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  1. Article: Pyopneumothorax Caused by

    Cai, De-Han / Fang, Xiao-Lin

    Infection and drug resistance

    2022  Volume 15, Page(s) 6101–6108

    Abstract: Background: Even with the advent of NGS and PCR diagnostic tools, cases of chest infections caused by : Case presentation: A 69-year-old man diagnosed with cerebral infarction a year ago sought medical attention for right-sided pyopneumothorax and ... ...

    Abstract Background: Even with the advent of NGS and PCR diagnostic tools, cases of chest infections caused by
    Case presentation: A 69-year-old man diagnosed with cerebral infarction a year ago sought medical attention for right-sided pyopneumothorax and respiratory failure. The pathogen found in the pleural fluid was highly suspected to be
    Conclusion: When chest infections occur in patients with poor oral hygiene and underlying diseases that may lead to aspiration, the identification of
    Language English
    Publishing date 2022-10-21
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S381859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Portulaca Oleracea-associated oxalate nephropathy complicated with an ANCA-positive acute renal injury: A case report.

    Cai, De-Han / Fang, Xiao-Lin

    Transplant immunology

    2022  Volume 72, Page(s) 101589

    Abstract: Oxalate nephropathy is a rare disease that can lead to acute kidney injury (AKI). In clinical practice, as renal biopsy is required for diagnosis, physicians often do not have sufficient understanding of this disease. When AKI is associated with positive ...

    Abstract Oxalate nephropathy is a rare disease that can lead to acute kidney injury (AKI). In clinical practice, as renal biopsy is required for diagnosis, physicians often do not have sufficient understanding of this disease. When AKI is associated with positive blood anti-neutrophil cytoplasmic antibodies (ANCA), a diagnosis of renal injury due to ANCA-associated vasculitis is likely to be made, leading to treatment with immunosuppressive therapy. A case of AKI after eating a large quantity of Portulaca oleracea is reported. While blood P-ANCA was positive, both urine proteinuria and urine occult blood were negative. Renal biopsy was performed and identified an acute tubulointerstitial injury: disc-shaped crystals were seen in the lumen of renal tubules that demonstrated birefringence under polarized light, and an oxalate nephropathy was therefore diagnosed. Typical histological changes of an ANCA-associated vasculitis with renal injury such as cellulose-like necrosis and crescent formation were not present. After the patient stopped eating P. oleracea, and following rehydration and hemodialysis, renal function returned to normal. In patients with AKI, the secondary causes of hyperoxalemia should be sought and attention paid to excluding an oxalate nephropathy. In patients with AKI who are ANCA-positive, it is prudent to complete the renal pathological diagnostic process before assuming that the renal injury is caused by an ANCA-associated vasculitis, and before starting hormone and immunosuppressive therapy.
    MeSH term(s) Acute Kidney Injury/complications ; Acute Kidney Injury/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/pathology ; Antibodies, Antineutrophil Cytoplasmic/therapeutic use ; Humans ; Oxalates/therapeutic use ; Portulaca
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Oxalates
    Language English
    Publishing date 2022-03-25
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 1160846-8
    ISSN 1878-5492 ; 0966-3274
    ISSN (online) 1878-5492
    ISSN 0966-3274
    DOI 10.1016/j.trim.2022.101589
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    Zs.A 3784: Show issues Location:
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  3. Article ; Online: Abstracts of randomized controlled trials in the field of dentofacial trauma: Reporting quality and spin.

    Fang, Xiaolin / Guo, Feiyang / Chen, Zhi / Hua, Fang / Zhang, Lu

    Dental traumatology : official publication of International Association for Dental Traumatology

    2023  , Page(s) 276–284

    Abstract: Background/aim: Abstracts of randomized controlled trials (RCTs) provide a summary of the entire trial report. Their transparent, detailed, and accurate reporting is essential for clinical decision-making and evidence-based dental practice. The aim of ... ...

