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Article ; Online: Mendelian randomization analysis reveals causal relationship between obstetric-related diseases and COVID-19.

Fang, Yan / Fang, Dajun

2024 Volume 21, Issue 1, Page(s) 73

Abstract: Background: Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women with COVID-19 diagnosis had adverse pregnancy outcomes.: Methods: ... ...

Abstract	Background: Several observational studies demonstrated that pregnant individuals with COVID-19 had a higher risk of preeclampsia and preterm birth. We aimed to determine whether women with COVID-19 diagnosis had adverse pregnancy outcomes. Methods: A two-sample Mendelian randomization (MR) analysis in this study was used to evaluate the casual relationships between COVID-19 infection and obstetric-related diseases based on genome-wide association studies (GWAS) dataset. Inverse-variance weighted (IVW), MR-Egger and MR-PRESSO were used to infer the connection and estimate the pleiotropy respectively. Results: The significant connection was observed between COVID-19 and placental disorders with beta Conclusion: There was no direct causal relationship between COVID-19 infection and maternal and neonatal poor outcomes. Our study could alleviate the anxiety of pregnant women under the COVID-19 pandemic conditions partly.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Humans ; Female ; COVID-19/epidemiology ; COVID-19 Testing ; Genome-Wide Association Study ; Mendelian Randomization Analysis ; Pandemics ; Placenta ; Premature Birth/epidemiology
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-024-02348-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Research on Renewal and Transformation of Smart Building in Luoyang Based on Reducing Energy Usage and Collective Memory

Fang Yan / Litao Zhang

Sustainability, Vol 15, Iss 8592, p

2023 Volume 8592

Abstract: Collective memory is a specific carrier for interpreting historical space and local emotions. With the help of collective memory theory, this paper constructs the industrial heritage system of an old industrial zone. Taking the old industrial area in ... ...

Abstract	Collective memory is a specific carrier for interpreting historical space and local emotions. With the help of collective memory theory, this paper constructs the industrial heritage system of an old industrial zone. Taking the old industrial area in Jianxi District of Luoyang as an example, this paper uses two types of memory representations, the material memory field and spiritual memory field, as the carriers of collective memory. It is divided into 11 types of spatial fields, such as production space, living space, landscape space and spiritual culture, and 76 memory connotations to construct a collective memory classification model of industrial culture. Through the investigation and analysis of the memory of the collective memory subject, it was found that: ① the collective production space is the most impressive. ② The living space is distributed in patches due to celebrity effects; and ③ People are more prominent in the symbolization of collective memory. On the foundations of memory analysis, Take the luoyang bearing factory for example, to research the sustainable development of intelligent and energy-efficient buildings.
Keywords	collective memory ; old industrial area ; renewal strategy ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	900
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Prevalence of Symptomatic Dry Eye Disease Among Coal Workers in Huainan Region of China.

Qiu, Cui / Fang, Yan

International journal of general medicine

2023 Volume 16, Page(s) 203–209

Abstract: Purpose: To investigate the prevalence and influencing factors of symptomatic dry eye disease (DED) in Chinese coal workers.: Methods: The prevalence of symptomatic DED in coal workers was investigated by using the questionnaire of Ocular Surface ... ...

Abstract	Purpose: To investigate the prevalence and influencing factors of symptomatic dry eye disease (DED) in Chinese coal workers. Methods: The prevalence of symptomatic DED in coal workers was investigated by using the questionnaire of Ocular Surface Disease Index (OSDI) and the influencing factors were explored. Results: The prevalence of symptomatic DED was 50.7% in coal workers. Of the influencing factors of symptomatic DED, the level of dust exposure had an odds ratio (OR) of 1.26, the time of dust exposure had an OR of 1.02, and the age had an OR of 1.03. Conclusion: There was a high morbidity of symptomatic DED among coal workers and the level and the time of dust exposure and the age of coal workers had important effects.
Language	English
Publishing date	2023-01-19
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S396670
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The development, feasibility and credibility of intra-abdominal pressure measurement techniques: A scoping review.

