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Article ; Online: Cuproptosis: A potential therapeutic target in clear cell renal cell carcinoma.

Zhao, Yuetong / Li, Jie / Lu, Xiaojie / Wu, Shuang / Xing, Yunze / Fang, Yaxuan / Yang, Bo

2024

Language	English
Publishing date	2024-04-12
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000003076
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Article ; Online: Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins.

Lan, Qiumei / Li, Jie / Zhang, Hanqing / Zhou, Zijun / Fang, Yaxuan / Yang, Bo

Journal of molecular medicine (Berlin, Germany)

2024

Abstract: Autosomal dominant polycystic kidney disease is a genetic kidney disease caused by mutations in the genes PKD1 or PKD2. Its course is characterized by the formation of progressively enlarged cysts in the renal tubules bilaterally. The basic genetic ... ...

Abstract	Autosomal dominant polycystic kidney disease is a genetic kidney disease caused by mutations in the genes PKD1 or PKD2. Its course is characterized by the formation of progressively enlarged cysts in the renal tubules bilaterally. The basic genetic explanation for autosomal dominant polycystic kidney disease is the double-hit theory, and many of its mechanistic issues can be explained by the cilia doctrine. However, the precise molecular mechanisms underpinning this condition's occurrence are still not completely understood. Experimental evidence suggests that aquaporins, a class of transmembrane channel proteins, including aquaporin-1, aquaporin-2, aquaporin-3, and aquaporin-11, are involved in the mechanism of autosomal dominant polycystic kidney disease. Aquaporins are either a potential new target for the treatment of autosomal dominant polycystic kidney disease, and further study into the physiopathological role of aquaporins in autosomal dominant polycystic kidney disease will assist to clarify the disease's pathophysiology and increase the pool of potential treatment options. We primarily cover pertinent findings on aquaporins in autosomal dominant polycystic kidney disease in this review.
Language	English
Publishing date	2024-04-26
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1223802-8
ISSN	1432-1440 ; 0946-2716
ISSN (online)	1432-1440
ISSN	0946-2716
DOI	10.1007/s00109-024-02446-4
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Article: High-efficiency depolymerization/degradation of polyethylene terephthalate plastic by a whole-cell biocatalyst.

Fang, Yaxuan / Chao, Kexin / He, Jin / Wang, Zhiguo / Chen, Zhenming

3 Biotech

2023 Volume 13, Issue 5, Page(s) 138

Abstract: Polyethylene terephthalate (PET) is the most abundantly produced plastic due to its excellent performance, but is also the primary source of poorly degradable plastic pollution. The development of environment-friendly PET biodegradation is attracting ... ...

Abstract	Polyethylene terephthalate (PET) is the most abundantly produced plastic due to its excellent performance, but is also the primary source of poorly degradable plastic pollution. The development of environment-friendly PET biodegradation is attracting increasing interest. The leaf-branch compost cutinase mutant ICCG (F243I/D238C/S283C/Y127G) exhibits the best hydrolytic activity and thermostability of all known PET hydrolases. However, its superior PET degradation is highly dependent on its preparation as a purified enzyme, which critically reduces its industrial utility. Herein, we report the use of rational design and combinatorial mutagenesis to develop a novel ICCG mutant RITK (D53R/R143I/D193T/E208K) that demonstrated excellent whole-cell biocatalytic activity. Whole cells expressing RITK showed an 8.33-fold increase in biocatalytic activity compared to those expressing ICCG. Thermostability was also improved. After reacting at 85 °C for 3 h, purified RITK exhibited a 12.75-fold increase in depolymerization compared to ICCG. These results will greatly enhance the industrial utility of PET hydrolytic enzymes and further the progress of PET recycling. Supplementary information: The online version contains supplementary material available at 10.1007/s13205-023-03557-4.
Language	English
Publishing date	2023-04-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-023-03557-4
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Article ; Online: Exploring the relations of NLR, hsCRP and MCP-1 with type 2 diabetic kidney disease: a cross-sectional study.

Fang, Yaxuan / Wang, Bin / Pang, Bo / Zhou, Zijun / Xing, Yunze / Pang, Pai / Zheng, Dingyuan / Zhang, Gang / Yang, Bo

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3211

Abstract: Type 2 diabetic kidney disease (T2DKD) is a common microvascular complication of type 2 diabetes mellitus (T2DM), and its incidence is significantly increasing. Microinflammation plays an important role in the development of T2DKD. Based on this, this ... ...