    Abstract Background/aim: Abstracts of randomized controlled trials (RCTs) provide a summary of the entire trial report. Their transparent, detailed, and accurate reporting is essential for clinical decision-making and evidence-based dental practice. The aim of this study was to assess the reporting quality and prevalence of spin in abstracts of RCTs in the field of dentofacial trauma.
    Materials and methods: The PubMed database was searched to identify RCT reports published between 2017 and 2021 in the field of dentofacial trauma. The reporting quality of abstracts was assessed according to the 16-item CONSORT for Abstracts checklist and measured with an overall quality score (OQS, range: 0-16). Linear regression analyses were used to identify factors associated with reporting quality. Among the included RCTs, parallel-group RCTs with non-significant primary outcomes were selected for spin assessment using predefined spin strategies.
    Results: One hundred and twelve eligible abstracts were identified and included. The mean OQS was 4.51 (SD, 1.35; 95% CI, 4.26-4.76). Abstracts with more than 250 words (p = .004) and a structured format (p = .032) had significantly better reporting quality. Of the 30 abstracts that were eligible for spin assessment, spin was identified in 23 (76.7%). Among these, spin was observed in the Conclusions sections of 22 abstracts (73.3%) and the Results sections of 9 abstracts (30.0%).
    Conclusions: Among RCT abstracts in the field of dentofacial trauma, the reporting quality was sub-optimal and the prevalence of spin was relatively high. Strict adherence to the CONSORT for Abstracts guidelines is needed to ensure complete and transparent reporting. Relevant stakeholders need to make concerted efforts to avoid spin.
    Language English
    Publishing date 2023-01-13
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 2030722-6
    ISSN 1600-9657 ; 1600-4469
    ISSN (online) 1600-9657
    ISSN 1600-4469
    DOI 10.1111/edt.12815
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    Zs.A 2038: Show issues Location:
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  4. Article ; Online: Successful treatment of Talaromyces marneffei pneumonia in a HIV-negative renal transplantation recipient: A case report.

    Cai, De-Han / Wang, Jun / Fang, Xiao-Lin

    Medicine

    2022  Volume 101, Issue 40, Page(s) e30958

    Abstract: Rationale: Talaromyces marneffei causes life-threatening opportunistic fungal infections in immunocompromised patients. It often has a poorer prognosis in non-human immunodeficiency virus (HIV)-infected than in HIV-infected individuals because of ... ...

    Abstract Rationale: Talaromyces marneffei causes life-threatening opportunistic fungal infections in immunocompromised patients. It often has a poorer prognosis in non-human immunodeficiency virus (HIV)-infected than in HIV-infected individuals because of delayed diagnosis and improper treatment.
    Patient concerns: A 51-year-old man presented with complaints of pyrexia, cough, and expectoration that had lasted for 15 day. This patient has been taking anti-rejection medication since kidney transplant in 2011.
    Diagnosis: T marneffei pneumonia; post renal transplantation; renal insufficiency; hypertension.
    Interventions: Intravenous moxifloxacin was administered on admission. After the etiology was established, moxifloxacin was discontinued and replaced with voriconazole. The tacrolimus dose was adjusted based on the blood concentration of tacrolimus and voriconazole.
    Outcomes: The patient was successfully treated and followed-up without recurrence for 1 year.
    Lessons: A high degree of caution should be maintained for the possibility of T marneffei infection in immunodeficient non-HIV patients who live in or have traveled to T marneffei endemic areas. Early diagnosis and appropriate treatment can prevent progression of T marneffei infection and achieve a cure. Metagenomic next-generation sequencing (mNGS) can aid the physician in reaching an early pathogenic diagnosis. Close monitoring of tacrolimus and voriconazole blood levels during treatment remains a practical approach at this time.
    MeSH term(s) Antifungal Agents/therapeutic use ; HIV Infections/drug therapy ; Humans ; Kidney Transplantation/adverse effects ; Moxifloxacin ; Mycoses ; Pneumonia/drug therapy ; Tacrolimus/therapeutic use ; Talaromyces ; Voriconazole/therapeutic use
    Chemical Substances Antifungal Agents ; Voriconazole (JFU09I87TR) ; Moxifloxacin (U188XYD42P) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000030958
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Strongyloides stercoralis hyperinfection syndrome mimicking pseudomembranous enteritis, complicated by Escherichia coli bacteremia and Pneumocystis jirovecii pneumonia in a patient after immunosuppressive therapy: a case report.

    Cai, De-Han / Wang, Jun / Fang, Xiao-Lin

    BMC infectious diseases

    2022  Volume 22, Issue 1, Page(s) 749

    Abstract: Background: Strongyloidiasis, caused by Strongyloides stercoralis (S. stercoralis), is endemic worldwide, especially in countries with warm and humid climates. Strongyloides stercoralis hyperinfection syndrome (SHS) is an extremely serious manifestation ...