Li, ZhiRu / Wang, HuaFen / Lu, FangYan

PloS one

2024 Volume 19, Issue 3, Page(s) e0297982

Abstract: Aim: To provide a comprehensive overview on emerging direct and alternative methods for intra-abdominal pressure (IAP) measurement techniques.: Methods: This was a scoping review study following Arksey and Malley's framework. The PubMed, EMBASE, Web ... ...

Abstract	Aim: To provide a comprehensive overview on emerging direct and alternative methods for intra-abdominal pressure (IAP) measurement techniques. Methods: This was a scoping review study following Arksey and Malley's framework. The PubMed, EMBASE, Web of Science, EBSCO, Scopus and ProQuest databases were searched, and we only considered studies published from 2000 as we have extended the data from two previous reviews. Original studies that reported on the development, feasibility and credibility of IAP measurement techniques were included. Results: Forty-two of 9954 screened articles were included. IAP measurement techniques include three major categories: direct, indirect and less invasive measurement techniques. Agreement analyses were performed in most studies, and some explored the safety, time expenditure and reproducibility of IAP measurement techniques. Conclusions: Clinical data assessing the validation of new IAP measurement techniques or the reliability of established measurement techniques remain lacking. Considering the cost and invasiveness, direct measurement is not recommended as a routine method for IAP measurement and should be preserved for critically ill patients where standard techniques are contraindicated or could be inaccurate. The measurement accuracy, reliability and sensitivity of the transrectal and transfemoral vein methods remain insufficient and cannot be recommended as surrogate IAP measures. Transvesical measurement is the most widely used method, which is the potentially most easy applicable technique and can be used as a reliable method for continuous and intermittent IAP measurement. Wireless transvaginal method facilitates the quantitative IAP measurement during exercise and activity, which laying the foundations for monitoring IAP outside of the clinic environment, but the accuracy of this technique in measuring absolute IAP cannot be determined at present. Less invasive technology will become a new trend to measure IAP and has substantial potential to replace traditional IAP measurement technologies, but further validation and standardization are still needed. Medical professionals should choose appropriate measurement tools based on the advantages and disadvantages of each IAP technique in combination with assessing specific clinical situations.
MeSH term(s)	Humans ; Reproducibility of Results ; Feasibility Studies ; Critical Illness ; Technology ; Abdomen ; Intra-Abdominal Hypertension
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0297982
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Homeostasis Model Assessment for Insulin Resistance Mediates the Positive Association of Triglycerides with Diabetes.

Wang, Yutang / Fang, Yan / Vrablik, Michal

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 7

Abstract: Elevated circulating triglyceride levels have been linked to an increased risk of diabetes, although the precise mechanisms remain unclear. This study aimed to investigate whether low-density lipoprotein (LDL) cholesterol, homeostatic model assessment ( ... ...

Abstract	Elevated circulating triglyceride levels have been linked to an increased risk of diabetes, although the precise mechanisms remain unclear. This study aimed to investigate whether low-density lipoprotein (LDL) cholesterol, homeostatic model assessment (HOMA) for insulin resistance, and C-reactive protein (CRP) served as mediators in this association across a sample of 18,435 US adults. Mediation analysis was conducted using the PROCESS Version 4.3 Macro for SPSS. Simple mediation analysis revealed that all three potential mediators played a role in mediating the association. However, in parallel mediation analysis, where all three mediators were simultaneously included, HOMA for insulin resistance remained a significant mediator (indirect effect coefficient, 0.47; 95% confidence interval [CI], 0.43-0.52;
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14070733
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Article ; Online: Fasting status modifies the association between triglyceride and all-cause mortality: A cohort study.

Fang, Yan / Wang, Yutang

Health science reports

2022 Volume 5, Issue 3, Page(s) e642

Abstract: Background and aims: Both fasting and non-fasting levels of triglyceride have been shown positively associated with all-cause mortality. It is unknown whether fasting status modifies this association. This study aimed to address this question.: ... ...

