LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Neochlorogenic Acid Combined with Bone Marrow Mesenchymal Stem Cells Encapsulated into GelMA Hydrogel for Transplantation to Repair Intervertebral Disk Degeneration.

    Fang, Yuekun / Hu, Jie / Zou, Yang / Wang, Zhichen / Ye, Yuchen / Zhang, Changchun

    Biomacromolecules

    2024  Volume 25, Issue 2, Page(s) 729–740

    Abstract: Intervertebral disk degeneration is a common disease with an unknown etiology. Currently, tissue engineering is considered to be an important method for intervertebral disk repair. Although transplanted stem cells may disrupt the repair process because ... ...

    Abstract Intervertebral disk degeneration is a common disease with an unknown etiology. Currently, tissue engineering is considered to be an important method for intervertebral disk repair. Although transplanted stem cells may disrupt the repair process because of apoptosis caused by the oxidative microenvironment. Herein, bone marrow mesenchymal stem cell (BMSC) and Neochlorogenic acid (Ncg) were encapsulated into a GelMA hydrogel as a carrier to protect transplanted stem cells. Ncg effectively inhibited the oxidative stress process and reduced the apoptosis rate. A 5% GelMA hydrogel had a large pore size and porosity that provided an enhanced survival space for cells. An in vivo assessment showed that treatment with GelMA + BMSC + Ncg produced greater repair of degenerated intervertebral disks than that found in other model groups. Thus, this study may help contribute to improving stem cell transplantation for treating intervertebral disk degeneration.
    MeSH term(s) Humans ; Intervertebral Disc Degeneration/therapy ; Hydrogels/pharmacology ; Intervertebral Disc ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells ; Bone Marrow Cells ; Chlorogenic Acid/analogs & derivatives ; Quinic Acid/analogs & derivatives
    Chemical Substances Hydrogels ; 5'-O-caffeoylquinic acid (O4601UER1Z) ; Chlorogenic Acid (318ADP12RI) ; Quinic Acid (058C04BGYI)
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c00923
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: Salvianolic acid B combined with bone marrow mesenchymal stem cells piggybacked on HAMA hydrogel re-transplantation improves intervertebral disc degeneration.

    Hu, Jie / Li, Cai / Jin, Shichang / Ye, Yuchen / Fang, Yuekun / Xu, Panpan / Zhang, Changchun

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 950625

    Abstract: Cell-based tissue engineering approaches have emerged as a realistic alternative for regenerative disc tissue repair. The multidirectional differentiation potential of bone marrow mesenchymal stem cells (BMSCs) to treat disc degeneration intervertebral ... ...

    Abstract Cell-based tissue engineering approaches have emerged as a realistic alternative for regenerative disc tissue repair. The multidirectional differentiation potential of bone marrow mesenchymal stem cells (BMSCs) to treat disc degeneration intervertebral disc degeneration has also become a viable option. We used 1% HAMA hydrogel as a carrier and co-encapsulated BMSCs and Salvianolic acid B (SalB) into the hydrogel to reduce the apoptosis of the transplanted cells. The protective effect of SalB on BMSCs was first verified
    Language English
    Publishing date 2022-09-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.950625
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: High-multiplex single-cell imaging analysis reveals tumor immune contexture associated with clinical outcomes after CAR T cell therapy.

    Jin, Jin / Lin, Li / Meng, Jiao / Jiang, Lijun / Zhang, Man / Fang, Yuekun / Liu, Wanying / Xin, Xiangke / Long, Xiaolu / Kuang, Dong / Ding, Xilai / Zheng, Miao / Zhang, Yicheng / Xiao, Yi / Chen, Liting

    Molecular therapy : the journal of the American Society of Gene Therapy

    2024  Volume 32, Issue 5, Page(s) 1252–1265

    Abstract: Chimeric antigen receptor (CAR) T cell therapy has made great progress in treating lymphoma, yet patient outcomes still vary greatly. The lymphoma microenvironment may be an important factor in the efficacy of CAR T therapy. In this study, we designed a ... ...