Abstract	Type 2 diabetic kidney disease (T2DKD) is a common microvascular complication of type 2 diabetes mellitus (T2DM), and its incidence is significantly increasing. Microinflammation plays an important role in the development of T2DKD. Based on this, this study investigated the value of inflammatory markers including neutrophil-lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1) in the prediction of T2DKD. This was a cross-sectional survey study. A total of 90 patients with T2DM, who were hospitalized in the nephrology and endocrinology departments of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from June 2021 to January 2022, were included and divided into three groups (A1, A2, A3) according to the urinary albumin-to-creatinine ratio (UACR). Observe and compare the basic information, clinical and laboratory data, and the inflammatory markers NLR, hs-CRP, MCP-1. Results revealed that high levels of NLR (OR = 6.562, 95% CI 2.060-20.902, P = 0.001) and MCP-1 (OR = 1.060, 95% CI 1.026-1.095, P < 0.001) were risk factors in the development of T2DKD. Receiver operating characteristic curve analysis showed that the area under curve of NLR and MCP-1 in diagnosing T2DKD were 0.760 (95% CI 0.6577-0.863, P < 0.001) and 0.862 (95% CI 0.7787-0.937, P < 0.001). Therefore, the inflammatory markers NLR and MCP-1 are risk factors affecting the development of T2DKD, which of clinical value may be used as novel markers of T2DKD.
MeSH term(s)	Humans ; C-Reactive Protein/analysis ; Chemokine CCL2/urine ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetic Nephropathies/urine ; Lymphocytes/chemistry ; Neutrophils/chemistry ; Retrospective Studies ; ROC Curve
Chemical Substances	C-Reactive Protein (9007-41-4) ; Chemokine CCL2 ; CCL2 protein, human ; CRP protein, human
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53567-2
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Article ; Online: Influence of Family-Learned Fear-of-Pain on Patients.

Fang, Yaxuan / Shi, Lei / Qin, Fang / Li, Ting / Zhang, Xishun / Li, Manman

Pain management nursing : official journal of the American Society of Pain Management Nurses

2023 Volume 25, Issue 1, Page(s) 11–18

Abstract: Background: Fear-of-pain is a common feeling of patients and their family who experience or witness severe or chronic pain. Fear-of-pain may disturb patient's recovery, and also influence family support to assist patients' recovery.: Aim: This study ... ...

Abstract	Background: Fear-of-pain is a common feeling of patients and their family who experience or witness severe or chronic pain. Fear-of-pain may disturb patient's recovery, and also influence family support to assist patients' recovery. Aim: This study is to measure the level of family support for each patient; evaluate the extent of the supporting families' fear-of-pain; and identify possible interventions in family support and family fear-of-pain. Methods: This cross-sectional descriptive research involved 77 participants in the orthopedics department of a tertiary hospital by convenience sampling. The online questionnaire includes general information, and scales of fear-of-pain, pain anxiety, pain vigilance and awareness, pain catastrophizing, and family support. T-test, Pearson correlation analysis and Spearman correlation analysis were used to analyze data. Results: Most participants reported that they experienced a moderate-to-high level of fear-of-pain, pain anxiety, pain vigilance and awareness. A total of 15.6% of participants are at risk of pain catastrophizing. The family's pain vigilance and awareness, and fear-of-pain were often similar to those of the patient, and their levels of pain anxiety and catastrophizing were often higher than the patient's. Family support and families' fear-of-pain affect patients' feelings of pain and families' behavior in decision-making for patient recovery, necessitating the development of interventions for patients' families. Conclusions: Family members can develop the fear-of-pain from witnessing painful experiences and may exhibit fear-avoidance behaviors in deciding on patients' rehabilitation plan. Family support, including the type of relationship with families, and length of time family spent with the patient, had an effect on patients' pain and fear-of-pain.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Fear ; Anxiety ; Emotions ; Chronic Pain ; Catastrophization ; Surveys and Questionnaires
Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2213260-0
ISSN	1532-8635 ; 1524-9042
ISSN (online)	1532-8635
ISSN	1524-9042
DOI	10.1016/j.pmn.2023.04.003
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Zs.MO 514: Show issues

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Article ; Online: Management capacity to promote nurse workplace health and safety.

Fang, Yaxuan / McDonald, Tracey

Journal of nursing management

2018 Volume 26, Issue 3, Page(s) 288–294

Abstract: Purpose: To investigate regarding workplace health and safety factors, and to identify strategies to preserve and promote a healthy nursing workplace.: Methods: Data collected using the Delphi technique with input from 41 key informants across four ... ...