    Abstract Background: Strongyloidiasis, caused by Strongyloides stercoralis (S. stercoralis), is endemic worldwide, especially in countries with warm and humid climates. Strongyloides stercoralis hyperinfection syndrome (SHS) is an extremely serious manifestation of strongyloidiasis, which results from an acute exacerbation of auto-infection and is often fatal.
    Case presentation: We present a case of SHS mimicking pseudomembranous enteritis with a final definitive diagnosis of a triple infection including S. stercoralis, Escherchia coli (E. coli) and Pneumocytis jirovecii (P. jirovecii) that occurred in a microscopic polyangiitis (MPA) patient after immunosuppressive therapy. SHS, together with E. coli bacteremia and Pneumocytis jirovecii pneumonia (PJP) in the same patient, is rare in clinical practice, which is first reported worldwide, to our knowledge. After the diagnosis was confirmed, the treatment protocol was quickly adjusted; however, the patient's life could not be saved.
    Conclusion: This case reminds us of the necessity to consider strongyloidiasis as a differential diagnosis in immunocompromised populations who live in or have visited to S. stercoralis endemic areas, especially patients with suspected pseudomembranous enteritis, even if stool examination, serological tests, and eosinophilia are negative. For this group, it is advisable to complete the relevant endoscopy and/or PCR as soon as possible. The fundamental solution to prevent this catastrophic outcome is to implement effective preventive measures at multiple levels, including physicians, patients, and relevant authorities.
    MeSH term(s) Animals ; Bacteremia/complications ; Enterocolitis, Pseudomembranous ; Escherichia coli ; Escherichia coli Infections/complications ; Humans ; Immunosuppression Therapy ; Pneumonia, Pneumocystis/complications ; Strongyloides stercoralis ; Strongyloidiasis/complications ; Strongyloidiasis/diagnosis ; Strongyloidiasis/drug therapy ; Syndrome
    Language English
    Publishing date 2022-09-24
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-022-07670-2
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  6. Article ; Online: The hypermethylation of

    Ma, Lu / Fang, Xiaolin / Zhang, Aihua

    Human & experimental toxicology

    2022  Volume 41, Page(s) 9603271221142819

    Abstract: Background and Purpose: ...

    Abstract Background and Purpose:
    MeSH term(s) Humans ; Arsenic Poisoning ; Arsenic ; DNA Methylation ; Biomarkers ; Epigenesis, Genetic ; Forkhead Transcription Factors/genetics
    Chemical Substances Arsenic (N712M78A8G) ; Biomarkers ; Forkhead Transcription Factors ; FOXP3 protein, human
    Language English
    Publishing date 2022-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1027454-6
    ISSN 1477-0903 ; 0144-5952 ; 0960-3271
    ISSN (online) 1477-0903
    ISSN 0144-5952 ; 0960-3271
    DOI 10.1177/09603271221142819
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    Zs.A 1697: Show issues Location:
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  7. Article ; Online: Caries risk assessment-related knowledge, attitude, and behaviors among Chinese dentists: a cross-sectional survey.

    Fang, Xiaolin / Hua, Fang / Chen, Zhi / Zhang, Lu

    Clinical oral investigations

    2022  Volume 27, Issue 3, Page(s) 1079–1087

    Abstract: Objectives: To investigate caries risk assessment (CRA)-related knowledge, attitudes, and practices among dentists in China, to describe their subjective ratings of the significance of specific caries risk factors and to identify factors associated with ...

    Abstract Objectives: To investigate caries risk assessment (CRA)-related knowledge, attitudes, and practices among dentists in China, to describe their subjective ratings of the significance of specific caries risk factors and to identify factors associated with the level of knowledge, attitudes, and use of CRA in routine clinical practice.
    Materials and methods: A cross-sectional anonymous online questionnaire survey was performed. The questionnaire was distributed via WeChat (Tencent, Shenzhen, China) to practicing dentists between November 25 and December 25, 2021. For participant recruitment, we employed purposive and snowball sampling techniques. Data were collected using a specialized web-based survey tool ( www.wjx.cn ) and analyzed with descriptive statistics and regression analyses.
    Results: A total of 826 valid questionnaires were collected. Only 292 (35.4%) respondents used CRA in routine practice, among whom a majority (243, 83.2%) did not use a specific CRA tool. The routine use of CRA was associated with the type of practicing office, attendance of caries-related lectures, the habit of reading caries-related literature, geographic location, and the total knowledge score. The mean total knowledge score was 3.13 (score range: 0 to 6). Knowledge levels were related to several sociodemographic characteristics, including geographic location, the type of practicing office, attendance of caries-related lectures and the habit of reading caries-related literature. The risk factor deemed most important was "current oral hygiene."
    Conclusions: Caries risk assessment has not widely entered clinical practice in China. The level of CRA-related knowledge among dentists was generally suboptimal.
    Clinical relevance: Strengthening CRA-related education may allow practitioners to develop a better understanding of caries risk assessment and hence promote its implementation.
    MeSH term(s) Humans ; Cross-Sectional Studies ; Health Knowledge, Attitudes, Practice ; Dental Caries Susceptibility ; East Asian People ; Risk Assessment ; Dental Caries/etiology ; Surveys and Questionnaires ; Dentists ; Practice Patterns, Dentists'
    Language English
    Publishing date 2022-08-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-022-04694-5
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    Zs.A 4788: Show issues Location:
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  8. Article ; Online: Preparation and evaluation of phytantriol liquid crystal as a liquid embolic agent.

