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  1. Article ; Online: Correction to: Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia.

    Chen, Yue / Pan, Mengge / Chen, Lanxin / Peng, Miaoxin / Liu, Zhenyu / Fang, Yiran / Du, Ying / Yang, Yonggong / Xu, Peipei

    Annals of hematology

    2024  Volume 103, Issue 5, Page(s) 1801

    Language English
    Publishing date 2024-03-26
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-024-05675-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Identification of a novel fusion gene, RARA::ANKRD34C, in acute promyelocytic leukemia.

    Chen, Yue / Pan, Mengge / Chen, Lanxin / Peng, Miaoxin / Liu, Zhenyu / Fang, Yiran / Du, Ying / Yang, Yonggong / Xu, Peipei

    Annals of hematology

    2024  Volume 103, Issue 4, Page(s) 1181–1185

    Abstract: Acute promyelocytic leukemia (APL) is a specific subtype of acute myeloid leukemia that is distinguished by the chromosomal translocation t(15;17)(q24;q21), which leads to the fusion of the promyelocytic leukemia (PML) gene with the retinoic acid ... ...

    Abstract Acute promyelocytic leukemia (APL) is a specific subtype of acute myeloid leukemia that is distinguished by the chromosomal translocation t(15;17)(q24;q21), which leads to the fusion of the promyelocytic leukemia (PML) gene with the retinoic acid receptor alpha (RARA). Recently, we identified a novel fusion gene in APL, RARA::ankyrin repeat domain 34C (ANKRD34C), identified its functions by morphological, cytogenetic, molecular biological and multiplex fluorescence in situ hybridization analyses, and demonstrated the potential therapeutic effect clinically and experimentally of all-trans retinoic acid (ATRA); the findings have important implications for the diagnosis and treatment of atypical APL.
    MeSH term(s) Humans ; Leukemia, Promyelocytic, Acute/diagnosis ; Leukemia, Promyelocytic, Acute/genetics ; Leukemia, Promyelocytic, Acute/drug therapy ; In Situ Hybridization, Fluorescence ; Tretinoin/therapeutic use ; Retinoic Acid Receptor alpha/genetics ; Carrier Proteins/genetics ; Translocation, Genetic ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism
    Chemical Substances Tretinoin (5688UTC01R) ; Retinoic Acid Receptor alpha ; Carrier Proteins ; Oncogene Proteins, Fusion
    Language English
    Publishing date 2024-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-024-05629-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.181: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Overcoming the blood-brain barrier by using a multistage exosome delivery system to inhibit central nervous system lymphoma.

    Liu, Xu / Xia, Tian / Fang, Yiran / Zuo, Huaqin / Dong, Xiaoqing / Xu, Peipei / Ouyang, Jian

    Nanomedicine : nanotechnology, biology, and medicine

    2022  Volume 41, Page(s) 102523

    Abstract: Due to the presence of blood-brain barrier (BBB), various chemotherapy drugs against B-cell lymphoma cannot be effectively transmitted into the brain, leading to poor prognosis of primary central nervous system lymphoma (PCNSL). Exosomes can cross the ... ...

    Abstract Due to the presence of blood-brain barrier (BBB), various chemotherapy drugs against B-cell lymphoma cannot be effectively transmitted into the brain, leading to poor prognosis of primary central nervous system lymphoma (PCNSL). Exosomes can cross the BBB as a bio- and immune-compatible drug carrier. In this study, we developed a novel drug delivery system, in which the exosomes (Exo) are conjugated with anti-CD22 monoclonal antibody fragments (CD22-F(ab')
    MeSH term(s) Animals ; Blood-Brain Barrier ; Doxorubicin ; Endothelial Cells ; Exosomes ; Immunoglobulin Fab Fragments ; Lymphoma/drug therapy ; Lymphoma/pathology ; Mice
    Chemical Substances Immunoglobulin Fab Fragments ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2022-01-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2183417-9
    ISSN 1549-9642 ; 1549-9634
    ISSN (online) 1549-9642
    ISSN 1549-9634
    DOI 10.1016/j.nano.2022.102523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Variation in Organ Biomass with Changing Climate and Forest Characteristics across Chinese Forests

    Fang, Yiran / Zou, Xiaojun / Lie, Zhiyang / Xue, Li

    Forests. 2018 Aug. 29, v. 9, no. 9

    2018  

    Abstract: Forest biomass allocation patterns are important for understanding global carbon cycling and climate change, which might change with environmental conditions and forest characteristics. However, the effects of climate and forest characteristics on ... ...

    Abstract Forest biomass allocation patterns are important for understanding global carbon cycling and climate change, which might change with environmental conditions and forest characteristics. However, the effects of climate and forest characteristics on biomass allocation fractions (the fraction of total forest biomass distributed in organs) remains unknown. The authors use a large Chinese biomass dataset (1081 forests encompassing 10 forest types) to analyse the responses of biomass allocation fractions to biogeography, climate, and forest characteristics. The authors found that the stem mass fraction significantly increased with age and precipitation and significantly decreased with latitude and temperature. The branch mass fraction significantly decreased with age and density, but significantly increased with temperature and latitude. The leaf mass fraction significantly decreased with age and precipitation and significantly increased with temperature. The root mass fraction significantly increased with latitude and density, and significantly decreased with precipitation. The results suggest that latitude, temperature, precipitation, stand age and density are good predictors of biomass partitioning. These findings support the hypotheses that variation in resource availability constrains organ allocation and provides biogeographically explicit relationships between biomass allocation and both environmental and forest characteristics, which might be used for assessing the impact of changing environmental and forest characteristics on forest carbon dynamics and fixation.
    Keywords biogeography ; biomass ; carbon ; carbon cycle ; climate ; climate change ; data collection ; dry matter partitioning ; environmental factors ; forest types ; latitude ; leaf mass ; stand age ; temperature
    Language English
    Dates of publication 2018-0829
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527081-3
    ISSN 1999-4907
    ISSN 1999-4907
    DOI 10.3390/f9090521
    Database NAL-Catalogue (AGRICOLA)

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