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  1. Article ; Online: Anti-Inflammatory Effects of Glucagon-Like Peptide-1 Receptor Agonists via the Neuroimmune Axis.

    Fang, Susanna / Wong, Chi Kin

    DNA and cell biology

    2024  

    Abstract: Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have shown efficacy in the treatment of metabolic disease-related complications, partially attributable to their anti-inflammatory properties. However, the specific cell types and pathways involved in ... ...

    Abstract Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have shown efficacy in the treatment of metabolic disease-related complications, partially attributable to their anti-inflammatory properties. However, the specific cell types and pathways involved in these effects were not fully understood. A recent study by Wong et al. demonstrated the importance of the brain GLP-1R in mediating the anti-inflammatory effects of GLP-1RAs in Toll-like receptor and sepsis-mediated inflammation. In this discussion, we review the existing literature on the action of GLP-1RAs in inflammation and explore the implications of these recent findings.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024454-2
    ISSN 1557-7430 ; 0198-0238 ; 1044-5498
    ISSN (online) 1557-7430
    ISSN 0198-0238 ; 1044-5498
    DOI 10.1089/dna.2024.0057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2061: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Clinical Best Practices for Radiation Safety During Lutetium-177 Therapy.

    Cappon, Derek John / Fang, Susanna / Berry, Kendall / Capone, Gina / Carlton, Gina L / Chrétien, Mario / Gough, John / Kamen, Jacob / Khoorshed, Anne / Miller, Andy / Nelli, Stephen / Petric, M Peter / Tourneur, Frank / Zic, Josip J

    Health physics

    2022  Volume 124, Issue 2, Page(s) 139–146

    Abstract: Importance: 177 Lu therapy as part of theranostic treatment for cancer is expanding but it can be a challenge for sites with limited radiation protection staff to implement the radiation safety program required for therapeutic nuclear medicine.: ... ...

    Abstract Importance: 177 Lu therapy as part of theranostic treatment for cancer is expanding but it can be a challenge for sites with limited radiation protection staff to implement the radiation safety program required for therapeutic nuclear medicine.
    Objective: To increase the adoption of 177 Lu therapy, especially in smaller centers and clinics, by providing a collection of radiation safety best practices and operational experience. To provide a resource for radiation safety officers supporting the implementation of a 177 Lu therapy program.
    Methods: A panel of 11 radiation safety professionals representing sites across Canada and the United States with experience delivering 177 Lu therapy was assembled and discussed their responses to a list of questions focused on the following radiation safety topics: facility layout and design; radiation safety program; and drug management and patient care.
    Results: A comprehensive set of best practice guidelines for clinical radiation safety during 177 Lu therapy has been developed based on the collective operational experience of a group of radiation safety professionals. Significant findings included that 177 Lu therapy is often safely administered in unshielded rooms, that staff radiation exposure associated with 177 Lu therapy is minimal relative to other nuclear medicine programs, and that some relatively simple preparation in advance including papering of common surfaces and planning for incontinence can effectively control contamination during therapy.
    Conclusion: The guidance contained in this paper will assist radiation safety professionals in the implementation of safe, effective 177 Lu therapy programs, even at smaller sites with limited to no experience in therapeutic nuclear medicine.
    MeSH term(s) Humans ; Radioisotopes/adverse effects ; Radiation Protection ; Lutetium/therapeutic use ; Nuclear Medicine
    Chemical Substances Lutetium-177 (BRH40Y9V1Q) ; Radioisotopes ; Lutetium (5H0DOZ21UJ)
    Language English
    Publishing date 2022-12-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2406-5
    ISSN 1538-5159 ; 0017-9078
    ISSN (online) 1538-5159
    ISSN 0017-9078
    DOI 10.1097/HP.0000000000001644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 128: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 253: Show issues

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  3. Article ; Online: Investigating the protective effects of estrogen on β-cell health and the progression of hyperglycemia-induced atherosclerosis.

    De Paoli, Monica / Wood, Dempsey W / Bohn, Mary K / Pandey, Arjun K / Borowitz, Dana K / Fang, Susanna / Patel, Zinal / Venegas-Pino, Daniel E / Shi, Yuanyuan / Werstuck, Geoff H

    American journal of physiology. Endocrinology and metabolism

    2022  Volume 323, Issue 3, Page(s) E254–E266

    Abstract: Sex differences in the prevalence and development of diabetes and associated cardiometabolic complications are well established. The objective of this study was to analyze the effects of estrogen on the maintenance of β-cell health/function and ... ...

    Abstract Sex differences in the prevalence and development of diabetes and associated cardiometabolic complications are well established. The objective of this study was to analyze the effects of estrogen on the maintenance of β-cell health/function and atherosclerosis progression, using a mouse model of hyperglycemia-induced atherosclerosis, the
    MeSH term(s) Animals ; Atherosclerosis/diagnosis ; Atherosclerosis/etiology ; Blood Glucose ; Disease Models, Animal ; Estradiol/pharmacology ; Estrogens/pharmacology ; Female ; Hyperglycemia/complications ; Insulin/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout, ApoE
    Chemical Substances Blood Glucose ; Estrogens ; Insulin ; Estradiol (4TI98Z838E)
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603841-4
    ISSN 1522-1555 ; 0193-1849
    ISSN (online) 1522-1555
    ISSN 0193-1849
    DOI 10.1152/ajpendo.00353.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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