    Fang, Xiaolin / Shen, Aizong

    Pharmaceutical development and technology

    2020  Volume 25, Issue 5, Page(s) 610–616

    Abstract: Transcatheter arterial chemoembolization (TACE) is the preferred treatment for patients with advanced hepatocellular carcinoma (HCC), but it lacks safe and effective embolic agents. 5-Fluorouracil (5-FU) is a broad-spectrum anticancer drug, but its ... ...

    Abstract Transcatheter arterial chemoembolization (TACE) is the preferred treatment for patients with advanced hepatocellular carcinoma (HCC), but it lacks safe and effective embolic agents. 5-Fluorouracil (5-FU) is a broad-spectrum anticancer drug, but its clinical application is limited due to drug resistance and toxic side effects. Therefore, in this study, we developed a new liquid embolic agent with 5-FU as the model drug. We found that this liquid embolic agent possesses good gelling properties and embolic effects. An
    MeSH term(s) Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacokinetics ; Carcinoma, Hepatocellular/therapy ; Cell Line, Tumor ; Cell Survival/drug effects ; Chemoembolization, Therapeutic/methods ; Drug Delivery Systems/methods ; Drug Liberation ; Fatty Alcohols/chemistry ; Fatty Alcohols/pharmacokinetics ; Fluorouracil/administration & dosage ; Fluorouracil/pharmacokinetics ; Liquid Crystals/chemistry ; Liver Neoplasms/therapy ; Rabbits ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Antineoplastic Agents ; Fatty Alcohols ; 3,7,11,15-tetramethyl-1,2,3-hexadecanetriol (8LVI07A72W) ; Fluorouracil (U3P01618RT)
    Language English
    Publishing date 2020-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1331774-x
    ISSN 1097-9867 ; 1083-7450
    ISSN (online) 1097-9867
    ISSN 1083-7450
    DOI 10.1080/10837450.2020.1725046
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    Zs.A 5043: Show issues Location:
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  9. Article ; Online: Relationship between Acute Respiratory Tract Infection and the Serum 25(OH) D3 Level in Chronic Kidney Disease Patients and Its Prevention and Treatment.

    Cai, De-Han / Wang, Jun / Zhong, Aimin / Fang, Xiao-Lin

    publication RETRACTED

    BioMed research international

    2022  Volume 2022, Page(s) 2550686

    Abstract: Observational studies and randomized controlled studies propose that vitamin D plays a significant role in preventing acute respiratory tract infection (RTI); however, results are inconsistent and the optimal serum 25-hydroxyvitamin D (25-OH-D3) ... ...

    Abstract Observational studies and randomized controlled studies propose that vitamin D plays a significant role in preventing acute respiratory tract infection (RTI); however, results are inconsistent and the optimal serum 25-hydroxyvitamin D (25-OH-D3) concentration remains unknown. This study explores the risk factors associated with acute RTI in patients with chronic kidney disease (CKD) and analyzes its correlation with serum 25-OH-D3 levels, to provide appropriate preventive treatment measures for CKD patients complicated with acute RTI. Seventy cases of CKD patients treated in the department of nephrology of Jiangxi Provincial People's Hospital are recruited as the research objects and divided into a control group (CKD without RTI) and an observation group (CKD with RTI), with 35 cases in each group. The laboratory indexes and serum 25-OH-D3 levels are compared between the two groups. The area under the receiver operating characteristic curve (ROC) of 25-OH-D3 in the diagnosis of CKD patients complicated with RTI is 0.892, and the standard error is 0.038. The glomerular filtration rates (GFR) are 48.32 ± 9.87 mL/min and 50.18 ± 20.71 mL/min in the control group and the experimental group, respectively, with no statistical significance between the two groups (
    MeSH term(s) Calcifediol ; Humans ; Receptors, Calcitriol ; Renal Insufficiency, Chronic/complications ; Respiratory Tract Infections/complications ; Vitamin D Deficiency
    Chemical Substances Receptors, Calcitriol ; Calcifediol (P6YZ13C99Q)
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/2550686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A case of triple infection including strongyloides stercoralis in a microscopic polyangiitis patient.

    Cai, De-Han / Wang, Jun / Fang, Xiao-Lin

    Respiratory medicine case reports

    2021  Volume 34, Page(s) 101479

    Abstract: We present the case of a microscopic polyangiitis (MPA) patient who developed strongyloidiasis, ...

    Abstract We present the case of a microscopic polyangiitis (MPA) patient who developed strongyloidiasis,
    Language English
    Publishing date 2021-07-30
    Publishing country England
    Document type Case Reports
    ZDB-ID 2666110-X
    ISSN 2213-0071
    ISSN 2213-0071
    DOI 10.1016/j.rmcr.2021.101479
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