Abstract	Background and aims: Both fasting and non-fasting levels of triglyceride have been shown positively associated with all-cause mortality. It is unknown whether fasting status modifies this association. This study aimed to address this question. Methods: This study included 34,512 US adults (27,036 fasting and 7476 nonfasting participants). All-cause mortality was ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios of triglyceride for mortality. Results: This cohort was followed up for a mean of 13.0 years. During the follow-up, 8491 all-cause deaths were recorded. A 1-natural-log-unit increase in triglyceride was associated with an 8% higher multivariate-adjusted risk of all-cause mortality. Interaction analyses showed that fasting status interacted with triglyceride in predicting all-cause mortality. Sub-analyses showed that a 1-natural-log-unit increase in triglyceride was associated with a 17% higher multivariate-adjusted risk of all-cause mortality in the nonfasting subcohort; however, there lacked such an association in the fasting sub-cohort. Similarly, high (200-499 mg/dL) and very high levels of triglyceride (≥500 mg/dL) were associated with higher all-cause mortality risks compared with low normal triglyceride (<100 mg/dL) only in the nonfasting subcohort. Conclusion: This study found that, compared to fasting triglyceride, nonfasting triglyceride was more sensitive in predicting all-cause mortality. This study supports the initiatives by some guidelines to recommend the use of nonfasting triglycerides for risk assessment.
Language	English
Publishing date	2022-05-16
Publishing country	United States
Document type	Journal Article
ISSN	2398-8835
ISSN (online)	2398-8835
DOI	10.1002/hsr2.642
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Corrigendum: Comparison of Ceramic-on-Ceramic vs. Ceramic-on-Polyethylene for Primary Total Hip Arthroplasty: A Meta-Analysis of 15 Randomized Trials.

Fang, Yan / Shang, Xiaobin

Frontiers in surgery

2022 Volume 9, Page(s) 876080

Abstract: This corrects the article DOI: 10.3389/fsurg.2021.751121.]. ...

Abstract	[This corrects the article DOI: 10.3389/fsurg.2021.751121.].
Language	English
Publishing date	2022-03-14
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.876080
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Article ; Online: Comprehensive analysis of placental gene-expression profiles and identification of EGFR-mediated autophagy and ferroptosis suppression in intrahepatic cholestasis of pregnancy.

Fang, Yan / Fang, Dajun

Gene

2022 Volume 834, Page(s) 146594

Abstract: Intrahepatic cholestasis of pregnancy (ICP) was the most common liver disease specific to pregnancy. The symptoms of ICP were maternal pruritus and increased bile acid level in serum which was related to preterm birth, fetal distress, meconium-stained ... ...

Abstract	Intrahepatic cholestasis of pregnancy (ICP) was the most common liver disease specific to pregnancy. The symptoms of ICP were maternal pruritus and increased bile acid level in serum which was related to preterm birth, fetal distress, meconium-stained amniotic fluid and stillbirth. However, the mechanism of ICP progression on fetal development remained obscure. Sequencing data of 2 normal placenta samples and 4 intrahepatic cholestasis samples during pregnancy was analyzed by GEO2R. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used for analysis of differentially expressed genes. MCODE - A plug-in of Cytoscape was used for molecular complex detection. STRING, Cytoscape, GeneMANIA, NetworkAnalyst, TransmiR, JASPAR, DGIdb and DrugBank were used in this study. Furthermore, histopathological and cell experiments were used to verify our results. Our study identified the key KEGG pathway and four MCODEs which were closely with ICP development, further, sorted by degree centrality, we showed top 30 genes from 7209 differential genes, such as TP53, SRC, EGFR, ESR1, IL10, CD8A, MAPK3, PTPRC, EGF, KIT, ITGAM, LEP and CSF2, etc. Moreover, these hub genes participated in JAK-STAT3 signaling pathway and STAT1/3 regulated these genes expression in a direct way or miRNA-mediated manner. Drug-target analysis about up-regulated genes among hub genes showed that these genes contained multiple drug action site. Furthermore, hub gene-EGFR was associated with destroyed autophagy and ferroptosis. In conclusion, our study analyzed key genes and pathways in ICP development. JAK-STAT3 pathway and EGFR might be a potential target for ICP therapy.
MeSH term(s)	Autophagy/genetics ; Cholestasis, Intrahepatic/genetics ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Female ; Ferroptosis ; Humans ; Infant, Newborn ; Placenta/metabolism ; Pregnancy ; Pregnancy Complications/genetics ; Premature Birth
Chemical Substances	EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2022-05-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2022.146594
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Article ; Online: Late non-fasting plasma glucose predicts cardiovascular mortality independent of hemoglobin A1c.

