the role of miR-216a-5p in the pathogenesis of small cell lung cancer (SCLC) remains obscure. The objective of this study was to investigate the role of the miR-216a-5p/Bcl-2 axis in SCLC pathogenesis.
    Materials and methods: All the experimental methods used were as follows: microarray analysis, cell culture, transient, and stable gene transfection; real-time fluorescence PCR; Western blot; flow cytometry for cell cycle analysis; in vitro proliferation assay; in vitro wound healing experiment; in vivo xenograft model in nude mice; and dual luciferase reporter assay. All statistical analyses were carried out using GraphPad Prism 7 software. Statistical significance was analyzed by Student's
    Results: In this study, we observed that miR-216a-5p is downregulated in SCLC cell lines compared to that in the normal human bronchial epithelial cell line 16-HBE. In vitro and in vivo experiments demonstrate that upregulation of miR-216a-5p significantly decreased cell growth and migration and its downregulation increased SCLC cell proliferation and migration and influenced the cell cycle. Using bioinformatics analyses, we predicted that the important antiapoptotic gene
    Conclusion: Taken together, these findings suggest that miR-216a-5p regulates SCLC biology via
    Language English
    Publishing date 2018-10-18
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S178380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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