Abstract	Purpose: To investigate regarding workplace health and safety factors, and to identify strategies to preserve and promote a healthy nursing workplace. Methods: Data collected using the Delphi technique with input from 41 key informants across four participant categories drawn from a Chinese university and four hospitals were thematically analysed. Results: Most respondents agreed on the importance of nurses' health and safety, and that nurse managers should act to protect nurses, but not enough on workplace safety. Hospital policies, staff disempowerment, workload and workplace conflicts are major obstacles. Conclusion: The reality of Chinese nurses' workplaces is that health and safety risks abound and relate to socio-cultural expectations of women. Self-management of risks is neccessary, gaps exist in understanding of workplace risks among different nursing groups and their perceptions of the professional status, and the value of nurses' contribution to ongoing risks in the hospital workplace. The Chinese hospital system must make these changes to produce a safer working environment for nurses. Implications for nursing management: This research, based in China, presents an instructive tale for all countries that need support on the types and amounts of management for nurses working at the clinical interface, and on the consequences of management neglect of relevant policies and procedures.
MeSH term(s)	Attitude of Health Personnel ; China ; Delphi Technique ; Humans ; Nurse Administrators/standards ; Nurse Administrators/trends ; Nurses/psychology ; Occupational Health/standards ; Perception ; Surveys and Questionnaires ; Workload ; Workplace/standards
Language	English
Publishing date	2018-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1162321-4
ISSN	1365-2834 ; 0966-0429
ISSN (online)	1365-2834
ISSN	0966-0429
DOI	10.1111/jonm.12544
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Article ; Online: Recent Understanding and Future Directions in the Application of MMP-2 in Encapsulating Peritoneal Sclerosis Clinical Practice.

Fang, Yaxuan / Chen, Xin / Zhong, Ke / Ni, Qingying / He, Zhenyang / Qiao, Yanheng / Zhao, Yanru / Li, Jie / Yang, Hongtao / Yang, Bo

Blood purification

2023 Volume 52, Issue 4, Page(s) 359–365

Abstract: Encapsulating peritoneal sclerosis (EPS) is an uncommon and harmful complication which may cause destructive outcomes. Matrix metalloproteinase-2 (MMP-2) as a protease can reduce constituents of the extracellular matrix and play a crucial role in the ... ...

Abstract	Encapsulating peritoneal sclerosis (EPS) is an uncommon and harmful complication which may cause destructive outcomes. Matrix metalloproteinase-2 (MMP-2) as a protease can reduce constituents of the extracellular matrix and play a crucial role in the progression of EPS. As a new biomarker, MMP-2 may improve the detection rate of EPS patients in clinical work. In this review, we summarize the recent study of MMP-2 in different etiologies and the assessment of its application value and draw attention to its future directions.
MeSH term(s)	Humans ; Peritoneal Fibrosis/etiology ; Matrix Metalloproteinase 2 ; Peritoneal Dialysis/adverse effects ; Biomarkers ; Peritoneum/pathology
Chemical Substances	Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Biomarkers
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	605548-5
ISSN	1421-9735 ; 0253-5068
ISSN (online)	1421-9735
ISSN	0253-5068
DOI	10.1159/000528001
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Article ; Online: Pain relief during wound care for patients with a deep open wound in an orthopedic trauma department: a best practice implementation project.

Fang, Yaxuan / Wang, Ning / Shi, Lei / Barker, Timothy / Zhang, Ping

JBI database of systematic reviews and implementation reports

2019 Volume 17, Issue 12, Page(s) 2559–2569

Abstract: Objectives: The aim of this project was to implement best practice in pain relief during wound care for patients with deep open wounds in the orthopedic trauma department of a tertiary teaching hospital in China.: Introduction: Patients with deep ... ...

Abstract	Objectives: The aim of this project was to implement best practice in pain relief during wound care for patients with deep open wounds in the orthopedic trauma department of a tertiary teaching hospital in China. Introduction: Patients with deep open wounds often suffer from severe pain during wound care. Inadequate pain relief for these patients calls for evidence-based changes to close the gap between current and best practice. Methods: The current quality improvement project was carried out over six months using the JBI Practical Application of Clinical Evidence System (JBI PACES). A baseline and two follow-up audits of wound pain management practice were conducted to identify practice gaps and post implementation compliance in pain management in wound care. The sample comprised 20 patients and two dressing nurses. The Getting Research into Practice tool identified barriers to and strategies for improvement in practice. The patients' pain experiences were measured following the implementation of changes. Results: The baseline audit identified poor compliance with best practice. Following implementation of the recommended changes, some significant improvements in practice were made by the dressing nurses; however, these were inadequately maintained at the second post implementation audit. Patients' pain scores improved following the nurses' practice changes (t = 2.272, P > 0.05). Conclusion: The implementation of best practice in pain relief during wound care for patients with deep open wounds has led to significant improvement in nurses' performance in the orthopedic trauma department. The most challenging barriers involved interdisciplinary collaborations and organizational structure.
MeSH term(s)	China ; Evidence-Based Practice/methods ; Evidence-Based Practice/standards ; Guideline Adherence/statistics & numerical data ; Health Plan Implementation ; Hospitals, Teaching/standards ; Humans ; Pain Management/methods ; Pain Management/standards ; Practice Guidelines as Topic ; Tertiary Care Centers/standards ; Trauma Centers/standards ; Wounds and Injuries/therapy
Language	English
Publishing date	2019-08-05
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2202-4433
ISSN (online)	2202-4433
DOI	10.11124/JBISRIR-D-19-00126
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Article: Nurse educators perceptions of simulation teaching in Chinese context: benefits and barriers.