    Abstract Chimeric antigen receptor (CAR) T cell therapy has made great progress in treating lymphoma, yet patient outcomes still vary greatly. The lymphoma microenvironment may be an important factor in the efficacy of CAR T therapy. In this study, we designed a highly multiplexed imaging mass cytometry (IMC) panel to simultaneously quantify 31 biomarkers from 13 patients with relapsed/refractory diffuse large B cell lymphoma (DLBCL) who received CAR19/22 T cell therapy. A total of 20 sections were sampled before CAR T cell infusion or after infusion when relapse occurred. A total of 35 cell clusters were identified, annotated, and subsequently redefined into 10 metaclusters. The CD4
    MeSH term(s) Humans ; Immunotherapy, Adoptive/methods ; Tumor Microenvironment/immunology ; Lymphoma, Large B-Cell, Diffuse/therapy ; Lymphoma, Large B-Cell, Diffuse/immunology ; Single-Cell Analysis/methods ; Receptors, Chimeric Antigen/metabolism ; Receptors, Chimeric Antigen/immunology ; Female ; Male ; Treatment Outcome ; Middle Aged ; Adult ; Biomarkers, Tumor ; Aged
    Chemical Substances Receptors, Chimeric Antigen ; Biomarkers, Tumor
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2024.03.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Biomechanical evaluation of lumbar spondylolysis repair with various fixation options: A finite element analysis.

    Ye, Yuchen / Jin, Shichang / Zou, Yang / Fang, Yuekun / Xu, Panpan / Zhang, Zhili / Wu, Nan / Zhang, Changchun

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 1024159

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.1024159
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: [Tongjingling improves sperm DNA integrity and reduces oxidative stress in the testis of experimental varicocele rats].

    DU, Bao-Xin / Zheng, Jun-Zhuang / Liu, Bing / Tao, Fang-Ze / Fang, Yue-Kun / Xu, Wen-Li / Cui, Yun

    Zhonghua nan ke xue = National journal of andrology

    2018  Volume 23, Issue 11, Page(s) 1025–1031

    Abstract: Objective: To explore the protective effect of Tongjingling (TJL) against sperm DNA damage and oxidative stress in the rat model of experimental varicocele (EVC).: Methods: We randomly divided 75 Wistar male rats into five groups of equal number: ... ...

    Abstract Objective: To explore the protective effect of Tongjingling (TJL) against sperm DNA damage and oxidative stress in the rat model of experimental varicocele (EVC).
    Methods: We randomly divided 75 Wistar male rats into five groups of equal number: sham operation, EVC model, high-dose TJL, mid-dose TJL, and low-dose TJL. The EVC model was established in the rats by partial ligation of the left renal vein, followed by 8 weeks of medication from the 4th week after modeling. Then we observed the general status of the rats, detected the sperm DNA fragmentation index (DFI) in the epididymis by sperm chromatin structure assay (SCSA), and measured the content of hydroperoxide (H2O2) and the activities of catalase (CAT) and superoxide dismutase (SOD) in the testis by colorimetry.
    Results: Compared with the sham operation group, the EVC models showed significantly increased sperm DFI in the epididymis (P <0.01) and elevated level of H2O2 and activities of CAT and SOD in the testis (P <0.01). In comparison with the EVC models, the rats of the TJL groups exhibited remarkably reduced sperm DFI and H2O2 content, but increased activities of SOD and CAT.
    Conclusions: TJL can improve sperm DNA integrity by increasing the activities of SOD and CAT and reducing the H2O2 level and hence oxidative stress in the testis tissue.
    MeSH term(s) Animals ; Catalase/analysis ; DNA/drug effects ; DNA Fragmentation ; Drugs, Chinese Herbal/pharmacology ; Epididymis/chemistry ; Humans ; Hydrogen Peroxide/analysis ; Ligation ; Male ; Oxidative Stress ; Random Allocation ; Rats ; Rats, Wistar ; Spermatozoa ; Superoxide Dismutase/analysis ; Testis/chemistry ; Testis/drug effects ; Varicocele/etiology ; Varicocele/genetics ; Varicocele/metabolism
    Chemical Substances Drugs, Chinese Herbal ; DNA (9007-49-2) ; Hydrogen Peroxide (BBX060AN9V) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1)
    Language Chinese
    Publishing date 2018-03-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6577: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top