Wang, Yutang / Fang, Yan

Scientific reports

2022 Volume 12, Issue 1, Page(s) 7778

Abstract: It is unknown whether non-fasting plasma glucose (PG) is associated with cardiovascular disease (CVD) mortality. This study aimed to investigate this association in US adults. This study included adults from the National Health and Nutrition Examination ... ...

Abstract	It is unknown whether non-fasting plasma glucose (PG) is associated with cardiovascular disease (CVD) mortality. This study aimed to investigate this association in US adults. This study included adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. Mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of PG for CVD mortality. Among 34,907 participants, 1956, 5564, and 27,387 had PG from participants in early non-fasting, late non-fasting, and fasting states, respectively (defined as a period since last calorie intake of 0-2.9, 3.0-7.9, or ≥ 8.0 h, respectively). This cohort was followed up for 455,177 person-years (mean follow-up, 13.0 years), with 2,387 CVD deaths being recorded. After adjustment for all confounders including hemoglobin A1c (HbA1c), only late non-fasting PG (continuous, natural log-transformed) was positively associated with CVD mortality risks (hazard ratio, 1.73; 95% confidence interval 1.12-2.67). Higher late non-fasting PG (dichotomous, at a cut-off of 105, 110, or 115 mg/dL) was associated with higher CVD mortality risks. In addition, at the cut-off of 115 mg/dL, higher late non-fasting PG was associated with higher CVD mortality risks in those with either a normal (< 5.7%) or prediabetic HbA1c level (from 5.7 to 6.4%). In conclusion, late non-fasting PG predicts CVD mortality independent of HbA1c. Late non-fasting PG with a cut-off of 115 mg/dL may be used to identify those at high CVD risk.
MeSH term(s)	Adult ; Blood Glucose ; Cardiovascular Diseases ; Fasting ; Glycated Hemoglobin A/analysis ; Humans ; Prediabetic State ; Risk Factors
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A
Language	English
Publishing date	2022-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-12034-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Three-dimensional mesenchymal stem cell laden scaffold of icariin sustained-release for bone regeneration.

Liu, Yanbing / Fang, Yan

Turkish journal of biology = Turk biyoloji dergisi

2022 Volume 46, Issue 5, Page(s) 414–425

Abstract: Background/aim: Icariin (ICA)-loaded zein/PLGA nanofiber membrane combined with MSCs was prepared by coaxial electrospinning and bioelectrospraying.: Materials and methods: SEM and TEM were used to evaluate the surface morphology and microstructure ... ...

Abstract	Background/aim: Icariin (ICA)-loaded zein/PLGA nanofiber membrane combined with MSCs was prepared by coaxial electrospinning and bioelectrospraying. Materials and methods: SEM and TEM were used to evaluate the surface morphology and microstructure of the fiber membrane. Ultraviolet spectrophotometry was used to detect drug release. A LIVE/DEAD Viability/Cytotoxicity Kit and fluorescence staining were used to detect cell morphology and activity. Alkaline phosphatase and calcium mineralization deposition were used to evaluate the osteoinductive activity of the scaffold. Dynamic mechanical analysis was used to determine the Young's modulus, maximum load, and maximum elongation of the prepared scaffold. Western blot was used to detect the related protein expression in MSCs induced by drug-loaded scaffolds. Results: Good mechanical properties and stability were observed in the prepared drug-loaded scaffolds. SEM showed that there were a considerable number of MSCs dispersed in the scaffold. MSCs were evenly distributed, could grow evenly between fibers, and were arranged orderly along the fibers. Sustained release of ICA confers cell laden scaffold higher ALP activity and ECM mineral deposition through Runx2, OPN and OCN pathways. Conclusion: Isotropic sustained release of ICA grant cell laden scaffolds rapid bone regeneration compacity which can provide a good osteogenic environment for loaded MSCs.
Language	English
Publishing date	2022-09-02
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2046470-8
ISSN	1303-6092 ; 1303-6092
ISSN (online)	1303-6092
ISSN	1303-6092
DOI	10.55730/1300-0152.2627
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