Luo, Dan / Yang, Bing-Xiang / Liu, Qian / Xu, Aijing / Fang, Yaxuan / Wang, Ailing / Yu, Sihong / Li, Ting

PeerJ

2021 Volume 9, Page(s) e11519

Abstract: Background: Although simulated teaching was introduced to China in the 1990s, it remains underused in nursing education. Determining how Chinese nurse educators feel about using simulation in their institutions is very important for faculty training and ...

Abstract	Background: Although simulated teaching was introduced to China in the 1990s, it remains underused in nursing education. Determining how Chinese nurse educators feel about using simulation in their institutions is very important for faculty training and has the potential to influence simulation implementation. Method: This cross-sectional descriptive study was undertaken to identify the nurse educators' experiences in the use of simulation from various regions of China. One hundred and thirty-six nurse educators provided demographic data and information about simulation implementation within their institutions and explored the perceived barriers and benefits of simulation usage. Results: The survey data shows that 108 participants have used simulation in their work, but less than 92 (67.6%) of the respondents had used this teaching strategy more than ten times in last year. The study identified four factors hindering nurse faculty from simulation adoption: (1) concerns with student readiness; (2) the need for faculty team-building for simulation teaching; (3) lack of adequate simulation resources; and (4) thoughtful integration of simulation into nursing curricula. Conclusions: Study data suggest that faculty training programs for simulation should be based on the nurse educators' training needs, including systematically designed training topics, and the provision of hands-on learning simulation activities with expert feedback to help nurse educators achieve the competencies required for effective simulation-based education.
Language	English
Publishing date	2021-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.11519
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Article ; Online: Nurse staffing, missed care, quality of care and adverse events: A cross-sectional study.

Nantsupawat, Apiradee / Poghosyan, Lusine / Wichaikhum, Orn-Anong / Kunaviktikul, Wipada / Fang, Yaxuan / Kueakomoldej, Supakorn / Thienthong, Hunsa / Turale, Sue

Journal of nursing management

2021 Volume 30, Issue 2, Page(s) 447–454

Abstract: Aim: This study aimed to illustrate the relationship between nurse staffing and missed care, and how missed care affects quality of care and adverse events in Thai hospitals.: Background: Quality and safety are major priorities for health care system. ...

Abstract	Aim: This study aimed to illustrate the relationship between nurse staffing and missed care, and how missed care affects quality of care and adverse events in Thai hospitals. Background: Quality and safety are major priorities for health care system. Nurse staffing and missed care are associated with low quality of care and adverse events. However, examination of this relationship is limited in Thailand. Methods: This cross-sectional study collected data from 1188 nurses in five university hospitals across Thailand. The participants completed questionnaires that assessed the patient-to-nurse ratio, adequacy of staffing, missed care, quality of care and adverse events. Logistic regression models were used to estimate associations. Results: Higher patient-to-nurse ratio, poor staffing and lack of resource adequacy were significantly associated with higher odds of reporting missed care. Higher nurse-reported missed care was significantly associated with higher odds of adverse events and poor quality of care. Conclusions: Poor nurse staffing was associated with missed care, and missed care was associated with adverse events and lower quality of care in Thai university hospitals. Implications for nursing management: Improving nurse staffing and assuring adequate resources are recommended to reduce missed care and adverse events and increase quality of care.
MeSH term(s)	Cross-Sectional Studies ; Humans ; Nursing Staff, Hospital ; Personnel Staffing and Scheduling ; Quality of Health Care ; Workforce
Language	English
Publishing date	2021-11-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1162321-4
ISSN	1365-2834 ; 0966-0429
ISSN (online)	1365-2834
ISSN	0966-0429
DOI	10.1111/jonm.13501
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